TWAS
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Genes
Traits
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Traits
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Arm fat-free mass (right)
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chr5:36,410,564-38,450,430
Best TWAS P=3.09e-12 · Best GWAS P=8.28e-16 conditioned to 3.18e-05
36.5M
37M
37.5M
38M
38.5M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
C5orf42
0.04
0.05
lasso
3
0.04
0.0011
-7.2
7.0
3.1e-12
-0.92
0.00
0.94
TRUE
1
GTEx
Cells Transformed fibroblasts
WDR70
0.06
0.03
lasso
8
0.03
0.0035
-5.5
6.0
2.2e-09
-0.72
0.38
0.42
FALSE
2
GTEx
Whole Blood
C5orf42
0.07
0.00
enet
16
0.01
0.0183
-8.1
5.7
1.4e-08
-0.68
0.01
0.88
FALSE