Best TWAS P=1.25e-18 · Best GWAS P=7.38e-16 conditioned to 0.056
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | RP11-250B2.6 | 0.16 | 0.05 | lasso | 6 | 0.06 | 7.8e-04 | 6.7 | -7.1 | 1.3e-12 | -0.57 | 0.21 | 0.46 | FALSE |
2 | GTEx | Brain Cerebellum | RP11-250B2.5 | 0.43 | 0.11 | lasso | 5 | 0.14 | 4.7e-05 | -7.2 | -7.4 | 1.8e-13 | -0.76 | 0.08 | 0.82 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | RP11-250B2.6 | 0.21 | 0.03 | enet | 37 | 0.13 | 4.7e-05 | 5.1 | -6.6 | 3.5e-11 | -0.23 | 0.14 | 0.08 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | BCKDHB | 0.16 | 0.02 | enet | 42 | 0.04 | 3.7e-04 | 4.4 | 7.9 | 3.2e-15 | 0.49 | 0.24 | 0.65 | FALSE |
5 | GTEx | Colon Transverse | RP11-250B2.5 | 0.13 | 0.02 | enet | 3 | 0.01 | 6.3e-02 | -2.4 | -5.2 | 2.1e-07 | -0.61 | 0.06 | 0.49 | TRUE |
6 | GTEx | Esophagus Mucosa | RP11-250B2.6 | 0.20 | 0.16 | lasso | 7 | 0.23 | 3.3e-15 | -7.1 | -7.0 | 2.1e-12 | -0.65 | 0.84 | 0.16 | FALSE |
7 | GTEx | Heart Atrial Appendage | RP11-250B2.6 | 0.20 | 0.00 | enet | 17 | 0.03 | 2.6e-02 | -4.0 | -8.8 | 1.3e-18 | -0.41 | 0.05 | 0.47 | TRUE |
8 | GTEx | Heart Left Ventricle | RP11-250B2.6 | 0.09 | 0.00 | enet | 6 | 0.02 | 2.0e-02 | 7.3 | -7.1 | 1.4e-12 | -0.82 | 0.05 | 0.70 | FALSE |
9 | GTEx | Lung | RP11-250B2.6 | 0.09 | 0.05 | enet | 16 | 0.07 | 5.3e-06 | 4.4 | -6.7 | 1.9e-11 | -0.36 | 0.78 | 0.09 | FALSE |
10 | GTEx | Muscle Skeletal | RP11-250B2.6 | 0.07 | 0.04 | lasso | 5 | 0.04 | 4.2e-05 | 7.7 | -7.9 | 2.1e-15 | -0.94 | 0.02 | 0.98 | FALSE |
11 | GTEx | Nerve Tibial | BCKDHB | 0.18 | 0.11 | lasso | 9 | 0.10 | 2.4e-07 | 5.1 | 5.1 | 2.7e-07 | 0.15 | 1.00 | 0.00 | FALSE |
12 | GTEx | Testis | RP11-250B2.5 | 0.13 | 0.17 | lasso | 3 | 0.14 | 7.0e-07 | -7.1 | -6.9 | 5.0e-12 | -0.88 | 0.03 | 0.96 | FALSE |
13 | GTEx | Thyroid | BCKDHB | 0.17 | 0.06 | lasso | 8 | 0.10 | 3.4e-08 | 4.4 | 6.1 | 1.3e-09 | 0.46 | 0.98 | 0.02 | FALSE |
14 | METSIM | Adipose | RP11-250B2.6 | 0.04 | 0.04 | lasso | 12 | 0.02 | 1.7e-04 | 7.1 | -6.2 | 6.0e-10 | -0.60 | 0.62 | 0.18 | FALSE |
15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BCKDHB | 0.12 | 0.06 | lasso | 4 | 0.06 | 4.2e-07 | 6.3 | -5.8 | 7.0e-09 | -0.75 | 0.45 | 0.54 | FALSE |