Best TWAS P=2.06e-08 · Best GWAS P=2.94e-08 conditioned to 0.0204
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | RAC1 | 0.19 | 0.07 | enet | 28 | 0.09 | 6.2e-07 | 4.8 | 5.2 | 1.5e-07 | 0.56 | 0.15 | 0.84 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | DAGLB | 0.09 | 0.06 | lasso | 5 | 0.06 | 4.8e-08 | 5.4 | -5.3 | 9.6e-08 | -0.83 | 0.01 | 0.99 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RAC1 | 0.03 | 0.02 | enet | 7 | 0.02 | 6.8e-05 | 4.5 | 5.6 | 2.1e-08 | 0.69 | 0.07 | 0.85 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RAC1 | 0.08 | 0.02 | blup | 63 | 0.06 | 7.0e-07 | 4.0 | 5.1 | 2.7e-07 | 0.28 | 0.23 | 0.75 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | DAGLB | 0.06 | 0.02 | blup | 71 | 0.03 | 7.4e-04 | 4.8 | -5.2 | 1.5e-07 | -0.70 | 0.01 | 0.76 | FALSE |