Best TWAS P=7.99e-11 · Best GWAS P=7.47e-11 conditioned to 0.33
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Spleen | NFATC4 | 0.45 | 0.00 | enet | 24 | 0.00 | 2.5e-01 | 4.0 | -5.6 | 1.6e-08 | -0.22 | 0.07 | 0.06 | TRUE |
| 2 | METSIM | Adipose | ADCY4 | 0.07 | 0.03 | lasso | 5 | 0.03 | 2.2e-05 | 6.1 | 6.5 | 8.0e-11 | 0.71 | 0.04 | 0.96 | TRUE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADCY4 | 0.06 | 0.06 | lasso | 6 | 0.09 | 3.0e-10 | 5.5 | 6.3 | 2.7e-10 | 0.75 | 0.05 | 0.95 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADCY4 | 0.07 | 0.09 | lasso | 3 | 0.08 | 4.4e-10 | 4.2 | 5.3 | 1.1e-07 | 0.73 | 0.83 | 0.17 | FALSE |
| 5 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LTB4R2 | 0.04 | 0.04 | lasso | 1 | 0.02 | 2.5e-02 | 5.1 | -5.1 | 2.6e-07 | -0.70 | 0.04 | 0.54 | FALSE |