Best TWAS P=9.95e-10 · Best GWAS P=5.73e-08 conditioned to 0.2
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | SLC51A | 0.15 | 0.08 | enet | 9 | 0.13 | 7.8e-08 | 4.2 | -5.4 | 6.3e-08 | -0.75 | 0.02 | 0.97 | FALSE |
2 | GTEx | Artery Coronary | SLC51A | 0.18 | 0.03 | enet | 8 | 0.05 | 8.8e-03 | 4.2 | -5.1 | 3.1e-07 | -0.61 | 0.04 | 0.70 | FALSE |
3 | GTEx | Artery Tibial | SLC51A | 0.28 | 0.17 | lasso | 9 | 0.21 | 4.3e-16 | 5.0 | -5.7 | 1.5e-08 | -0.86 | 0.01 | 0.98 | FALSE |
4 | GTEx | Breast Mammary Tissue | PCYT1A | 0.11 | 0.03 | lasso | 3 | 0.00 | 3.9e-01 | 5.4 | -5.5 | 3.2e-08 | -0.96 | 0.01 | 0.89 | FALSE |
5 | GTEx | Breast Mammary Tissue | SLC51A | 0.28 | 0.06 | lasso | 6 | 0.14 | 1.3e-07 | 4.2 | -6.0 | 1.8e-09 | -0.58 | 0.02 | 0.97 | FALSE |
6 | GTEx | Breast Mammary Tissue | UBXN7 | 0.20 | 0.00 | enet | 16 | 0.02 | 3.5e-02 | -4.3 | -5.6 | 2.3e-08 | -0.65 | 0.03 | 0.86 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | SLC51A | 0.30 | 0.22 | lasso | 4 | 0.24 | 5.0e-18 | 4.2 | -5.8 | 7.7e-09 | -0.66 | 0.43 | 0.52 | FALSE |
8 | GTEx | Esophagus Muscularis | SLC51A | 0.39 | 0.35 | lasso | 6 | 0.38 | 3.4e-24 | 4.2 | -5.3 | 1.1e-07 | -0.64 | 0.50 | 0.43 | FALSE |
9 | GTEx | Heart Atrial Appendage | SLC51A | 0.27 | 0.11 | lasso | 4 | 0.15 | 2.9e-07 | 4.2 | -5.8 | 7.2e-09 | -0.70 | 0.03 | 0.96 | FALSE |
10 | GTEx | Nerve Tibial | SLC51A | 0.26 | 0.12 | lasso | 7 | 0.22 | 1.9e-15 | 4.2 | -5.7 | 1.6e-08 | -0.73 | 0.04 | 0.95 | FALSE |
11 | GTEx | Skin Not Sun Exposed Suprapubic | SLC51A | 0.17 | 0.04 | enet | 11 | 0.01 | 5.7e-02 | 4.2 | -5.4 | 8.1e-08 | -0.46 | 0.05 | 0.55 | FALSE |
12 | GTEx | Stomach | SLC51A | 0.13 | 0.06 | enet | 12 | 0.03 | 1.9e-02 | 4.9 | -6.0 | 2.1e-09 | -0.86 | 0.01 | 0.96 | FALSE |
13 | GTEx | Thyroid | PCYT1A | 0.09 | 0.01 | enet | 16 | 0.01 | 7.7e-02 | 4.2 | -5.1 | 2.8e-07 | -0.79 | 0.02 | 0.93 | FALSE |
14 | GTEx | Thyroid | SLC51A | 0.17 | 0.06 | enet | 17 | 0.06 | 1.9e-05 | 4.9 | -5.2 | 2.0e-07 | -0.78 | 0.02 | 0.98 | FALSE |
15 | YFS | Blood | PCYT1A | 0.04 | 0.02 | lasso | 5 | 0.03 | 1.6e-09 | 4.9 | -5.3 | 1.3e-07 | -0.78 | 0.03 | 0.96 | FALSE |
16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | OSTalpha | 0.11 | 0.05 | blup | 52 | 0.10 | 1.4e-11 | 4.9 | -5.6 | 2.4e-08 | -0.79 | 0.01 | 0.99 | FALSE |
17 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PCYT1A | 0.08 | 0.03 | enet | 10 | 0.05 | 2.1e-03 | 4.9 | -5.2 | 2.2e-07 | -0.66 | 0.02 | 0.68 | FALSE |
18 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PCYT1A | 0.12 | 0.05 | blup | 68 | 0.06 | 2.0e-04 | 5.0 | -6.1 | 9.9e-10 | -0.75 | 0.01 | 0.90 | TRUE |