TWAS hub - OSTalpha

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.115	0.0377	2.3e-10	0.053	0.101	0.085	NA	0.087	1.1e-06	1.4e-11	6.2e-10	NA	4.5e-10
2	TCGA	Pheochromocytoma and Paraganglioma	0.237	0.0720	5.0e-07	0.269	0.161	0.239	NA	0.260	3.6e-11	5.9e-07	6.4e-10	NA	8.6e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Knee pain experienced in last month	5.2	8.1	10.0	-2.5	-3.2
Smoking status: Previous	4.7	7.0	8.1	-2.9	-2.4
Arm predicted mass (right)	4.5	23.2	31.1	-5.6	-3.9
Bilateral oophorectomy (both ovaries removed)	4.2	4.9	6.6	-2.6	-1.8
Mother’s age at death	4.2	5.2	8.3	1.5	2.9
Neck or shoulder pain in last month	4.1	5.8	6.2	-2.5	-2.3
Frequency of depressed mood in last 2 weeks	4.0	5.5	6.3	-2.5	-2.2
Leg pain on walking	4.0	5.0	5.6	-2.4	-2.1
Pain type(s) experienced in last month: Hip pain	4.0	5.1	6.1	-2.0	-2.5
Arm fat-free mass (left)	3.9	19.9	26.8	-5.2	-3.6
Arm fat-free mass (right)	3.8	19.3	27.4	-5.2	-3.4
Weight	3.7	18.0	25.4	-5.0	-3.2
Hip circumference	3.6	15.4	19.9	-4.5	-3.3
Ever highly irritable/argumentative for 2 days	3.6	4.4	4.8	-2.2	-2.0
Leg fat mass (right)	3.6	14.0	20.3	-4.5	-2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.6	4.3	4.9	-2.2	-1.9
Mood swings	3.6	6.5	9.6	-3.1	-1.8
Leg fat-free mass (left)	3.5	18.5	23.4	-4.8	-3.7
Leg predicted mass (left)	3.5	18.6	23.4	-4.8	-3.7
Past tobacco smoking	3.5	6.4	8.4	2.9	2.1
Ever smoked	3.5	6.1	7.4	-2.7	-2.2
Leg fat mass (left)	3.5	13.8	20.4	-4.5	-2.7
Arm predicted mass (left)	3.4	17.5	23.4	-4.8	-3.4
Eye problems/disorders: None of the above	3.3	3.8	7.6	-0.2	-2.8
Basal metabolic rate	3.3	18.3	24.2	-4.9	-3.5
Depression (Nagel 2018)	3.2	4.8	6.6	-2.6	-1.7
Smoking Status	3.2	7.7	8.8	-3.0	-2.6
Whole body fat mass	3.2	13.2	18.5	-4.3	-2.8
Whole body fat-free mass	3.2	18.5	23.8	-4.9	-3.6
Whole body water mass	3.1	17.8	23.0	-4.8	-3.6
Qualifications: CSEs or equivalent	3.0	4.0	5.4	-1.6	-2.3
Trunk fat mass	3.0	13.1	17.9	-4.2	-2.9
Trunk predicted mass	3.0	17.2	22.3	-4.7	-3.5
Leg fat-free mass (right)	3.0	16.1	20.7	-4.6	-3.4
Leg predicted mass (right)	3.0	16.2	20.8	-4.6	-3.4
Pain experienced in last month	3.0	5.0	5.0	2.2	2.2
Waist circumference	2.9	10.7	16.4	-4.0	-2.2
Trunk fat-free mass	2.9	16.4	21.4	-4.6	-3.4
Body mass index (BMI)	2.8	11.9	19.0	-4.4	-2.2
Alcohol intake versus 10 years previously	2.8	4.2	5.4	-2.3	-1.7
Arm fat mass (right)	2.8	11.7	17.1	-4.1	-2.5
Age at First Birth	2.6	3.8	4.9	1.6	2.2
Average weekly spirits intake	2.6	3.2	5.8	-2.4	-0.8
Arm fat mass (left)	2.6	10.8	16.1	-4.0	-2.3
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	3.2	-1.7	-1.8
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	5.8	-0.6	-2.4
Illnesses of father: High blood pressure	2.4	2.9	4.9	2.2	1.0
Impedance of arm (left)	2.3	10.5	16.2	4.0	2.2
Depressed Affect (Nagel 2018)	2.2	4.7	5.9	-2.4	-1.9
Leg fat percentage (right)	2.1	7.5	11.6	-3.4	-1.8
Shortness of breath walking on level ground	2.1	2.5	2.9	-1.7	-1.5
Unable to work because of sickness or disability	2.1	2.7	3.4	-1.4	-1.9
Alcohol intake frequency.	2.0	4.7	7.1	-2.7	-1.5
Medication: Paracetamol	2.0	3.1	3.6	-1.6	-1.9
Bipolar Disorder or Schizophrenia	1.9	4.6	6.6	-1.6	-2.6
BMI	1.9	11.3	18.7	-4.3	-2.0
Impedance of arm (right)	1.9	9.0	15.4	3.9	1.6
Qualifications: O levels/GCSEs or equivalent	1.9	3.1	4.9	2.2	1.1
Leg fat percentage (left)	1.9	6.9	10.9	-3.3	-1.7
Body fat percentage	1.8	6.9	10.3	-3.2	-1.9
Medication for pain relief, constipation, heartburn	1.8	3.1	5.0	2.2	1.1
Qualifications: nursing, teaching	1.8	2.7	3.6	1.9	1.4
Medication: Lisinopril	1.8	2.3	2.3	1.5	1.5
Schizophrenia (2018)	1.7	3.5	4.7	-1.5	-2.2
Diabetes (father)	1.7	2.0	2.7	1.6	1.2
Trunk fat percentage	1.7	6.6	9.7	-3.1	-1.9
Alcohol usually taken with meals	1.7	2.7	2.8	1.6	1.7
Back pain experienced in last month	1.7	2.4	3.1	-1.3	-1.8
Impedance of whole body	1.7	8.6	13.1	3.6	2.0
Schizophrenia (2014)	1.6	3.6	5.8	-1.2	-2.4
Fed-up feelings	1.6	3.0	3.9	-2.0	-1.4
Time employed in main current job	1.6	1.8	2.7	1.7	1.0
Eye problems/disorders: Cataract	1.6	1.9	3.6	-0.4	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	2.2	-1.5	-1.3
Miserableness	1.6	2.8	5.1	-2.3	-0.8
Financial situation satisfaction	1.6	1.9	2.5	1.2	1.6
Pack years of smoking	1.6	2.3	4.2	-2.1	-0.6
Major Depression (MDD)	1.5	1.8	2.1	-1.3	-1.4
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	2.6	-1.6	-0.8
Severe depression (siblings)	1.5	1.7	3.4	-0.3	-1.8
Pack years adult smoking proportion	1.5	2.3	3.9	-2.0	-0.8
Depression (self-reported)	1.5	1.8	3.1	-0.8	-1.8
Length of working week for main job	1.5	1.6	2.7	0.8	1.6
Exposure to tobacco smoke at home	1.5	1.6	2.1	-1.1	-1.5
Heart disease (mother)	1.5	1.8	2.0	-1.3	-1.4
Irritability	1.5	2.5	3.9	-2.0	-1.0
Medication: Metformin	1.4	2.0	2.2	-1.3	-1.5
Chronic bronchitis/emphysema (father)	1.4	1.7	2.7	0.8	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	4.3	-2.1	-1.5
Qualifications: A levels/AS levels or equivalent	1.4	3.2	5.7	2.4	0.8
Peak expiratory flow (PEF)	1.4	3.2	4.8	-2.2	-1.2
High blood pressure (siblings)	1.4	2.0	3.1	1.0	1.8
Illnesses of siblings: Diabetes	1.4	1.7	2.5	-1.6	-0.9
Alzheimer’s Disease (in mother)	1.3	1.5	2.4	1.5	0.8
Verbal and Numeric Reasoning (VNR)	1.3	3.2	3.7	1.9	1.7
Crohns Disease (2012)	1.3	2.0	3.7	1.9	0.6
Systolic Blood Pressure	1.3	6.8	11.3	3.4	1.5
Lung FVC	1.3	6.8	9.0	3.0	2.1
Sitting height	1.3	9.2	11.8	-2.6	-3.4
Arm fat percentage (right)	1.3	5.2	8.0	-2.8	-1.5
Medication: Paracetamol	1.3	2.2	2.4	-1.4	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	1.9	-1.4	-1.1
Arm fat percentage (left)	1.3	5.0	8.1	-2.8	-1.4
Alzheimer’s Disease (including proxy)	1.2	1.7	3.1	1.7	0.6
Ulcerative Colitis (UC)	1.2	2.3	4.6	-0.1	-2.1
Ovarian Cancer	1.2	1.6	3.2	-1.8	0.1
Lupus	1.2	1.8	3.5	0.5	1.9
Hand grip strength (left)	1.2	3.2	4.1	-2.0	-1.5
Ever had hysterectomy (womb removed)	1.2	1.4	1.9	-1.4	-0.9
Medication: Ventolin 100micrograms inhaler	1.2	1.6	2.4	-1.5	-0.9
Average weekly red wine intake	1.2	1.8	2.4	1.6	1.1
Medication: Atorvastatin	1.2	1.5	1.6	1.3	1.2
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.2	0.8	1.5
Fractured/broken bones in last 5 years	1.2	1.6	2.2	-1.5	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	1.6	-1.3	-1.2
Intelligence (Savage-Jansen 2018)	1.1	3.5	4.0	1.7	2.0
Impedance of leg (left)	1.1	5.3	7.7	2.8	1.7
Blood clot in the leg (DVT)	1.1	1.5	1.5	-1.2	-1.2
Health satisfaction	1.1	1.4	2.6	-0.5	-1.6
Medication: Seretide 50 evohaler	1.1	1.3	1.7	-1.3	-1.0
Long-standing illness, disability or infirmity	1.1	1.7	2.9	-0.7	-1.7
Commuting to job workplace: Cycle	1.1	1.3	2.3	1.5	0.5
Supplements: Calcium	1.1	1.2	1.4	-1.0	-1.2
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.1	0.9	1.4
Schizophrenia vs Biploar Disorder	1.0	1.3	2.0	-0.8	-1.4
Fasting Glucose	1.0	1.2	2.2	-0.3	-1.5
HbA1C	1.0	1.2	2.2	-1.5	-0.3
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.2	-1.5	-0.5
Heart attack	1.0	1.2	1.8	0.8	1.3
Glaucoma (self-reported)	1.0	1.2	2.0	-0.6	1.4
Number of full brothers	1.0	1.2	1.5	-1.2	-1.0
Eye problems/disorders: Glaucoma	1.0	1.2	1.6	-0.9	1.3
Alzheimer’s Disease (in father)	0.9	1.0	1.9	1.4	0.3
Triglycerides	0.9	1.5	1.5	-1.2	-1.2
Blood Eosinophil Count	0.9	7.2	11.4	-3.4	-1.7
Number of treatments/medications taken	0.9	1.6	2.9	-1.7	-0.6
Current tobacco smoking	0.9	1.4	2.3	-1.5	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	2.0	-1.4	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	2.8	-1.7	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	1.9	-1.1	-1.4
Falls in the last year	0.9	1.2	1.4	-1.2	-1.0
Pulse rate	0.9	1.5	2.9	-0.2	-1.7
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	2.3	-1.0	-1.5
Age at first live birth	0.9	1.6	3.2	1.8	0.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	2.3	1.5	0.8
Bipolar Disorder (2018)	0.8	1.2	1.9	-0.7	-1.4
Irritable Bowel Disease (IBD)	0.8	2.0	3.6	0.5	-1.9
Prostate Cancer	0.8	1.1	1.1	1.0	1.1
Impedance of leg (right)	0.8	3.9	6.1	2.5	1.3
Hand grip strength (right)	0.8	2.1	3.4	-1.8	-0.9
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.7	1.3	0.5
Qualifications: None of the above	0.8	1.8	2.6	-1.6	-1.0
Hair/balding pattern: Pattern 3	0.8	1.2	1.7	0.8	1.3
Prospective memory result	0.8	1.0	2.0	-0.0	-1.4
Angina	0.7	0.9	1.0	-1.0	0.9
Had other major operations	0.7	0.8	0.8	0.9	0.9
Mouth/teeth dental problems	0.7	1.1	2.2	-1.5	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.7	1.5	0.2	1.2
Medication: Lansoprazole	0.7	0.8	0.9	-0.9	-0.9
Birth weight of first child	0.7	1.2	1.3	-1.1	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.1	1.1	0.8
Overall health rating	0.7	1.5	2.1	-0.9	-1.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	0.9	-0.8	-0.9
Alcohol drinker status: Previous	0.7	0.9	1.5	-0.4	-1.2
Rheumatoid Arthritis	0.6	0.9	1.7	-1.3	-0.1
Hearing difficulty/problems: Yes	0.6	0.9	1.5	0.6	1.2
Taking other prescription medications	0.6	0.9	1.1	-1.0	-0.8
Nervous feelings	0.6	1.1	2.2	1.5	0.3
Illnesses of siblings	0.6	0.9	1.8	-0.1	-1.3
Noisy workplace	0.6	0.8	0.8	-0.9	-0.9
Pulse wave Arterial Stiffness index	0.6	0.7	0.9	-0.6	-1.0
Standing height	0.6	6.3	7.1	-2.3	-2.7
Birth weight	0.6	1.3	1.8	-0.9	-1.3
Wheeze or whistling in the chest in last year	0.6	1.0	1.7	-1.3	-0.6
Mean time to correctly identify matches	0.6	1.1	2.0	0.4	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	0.9	-1.0	-0.8
Illnesses of father: Heart disease	0.6	0.8	0.9	-0.9	-0.9
Loneliness, isolation	0.6	0.8	1.2	1.1	0.6
Ever taken oral contraceptive pill	0.6	0.7	1.3	-0.0	-1.2
Alcohol drinker status: Never	0.6	0.7	0.9	-0.9	-0.8
Average weekly beer plus cider intake	0.6	0.8	0.9	-1.0	-0.8
Basal cell carcinoma (self-reported)	0.6	0.7	1.0	-1.0	-0.7
Reaction Time	0.5	1.0	1.3	0.9	1.2
LDL Cholesterol	0.5	0.7	1.3	-0.4	-1.1
Blood Red Count	0.5	4.6	9.1	-3.0	0.3
Allergy or Eczema	0.5	1.3	1.7	1.3	0.9
Hypothyroidism (self reported)	0.5	1.1	1.2	-1.0	-1.1
Chronotype (morning person)	0.5	1.1	1.3	1.1	-1.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.5	0.7	0.7
Number of incorrect matches in round	0.5	0.8	1.2	0.6	1.1
Had menopause	0.5	0.6	0.9	-1.0	0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	0.1	-1.1
Angina (self-reported)	0.5	0.7	0.9	-0.9	0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.2	1.1	-0.2
Commuting to job workplace: Walk	0.5	0.5	0.9	0.9	0.4
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	-1.1	-0.2
Age started oral contraceptive pill	0.5	0.6	0.8	0.7	0.9
Myopia	0.5	0.7	1.1	-1.1	-0.4
Neuroticism (Nagel 2018)	0.4	0.9	1.1	-0.8	-1.1
Neuroticism (2016)	0.4	0.5	1.1	0.0	-1.0
Blood Platelet Count	0.4	5.2	9.6	3.1	0.9
Sensitivity / hurt feelings	0.4	0.7	1.3	-1.1	-0.3
Supplements: Zinc	0.4	0.5	0.7	-0.5	-0.8
Hayfever, allergic rhinitis or eczema	0.4	0.8	0.8	0.9	0.9
Supplements: Glucosamine	0.4	0.5	0.6	-0.8	-0.6
Medication: Ramipril	0.4	0.5	0.9	-1.0	-0.1
Medication: Cholesterol lowering	0.4	0.7	0.7	0.8	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.2	-1.1	-0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	0.8	-0.9	-0.8
Pulse wave peak to peak time	0.4	0.5	0.7	0.6	0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.0	1.0	-0.2
Asthma (self-reported)	0.4	0.8	1.6	-0.2	-1.3
Osteoporosis (self-reported)	0.4	0.4	0.5	-0.6	0.7
Smoking status: Current	0.4	0.6	1.1	-1.1	-0.2
Worry (Nagel 2018)	0.3	0.6	1.1	1.1	0.3
Breast Cancer	0.3	0.7	1.1	1.0	0.5
Ulcerative Colitis	0.3	0.4	0.5	0.7	-0.6
Heel T-Score	0.3	2.6	3.2	1.4	1.8
Height	0.3	6.7	10.3	-3.2	-1.8
Lung FEV1/FVC ratio	0.3	1.5	1.8	-1.4	1.1
Neuroticism	0.3	0.7	0.9	-0.9	-0.8
Relative age voice broke	0.3	0.5	0.7	0.5	0.8
High blood pressure	0.3	0.8	1.4	-0.3	-1.2
Medication: Levothyroxine sodium	0.3	0.6	0.6	-0.7	-0.8
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	0.9	0.0
Financial difficulties in last 2 years	0.3	0.5	0.7	-0.8	-0.5
Neuroticism score	0.3	0.6	0.6	-0.7	-0.8
Father’s age at death	0.3	0.4	0.6	-0.4	-0.8
Asthma	0.3	0.6	1.3	-0.0	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	-0.9	0.3
Illnesses of mother	0.3	0.4	0.8	-0.9	-0.1
Medication: Amlodipine	0.3	0.4	0.5	0.7	-0.5
Comparative body size at age 10	0.3	0.8	1.4	-1.2	-0.4
Qualifications: College or University degree	0.3	0.9	1.7	1.3	0.1
Medication: Ibuprofen	0.3	0.4	0.7	-0.8	0.3
Had major operations	0.3	0.3	0.6	-0.3	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.7	-0.3
Friendships satisfaction	0.3	0.3	0.6	0.7	0.3
Osteoarthritis (self-reported)	0.3	0.4	0.5	0.7	-0.5
Guilty feelings	0.3	0.5	0.8	-0.4	-0.9
Wears glasses or contact lenses	0.3	0.4	0.5	-0.4	0.7
Hearing aid user	0.3	0.4	0.6	-0.4	0.8
Number of operations (self-reported)	0.3	0.4	0.8	-0.9	-0.3
Crohns Disease (2017)	0.2	0.5	0.7	0.8	-0.4
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	-0.6	-0.3
Mean Putamen Volume	0.2	0.3	0.5	0.7	0.0
HDL Cholesterol	0.2	0.3	0.3	-0.5	-0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.3	0.6
Respiratory disease	0.2	0.4	0.7	-0.0	-0.8
Relative age of first facial hair	0.2	0.5	0.8	-0.9	-0.4
Medication for hormone replacement therapy	0.2	0.3	0.5	-0.7	-0.1
Average weekly fortified wine intake	0.2	0.2	0.3	-0.5	-0.3
Maternal smoking around birth	0.2	0.3	0.7	-0.8	-0.0
Serious illness, injury or assault to yourself	0.2	0.3	0.3	-0.6	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.4	-0.4	-0.6
Allergy	0.2	0.4	0.8	0.1	0.9
Fluid intelligence score	0.2	0.4	0.6	0.6	0.8
Happiness	0.2	0.2	0.4	0.7	0.1
Mouth/teeth dental problems: Dentures	0.2	0.4	0.6	0.8	0.5
Tense / ‘highly strung’	0.2	0.3	0.4	0.6	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.3	-0.6	0.4
Exposure to tobacco smoke outside home	0.2	0.2	0.4	-0.2	-0.6
Worry too long after embarrassment	0.2	0.3	0.5	0.7	0.1
Emphysema/chronic bronchitis	0.2	0.3	0.3	-0.5	-0.5
Medication: Omeprazole	0.2	0.2	0.4	-0.6	0.3
Pulse rate, automated reading	0.2	0.8	1.6	-0.1	-1.3
Comparative height size at age 10	0.2	0.9	1.8	-1.4	-0.2
Age at last live birth	0.2	0.3	0.3	0.6	-0.6
Supplements: Vitamin C	0.2	0.3	0.4	-0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.8	-0.1	-0.9
Diabetes diagnosed by doctor	0.2	0.2	0.3	-0.6	-0.4
Medication: Gliclazide	0.2	0.2	0.3	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.5	-0.5	0.7
Risk taking	0.2	0.2	0.3	-0.5	-0.4
Ever depressed for a whole week	0.2	0.3	0.6	0.8	-0.2
Cholesterol lowering medication	0.2	0.2	0.4	0.2	0.6
Blood White Count	0.1	0.5	0.7	0.8	0.5
Waist Hip Ratio (WHR)	0.1	0.3	0.4	0.4	0.6
Cardiovascular Disease	0.1	0.4	0.5	0.6	-0.7
Hair Pigment	0.1	1.6	2.9	-1.7	-0.5
Tanning	0.1	0.9	1.0	0.9	1.0
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	-0.4	-0.3
Age when periods started (menarche)	0.1	0.1	0.2	0.2	-0.4
Medication: Atenolol	0.1	0.1	0.2	-0.0	-0.4
High blood pressure (mother)	0.1	0.1	0.3	0.5	-0.0
Hearing difficulty/problems with background noise	0.1	0.2	0.2	-0.4	-0.5
Pain all over the body in last month	0.1	0.1	0.2	-0.2	-0.5
Diabetes (self-reported)	0.1	0.2	0.3	-0.6	-0.2
Worrier / anxious feelings	0.1	0.1	0.2	0.0	-0.5
Number of live births	0.1	0.1	0.2	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.3	-0.6	-0.4
Pulse wave reflection index	0.1	0.1	0.2	-0.1	0.4
Loud music exposure frequency	0.1	0.1	0.2	0.1	-0.5
Medication: Blood pressure	0.1	0.3	0.3	0.5	0.6
Migraine (self-reported)	0.1	0.1	0.2	0.4	-0.2
Suffer from ‘nerves’	0.1	0.1	0.1	-0.4	-0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.2	0.4
Hypertension (Self-reported)	0.1	0.3	0.6	-0.2	-0.8
Medication: Aspirin	0.1	0.1	0.1	-0.3	-0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.2	-0.4	-0.4
Medication: Blood pressure	0.1	0.2	0.4	-0.6	-0.2
High cholesterol (Self-reported)	0.1	0.2	0.4	0.2	-0.6
Medication: Bendroflumethiazide	0.1	0.1	0.3	0.1	0.5
Diastolic blood pressure, automated reading	0.1	0.4	0.4	-0.6	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.2	0.4
Heart disease (siblings)	0.1	0.1	0.3	-0.5	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.1	-0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	0.0	-0.3
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.1	0.5
Vitamin and mineral supplements	0.0	0.0	0.1	0.1	0.3
Medication: Co-codamol	0.0	0.0	0.1	-0.2	-0.2
Diabetes (mother)	0.0	0.0	0.1	-0.1	-0.3
Townsend deprivation index at recruitment	0.0	0.0	0.1	0.3	-0.0
Multivitamins +/- minerals	0.0	0.0	0.0	-0.0	-0.1
Stomach or abdominal pain in last month	0.0	0.0	0.1	-0.3	0.0
Forced vital capacity (FVC)	0.0	0.1	0.1	0.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.0	-0.3
Medication: Simvastatin	0.0	0.0	0.1	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.0	-0.2	-0.1
Lung cancer (father)	0.0	0.1	0.1	-0.2	0.2
Breastfed as a baby	0.0	0.0	0.0	-0.1	-0.0
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.1	0.4
Headache pain in last month	0.0	0.1	0.1	-0.3	0.2
Gout (self-reported)	0.0	0.1	0.1	0.1	-0.3
Forced vital capacity (FVC), Best measure	0.0	0.2	0.3	0.1	-0.5
Number of children fathered	0.0	0.0	0.1	-0.3	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.2	0.1
Medication: Allopurinol	0.0	0.0	0.1	0.1	0.3
Number of full sisters	0.0	0.0	0.1	0.1	0.2
Chest pain or discomfort	0.0	0.1	0.1	0.2	0.3
Family relationship satisfaction	0.0	0.0	0.0	0.1	0.1
Medication: Aspirin	0.0	0.0	0.1	-0.3	-0.1
Ever had bowel cancer screening	0.0	0.0	0.0	0.0	0.1
Medication for cholesterol	0.0	0.1	0.1	0.1	-0.3
Mineral and other dietary supplements	0.0	0.0	0.1	-0.2	0.1
Breast cancer (self-reported)	0.0	0.0	0.1	0.3	0.0
Average weekly champagne plus white wine intake	0.0	0.0	0.0	0.1	0.1
Commuting to job workplace: Public transport	0.0	0.0	0.0	-0.1	-0.1
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	0.1	0.3
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.3	0.1	0.5

Hub : Genes

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Trait associations