Best TWAS P=3.64e-24 · Best GWAS P=1.5e-33 conditioned to 5.78e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | KRT8P33 | 0.10 | 0.04 | lasso | 6 | 0.05 | 9.1e-04 | -4.8 | 7.2 | 4.5e-13 | -0.62 | 0.04 | 0.86 | FALSE |
| 2 | GTEx | Esophagus Mucosa | CSNK1G3 | 0.14 | 0.05 | lasso | 3 | 0.07 | 2.0e-05 | 5.7 | 5.7 | 1.2e-08 | -0.44 | 0.79 | 0.10 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CSNK1G3 | 0.04 | 0.02 | enet | 8 | 0.02 | 1.2e-04 | 6.0 | 8.0 | 1.8e-15 | -0.56 | 0.02 | 0.40 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | CEP120 | 0.06 | 0.02 | blup | 70 | 0.04 | 3.6e-03 | 6.5 | 8.9 | 8.2e-19 | -0.64 | 0.12 | 0.16 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CEP120 | 0.03 | 0.02 | enet | 5 | 0.04 | 7.3e-05 | -4.8 | 7.9 | 1.9e-15 | -0.66 | 0.03 | 0.83 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | CSNK1G3 | 0.06 | 0.05 | lasso | 2 | 0.04 | 2.0e-05 | 5.7 | 5.6 | 1.8e-08 | -0.44 | 0.08 | 0.89 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CEP120 | 0.10 | 0.14 | blup | 70 | 0.14 | 2.6e-14 | -11.5 | 10.1 | 3.6e-24 | -0.83 | 0.16 | 0.84 | TRUE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CSNK1G3 | 0.06 | 0.04 | enet | 10 | 0.05 | 2.3e-06 | 5.3 | 6.4 | 1.2e-10 | -0.57 | 0.46 | 0.44 | FALSE |