Hub : Genes

CSNK1G3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1610 0.0360 1.8e-15 0.163 0.134 0.153 0.095 0.054 2.5e-19 5.0e-16 3.0e-18 1.2e-11 3.3e-07
2 GTEx Artery Aorta 0.1070 0.0440 5.7e-03 0.065 NA -0.002 NA 0.012 1.8e-04 NA 4.2e-01 NA 6.5e-02
3 GTEx Brain Cerebellum 0.2690 0.1030 2.3e-03 -0.010 NA 0.034 NA -0.009 8.3e-01 NA 3.6e-02 NA 7.2e-01
4 GTEx Esophagus Mucosa 0.1370 0.0500 5.1e-04 0.046 NA 0.056 NA 0.070 4.6e-04 NA 1.2e-04 NA 2.0e-05
5 GTEx Pancreas 0.1290 0.0540 3.4e-03 0.044 NA 0.032 NA 0.064 6.3e-03 NA 1.7e-02 NA 1.1e-03
6 ROSMAP Brain Pre-frontal Cortex 0.0760 0.0241 3.0e-05 0.013 0.049 0.018 0.047 0.018 7.4e-03 5.5e-07 2.1e-03 1.1e-06 1.9e-03
7 TCGA Breast Invasive Carcinoma 0.0426 0.0249 3.3e-03 0.015 0.017 0.018 NA 0.010 3.1e-04 1.7e-04 1.2e-04 NA 2.6e-03
8 TCGA Head and Neck Squamous Cell Carcinoma 0.2129 0.0769 1.2e-05 0.009 0.042 0.030 NA 0.018 2.7e-02 1.6e-05 2.4e-04 NA 3.9e-03
9 TCGA Lung Adenocarcinoma 0.0569 0.0331 4.7e-04 0.050 0.026 0.029 NA 0.039 1.6e-06 4.6e-04 2.2e-04 NA 2.0e-05
10 TCGA Prostate Adenocarcinoma 0.0587 0.0297 3.3e-05 0.042 0.049 0.054 NA 0.051 2.9e-05 6.2e-06 2.3e-06 NA 4.2e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 1.1 1.7 5.3 0.5 -0.8 -0.5 2.3 0.3 -0.6 1.3 -0.2 2.1 1.9
Bipolar Disorder or Schizophrenia 0.5 1.2 3.8 -0.3 -1.5 -0.8 0.8 -1.4 -0.2 0.7 -1.2 1.2 1.9
Depressed Affect (Nagel 2018) 1.6 3.3 6.5 -2.2 1.9 -1.7 -1.9 -0.1 -0.5 -1.9 2.1 -2.5 -1.8
Depression (Nagel 2018) 0.6 0.8 1.9 -1.4 1.1 0.9 -0.8 -0.1 -0.1 -0.1 0.9 -1.1 -1.4
Intelligence (Savage-Jansen 2018) 0.6 1.7 5.6 -1.6 -0.8 -1.7 0.7 -0.5 0.9 2.0 2.4 0.4 0.3
Neuroticism (Nagel 2018) 2.1 4.9 13.4 -1.5 2.2 -1.8 -3.0 -0.4 -0.1 -3.7 1.2 -3.3 -2.0
Schizophrenia (2018) 0.5 1.0 4.1 -0.8 -1.2 -0.6 -0.9 -2.0 0.2 -0.2 -1.3 -0.2 0.9
Schizophrenia vs Biploar Disorder 0.6 0.7 3.5 0.4 -0.1 0.6 -1.1 -0.9 0.3 -0.9 -1.9 -0.5 -0.3
Worry (Nagel 2018) 2.0 4.3 12.6 -1.4 2.1 -1.3 -2.5 -0.6 0.2 -3.6 1.3 -2.8 -2.4
Alzheimer’s Disease (in mother) 1.2 1.5 7.7 1.4 1.3 1.4 0.1 0.7 0.6 0.2 -2.8 0.4 -0.1
Alzheimer’s Disease (in father) 2.3 2.5 6.6 0.7 -0.7 1.5 2.2 1.0 0.2 2.6 1.1 2.2 1.8
Alzheimer’s Disease (including proxy) 1.5 2.1 4.5 1.4 1.0 2.1 1.3 1.6 1.4 1.7 -1.3 1.5 0.9
Crohns Disease (2017) 0.4 0.8 2.2 0.7 0.3 -0.9 -0.9 -0.8 -0.8 -1.2 -1.5 -0.7 -0.4
Irritable Bowel Disease (IBD) 0.1 0.3 1.4 0.2 0.1 -1.2 -0.5 -0.4 -0.7 -0.2 -0.3 -0.4 -0.1
Ulcerative Colitis (UC) 0.2 0.3 1.5 -0.6 -0.1 -0.8 -0.2 -0.0 -0.6 0.7 1.2 -0.1 0.0
Major Depression (MDD) 0.8 1.0 4.0 -2.0 0.2 0.3 -0.9 -0.6 -0.4 -0.1 1.2 -1.2 -1.1
Reaction Time 0.6 1.2 3.4 -1.4 -1.3 -0.9 -0.5 -1.7 0.0 -1.8 0.5 -0.4 -0.3
Verbal and Numeric Reasoning (VNR) 0.5 1.2 5.2 -1.2 -0.8 -0.5 0.6 -0.9 0.3 1.8 2.3 0.3 -0.1
Breast Cancer 0.3 0.7 2.3 -0.4 -0.0 0.2 -0.3 -1.2 1.2 -1.5 0.6 -0.5 -1.0
Ovarian Cancer 0.4 0.5 2.0 0.4 0.7 -0.3 -0.1 0.6 1.1 -1.4 -0.2 -0.2 -0.6
Prostate Cancer 1.1 1.5 3.4 -0.6 -1.5 0.2 1.3 0.5 0.2 1.9 1.4 1.3 1.8
Age at First Birth 1.0 1.5 4.4 1.2 -1.7 0.0 1.4 0.3 0.3 0.8 -0.8 1.7 2.1
Bipolar Disorder (2011) 0.7 0.7 3.3 1.0 0.1 0.8 0.0 0.7 -0.3 0.0 -1.8 0.6 1.0
Body Mass Index (BMI) (2010) 1.2 1.6 5.3 -0.6 -1.5 0.9 1.1 0.1 -1.1 2.3 1.2 1.2 1.4
Coronary Artery Disease (CAD) 0.7 0.8 3.3 -0.4 0.4 0.2 -0.9 -0.9 -1.8 -0.8 -0.2 -1.0 -1.0
Crohns Disease (2012) 0.7 1.1 2.9 0.1 1.3 -0.4 -1.7 0.5 -0.1 -1.4 -1.0 -1.5 -0.8
Mean Putamen Volume 1.3 1.5 3.1 1.6 0.1 1.1 1.8 1.5 1.0 0.0 -0.6 1.7 1.2
Fasting Glucose 0.2 0.2 1.0 -0.4 -0.4 -0.5 0.5 -0.4 -0.3 0.2 1.0 0.3 0.1
HbA1C 1.0 1.1 3.6 -1.5 0.4 -0.2 -0.9 -0.6 -0.8 -0.3 1.9 -1.4 -0.9
HDL Cholesterol 0.6 1.0 2.9 0.4 0.2 -0.4 -0.4 -1.7 -0.9 -1.3 -0.8 -0.8 -1.6
LDL Cholesterol 3.4 5.3 13.2 3.0 2.9 1.9 0.9 3.6 3.4 -0.0 -2.3 1.0 0.4
Lupus 0.4 0.6 1.6 0.4 0.0 -0.6 1.3 1.0 -1.1 -0.6 1.1 0.6 -0.1
Neuroticism (2016) 0.5 0.7 3.2 -0.6 0.1 -0.1 -0.5 0.3 1.0 0.5 1.8 -0.6 -1.0
Primary Biliary Cirrhosis 0.5 0.7 2.2 -0.6 -0.8 -1.0 -0.8 -1.5 -1.1 -0.2 0.0 -0.4 0.9
Rheumatoid Arthritis 1.1 1.5 5.0 0.6 -1.7 -0.8 1.3 -0.2 -0.0 1.7 0.1 1.3 2.2
Schizophrenia (2014) 0.5 1.2 4.0 -0.3 -1.4 -0.5 -0.8 -2.0 -0.4 -0.1 -1.6 0.0 1.4
Triglycerides 0.3 0.5 2.0 0.3 0.6 1.4 0.2 1.2 0.5 -0.1 0.7 0.2 0.0
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.7 1.1 -0.2 -1.3 -0.3 0.3 -1.2 -0.6 -0.8 -0.1 0.4
Ulcerative Colitis 1.1 1.6 6.2 -0.8 -1.0 -0.7 1.3 0.8 0.3 2.0 2.5 1.2 0.6
Blood Eosinophil Count 0.1 1.1 2.7 -0.7 0.8 0.8 -1.3 -0.6 -1.4 -0.4 -1.2 -1.3 -1.6
Blood Platelet Count 0.6 7.5 18.2 1.8 4.3 -0.8 -2.4 1.3 2.6 -3.8 -2.0 -2.4 -3.6
Blood Red Count 0.7 7.1 14.7 -3.8 -2.5 -2.9 -0.4 -3.6 -2.7 0.6 3.8 -1.3 -2.2
Blood White Count 1.0 7.6 19.8 -1.5 3.0 -1.5 -3.8 -0.5 0.7 -3.4 0.5 -3.9 -4.5
Heel T-Score 4.8 38.0 110.2 -7.1 2.2 -3.2 -7.0 -4.9 -2.3 -5.2 5.3 -8.4 -10.5
BMI 0.9 5.1 19.2 -0.3 -2.8 0.7 2.8 0.2 -1.2 4.4 1.2 2.5 2.4
Height 2.5 48.9 121.4 0.4 -9.0 1.4 9.5 -0.3 -0.9 11.0 2.2 9.3 10.1
Waist Hip Ratio (WHR) 0.0 0.2 0.6 -0.1 0.8 -0.0 -0.6 -0.1 -0.3 -0.2 0.1 -0.7 -0.4
Systolic Blood Pressure 1.8 9.2 46.7 -1.3 2.7 1.7 -3.1 -0.9 -1.0 -2.2 1.6 -3.8 -6.8
Smoking Status 1.6 3.8 9.6 -2.8 1.0 -0.9 -3.0 -1.2 0.0 -1.4 1.8 -3.1 -1.8
Allergy or Eczema 0.5 1.3 3.4 1.4 -1.2 0.3 1.3 -0.2 0.5 0.2 -1.4 1.2 1.9
Cardiovascular Disease 1.3 4.4 10.5 -0.4 3.0 1.8 -2.8 0.8 0.3 -2.1 -0.2 -2.8 -3.2
Hypothyroidism (self reported) 2.4 5.6 16.4 -2.1 -4.1 -3.9 0.4 -3.1 -1.4 1.0 0.2 0.5 2.6
Respiratory disease 1.0 2.3 6.4 0.7 2.0 2.5 -0.3 1.9 1.9 -1.0 0.3 -0.4 -2.0
Type 2 Diabetes (T2D) (2018) 0.4 0.8 3.6 -0.4 -0.1 0.1 -1.0 -1.1 -1.9 -0.9 0.3 -1.0 -0.8
Lung FEV1/FVC ratio 0.9 4.4 15.1 0.4 -3.2 -0.4 1.4 -1.5 -1.3 2.9 -0.9 1.9 3.9
Lung FVC 1.1 5.6 13.4 2.3 -2.0 2.0 2.6 0.7 -1.2 3.7 -1.9 3.1 2.9
Neuroticism 1.9 4.7 10.4 -2.3 1.4 -2.5 -2.7 -0.9 0.1 -2.5 2.3 -3.2 -1.7
Chronotype (morning person) 2.2 5.1 13.8 2.7 2.1 3.4 1.3 3.7 2.7 0.4 -1.6 1.6 0.6
Hair Pigment 0.1 3.6 8.8 1.6 3.0 0.7 -1.2 1.7 0.5 -2.6 -2.3 -1.2 -2.6
Tanning 0.1 1.8 4.1 0.9 1.6 1.9 1.0 1.4 2.0 1.5 0.3 0.6 -0.8
Hand grip strength (left) 0.8 2.2 6.4 2.5 0.5 2.0 0.4 1.5 -0.0 1.1 -2.4 0.7 1.2
Number of treatments/medications taken 0.6 1.2 4.1 0.1 0.9 0.8 -1.2 -0.2 -0.0 -1.5 -0.6 -1.4 -2.0
Average weekly spirits intake 1.2 1.5 4.8 1.7 0.8 1.9 0.8 2.2 0.8 0.1 -0.8 0.8 0.4
Sensitivity / hurt feelings 0.6 1.0 4.9 -0.5 0.1 -2.2 -0.1 0.5 0.4 -0.8 1.6 -0.3 1.1
Frequency of depressed mood in last 2 weeks 0.8 1.2 6.0 -1.7 -0.4 -1.3 0.0 -0.6 0.4 0.0 2.5 -0.4 -0.2
Hearing difficulty/problems: Yes 1.0 1.5 6.4 1.6 1.6 2.5 -0.5 0.5 -0.1 -0.1 -1.1 -0.6 -1.0
Relative age of first facial hair 0.4 0.8 2.8 -0.5 -1.5 0.6 0.7 0.1 -0.3 0.9 0.8 0.8 1.7
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.6 -0.3 -1.3 -1.1 0.2 -0.5 -0.1 0.2 0.8 0.4 0.0
Ever used hormone-replacement therapy (HRT) 0.4 0.5 2.6 -0.3 0.8 0.2 -0.2 0.5 -0.6 -1.6 0.1 -0.3 -1.0
Ever had hysterectomy (womb removed) 0.6 0.7 1.9 -1.0 0.7 0.2 0.5 1.0 0.9 -0.6 1.4 0.4 -0.6
Systolic blood pressure, automated reading 0.6 1.7 7.9 -0.4 -0.1 1.9 -0.0 -0.8 -1.5 0.5 1.3 -0.5 -2.8
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 6.4 -0.2 -0.1 0.7 1.7 0.5 0.5 0.3 2.5 1.1 -1.3
Angina 0.5 0.7 2.5 -0.6 -0.6 1.0 0.0 -0.8 -1.6 0.9 0.7 -0.1 -0.7
Medication for hormone replacement therapy 0.1 0.2 0.5 0.5 -0.1 0.0 0.4 -0.0 -0.5 0.2 -0.7 0.4 0.3
Vitamin and mineral supplements 0.4 0.5 1.8 -0.9 0.6 0.0 -1.2 -0.3 -0.4 0.5 0.6 -1.3 -0.4
Supplements: Zinc 0.4 0.5 1.5 -0.6 -0.8 -1.2 0.3 -0.6 0.4 -0.4 1.2 0.1 -0.5
Medication: Co-codamol 1.4 1.6 3.8 -0.4 1.9 -0.3 -1.8 0.3 0.2 -2.0 -0.2 -1.8 -1.3
Medication: Metformin 1.1 1.6 4.6 -0.8 -1.8 -0.8 1.1 -1.3 -1.7 0.5 2.2 1.0 0.3
Diabetes (father) 0.4 0.5 1.3 -1.0 0.9 0.1 -0.2 -0.1 -0.3 0.1 1.1 -0.6 -1.2
Diabetes (mother) 0.5 0.6 2.6 -0.6 -0.9 -0.6 -0.2 -1.2 -0.3 -0.8 1.6 -0.3 0.1
Severe depression (siblings) 0.7 0.7 1.6 1.0 0.1 1.0 0.9 1.1 1.0 -0.3 -0.4 1.2 0.6
Pack years adult smoking proportion 1.0 1.5 6.0 -0.3 2.4 2.3 0.3 1.7 -0.6 -0.5 0.4 -0.3 -0.4
Impedance of leg (right) 4.4 21.1 63.7 -1.6 5.2 -0.2 -6.0 -0.7 0.0 -6.5 -0.5 -6.2 -8.0
Leg fat-free mass (left) 5.1 27.2 72.4 0.7 -6.5 0.5 6.9 0.0 -0.6 8.5 1.6 6.8 7.8
Trunk fat percentage 0.1 0.4 1.2 -0.9 -0.8 0.1 0.2 -0.7 -0.8 1.1 0.8 -0.1 0.1
Hand grip strength (right) 1.2 3.3 7.6 2.2 -0.6 1.8 1.4 1.1 -0.5 2.7 -1.9 1.7 2.8
Townsend deprivation index at recruitment 3.7 5.2 16.4 -3.1 -2.2 -3.4 0.2 -2.3 -1.5 1.3 4.0 -0.1 -0.5
Current tobacco smoking 1.5 2.4 7.7 -2.8 0.8 -0.9 -1.9 -0.7 -0.6 -0.5 2.0 -2.0 -1.4
Average weekly fortified wine intake 2.5 3.0 10.5 -0.7 -3.2 -1.0 1.2 -2.0 -0.1 2.0 1.2 1.1 2.3
Maternal smoking around birth 0.4 0.6 2.3 -0.5 1.5 -0.4 -0.4 0.5 0.3 -1.0 0.2 -0.8 -0.8
Fed-up feelings 0.8 1.4 6.2 -1.3 1.2 -0.3 -0.1 0.9 1.2 -0.1 2.5 -0.6 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.8 -1.7 0.5 -0.6 -1.0 -0.8 0.0 0.1 1.3 -1.3 -1.1
Relative age voice broke 0.2 0.3 0.8 0.4 -0.3 -0.6 -0.5 -0.0 0.3 -0.9 -0.6 -0.0 0.7
Taking other prescription medications 0.1 0.1 0.4 0.1 -0.3 -0.3 0.1 -0.7 0.6 -0.1 -0.5 0.2 -0.3
Age when periods started (menarche) 0.5 1.3 2.8 1.7 1.6 0.3 0.2 1.6 0.4 -1.5 -1.5 0.5 0.4
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 2.1 0.9 0.6 0.4 -0.2 0.6 0.3 -0.8 -1.4 -0.2 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 4.6 10.5 23.6 -2.6 1.7 -1.4 -4.5 -3.1 -2.7 -3.6 -0.1 -4.9 -4.5
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.8 0.2 0.4 1.4 0.7 1.1 1.0 0.3 0.5 0.2 -0.2
Qualifications: CSEs or equivalent 0.2 0.3 1.2 -0.0 -0.0 -1.1 -0.6 0.3 -0.0 0.8 0.2 -0.4 0.7
Serious illness, injury or assault to yourself 1.1 1.3 3.8 -1.5 -1.9 -1.3 0.5 -1.3 -1.1 0.4 0.6 0.6 1.2
High blood pressure 1.1 3.0 10.2 -0.8 1.4 1.3 -2.5 -0.6 -0.5 -1.6 0.3 -2.4 -3.2
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.9 0.6 -0.5 0.0 -0.2 -1.0 -0.4 -1.0 -1.4 -0.4 0.2
Multivitamins +/- minerals 0.4 0.5 1.3 1.1 -0.1 -0.5 0.6 0.3 -0.2 -0.9 -1.1 0.7 0.7
Stomach or abdominal pain in last month 0.4 0.5 1.6 -0.3 0.7 0.1 -1.1 0.5 0.7 0.2 -0.7 -1.3 -0.5
Supplements: Glucosamine 0.6 0.7 1.8 1.3 0.0 0.9 0.7 0.9 0.4 0.5 -1.1 0.9 0.9
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.9 1.0 1.3 1.0 0.5 1.4 -0.1 -0.4 -0.0 0.3 -0.7
Medication: Atenolol 0.9 1.2 3.1 0.6 1.6 1.3 -0.7 1.4 1.1 -0.3 -0.3 -0.6 -1.8
Medication: Levothyroxine sodium 1.9 3.3 9.4 -1.9 -3.1 -2.6 0.4 -2.1 -1.7 1.4 0.4 0.3 1.8
Sitting height 3.2 22.7 62.1 -1.0 -7.3 0.4 5.7 -2.1 -1.3 7.9 1.8 5.5 6.0
Chronic bronchitis/emphysema (father) 0.6 0.7 1.8 -0.2 1.3 0.4 -0.4 0.7 1.1 -1.0 0.3 -0.7 -1.3
High blood pressure (mother) 2.4 3.4 8.3 1.5 2.9 2.6 -1.4 0.5 0.8 -1.5 -1.4 -1.6 -2.7
Body mass index (BMI) 0.5 2.2 8.9 -0.3 -1.6 0.5 1.6 -0.1 -1.4 3.0 0.7 1.4 1.8
Impedance of leg (left) 4.1 19.8 55.7 -1.0 5.1 -0.3 -5.8 -0.7 0.2 -6.7 -1.1 -5.9 -7.5
Leg predicted mass (left) 5.3 28.2 74.3 0.7 -6.5 0.6 7.1 0.1 -0.6 8.6 1.8 6.9 7.9
Trunk fat mass 0.7 3.0 11.2 -0.6 -2.3 0.5 2.0 -0.4 -0.9 3.3 1.1 1.7 2.0
Waist circumference 1.4 5.2 19.3 -0.4 -2.6 0.8 2.8 -0.0 -1.4 4.4 1.5 2.4 2.7
Number of incorrect matches in round 1.9 3.2 18.4 2.2 0.8 1.1 -1.1 -0.1 -0.7 -2.2 -4.3 -0.7 -0.5
Past tobacco smoking 1.1 2.0 5.8 2.4 0.4 1.2 1.4 1.4 0.0 0.1 -2.1 1.7 1.3
Alcohol usually taken with meals 3.7 6.0 15.7 3.6 2.4 4.0 0.5 2.8 2.6 -0.4 -3.1 0.9 -0.5
Nervous feelings 2.2 4.0 16.1 -0.2 1.6 -1.5 -2.7 -1.0 -0.5 -4.0 -0.5 -2.7 -1.9
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 4.3 -2.0 0.2 -1.1 -0.5 -0.7 0.6 0.3 2.1 -0.9 -0.8
Hearing difficulty/problems with background noise 1.6 2.6 5.0 1.4 2.1 1.6 -2.2 0.6 0.6 -0.9 -2.0 -1.9 -1.5
Hair/balding pattern: Pattern 2 0.5 0.6 5.6 -0.5 0.4 0.1 -0.3 -0.2 -0.1 -2.4 0.5 -0.1 0.0
Had menopause 0.3 0.4 1.7 -1.3 -0.6 0.3 0.2 -0.2 0.0 0.7 1.0 0.4 0.6
Had other major operations 2.1 2.5 6.5 -2.6 -1.4 -2.5 -0.2 -1.4 -1.4 0.4 2.4 -0.5 0.7
Forced vital capacity (FVC) 2.2 8.6 22.6 1.5 -3.9 1.3 3.4 -0.6 -0.8 4.8 -1.4 3.7 4.0
Heel bone mineral density (BMD) T-score, automated (right) 3.9 9.0 22.7 -1.8 2.2 -0.5 -4.4 -2.5 -2.3 -3.4 -0.5 -4.8 -4.1
Ever unenthusiastic/disinterested for a whole week 2.1 2.5 8.4 -2.2 -0.4 -2.9 -0.5 -1.2 -1.0 0.6 2.8 -1.0 -0.1
Qualifications: None of the above 0.2 0.5 1.4 -0.7 0.9 0.6 -1.0 0.5 -0.3 -1.2 0.1 -0.9 -0.0
Financial difficulties in last 2 years 0.5 0.6 1.6 -0.1 1.1 0.0 1.1 1.3 -0.7 0.4 1.1 0.5 0.3
Mouth/teeth dental problems 0.5 0.8 2.0 1.3 0.5 -0.1 -0.8 -0.0 1.3 -1.2 -1.4 -0.6 -0.2
Heart attack 0.6 0.8 2.0 -1.2 0.4 -0.3 -1.4 -1.0 -1.1 -0.7 -0.3 -1.3 -0.1
Allergy 0.2 0.5 2.2 -0.6 -0.4 -0.9 0.1 -0.1 -0.2 1.5 0.8 0.4 0.6
Pain all over the body in last month 0.3 0.3 1.4 -0.1 -0.1 0.2 -0.0 0.1 0.9 0.1 0.9 -0.1 -1.2
Diabetes (self-reported) 0.2 0.3 2.5 -0.0 -0.3 -0.4 -0.1 -0.6 -1.6 -0.3 0.2 -0.1 0.5
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 3.6 1.3 0.3 -0.8 -0.9 0.6 0.8 -1.7 -1.9 -0.5 0.1
Medication: Ramipril 0.8 1.0 2.0 -1.4 0.5 1.3 -0.8 -0.9 -1.3 1.0 0.8 -0.9 -0.5
Medication: Simvastatin 0.4 0.6 2.2 0.5 0.9 0.2 0.2 1.5 1.5 0.3 -0.0 0.3 0.1
Fluid intelligence score 0.3 0.6 2.9 -0.3 0.2 -1.1 0.2 0.5 0.8 0.9 1.7 0.1 -0.1
Illnesses of siblings 0.8 1.1 3.0 1.2 -0.8 -0.1 1.5 0.4 0.5 0.8 -1.0 1.7 1.4
Neuroticism score 2.5 5.2 10.4 -2.6 1.3 -2.7 -2.6 -1.2 -0.8 -2.8 2.2 -3.2 -2.1
Weight 2.5 12.3 40.4 -0.2 -4.5 0.9 4.4 -0.3 -1.3 6.4 1.4 4.2 4.6
Impedance of arm (right) 1.0 4.5 11.7 -1.8 0.6 -1.6 -2.3 -2.1 -0.0 -3.4 0.9 -2.5 -3.3
Arm fat percentage (right) 0.2 0.8 2.7 -0.7 -1.2 0.2 0.8 -0.4 -0.8 1.6 1.1 0.6 0.6
Trunk fat-free mass 4.7 27.2 82.3 0.9 -6.0 1.3 6.8 0.7 -0.6 9.1 1.2 6.8 7.4
Hip circumference 1.2 5.3 19.5 -0.1 -2.6 1.2 3.0 -0.1 -1.8 4.4 1.0 2.5 2.3
Time employed in main current job 0.8 0.9 3.0 1.3 0.8 0.1 -0.2 0.8 0.8 -0.9 -1.7 0.1 1.1
Alcohol intake versus 10 years previously 0.6 0.9 2.8 -1.3 0.9 0.1 -0.0 0.1 -0.2 -0.6 1.6 -0.7 -1.7
Father’s age at death 0.6 0.9 2.6 -1.2 -1.4 -0.8 -0.3 -1.6 0.8 0.3 1.0 -0.4 0.4
Worrier / anxious feelings 1.3 2.5 7.4 0.2 2.1 -0.3 -1.4 0.4 2.0 -2.7 0.0 -1.5 -2.1
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 5.9 -0.5 2.4 1.3 -0.5 1.2 1.0 -0.4 0.8 -1.0 -1.3
Falls in the last year 1.2 1.6 5.9 -0.5 -1.3 1.9 1.3 -0.4 -2.4 0.7 0.2 1.2 0.9
Hair/balding pattern: Pattern 3 0.9 1.3 4.7 2.2 1.3 0.3 -0.2 1.7 0.6 0.2 -1.9 0.0 0.2
Number of live births 2.0 2.9 7.1 -1.7 -1.4 -1.0 1.8 0.1 -0.2 2.6 2.7 1.8 1.5
Forced expiratory volume in 1-second (FEV1) 2.5 8.4 19.4 1.7 -3.7 1.1 3.4 -0.6 -0.9 4.4 -1.5 3.7 4.3
Pulse rate 2.0 3.3 10.0 -0.8 1.9 -0.8 -2.0 -0.4 1.4 -2.2 0.9 -2.4 -3.2
Happiness 0.8 1.0 2.1 0.5 -0.3 0.2 0.9 1.3 1.4 1.2 0.2 1.1 1.4
Noisy workplace 0.4 0.5 1.6 -0.0 0.3 1.3 -0.6 -0.4 -1.2 -0.5 -0.1 -0.6 -0.5
Qualifications: A levels/AS levels or equivalent 0.3 0.6 2.7 -0.3 -0.3 -0.0 -0.9 -1.7 0.3 -0.4 -0.1 -0.9 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.8 -0.6 -0.4 -0.3 -0.5 -0.9 -0.3 -0.3 0.5 -0.5 0.9
Mouth/teeth dental problems: Dentures 0.6 1.1 3.8 0.6 -0.9 0.5 1.8 0.3 -0.8 0.9 -0.4 1.9 0.8
Asthma 0.8 1.6 4.5 0.6 1.6 2.1 -0.2 1.2 1.9 -1.0 -0.7 -0.4 -1.3
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.2 5.6 1.7 2.2 1.7 0.2 2.3 2.4 0.6 0.3 0.1 -0.7
Medication: Cholesterol lowering 1.0 1.6 3.3 1.4 1.8 0.8 -0.3 1.6 1.6 -1.4 -1.6 -0.0 -0.1
Depression (self-reported) 0.9 1.1 5.3 -1.1 -1.1 -2.3 -0.1 -1.4 -0.1 0.4 0.8 -0.1 0.4
Medication: Lansoprazole 2.0 2.3 5.7 2.4 0.8 1.6 1.5 2.0 2.4 -0.3 -0.4 1.3 0.3
Prospective memory result 2.7 3.3 6.1 2.5 2.3 1.4 -0.2 2.2 2.4 -1.7 -2.4 0.1 -0.5
Lung cancer (father) 0.3 0.3 1.7 -0.1 -0.4 -0.3 -0.4 -0.6 -1.3 0.8 -0.5 -0.2 0.0
Illnesses of mother 1.2 1.4 3.4 -1.5 -1.4 -1.9 0.7 -0.5 -0.3 0.9 1.6 0.8 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 2.8 8.9 25.8 1.7 -3.5 1.0 3.5 -0.1 -0.4 5.1 -1.1 4.0 4.2
Pulse wave Arterial Stiffness index 0.9 1.1 3.3 -0.8 -0.1 -0.0 -1.6 -0.9 0.9 -0.7 -0.1 -1.4 -1.8
Impedance of arm (left) 1.3 5.8 15.7 -1.9 1.0 -1.8 -2.9 -2.2 0.1 -4.0 0.6 -3.1 -3.4
Arm fat mass (right) 1.1 4.5 16.7 -0.4 -2.6 0.7 2.5 -0.2 -1.1 4.1 1.1 2.4 2.6
Trunk predicted mass 4.8 27.3 83.5 0.9 -6.0 1.3 6.8 0.7 -0.6 9.1 1.3 6.8 7.5
Standing height 2.3 23.0 65.2 0.6 -6.1 1.7 6.5 0.1 0.2 8.1 1.1 6.3 6.5
Length of working week for main job 1.3 1.4 4.1 1.6 -0.2 1.9 1.0 0.2 -0.3 2.0 -1.0 1.1 0.2
Exposure to tobacco smoke at home 2.2 2.5 6.6 -1.6 -1.9 -2.0 -0.7 -2.6 -2.4 0.5 0.7 -0.7 0.1
Breastfed as a baby 1.6 2.0 4.7 -1.5 -2.2 -0.7 0.9 -0.4 0.7 2.0 1.6 1.0 1.7
Tense / ‘highly strung’ 0.5 0.9 2.0 -0.5 1.1 0.0 -1.2 -0.3 0.1 -1.2 1.0 -1.4 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 5.9 -1.7 0.2 -2.4 -1.6 -0.7 -0.5 0.1 1.3 -1.5 -0.7
Hair/balding pattern: Pattern 4 0.9 2.1 10.0 0.4 1.1 2.3 1.0 1.1 3.2 -0.2 0.5 0.6 -1.2
Birth weight of first child 0.3 0.6 1.8 -0.5 0.1 -0.4 -1.0 -0.9 -0.0 -0.1 -0.1 -1.3 -1.3
Peak expiratory flow (PEF) 0.4 1.0 4.7 1.4 0.1 2.2 0.4 0.6 0.6 0.9 -1.2 0.5 0.3
Pulse wave reflection index 1.7 2.1 6.9 2.6 0.6 1.7 0.4 2.1 0.9 0.0 -2.0 0.9 0.8
Ever highly irritable/argumentative for 2 days 0.4 0.5 2.5 -0.2 0.6 -1.6 -0.7 -0.4 -0.1 -0.7 0.1 -0.7 0.1
Loud music exposure frequency 0.3 0.3 1.1 0.5 0.3 0.6 0.6 0.4 1.1 0.1 0.5 0.5 0.3
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 5.2 -1.0 0.8 0.2 -1.2 -1.2 -1.1 -0.2 -0.2 -1.3 -2.3
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.7 -1.3 -0.5 0.0 0.6 -0.1 -0.8 1.7 1.3 0.4 0.7
Blood clot in the leg (DVT) 0.7 0.9 2.9 -1.4 -1.0 -0.5 1.0 0.5 -0.7 0.5 1.7 0.8 0.8
Medication: Paracetamol 2.0 3.3 8.2 0.6 2.9 1.7 -0.7 2.0 1.9 -2.0 0.1 -0.9 -2.9
Headache pain in last month 2.3 3.9 9.1 2.4 2.7 2.5 0.2 2.6 3.0 -0.4 -1.6 0.4 -0.9
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 5.8 -1.2 -2.4 -1.3 1.2 -1.3 -1.0 1.6 1.4 0.9 1.4
Glaucoma (self-reported) 0.1 0.2 0.6 -0.1 -0.5 0.6 0.4 -0.1 0.2 -0.0 0.1 0.8 0.2
Gout (self-reported) 0.2 0.2 0.8 0.3 0.6 0.1 -0.2 -0.2 0.9 -0.5 0.1 -0.3 -0.8
Hypothyroidism/myxoedema (self-reported) 1.8 3.4 10.4 -1.1 -3.1 -3.2 0.2 -2.4 -1.3 0.9 -0.7 0.3 2.1
Medication: Amlodipine 3.6 5.0 12.1 -1.9 0.7 -0.6 -3.5 -1.9 -1.6 -2.1 0.6 -3.5 -3.3
Medication: Ventolin 100micrograms inhaler 0.7 1.0 2.9 -0.7 0.8 0.8 -1.3 0.0 0.5 -1.7 0.4 -1.2 -1.2
Birth weight 1.4 3.1 11.5 -0.6 -2.3 0.3 1.5 -0.3 0.4 3.4 0.6 1.6 2.9
Chronic bronchitis/emphysema (mother) 1.9 2.2 4.8 -2.2 0.1 -1.3 -1.5 -1.1 -1.8 -1.1 1.5 -1.7 -1.7
High blood pressure (siblings) 1.7 2.5 5.8 -1.9 1.1 -0.3 -1.6 -0.7 -0.7 -2.0 1.8 -1.9 -2.4
Forced vital capacity (FVC), Best measure 2.4 8.6 24.7 2.0 -3.0 1.4 3.5 0.5 -0.2 5.0 -1.6 3.9 4.0
Body fat percentage 0.1 0.2 0.5 -0.6 -0.2 0.3 -0.1 -0.3 -0.7 0.6 0.5 -0.4 -0.4
Leg fat percentage (right) 0.5 1.9 6.8 -1.0 1.4 0.4 -1.7 -0.1 -0.9 -0.9 0.6 -2.1 -2.6
Arm fat-free mass (right) 3.6 18.7 60.5 0.8 -4.6 1.4 5.6 1.0 -0.4 7.8 1.0 5.5 6.2
Exposure to tobacco smoke outside home 0.6 0.7 3.1 -0.8 1.3 -0.2 -0.2 0.4 -0.2 -0.5 0.9 -0.7 -1.8
Comparative body size at age 10 0.8 2.3 7.9 -1.5 -2.4 -0.7 0.3 -1.4 0.1 2.8 0.5 0.4 2.0
Number of full brothers 1.3 1.7 4.9 -1.8 0.6 0.3 -0.7 -0.7 -1.4 -0.7 2.2 -1.1 -1.8
Worry too long after embarrassment 0.9 1.6 4.4 -0.5 1.4 -0.2 -2.1 -0.4 0.1 -1.7 0.1 -2.1 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 5.0 -1.0 -0.3 -2.2 -0.5 -1.1 0.3 0.5 0.9 -0.6 0.3
Wheeze or whistling in the chest in last year 0.7 1.3 4.4 -0.0 2.0 1.9 -0.3 0.3 0.3 -0.5 0.2 -0.8 -2.1
Number of children fathered 0.7 0.8 2.2 -0.5 1.1 1.5 -0.4 0.3 -0.4 -1.2 0.8 -0.3 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.7 -0.3 -1.0 -1.3 -0.5 -1.1 -0.9 0.5 -0.7 0.0 1.2
Age at first live birth 0.3 0.6 1.4 1.0 -1.0 -0.2 0.7 -0.3 0.7 0.0 -0.6 0.8 1.2
Pulse wave peak to peak time 1.2 1.4 4.4 0.7 -0.2 0.1 1.9 1.0 -0.8 1.1 0.3 1.7 2.1
Health satisfaction 0.4 0.5 1.9 -0.5 -0.3 -0.6 0.5 0.2 1.4 0.1 1.4 0.2 0.5
Shortness of breath walking on level ground 1.2 1.5 4.2 1.0 1.9 2.0 0.1 1.7 0.8 -0.6 -0.8 -0.1 -1.2
Qualifications: College or University degree 1.7 5.5 17.6 -1.1 -4.2 -1.4 1.1 -2.7 -0.1 3.4 1.4 1.3 3.2
Eye problems/disorders: None of the above 0.8 0.9 2.4 -0.2 -1.5 -1.5 0.1 -1.2 -1.0 0.4 -0.5 0.3 1.4
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.9 -0.3 -0.3 -0.8 -0.0 -0.5 -0.9 -1.0 0.7 -0.1 -0.2
Emphysema/chronic bronchitis 2.2 2.4 7.1 -0.4 2.2 1.2 -1.3 0.8 0.3 -1.8 1.5 -1.7 -2.7
Medication for pain relief, constipation, heartburn 1.7 2.9 9.0 -0.2 -2.6 -1.9 0.9 -1.6 -0.8 1.9 -0.6 1.3 3.0
Neck or shoulder pain in last month 3.1 4.3 17.1 1.1 4.1 2.5 -0.4 3.3 0.7 -1.1 -1.0 -0.7 -2.0
Medication: Blood pressure 1.8 3.2 8.3 -0.3 1.6 0.1 -2.7 -1.2 -0.9 -2.2 -0.5 -2.4 -2.9
Angina (self-reported) 0.5 0.6 2.6 -0.6 -0.4 0.8 -0.0 -0.8 -1.6 0.7 0.6 -0.2 -0.9
Migraine (self-reported) 1.8 2.3 5.2 1.7 1.9 2.3 1.2 2.1 1.8 0.6 -0.1 1.1 -0.4
Medication: Ibuprofen 2.0 2.4 6.8 1.6 1.9 1.9 0.4 2.4 2.6 1.0 0.6 0.4 -0.3
Medication: Allopurinol 0.3 0.4 2.1 0.6 0.5 1.4 0.4 0.3 0.3 -0.5 -0.5 0.4 -0.4
Medication: Omeprazole 1.8 2.2 5.0 0.2 2.2 2.2 -1.4 0.7 0.4 -1.4 0.4 -1.9 -2.0
Medication: Seretide 50 evohaler 0.5 0.5 1.7 -0.2 0.2 -1.2 0.3 -0.1 0.8 -1.3 1.2 0.2 -0.0
Mean time to correctly identify matches 0.7 1.3 4.0 -1.2 -1.9 -1.1 -0.7 -2.0 0.2 -1.5 -0.2 -0.3 0.4
Heart disease (mother) 0.5 0.7 2.4 0.2 -1.5 0.8 -0.0 -0.9 -0.5 0.5 -1.3 0.3 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.3 0.1 0.0 -0.1 -0.1 0.1 -0.5 0.6 0.1 0.1 0.5
Whole body fat mass 0.6 2.7 10.4 -0.3 -1.9 0.8 2.0 -0.1 -1.0 3.2 0.9 1.7 1.8
Leg fat mass (right) 0.4 1.4 6.2 -0.4 -1.4 0.6 1.2 -0.2 -1.2 2.5 0.6 1.0 1.0
Arm predicted mass (right) 3.8 19.6 63.3 0.9 -4.8 1.3 5.7 0.7 -0.5 8.0 0.9 5.6 6.4
Pulse rate, automated reading 3.1 9.9 31.0 -1.2 4.0 -1.1 -3.6 -0.6 1.2 -4.4 0.1 -3.9 -5.6
Alcohol intake frequency. 0.7 1.7 5.9 -2.3 -0.7 -2.0 0.2 -0.2 -0.1 1.1 2.4 -0.3 -0.2
Comparative height size at age 10 1.7 9.4 31.4 -0.2 -4.1 1.1 4.0 -0.4 0.6 5.6 1.4 3.8 3.5
Number of full sisters 0.9 1.1 3.7 -0.1 1.2 1.7 1.0 1.9 0.1 0.9 0.8 0.8 0.3
Suffer from ‘nerves’ 0.9 1.4 4.1 -1.8 -0.7 -2.0 0.2 -1.1 -0.6 -0.4 1.8 -0.3 -0.8
Overall health rating 0.7 1.5 3.7 -1.1 1.5 -0.4 -1.3 -0.5 -0.3 -1.4 1.0 -1.6 -1.9
Chest pain or discomfort 1.5 2.2 5.1 0.9 1.4 2.0 1.6 2.3 1.9 0.6 0.6 1.5 -1.1
Had major operations 0.3 0.3 1.1 -0.5 0.4 0.3 -0.3 0.3 -0.2 -1.0 0.6 -0.2 -1.0
Age at last live birth 1.3 1.9 5.2 0.6 -2.3 -0.1 1.8 -0.9 -0.5 1.6 0.4 1.6 2.0
Family relationship satisfaction 1.3 1.6 4.2 -1.3 -1.2 -1.3 0.9 -0.3 -0.1 1.8 2.0 0.7 1.5
Leg pain on walking 1.5 1.9 7.0 -1.1 -1.6 -1.1 1.4 -0.6 -0.4 1.5 2.6 0.9 1.1
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 5.6 1.0 2.4 1.4 0.1 2.1 0.7 -1.7 -0.3 -0.3 -1.2
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.4 -0.3 0.8 -0.8 -1.0 0.0 0.1 -0.8 0.0 -1.2 -1.0
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 3.2 1.2 0.8 -1.5 -0.7 0.4 0.7 -0.9 -1.8 -0.5 -0.4
Medication: Aspirin 0.8 1.1 2.8 -1.7 0.4 -0.4 -1.1 -0.5 -1.6 -0.8 0.8 -1.4 -0.9
Supplements: Vitamin C 1.7 2.0 5.4 0.2 -2.3 -0.4 2.0 -0.7 0.0 2.0 0.6 1.9 1.5
Knee pain experienced in last month 0.3 0.5 2.2 0.8 1.1 0.4 0.1 1.5 0.3 -0.7 -0.3 0.7 0.3
Hypertension (Self-reported) 1.4 3.9 12.9 -0.9 1.8 1.5 -2.8 -0.6 -0.9 -1.9 0.2 -2.7 -3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 5.2 0.5 0.5 2.3 0.5 0.5 0.2 0.9 0.1 0.3 -0.7
Illnesses of father: Heart disease 0.3 0.5 1.3 1.2 -0.3 1.1 0.4 -0.1 -0.3 0.5 -1.0 0.6 0.5
Illnesses of siblings: Diabetes 0.3 0.4 1.1 -0.1 0.8 0.5 -0.4 0.2 0.0 -1.0 0.3 -0.5 -1.0
Smoking status: Previous 0.5 0.7 1.6 -0.8 0.1 -0.9 -1.2 -0.4 0.8 -0.7 0.9 -1.3 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.0 9.9 0.5 -1.5 -0.4 1.2 0.1 0.5 2.0 -0.2 1.4 3.1
Whole body fat-free mass 5.1 29.1 82.3 1.0 -6.3 1.1 7.2 0.7 -0.4 9.1 1.4 7.1 7.9
Leg fat-free mass (right) 5.5 29.6 74.0 1.1 -6.6 0.5 7.2 0.2 -0.3 8.6 1.4 7.2 8.4
Arm fat percentage (left) 0.1 0.5 1.8 -0.6 -0.9 0.2 0.6 -0.4 -0.8 1.3 1.0 0.3 0.5
Average weekly red wine intake 1.0 1.5 3.0 1.3 -0.8 0.9 1.0 0.7 0.3 1.7 -1.5 1.5 1.7
Handedness (chirality/laterality): Left-handed 1.8 2.2 4.4 -2.1 -1.0 -0.5 -1.9 -2.0 -1.7 0.0 1.4 -1.9 -0.4
Mood swings 1.5 2.8 5.4 -1.8 2.3 -1.1 -1.5 0.7 -0.7 -1.8 2.1 -1.9 -1.9
Loneliness, isolation 1.5 2.0 9.8 -2.0 0.3 -2.2 -0.0 -0.3 -0.4 -0.2 3.1 -0.8 -0.6
Long-standing illness, disability or infirmity 0.6 0.9 4.9 -0.6 -0.5 -1.0 1.0 -0.3 -0.2 -0.1 2.2 0.7 -0.6
Ever had bowel cancer screening 1.1 1.2 4.1 1.6 0.5 2.0 0.9 0.8 0.2 -0.4 -1.6 1.0 -0.2
Diabetes diagnosed by doctor 0.3 0.5 2.9 -0.3 -0.6 -0.9 -0.1 -0.9 -1.7 -0.3 0.6 -0.1 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.9 1.4 1.3 1.7 0.0 1.2 0.5 -1.1 -1.1 0.0 -0.6
Friendships satisfaction 1.9 2.4 9.3 -1.5 -0.8 -3.1 0.5 -0.5 1.0 0.9 3.0 0.5 0.7
Qualifications: nursing, teaching 1.3 2.0 7.0 -1.4 -1.7 -1.3 0.9 -1.6 -1.1 1.3 2.6 0.3 0.4
Commuting to job workplace: Walk 1.8 2.0 6.0 -0.2 -1.1 1.0 2.5 0.9 -0.6 1.3 1.3 2.1 1.5
Eye problems/disorders: Cataract 0.9 1.1 2.8 0.4 1.5 1.7 -0.1 1.6 1.1 0.6 0.3 -0.2 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.3 1.0 1.6 0.5 -1.0 0.5 1.8 -1.2 -0.9 -0.9 -1.4
Medication for cholesterol 0.6 0.9 2.0 1.2 -0.0 -0.1 1.0 1.0 0.9 0.9 -0.6 1.4 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.7 -0.7 -1.3 0.6 1.1 -0.6 -0.5 1.2 1.1 0.9 -0.0
Back pain experienced in last month 2.2 3.2 8.2 1.3 2.9 2.3 -0.2 2.0 2.1 -1.7 -0.3 -0.5 -2.2
Mineral and other dietary supplements 0.0 0.1 0.3 -0.3 0.2 0.0 -0.2 -0.5 0.5 -0.1 0.1 -0.1 -0.1
Breast cancer (self-reported) 2.8 3.3 6.7 -2.2 -1.3 -2.2 -2.3 -2.2 -2.6 -0.5 0.5 -2.1 -0.2
Asthma (self-reported) 0.9 1.8 3.8 0.8 1.9 1.9 -0.3 1.3 1.9 -1.2 -0.7 -0.4 -1.4
Osteoporosis (self-reported) 0.4 0.5 1.7 0.7 -0.4 -0.1 0.9 -0.1 0.1 1.0 -0.1 0.8 1.3
Osteoarthritis (self-reported) 1.0 1.4 4.0 0.3 2.0 -0.4 -0.5 1.4 1.2 -1.4 0.1 -0.7 -1.7
Medication: Aspirin 0.8 1.0 3.0 -1.7 0.5 -0.4 -1.2 -0.3 -1.2 -0.5 1.0 -1.4 -0.7
Medication: Gliclazide 0.5 0.5 1.4 -0.6 -1.2 -0.5 0.1 -0.9 -0.4 -1.0 1.1 0.2 0.3
Illnesses of father: None of the above (group 1) 0.4 0.5 1.2 1.0 -0.5 -0.5 0.8 0.4 0.6 1.1 -0.1 0.9 0.4
Smoking status: Current 1.6 2.5 8.6 -2.9 0.4 -1.1 -2.0 -1.2 -0.9 -0.6 1.9 -2.0 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.1 6.5 13.9 2.8 -2.3 1.8 3.4 0.9 -0.8 3.6 -1.2 3.7 2.8
Whole body water mass 5.1 29.0 83.7 0.9 -6.3 1.1 7.1 0.6 -0.6 9.2 1.4 7.1 7.8
Leg predicted mass (right) 5.6 30.0 73.6 1.1 -6.7 0.6 7.3 0.2 -0.3 8.6 1.3 7.3 8.5
Arm fat mass (left) 1.1 4.7 16.9 -0.4 -2.6 0.6 2.6 -0.1 -1.1 4.1 1.4 2.3 2.7
Number of self-reported non-cancer illnesses 0.4 0.7 1.8 0.2 0.9 0.8 -0.7 0.4 0.9 -1.1 -0.4 -0.7 -1.3
Average weekly champagne plus white wine intake 0.4 0.5 1.2 1.1 -0.5 1.0 -0.3 -0.1 0.9 -0.7 -1.1 0.1 0.6
Miserableness 1.6 2.7 7.1 -2.6 -0.0 -2.7 -1.5 -1.4 -1.4 -0.1 1.4 -2.1 -0.8
Guilty feelings 1.2 1.8 7.6 -0.7 0.1 -2.8 -1.5 -1.0 0.0 -2.1 0.2 -1.4 0.2
Wears glasses or contact lenses 0.7 0.8 2.5 0.6 0.8 1.3 -0.6 0.7 1.6 -0.5 -1.1 -0.3 -0.8
Ever taken oral contraceptive pill 0.5 0.6 2.1 0.1 -1.1 -1.2 0.6 -0.3 -0.3 0.1 0.2 0.7 1.5
Hearing aid user 0.6 0.7 5.2 -0.1 0.1 -0.1 -0.2 0.0 -2.3 1.0 0.1 -0.5 0.3
Mother’s age at death 1.2 1.5 3.3 0.8 -1.4 0.2 1.4 0.4 1.8 1.8 0.3 1.4 1.2
Financial situation satisfaction 0.9 1.1 4.0 0.3 1.1 -0.5 1.1 2.0 1.2 0.8 1.1 0.8 0.3
Tinnitus: Yes, now most or all of the time 2.3 2.7 9.3 1.6 1.8 3.0 -0.5 1.3 0.7 -0.6 -2.0 -0.6 -2.1
Commuting to job workplace: Public transport 0.4 0.5 1.9 0.8 0.5 1.1 -0.1 0.3 -0.6 0.6 -1.4 -0.1 0.4
Eye problems/disorders: Glaucoma 0.5 0.5 1.7 0.8 0.5 1.2 -0.0 0.7 1.3 -0.7 -0.3 0.5 0.1
Medication: Blood pressure 1.3 2.4 6.0 -1.9 0.3 0.7 -1.8 -1.4 -1.6 -0.7 1.0 -2.3 -2.5
Pain type(s) experienced in last month: Hip pain 1.1 1.3 4.9 1.2 1.9 0.7 0.5 2.2 1.5 -0.4 -0.0 0.5 0.1
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.7 -0.4 0.2 -0.7 -0.2 0.2 -0.8 -0.7 -0.1 -0.3 -0.7
High cholesterol (Self-reported) 0.9 1.5 6.6 0.4 1.7 0.8 0.3 2.6 2.1 0.4 0.4 0.2 0.2
Medication: Bendroflumethiazide 1.5 2.3 5.6 -1.4 0.8 0.2 -2.1 -1.1 -1.4 -1.6 -0.2 -2.1 -2.4
Medication: Paracetamol 1.7 2.7 7.2 0.2 2.7 1.4 -1.0 2.0 1.7 -1.5 0.6 -1.1 -2.4
Medication: Lisinopril 1.6 2.0 4.4 -1.5 -0.5 -1.4 -1.7 -2.0 -2.1 -0.6 0.9 -1.8 -0.4
Medication: Atorvastatin 0.5 0.7 2.5 0.5 1.0 1.6 0.7 1.1 -0.2 0.6 0.0 0.4 0.9
Illnesses of father: High blood pressure 1.1 1.4 4.4 -2.1 -0.4 0.4 -0.9 -1.3 -1.2 -0.8 1.5 -1.3 -0.9
Alcohol drinker status: Never 0.1 0.2 0.5 -0.1 -0.5 -0.2 0.2 0.4 0.7 0.3 0.7 0.1 0.5
Ever smoked 1.4 2.4 8.6 -2.8 0.1 -0.8 -1.1 -0.8 0.0 0.2 2.9 -1.5 -1.6
Basal metabolic rate 4.4 24.6 72.6 0.6 -5.9 0.9 6.5 0.4 -0.7 8.5 1.5 6.4 7.2
Leg fat percentage (left) 0.4 1.5 5.2 -0.7 1.4 0.4 -1.6 0.0 -0.7 -0.9 0.3 -1.9 -2.3
Arm fat-free mass (left) 4.3 21.6 69.4 0.6 -5.2 1.2 6.1 0.7 -0.4 8.3 1.4 6.0 6.5
Number of operations (self-reported) 1.1 1.6 4.0 -1.9 -1.7 -1.7 1.0 -0.5 0.3 0.2 2.0 0.7 1.0
Average weekly beer plus cider intake 1.0 1.4 3.5 -0.5 0.9 0.4 -1.9 -1.0 -0.8 -1.5 -1.2 -1.9 -0.9
Irritability 1.3 2.3 6.0 -0.4 1.8 -0.7 -2.2 -0.3 0.1 -2.1 -0.0 -2.4 -1.8
Risk taking 0.4 0.6 2.5 -0.2 0.4 -0.3 -0.8 -0.1 -1.1 -0.7 -0.4 -0.5 1.6
Ever had prostate specific antigen (PSA) test 2.2 2.6 8.1 2.3 0.4 2.8 1.5 1.4 1.8 0.7 -1.2 1.6 0.6
Fractured/broken bones in last 5 years 1.4 1.9 3.8 -0.3 -1.8 -0.6 1.8 -0.1 -1.2 1.6 1.1 1.9 1.7
Age started oral contraceptive pill 1.7 2.2 5.4 0.4 -2.2 0.6 1.9 -0.0 -0.2 1.7 0.2 2.3 2.1
Diastolic blood pressure, automated reading 7.1 21.9 48.6 1.9 7.0 1.6 -5.5 1.5 1.9 -6.6 -3.4 -5.2 -6.8
Ever depressed for a whole week 2.1 2.6 8.2 -1.7 -0.6 -2.9 -1.1 -2.0 -2.0 -1.1 1.0 -1.5 -0.3
Unable to work because of sickness or disability 0.6 0.8 2.6 -0.8 0.4 -0.1 -1.0 -0.6 -1.6 -0.6 0.2 -1.2 -1.1
Commuting to job workplace: Cycle 0.3 0.4 1.3 0.5 -0.2 1.1 0.7 -0.5 -0.9 0.1 -0.2 0.7 0.3
Myopia 1.0 1.5 5.8 0.7 -2.0 0.0 0.8 -0.3 1.2 0.2 -1.0 1.1 2.4
Vascular/heart problems diagnosed by doctor 1.3 3.7 11.9 0.8 -1.8 -1.4 2.7 0.6 0.9 1.7 0.0 2.7 3.4
Cholesterol lowering medication 1.0 1.5 4.7 -1.0 -0.7 0.2 1.5 0.9 0.1 1.9 2.2 1.0 1.1
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 6.1 0.2 1.5 2.5 -0.5 0.7 0.6 -0.7 0.7 -1.1 -1.5
Pain experienced in last month 4.5 7.5 21.4 -2.6 -4.6 -2.4 1.7 -3.3 -2.4 2.5 2.8 1.4 2.0
Supplements: Calcium 0.8 0.9 2.9 -0.8 -1.7 -0.9 0.4 -0.0 0.6 1.1 1.6 0.4 0.6
Basal cell carcinoma (self-reported) 1.7 2.0 5.6 -1.9 -1.5 -0.1 -0.8 -2.1 -2.4 0.2 1.5 -1.2 -0.8
Heart attack/myocardial infarction (self-reported) 0.7 1.0 2.6 -1.1 0.8 -0.1 -1.6 -0.8 -1.0 -0.8 -0.6 -1.5 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.4 -1.2 -0.6 -0.3 0.5 0.5 -0.6 -0.0 1.1 0.4 0.2
Heart disease (siblings) 0.9 1.1 3.5 -1.2 0.1 0.4 -1.9 -0.8 -0.7 -0.3 -0.3 -1.9 -0.9
Alcohol drinker status: Previous 0.4 0.5 1.3 -0.9 0.7 -0.7 -0.2 0.8 0.6 0.7 1.1 -0.5 0.0
Pack years of smoking 1.1 1.5 6.4 -0.1 2.5 2.2 0.3 1.8 -0.5 -0.5 0.2 -0.3 -0.2
Impedance of whole body 2.5 12.8 34.1 -1.6 3.2 -1.2 -4.7 -1.6 0.4 -5.8 -0.4 -4.9 -5.6
Leg fat mass (left) 0.4 1.5 6.4 -0.1 -1.4 0.7 1.4 -0.1 -1.0 2.5 0.5 1.1 1.2
Arm predicted mass (left) 4.4 22.5 70.4 0.8 -5.2 1.3 6.3 0.8 -0.6 8.4 1.2 6.2 6.7