Hub : Genes

CSNK1G3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1610	0.0360	1.8e-15	0.163	0.134	0.153	0.095	0.054	2.5e-19	5.0e-16	3.0e-18	1.2e-11	3.3e-07
2	GTEx	Artery Aorta	0.1070	0.0440	5.7e-03	0.065	NA	-0.002	NA	0.012	1.8e-04	NA	4.2e-01	NA	6.5e-02
3	GTEx	Brain Cerebellum	0.2690	0.1030	2.3e-03	-0.010	NA	0.034	NA	-0.009	8.3e-01	NA	3.6e-02	NA	7.2e-01
4	GTEx	Esophagus Mucosa	0.1370	0.0500	5.1e-04	0.046	NA	0.056	NA	0.070	4.6e-04	NA	1.2e-04	NA	2.0e-05
5	GTEx	Pancreas	0.1290	0.0540	3.4e-03	0.044	NA	0.032	NA	0.064	6.3e-03	NA	1.7e-02	NA	1.1e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.0760	0.0241	3.0e-05	0.013	0.049	0.018	0.047	0.018	7.4e-03	5.5e-07	2.1e-03	1.1e-06	1.9e-03
7	TCGA	Breast Invasive Carcinoma	0.0426	0.0249	3.3e-03	0.015	0.017	0.018	NA	0.010	3.1e-04	1.7e-04	1.2e-04	NA	2.6e-03
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.2129	0.0769	1.2e-05	0.009	0.042	0.030	NA	0.018	2.7e-02	1.6e-05	2.4e-04	NA	3.9e-03
9	TCGA	Lung Adenocarcinoma	0.0569	0.0331	4.7e-04	0.050	0.026	0.029	NA	0.039	1.6e-06	4.6e-04	2.2e-04	NA	2.0e-05
10	TCGA	Prostate Adenocarcinoma	0.0587	0.0297	3.3e-05	0.042	0.049	0.054	NA	0.051	2.9e-05	6.2e-06	2.3e-06	NA	4.2e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.1	1.7	5.3	0.5	-0.8	-0.5	2.3	0.3	-0.6	1.3	-0.2	2.1	1.9
Bipolar Disorder or Schizophrenia	0.5	1.2	3.8	-0.3	-1.5	-0.8	0.8	-1.4	-0.2	0.7	-1.2	1.2	1.9
Depressed Affect (Nagel 2018)	1.6	3.3	6.5	-2.2	1.9	-1.7	-1.9	-0.1	-0.5	-1.9	2.1	-2.5	-1.8
Depression (Nagel 2018)	0.6	0.8	1.9	-1.4	1.1	0.9	-0.8	-0.1	-0.1	-0.1	0.9	-1.1	-1.4
Intelligence (Savage-Jansen 2018)	0.6	1.7	5.6	-1.6	-0.8	-1.7	0.7	-0.5	0.9	2.0	2.4	0.4	0.3
Neuroticism (Nagel 2018)	2.1	4.9	13.4	-1.5	2.2	-1.8	-3.0	-0.4	-0.1	-3.7	1.2	-3.3	-2.0
Schizophrenia (2018)	0.5	1.0	4.1	-0.8	-1.2	-0.6	-0.9	-2.0	0.2	-0.2	-1.3	-0.2	0.9
Schizophrenia vs Biploar Disorder	0.6	0.7	3.5	0.4	-0.1	0.6	-1.1	-0.9	0.3	-0.9	-1.9	-0.5	-0.3
Worry (Nagel 2018)	2.0	4.3	12.6	-1.4	2.1	-1.3	-2.5	-0.6	0.2	-3.6	1.3	-2.8	-2.4
Alzheimer’s Disease (in mother)	1.2	1.5	7.7	1.4	1.3	1.4	0.1	0.7	0.6	0.2	-2.8	0.4	-0.1
Alzheimer’s Disease (in father)	2.3	2.5	6.6	0.7	-0.7	1.5	2.2	1.0	0.2	2.6	1.1	2.2	1.8
Alzheimer’s Disease (including proxy)	1.5	2.1	4.5	1.4	1.0	2.1	1.3	1.6	1.4	1.7	-1.3	1.5	0.9
Crohns Disease (2017)	0.4	0.8	2.2	0.7	0.3	-0.9	-0.9	-0.8	-0.8	-1.2	-1.5	-0.7	-0.4
Irritable Bowel Disease (IBD)	0.1	0.3	1.4	0.2	0.1	-1.2	-0.5	-0.4	-0.7	-0.2	-0.3	-0.4	-0.1
Ulcerative Colitis (UC)	0.2	0.3	1.5	-0.6	-0.1	-0.8	-0.2	-0.0	-0.6	0.7	1.2	-0.1	0.0
Major Depression (MDD)	0.8	1.0	4.0	-2.0	0.2	0.3	-0.9	-0.6	-0.4	-0.1	1.2	-1.2	-1.1
Reaction Time	0.6	1.2	3.4	-1.4	-1.3	-0.9	-0.5	-1.7	0.0	-1.8	0.5	-0.4	-0.3
Verbal and Numeric Reasoning (VNR)	0.5	1.2	5.2	-1.2	-0.8	-0.5	0.6	-0.9	0.3	1.8	2.3	0.3	-0.1
Breast Cancer	0.3	0.7	2.3	-0.4	-0.0	0.2	-0.3	-1.2	1.2	-1.5	0.6	-0.5	-1.0
Ovarian Cancer	0.4	0.5	2.0	0.4	0.7	-0.3	-0.1	0.6	1.1	-1.4	-0.2	-0.2	-0.6
Prostate Cancer	1.1	1.5	3.4	-0.6	-1.5	0.2	1.3	0.5	0.2	1.9	1.4	1.3	1.8
Age at First Birth	1.0	1.5	4.4	1.2	-1.7	0.0	1.4	0.3	0.3	0.8	-0.8	1.7	2.1
Bipolar Disorder (2011)	0.7	0.7	3.3	1.0	0.1	0.8	0.0	0.7	-0.3	0.0	-1.8	0.6	1.0
Body Mass Index (BMI) (2010)	1.2	1.6	5.3	-0.6	-1.5	0.9	1.1	0.1	-1.1	2.3	1.2	1.2	1.4
Coronary Artery Disease (CAD)	0.7	0.8	3.3	-0.4	0.4	0.2	-0.9	-0.9	-1.8	-0.8	-0.2	-1.0	-1.0
Crohns Disease (2012)	0.7	1.1	2.9	0.1	1.3	-0.4	-1.7	0.5	-0.1	-1.4	-1.0	-1.5	-0.8
Mean Putamen Volume	1.3	1.5	3.1	1.6	0.1	1.1	1.8	1.5	1.0	0.0	-0.6	1.7	1.2
Fasting Glucose	0.2	0.2	1.0	-0.4	-0.4	-0.5	0.5	-0.4	-0.3	0.2	1.0	0.3	0.1
HbA1C	1.0	1.1	3.6	-1.5	0.4	-0.2	-0.9	-0.6	-0.8	-0.3	1.9	-1.4	-0.9
HDL Cholesterol	0.6	1.0	2.9	0.4	0.2	-0.4	-0.4	-1.7	-0.9	-1.3	-0.8	-0.8	-1.6
LDL Cholesterol	3.4	5.3	13.2	3.0	2.9	1.9	0.9	3.6	3.4	-0.0	-2.3	1.0	0.4
Lupus	0.4	0.6	1.6	0.4	0.0	-0.6	1.3	1.0	-1.1	-0.6	1.1	0.6	-0.1
Neuroticism (2016)	0.5	0.7	3.2	-0.6	0.1	-0.1	-0.5	0.3	1.0	0.5	1.8	-0.6	-1.0
Primary Biliary Cirrhosis	0.5	0.7	2.2	-0.6	-0.8	-1.0	-0.8	-1.5	-1.1	-0.2	0.0	-0.4	0.9
Rheumatoid Arthritis	1.1	1.5	5.0	0.6	-1.7	-0.8	1.3	-0.2	-0.0	1.7	0.1	1.3	2.2
Schizophrenia (2014)	0.5	1.2	4.0	-0.3	-1.4	-0.5	-0.8	-2.0	-0.4	-0.1	-1.6	0.0	1.4
Triglycerides	0.3	0.5	2.0	0.3	0.6	1.4	0.2	1.2	0.5	-0.1	0.7	0.2	0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	1.1	-0.2	-1.3	-0.3	0.3	-1.2	-0.6	-0.8	-0.1	0.4
Ulcerative Colitis	1.1	1.6	6.2	-0.8	-1.0	-0.7	1.3	0.8	0.3	2.0	2.5	1.2	0.6
Blood Eosinophil Count	0.1	1.1	2.7	-0.7	0.8	0.8	-1.3	-0.6	-1.4	-0.4	-1.2	-1.3	-1.6
Blood Platelet Count	0.6	7.5	18.2	1.8	4.3	-0.8	-2.4	1.3	2.6	-3.8	-2.0	-2.4	-3.6
Blood Red Count	0.7	7.1	14.7	-3.8	-2.5	-2.9	-0.4	-3.6	-2.7	0.6	3.8	-1.3	-2.2
Blood White Count	1.0	7.6	19.8	-1.5	3.0	-1.5	-3.8	-0.5	0.7	-3.4	0.5	-3.9	-4.5
Heel T-Score	4.8	38.0	110.2	-7.1	2.2	-3.2	-7.0	-4.9	-2.3	-5.2	5.3	-8.4	-10.5
BMI	0.9	5.1	19.2	-0.3	-2.8	0.7	2.8	0.2	-1.2	4.4	1.2	2.5	2.4
Height	2.5	48.9	121.4	0.4	-9.0	1.4	9.5	-0.3	-0.9	11.0	2.2	9.3	10.1
Waist Hip Ratio (WHR)	0.0	0.2	0.6	-0.1	0.8	-0.0	-0.6	-0.1	-0.3	-0.2	0.1	-0.7	-0.4
Systolic Blood Pressure	1.8	9.2	46.7	-1.3	2.7	1.7	-3.1	-0.9	-1.0	-2.2	1.6	-3.8	-6.8
Smoking Status	1.6	3.8	9.6	-2.8	1.0	-0.9	-3.0	-1.2	0.0	-1.4	1.8	-3.1	-1.8
Allergy or Eczema	0.5	1.3	3.4	1.4	-1.2	0.3	1.3	-0.2	0.5	0.2	-1.4	1.2	1.9
Cardiovascular Disease	1.3	4.4	10.5	-0.4	3.0	1.8	-2.8	0.8	0.3	-2.1	-0.2	-2.8	-3.2
Hypothyroidism (self reported)	2.4	5.6	16.4	-2.1	-4.1	-3.9	0.4	-3.1	-1.4	1.0	0.2	0.5	2.6
Respiratory disease	1.0	2.3	6.4	0.7	2.0	2.5	-0.3	1.9	1.9	-1.0	0.3	-0.4	-2.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.6	-0.4	-0.1	0.1	-1.0	-1.1	-1.9	-0.9	0.3	-1.0	-0.8
Lung FEV1/FVC ratio	0.9	4.4	15.1	0.4	-3.2	-0.4	1.4	-1.5	-1.3	2.9	-0.9	1.9	3.9
Lung FVC	1.1	5.6	13.4	2.3	-2.0	2.0	2.6	0.7	-1.2	3.7	-1.9	3.1	2.9
Neuroticism	1.9	4.7	10.4	-2.3	1.4	-2.5	-2.7	-0.9	0.1	-2.5	2.3	-3.2	-1.7
Chronotype (morning person)	2.2	5.1	13.8	2.7	2.1	3.4	1.3	3.7	2.7	0.4	-1.6	1.6	0.6
Hair Pigment	0.1	3.6	8.8	1.6	3.0	0.7	-1.2	1.7	0.5	-2.6	-2.3	-1.2	-2.6
Tanning	0.1	1.8	4.1	0.9	1.6	1.9	1.0	1.4	2.0	1.5	0.3	0.6	-0.8
Hand grip strength (left)	0.8	2.2	6.4	2.5	0.5	2.0	0.4	1.5	-0.0	1.1	-2.4	0.7	1.2
Number of treatments/medications taken	0.6	1.2	4.1	0.1	0.9	0.8	-1.2	-0.2	-0.0	-1.5	-0.6	-1.4	-2.0
Average weekly spirits intake	1.2	1.5	4.8	1.7	0.8	1.9	0.8	2.2	0.8	0.1	-0.8	0.8	0.4
Sensitivity / hurt feelings	0.6	1.0	4.9	-0.5	0.1	-2.2	-0.1	0.5	0.4	-0.8	1.6	-0.3	1.1
Frequency of depressed mood in last 2 weeks	0.8	1.2	6.0	-1.7	-0.4	-1.3	0.0	-0.6	0.4	0.0	2.5	-0.4	-0.2
Hearing difficulty/problems: Yes	1.0	1.5	6.4	1.6	1.6	2.5	-0.5	0.5	-0.1	-0.1	-1.1	-0.6	-1.0
Relative age of first facial hair	0.4	0.8	2.8	-0.5	-1.5	0.6	0.7	0.1	-0.3	0.9	0.8	0.8	1.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.6	-0.3	-1.3	-1.1	0.2	-0.5	-0.1	0.2	0.8	0.4	0.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.6	-0.3	0.8	0.2	-0.2	0.5	-0.6	-1.6	0.1	-0.3	-1.0
Ever had hysterectomy (womb removed)	0.6	0.7	1.9	-1.0	0.7	0.2	0.5	1.0	0.9	-0.6	1.4	0.4	-0.6
Systolic blood pressure, automated reading	0.6	1.7	7.9	-0.4	-0.1	1.9	-0.0	-0.8	-1.5	0.5	1.3	-0.5	-2.8
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	6.4	-0.2	-0.1	0.7	1.7	0.5	0.5	0.3	2.5	1.1	-1.3
Angina	0.5	0.7	2.5	-0.6	-0.6	1.0	0.0	-0.8	-1.6	0.9	0.7	-0.1	-0.7
Medication for hormone replacement therapy	0.1	0.2	0.5	0.5	-0.1	0.0	0.4	-0.0	-0.5	0.2	-0.7	0.4	0.3
Vitamin and mineral supplements	0.4	0.5	1.8	-0.9	0.6	0.0	-1.2	-0.3	-0.4	0.5	0.6	-1.3	-0.4
Supplements: Zinc	0.4	0.5	1.5	-0.6	-0.8	-1.2	0.3	-0.6	0.4	-0.4	1.2	0.1	-0.5
Medication: Co-codamol	1.4	1.6	3.8	-0.4	1.9	-0.3	-1.8	0.3	0.2	-2.0	-0.2	-1.8	-1.3
Medication: Metformin	1.1	1.6	4.6	-0.8	-1.8	-0.8	1.1	-1.3	-1.7	0.5	2.2	1.0	0.3
Diabetes (father)	0.4	0.5	1.3	-1.0	0.9	0.1	-0.2	-0.1	-0.3	0.1	1.1	-0.6	-1.2
Diabetes (mother)	0.5	0.6	2.6	-0.6	-0.9	-0.6	-0.2	-1.2	-0.3	-0.8	1.6	-0.3	0.1
Severe depression (siblings)	0.7	0.7	1.6	1.0	0.1	1.0	0.9	1.1	1.0	-0.3	-0.4	1.2	0.6
Pack years adult smoking proportion	1.0	1.5	6.0	-0.3	2.4	2.3	0.3	1.7	-0.6	-0.5	0.4	-0.3	-0.4
Impedance of leg (right)	4.4	21.1	63.7	-1.6	5.2	-0.2	-6.0	-0.7	0.0	-6.5	-0.5	-6.2	-8.0
Leg fat-free mass (left)	5.1	27.2	72.4	0.7	-6.5	0.5	6.9	0.0	-0.6	8.5	1.6	6.8	7.8
Trunk fat percentage	0.1	0.4	1.2	-0.9	-0.8	0.1	0.2	-0.7	-0.8	1.1	0.8	-0.1	0.1
Hand grip strength (right)	1.2	3.3	7.6	2.2	-0.6	1.8	1.4	1.1	-0.5	2.7	-1.9	1.7	2.8
Townsend deprivation index at recruitment	3.7	5.2	16.4	-3.1	-2.2	-3.4	0.2	-2.3	-1.5	1.3	4.0	-0.1	-0.5
Current tobacco smoking	1.5	2.4	7.7	-2.8	0.8	-0.9	-1.9	-0.7	-0.6	-0.5	2.0	-2.0	-1.4
Average weekly fortified wine intake	2.5	3.0	10.5	-0.7	-3.2	-1.0	1.2	-2.0	-0.1	2.0	1.2	1.1	2.3
Maternal smoking around birth	0.4	0.6	2.3	-0.5	1.5	-0.4	-0.4	0.5	0.3	-1.0	0.2	-0.8	-0.8
Fed-up feelings	0.8	1.4	6.2	-1.3	1.2	-0.3	-0.1	0.9	1.2	-0.1	2.5	-0.6	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.8	-1.7	0.5	-0.6	-1.0	-0.8	0.0	0.1	1.3	-1.3	-1.1
Relative age voice broke	0.2	0.3	0.8	0.4	-0.3	-0.6	-0.5	-0.0	0.3	-0.9	-0.6	-0.0	0.7
Taking other prescription medications	0.1	0.1	0.4	0.1	-0.3	-0.3	0.1	-0.7	0.6	-0.1	-0.5	0.2	-0.3
Age when periods started (menarche)	0.5	1.3	2.8	1.7	1.6	0.3	0.2	1.6	0.4	-1.5	-1.5	0.5	0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.1	0.9	0.6	0.4	-0.2	0.6	0.3	-0.8	-1.4	-0.2	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	4.6	10.5	23.6	-2.6	1.7	-1.4	-4.5	-3.1	-2.7	-3.6	-0.1	-4.9	-4.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.8	0.2	0.4	1.4	0.7	1.1	1.0	0.3	0.5	0.2	-0.2
Qualifications: CSEs or equivalent	0.2	0.3	1.2	-0.0	-0.0	-1.1	-0.6	0.3	-0.0	0.8	0.2	-0.4	0.7
Serious illness, injury or assault to yourself	1.1	1.3	3.8	-1.5	-1.9	-1.3	0.5	-1.3	-1.1	0.4	0.6	0.6	1.2
High blood pressure	1.1	3.0	10.2	-0.8	1.4	1.3	-2.5	-0.6	-0.5	-1.6	0.3	-2.4	-3.2
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.9	0.6	-0.5	0.0	-0.2	-1.0	-0.4	-1.0	-1.4	-0.4	0.2
Multivitamins +/- minerals	0.4	0.5	1.3	1.1	-0.1	-0.5	0.6	0.3	-0.2	-0.9	-1.1	0.7	0.7
Stomach or abdominal pain in last month	0.4	0.5	1.6	-0.3	0.7	0.1	-1.1	0.5	0.7	0.2	-0.7	-1.3	-0.5
Supplements: Glucosamine	0.6	0.7	1.8	1.3	0.0	0.9	0.7	0.9	0.4	0.5	-1.1	0.9	0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.9	1.0	1.3	1.0	0.5	1.4	-0.1	-0.4	-0.0	0.3	-0.7
Medication: Atenolol	0.9	1.2	3.1	0.6	1.6	1.3	-0.7	1.4	1.1	-0.3	-0.3	-0.6	-1.8
Medication: Levothyroxine sodium	1.9	3.3	9.4	-1.9	-3.1	-2.6	0.4	-2.1	-1.7	1.4	0.4	0.3	1.8
Sitting height	3.2	22.7	62.1	-1.0	-7.3	0.4	5.7	-2.1	-1.3	7.9	1.8	5.5	6.0
Chronic bronchitis/emphysema (father)	0.6	0.7	1.8	-0.2	1.3	0.4	-0.4	0.7	1.1	-1.0	0.3	-0.7	-1.3
High blood pressure (mother)	2.4	3.4	8.3	1.5	2.9	2.6	-1.4	0.5	0.8	-1.5	-1.4	-1.6	-2.7
Body mass index (BMI)	0.5	2.2	8.9	-0.3	-1.6	0.5	1.6	-0.1	-1.4	3.0	0.7	1.4	1.8
Impedance of leg (left)	4.1	19.8	55.7	-1.0	5.1	-0.3	-5.8	-0.7	0.2	-6.7	-1.1	-5.9	-7.5
Leg predicted mass (left)	5.3	28.2	74.3	0.7	-6.5	0.6	7.1	0.1	-0.6	8.6	1.8	6.9	7.9
Trunk fat mass	0.7	3.0	11.2	-0.6	-2.3	0.5	2.0	-0.4	-0.9	3.3	1.1	1.7	2.0
Waist circumference	1.4	5.2	19.3	-0.4	-2.6	0.8	2.8	-0.0	-1.4	4.4	1.5	2.4	2.7
Number of incorrect matches in round	1.9	3.2	18.4	2.2	0.8	1.1	-1.1	-0.1	-0.7	-2.2	-4.3	-0.7	-0.5
Past tobacco smoking	1.1	2.0	5.8	2.4	0.4	1.2	1.4	1.4	0.0	0.1	-2.1	1.7	1.3
Alcohol usually taken with meals	3.7	6.0	15.7	3.6	2.4	4.0	0.5	2.8	2.6	-0.4	-3.1	0.9	-0.5
Nervous feelings	2.2	4.0	16.1	-0.2	1.6	-1.5	-2.7	-1.0	-0.5	-4.0	-0.5	-2.7	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	4.3	-2.0	0.2	-1.1	-0.5	-0.7	0.6	0.3	2.1	-0.9	-0.8
Hearing difficulty/problems with background noise	1.6	2.6	5.0	1.4	2.1	1.6	-2.2	0.6	0.6	-0.9	-2.0	-1.9	-1.5
Hair/balding pattern: Pattern 2	0.5	0.6	5.6	-0.5	0.4	0.1	-0.3	-0.2	-0.1	-2.4	0.5	-0.1	0.0
Had menopause	0.3	0.4	1.7	-1.3	-0.6	0.3	0.2	-0.2	0.0	0.7	1.0	0.4	0.6
Had other major operations	2.1	2.5	6.5	-2.6	-1.4	-2.5	-0.2	-1.4	-1.4	0.4	2.4	-0.5	0.7
Forced vital capacity (FVC)	2.2	8.6	22.6	1.5	-3.9	1.3	3.4	-0.6	-0.8	4.8	-1.4	3.7	4.0
Heel bone mineral density (BMD) T-score, automated (right)	3.9	9.0	22.7	-1.8	2.2	-0.5	-4.4	-2.5	-2.3	-3.4	-0.5	-4.8	-4.1
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	8.4	-2.2	-0.4	-2.9	-0.5	-1.2	-1.0	0.6	2.8	-1.0	-0.1
Qualifications: None of the above	0.2	0.5	1.4	-0.7	0.9	0.6	-1.0	0.5	-0.3	-1.2	0.1	-0.9	-0.0
Financial difficulties in last 2 years	0.5	0.6	1.6	-0.1	1.1	0.0	1.1	1.3	-0.7	0.4	1.1	0.5	0.3
Mouth/teeth dental problems	0.5	0.8	2.0	1.3	0.5	-0.1	-0.8	-0.0	1.3	-1.2	-1.4	-0.6	-0.2
Heart attack	0.6	0.8	2.0	-1.2	0.4	-0.3	-1.4	-1.0	-1.1	-0.7	-0.3	-1.3	-0.1
Allergy	0.2	0.5	2.2	-0.6	-0.4	-0.9	0.1	-0.1	-0.2	1.5	0.8	0.4	0.6
Pain all over the body in last month	0.3	0.3	1.4	-0.1	-0.1	0.2	-0.0	0.1	0.9	0.1	0.9	-0.1	-1.2
Diabetes (self-reported)	0.2	0.3	2.5	-0.0	-0.3	-0.4	-0.1	-0.6	-1.6	-0.3	0.2	-0.1	0.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.6	1.3	0.3	-0.8	-0.9	0.6	0.8	-1.7	-1.9	-0.5	0.1
Medication: Ramipril	0.8	1.0	2.0	-1.4	0.5	1.3	-0.8	-0.9	-1.3	1.0	0.8	-0.9	-0.5
Medication: Simvastatin	0.4	0.6	2.2	0.5	0.9	0.2	0.2	1.5	1.5	0.3	-0.0	0.3	0.1
Fluid intelligence score	0.3	0.6	2.9	-0.3	0.2	-1.1	0.2	0.5	0.8	0.9	1.7	0.1	-0.1
Illnesses of siblings	0.8	1.1	3.0	1.2	-0.8	-0.1	1.5	0.4	0.5	0.8	-1.0	1.7	1.4
Neuroticism score	2.5	5.2	10.4	-2.6	1.3	-2.7	-2.6	-1.2	-0.8	-2.8	2.2	-3.2	-2.1
Weight	2.5	12.3	40.4	-0.2	-4.5	0.9	4.4	-0.3	-1.3	6.4	1.4	4.2	4.6
Impedance of arm (right)	1.0	4.5	11.7	-1.8	0.6	-1.6	-2.3	-2.1	-0.0	-3.4	0.9	-2.5	-3.3
Arm fat percentage (right)	0.2	0.8	2.7	-0.7	-1.2	0.2	0.8	-0.4	-0.8	1.6	1.1	0.6	0.6
Trunk fat-free mass	4.7	27.2	82.3	0.9	-6.0	1.3	6.8	0.7	-0.6	9.1	1.2	6.8	7.4
Hip circumference	1.2	5.3	19.5	-0.1	-2.6	1.2	3.0	-0.1	-1.8	4.4	1.0	2.5	2.3
Time employed in main current job	0.8	0.9	3.0	1.3	0.8	0.1	-0.2	0.8	0.8	-0.9	-1.7	0.1	1.1
Alcohol intake versus 10 years previously	0.6	0.9	2.8	-1.3	0.9	0.1	-0.0	0.1	-0.2	-0.6	1.6	-0.7	-1.7
Father’s age at death	0.6	0.9	2.6	-1.2	-1.4	-0.8	-0.3	-1.6	0.8	0.3	1.0	-0.4	0.4
Worrier / anxious feelings	1.3	2.5	7.4	0.2	2.1	-0.3	-1.4	0.4	2.0	-2.7	0.0	-1.5	-2.1
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	5.9	-0.5	2.4	1.3	-0.5	1.2	1.0	-0.4	0.8	-1.0	-1.3
Falls in the last year	1.2	1.6	5.9	-0.5	-1.3	1.9	1.3	-0.4	-2.4	0.7	0.2	1.2	0.9
Hair/balding pattern: Pattern 3	0.9	1.3	4.7	2.2	1.3	0.3	-0.2	1.7	0.6	0.2	-1.9	0.0	0.2
Number of live births	2.0	2.9	7.1	-1.7	-1.4	-1.0	1.8	0.1	-0.2	2.6	2.7	1.8	1.5
Forced expiratory volume in 1-second (FEV1)	2.5	8.4	19.4	1.7	-3.7	1.1	3.4	-0.6	-0.9	4.4	-1.5	3.7	4.3
Pulse rate	2.0	3.3	10.0	-0.8	1.9	-0.8	-2.0	-0.4	1.4	-2.2	0.9	-2.4	-3.2
Happiness	0.8	1.0	2.1	0.5	-0.3	0.2	0.9	1.3	1.4	1.2	0.2	1.1	1.4
Noisy workplace	0.4	0.5	1.6	-0.0	0.3	1.3	-0.6	-0.4	-1.2	-0.5	-0.1	-0.6	-0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.7	-0.3	-0.3	-0.0	-0.9	-1.7	0.3	-0.4	-0.1	-0.9	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	-0.6	-0.4	-0.3	-0.5	-0.9	-0.3	-0.3	0.5	-0.5	0.9
Mouth/teeth dental problems: Dentures	0.6	1.1	3.8	0.6	-0.9	0.5	1.8	0.3	-0.8	0.9	-0.4	1.9	0.8
Asthma	0.8	1.6	4.5	0.6	1.6	2.1	-0.2	1.2	1.9	-1.0	-0.7	-0.4	-1.3
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	5.6	1.7	2.2	1.7	0.2	2.3	2.4	0.6	0.3	0.1	-0.7
Medication: Cholesterol lowering	1.0	1.6	3.3	1.4	1.8	0.8	-0.3	1.6	1.6	-1.4	-1.6	-0.0	-0.1
Depression (self-reported)	0.9	1.1	5.3	-1.1	-1.1	-2.3	-0.1	-1.4	-0.1	0.4	0.8	-0.1	0.4
Medication: Lansoprazole	2.0	2.3	5.7	2.4	0.8	1.6	1.5	2.0	2.4	-0.3	-0.4	1.3	0.3
Prospective memory result	2.7	3.3	6.1	2.5	2.3	1.4	-0.2	2.2	2.4	-1.7	-2.4	0.1	-0.5
Lung cancer (father)	0.3	0.3	1.7	-0.1	-0.4	-0.3	-0.4	-0.6	-1.3	0.8	-0.5	-0.2	0.0
Illnesses of mother	1.2	1.4	3.4	-1.5	-1.4	-1.9	0.7	-0.5	-0.3	0.9	1.6	0.8	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	8.9	25.8	1.7	-3.5	1.0	3.5	-0.1	-0.4	5.1	-1.1	4.0	4.2
Pulse wave Arterial Stiffness index	0.9	1.1	3.3	-0.8	-0.1	-0.0	-1.6	-0.9	0.9	-0.7	-0.1	-1.4	-1.8
Impedance of arm (left)	1.3	5.8	15.7	-1.9	1.0	-1.8	-2.9	-2.2	0.1	-4.0	0.6	-3.1	-3.4
Arm fat mass (right)	1.1	4.5	16.7	-0.4	-2.6	0.7	2.5	-0.2	-1.1	4.1	1.1	2.4	2.6
Trunk predicted mass	4.8	27.3	83.5	0.9	-6.0	1.3	6.8	0.7	-0.6	9.1	1.3	6.8	7.5
Standing height	2.3	23.0	65.2	0.6	-6.1	1.7	6.5	0.1	0.2	8.1	1.1	6.3	6.5
Length of working week for main job	1.3	1.4	4.1	1.6	-0.2	1.9	1.0	0.2	-0.3	2.0	-1.0	1.1	0.2
Exposure to tobacco smoke at home	2.2	2.5	6.6	-1.6	-1.9	-2.0	-0.7	-2.6	-2.4	0.5	0.7	-0.7	0.1
Breastfed as a baby	1.6	2.0	4.7	-1.5	-2.2	-0.7	0.9	-0.4	0.7	2.0	1.6	1.0	1.7
Tense / ‘highly strung’	0.5	0.9	2.0	-0.5	1.1	0.0	-1.2	-0.3	0.1	-1.2	1.0	-1.4	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.9	-1.7	0.2	-2.4	-1.6	-0.7	-0.5	0.1	1.3	-1.5	-0.7
Hair/balding pattern: Pattern 4	0.9	2.1	10.0	0.4	1.1	2.3	1.0	1.1	3.2	-0.2	0.5	0.6	-1.2
Birth weight of first child	0.3	0.6	1.8	-0.5	0.1	-0.4	-1.0	-0.9	-0.0	-0.1	-0.1	-1.3	-1.3
Peak expiratory flow (PEF)	0.4	1.0	4.7	1.4	0.1	2.2	0.4	0.6	0.6	0.9	-1.2	0.5	0.3
Pulse wave reflection index	1.7	2.1	6.9	2.6	0.6	1.7	0.4	2.1	0.9	0.0	-2.0	0.9	0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.5	-0.2	0.6	-1.6	-0.7	-0.4	-0.1	-0.7	0.1	-0.7	0.1
Loud music exposure frequency	0.3	0.3	1.1	0.5	0.3	0.6	0.6	0.4	1.1	0.1	0.5	0.5	0.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	5.2	-1.0	0.8	0.2	-1.2	-1.2	-1.1	-0.2	-0.2	-1.3	-2.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.7	-1.3	-0.5	0.0	0.6	-0.1	-0.8	1.7	1.3	0.4	0.7
Blood clot in the leg (DVT)	0.7	0.9	2.9	-1.4	-1.0	-0.5	1.0	0.5	-0.7	0.5	1.7	0.8	0.8
Medication: Paracetamol	2.0	3.3	8.2	0.6	2.9	1.7	-0.7	2.0	1.9	-2.0	0.1	-0.9	-2.9
Headache pain in last month	2.3	3.9	9.1	2.4	2.7	2.5	0.2	2.6	3.0	-0.4	-1.6	0.4	-0.9
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	5.8	-1.2	-2.4	-1.3	1.2	-1.3	-1.0	1.6	1.4	0.9	1.4
Glaucoma (self-reported)	0.1	0.2	0.6	-0.1	-0.5	0.6	0.4	-0.1	0.2	-0.0	0.1	0.8	0.2
Gout (self-reported)	0.2	0.2	0.8	0.3	0.6	0.1	-0.2	-0.2	0.9	-0.5	0.1	-0.3	-0.8
Hypothyroidism/myxoedema (self-reported)	1.8	3.4	10.4	-1.1	-3.1	-3.2	0.2	-2.4	-1.3	0.9	-0.7	0.3	2.1
Medication: Amlodipine	3.6	5.0	12.1	-1.9	0.7	-0.6	-3.5	-1.9	-1.6	-2.1	0.6	-3.5	-3.3
Medication: Ventolin 100micrograms inhaler	0.7	1.0	2.9	-0.7	0.8	0.8	-1.3	0.0	0.5	-1.7	0.4	-1.2	-1.2
Birth weight	1.4	3.1	11.5	-0.6	-2.3	0.3	1.5	-0.3	0.4	3.4	0.6	1.6	2.9
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.8	-2.2	0.1	-1.3	-1.5	-1.1	-1.8	-1.1	1.5	-1.7	-1.7
High blood pressure (siblings)	1.7	2.5	5.8	-1.9	1.1	-0.3	-1.6	-0.7	-0.7	-2.0	1.8	-1.9	-2.4
Forced vital capacity (FVC), Best measure	2.4	8.6	24.7	2.0	-3.0	1.4	3.5	0.5	-0.2	5.0	-1.6	3.9	4.0
Body fat percentage	0.1	0.2	0.5	-0.6	-0.2	0.3	-0.1	-0.3	-0.7	0.6	0.5	-0.4	-0.4
Leg fat percentage (right)	0.5	1.9	6.8	-1.0	1.4	0.4	-1.7	-0.1	-0.9	-0.9	0.6	-2.1	-2.6
Arm fat-free mass (right)	3.6	18.7	60.5	0.8	-4.6	1.4	5.6	1.0	-0.4	7.8	1.0	5.5	6.2
Exposure to tobacco smoke outside home	0.6	0.7	3.1	-0.8	1.3	-0.2	-0.2	0.4	-0.2	-0.5	0.9	-0.7	-1.8
Comparative body size at age 10	0.8	2.3	7.9	-1.5	-2.4	-0.7	0.3	-1.4	0.1	2.8	0.5	0.4	2.0
Number of full brothers	1.3	1.7	4.9	-1.8	0.6	0.3	-0.7	-0.7	-1.4	-0.7	2.2	-1.1	-1.8
Worry too long after embarrassment	0.9	1.6	4.4	-0.5	1.4	-0.2	-2.1	-0.4	0.1	-1.7	0.1	-2.1	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	5.0	-1.0	-0.3	-2.2	-0.5	-1.1	0.3	0.5	0.9	-0.6	0.3
Wheeze or whistling in the chest in last year	0.7	1.3	4.4	-0.0	2.0	1.9	-0.3	0.3	0.3	-0.5	0.2	-0.8	-2.1
Number of children fathered	0.7	0.8	2.2	-0.5	1.1	1.5	-0.4	0.3	-0.4	-1.2	0.8	-0.3	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.7	-0.3	-1.0	-1.3	-0.5	-1.1	-0.9	0.5	-0.7	0.0	1.2
Age at first live birth	0.3	0.6	1.4	1.0	-1.0	-0.2	0.7	-0.3	0.7	0.0	-0.6	0.8	1.2
Pulse wave peak to peak time	1.2	1.4	4.4	0.7	-0.2	0.1	1.9	1.0	-0.8	1.1	0.3	1.7	2.1
Health satisfaction	0.4	0.5	1.9	-0.5	-0.3	-0.6	0.5	0.2	1.4	0.1	1.4	0.2	0.5
Shortness of breath walking on level ground	1.2	1.5	4.2	1.0	1.9	2.0	0.1	1.7	0.8	-0.6	-0.8	-0.1	-1.2
Qualifications: College or University degree	1.7	5.5	17.6	-1.1	-4.2	-1.4	1.1	-2.7	-0.1	3.4	1.4	1.3	3.2
Eye problems/disorders: None of the above	0.8	0.9	2.4	-0.2	-1.5	-1.5	0.1	-1.2	-1.0	0.4	-0.5	0.3	1.4
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.9	-0.3	-0.3	-0.8	-0.0	-0.5	-0.9	-1.0	0.7	-0.1	-0.2
Emphysema/chronic bronchitis	2.2	2.4	7.1	-0.4	2.2	1.2	-1.3	0.8	0.3	-1.8	1.5	-1.7	-2.7
Medication for pain relief, constipation, heartburn	1.7	2.9	9.0	-0.2	-2.6	-1.9	0.9	-1.6	-0.8	1.9	-0.6	1.3	3.0
Neck or shoulder pain in last month	3.1	4.3	17.1	1.1	4.1	2.5	-0.4	3.3	0.7	-1.1	-1.0	-0.7	-2.0
Medication: Blood pressure	1.8	3.2	8.3	-0.3	1.6	0.1	-2.7	-1.2	-0.9	-2.2	-0.5	-2.4	-2.9
Angina (self-reported)	0.5	0.6	2.6	-0.6	-0.4	0.8	-0.0	-0.8	-1.6	0.7	0.6	-0.2	-0.9
Migraine (self-reported)	1.8	2.3	5.2	1.7	1.9	2.3	1.2	2.1	1.8	0.6	-0.1	1.1	-0.4
Medication: Ibuprofen	2.0	2.4	6.8	1.6	1.9	1.9	0.4	2.4	2.6	1.0	0.6	0.4	-0.3
Medication: Allopurinol	0.3	0.4	2.1	0.6	0.5	1.4	0.4	0.3	0.3	-0.5	-0.5	0.4	-0.4
Medication: Omeprazole	1.8	2.2	5.0	0.2	2.2	2.2	-1.4	0.7	0.4	-1.4	0.4	-1.9	-2.0
Medication: Seretide 50 evohaler	0.5	0.5	1.7	-0.2	0.2	-1.2	0.3	-0.1	0.8	-1.3	1.2	0.2	-0.0
Mean time to correctly identify matches	0.7	1.3	4.0	-1.2	-1.9	-1.1	-0.7	-2.0	0.2	-1.5	-0.2	-0.3	0.4
Heart disease (mother)	0.5	0.7	2.4	0.2	-1.5	0.8	-0.0	-0.9	-0.5	0.5	-1.3	0.3	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.1	0.0	-0.1	-0.1	0.1	-0.5	0.6	0.1	0.1	0.5
Whole body fat mass	0.6	2.7	10.4	-0.3	-1.9	0.8	2.0	-0.1	-1.0	3.2	0.9	1.7	1.8
Leg fat mass (right)	0.4	1.4	6.2	-0.4	-1.4	0.6	1.2	-0.2	-1.2	2.5	0.6	1.0	1.0
Arm predicted mass (right)	3.8	19.6	63.3	0.9	-4.8	1.3	5.7	0.7	-0.5	8.0	0.9	5.6	6.4
Pulse rate, automated reading	3.1	9.9	31.0	-1.2	4.0	-1.1	-3.6	-0.6	1.2	-4.4	0.1	-3.9	-5.6
Alcohol intake frequency.	0.7	1.7	5.9	-2.3	-0.7	-2.0	0.2	-0.2	-0.1	1.1	2.4	-0.3	-0.2
Comparative height size at age 10	1.7	9.4	31.4	-0.2	-4.1	1.1	4.0	-0.4	0.6	5.6	1.4	3.8	3.5
Number of full sisters	0.9	1.1	3.7	-0.1	1.2	1.7	1.0	1.9	0.1	0.9	0.8	0.8	0.3
Suffer from ‘nerves’	0.9	1.4	4.1	-1.8	-0.7	-2.0	0.2	-1.1	-0.6	-0.4	1.8	-0.3	-0.8
Overall health rating	0.7	1.5	3.7	-1.1	1.5	-0.4	-1.3	-0.5	-0.3	-1.4	1.0	-1.6	-1.9
Chest pain or discomfort	1.5	2.2	5.1	0.9	1.4	2.0	1.6	2.3	1.9	0.6	0.6	1.5	-1.1
Had major operations	0.3	0.3	1.1	-0.5	0.4	0.3	-0.3	0.3	-0.2	-1.0	0.6	-0.2	-1.0
Age at last live birth	1.3	1.9	5.2	0.6	-2.3	-0.1	1.8	-0.9	-0.5	1.6	0.4	1.6	2.0
Family relationship satisfaction	1.3	1.6	4.2	-1.3	-1.2	-1.3	0.9	-0.3	-0.1	1.8	2.0	0.7	1.5
Leg pain on walking	1.5	1.9	7.0	-1.1	-1.6	-1.1	1.4	-0.6	-0.4	1.5	2.6	0.9	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	5.6	1.0	2.4	1.4	0.1	2.1	0.7	-1.7	-0.3	-0.3	-1.2
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.4	-0.3	0.8	-0.8	-1.0	0.0	0.1	-0.8	0.0	-1.2	-1.0
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.2	1.2	0.8	-1.5	-0.7	0.4	0.7	-0.9	-1.8	-0.5	-0.4
Medication: Aspirin	0.8	1.1	2.8	-1.7	0.4	-0.4	-1.1	-0.5	-1.6	-0.8	0.8	-1.4	-0.9
Supplements: Vitamin C	1.7	2.0	5.4	0.2	-2.3	-0.4	2.0	-0.7	0.0	2.0	0.6	1.9	1.5
Knee pain experienced in last month	0.3	0.5	2.2	0.8	1.1	0.4	0.1	1.5	0.3	-0.7	-0.3	0.7	0.3
Hypertension (Self-reported)	1.4	3.9	12.9	-0.9	1.8	1.5	-2.8	-0.6	-0.9	-1.9	0.2	-2.7	-3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	5.2	0.5	0.5	2.3	0.5	0.5	0.2	0.9	0.1	0.3	-0.7
Illnesses of father: Heart disease	0.3	0.5	1.3	1.2	-0.3	1.1	0.4	-0.1	-0.3	0.5	-1.0	0.6	0.5
Illnesses of siblings: Diabetes	0.3	0.4	1.1	-0.1	0.8	0.5	-0.4	0.2	0.0	-1.0	0.3	-0.5	-1.0
Smoking status: Previous	0.5	0.7	1.6	-0.8	0.1	-0.9	-1.2	-0.4	0.8	-0.7	0.9	-1.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	9.9	0.5	-1.5	-0.4	1.2	0.1	0.5	2.0	-0.2	1.4	3.1
Whole body fat-free mass	5.1	29.1	82.3	1.0	-6.3	1.1	7.2	0.7	-0.4	9.1	1.4	7.1	7.9
Leg fat-free mass (right)	5.5	29.6	74.0	1.1	-6.6	0.5	7.2	0.2	-0.3	8.6	1.4	7.2	8.4
Arm fat percentage (left)	0.1	0.5	1.8	-0.6	-0.9	0.2	0.6	-0.4	-0.8	1.3	1.0	0.3	0.5
Average weekly red wine intake	1.0	1.5	3.0	1.3	-0.8	0.9	1.0	0.7	0.3	1.7	-1.5	1.5	1.7
Handedness (chirality/laterality): Left-handed	1.8	2.2	4.4	-2.1	-1.0	-0.5	-1.9	-2.0	-1.7	0.0	1.4	-1.9	-0.4
Mood swings	1.5	2.8	5.4	-1.8	2.3	-1.1	-1.5	0.7	-0.7	-1.8	2.1	-1.9	-1.9
Loneliness, isolation	1.5	2.0	9.8	-2.0	0.3	-2.2	-0.0	-0.3	-0.4	-0.2	3.1	-0.8	-0.6
Long-standing illness, disability or infirmity	0.6	0.9	4.9	-0.6	-0.5	-1.0	1.0	-0.3	-0.2	-0.1	2.2	0.7	-0.6
Ever had bowel cancer screening	1.1	1.2	4.1	1.6	0.5	2.0	0.9	0.8	0.2	-0.4	-1.6	1.0	-0.2
Diabetes diagnosed by doctor	0.3	0.5	2.9	-0.3	-0.6	-0.9	-0.1	-0.9	-1.7	-0.3	0.6	-0.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.9	1.4	1.3	1.7	0.0	1.2	0.5	-1.1	-1.1	0.0	-0.6
Friendships satisfaction	1.9	2.4	9.3	-1.5	-0.8	-3.1	0.5	-0.5	1.0	0.9	3.0	0.5	0.7
Qualifications: nursing, teaching	1.3	2.0	7.0	-1.4	-1.7	-1.3	0.9	-1.6	-1.1	1.3	2.6	0.3	0.4
Commuting to job workplace: Walk	1.8	2.0	6.0	-0.2	-1.1	1.0	2.5	0.9	-0.6	1.3	1.3	2.1	1.5
Eye problems/disorders: Cataract	0.9	1.1	2.8	0.4	1.5	1.7	-0.1	1.6	1.1	0.6	0.3	-0.2	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.3	1.0	1.6	0.5	-1.0	0.5	1.8	-1.2	-0.9	-0.9	-1.4
Medication for cholesterol	0.6	0.9	2.0	1.2	-0.0	-0.1	1.0	1.0	0.9	0.9	-0.6	1.4	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.7	-0.7	-1.3	0.6	1.1	-0.6	-0.5	1.2	1.1	0.9	-0.0
Back pain experienced in last month	2.2	3.2	8.2	1.3	2.9	2.3	-0.2	2.0	2.1	-1.7	-0.3	-0.5	-2.2
Mineral and other dietary supplements	0.0	0.1	0.3	-0.3	0.2	0.0	-0.2	-0.5	0.5	-0.1	0.1	-0.1	-0.1
Breast cancer (self-reported)	2.8	3.3	6.7	-2.2	-1.3	-2.2	-2.3	-2.2	-2.6	-0.5	0.5	-2.1	-0.2
Asthma (self-reported)	0.9	1.8	3.8	0.8	1.9	1.9	-0.3	1.3	1.9	-1.2	-0.7	-0.4	-1.4
Osteoporosis (self-reported)	0.4	0.5	1.7	0.7	-0.4	-0.1	0.9	-0.1	0.1	1.0	-0.1	0.8	1.3
Osteoarthritis (self-reported)	1.0	1.4	4.0	0.3	2.0	-0.4	-0.5	1.4	1.2	-1.4	0.1	-0.7	-1.7
Medication: Aspirin	0.8	1.0	3.0	-1.7	0.5	-0.4	-1.2	-0.3	-1.2	-0.5	1.0	-1.4	-0.7
Medication: Gliclazide	0.5	0.5	1.4	-0.6	-1.2	-0.5	0.1	-0.9	-0.4	-1.0	1.1	0.2	0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	1.0	-0.5	-0.5	0.8	0.4	0.6	1.1	-0.1	0.9	0.4
Smoking status: Current	1.6	2.5	8.6	-2.9	0.4	-1.1	-2.0	-1.2	-0.9	-0.6	1.9	-2.0	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.1	6.5	13.9	2.8	-2.3	1.8	3.4	0.9	-0.8	3.6	-1.2	3.7	2.8
Whole body water mass	5.1	29.0	83.7	0.9	-6.3	1.1	7.1	0.6	-0.6	9.2	1.4	7.1	7.8
Leg predicted mass (right)	5.6	30.0	73.6	1.1	-6.7	0.6	7.3	0.2	-0.3	8.6	1.3	7.3	8.5
Arm fat mass (left)	1.1	4.7	16.9	-0.4	-2.6	0.6	2.6	-0.1	-1.1	4.1	1.4	2.3	2.7
Number of self-reported non-cancer illnesses	0.4	0.7	1.8	0.2	0.9	0.8	-0.7	0.4	0.9	-1.1	-0.4	-0.7	-1.3
Average weekly champagne plus white wine intake	0.4	0.5	1.2	1.1	-0.5	1.0	-0.3	-0.1	0.9	-0.7	-1.1	0.1	0.6
Miserableness	1.6	2.7	7.1	-2.6	-0.0	-2.7	-1.5	-1.4	-1.4	-0.1	1.4	-2.1	-0.8
Guilty feelings	1.2	1.8	7.6	-0.7	0.1	-2.8	-1.5	-1.0	0.0	-2.1	0.2	-1.4	0.2
Wears glasses or contact lenses	0.7	0.8	2.5	0.6	0.8	1.3	-0.6	0.7	1.6	-0.5	-1.1	-0.3	-0.8
Ever taken oral contraceptive pill	0.5	0.6	2.1	0.1	-1.1	-1.2	0.6	-0.3	-0.3	0.1	0.2	0.7	1.5
Hearing aid user	0.6	0.7	5.2	-0.1	0.1	-0.1	-0.2	0.0	-2.3	1.0	0.1	-0.5	0.3
Mother’s age at death	1.2	1.5	3.3	0.8	-1.4	0.2	1.4	0.4	1.8	1.8	0.3	1.4	1.2
Financial situation satisfaction	0.9	1.1	4.0	0.3	1.1	-0.5	1.1	2.0	1.2	0.8	1.1	0.8	0.3
Tinnitus: Yes, now most or all of the time	2.3	2.7	9.3	1.6	1.8	3.0	-0.5	1.3	0.7	-0.6	-2.0	-0.6	-2.1
Commuting to job workplace: Public transport	0.4	0.5	1.9	0.8	0.5	1.1	-0.1	0.3	-0.6	0.6	-1.4	-0.1	0.4
Eye problems/disorders: Glaucoma	0.5	0.5	1.7	0.8	0.5	1.2	-0.0	0.7	1.3	-0.7	-0.3	0.5	0.1
Medication: Blood pressure	1.3	2.4	6.0	-1.9	0.3	0.7	-1.8	-1.4	-1.6	-0.7	1.0	-2.3	-2.5
Pain type(s) experienced in last month: Hip pain	1.1	1.3	4.9	1.2	1.9	0.7	0.5	2.2	1.5	-0.4	-0.0	0.5	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	-0.4	0.2	-0.7	-0.2	0.2	-0.8	-0.7	-0.1	-0.3	-0.7
High cholesterol (Self-reported)	0.9	1.5	6.6	0.4	1.7	0.8	0.3	2.6	2.1	0.4	0.4	0.2	0.2
Medication: Bendroflumethiazide	1.5	2.3	5.6	-1.4	0.8	0.2	-2.1	-1.1	-1.4	-1.6	-0.2	-2.1	-2.4
Medication: Paracetamol	1.7	2.7	7.2	0.2	2.7	1.4	-1.0	2.0	1.7	-1.5	0.6	-1.1	-2.4
Medication: Lisinopril	1.6	2.0	4.4	-1.5	-0.5	-1.4	-1.7	-2.0	-2.1	-0.6	0.9	-1.8	-0.4
Medication: Atorvastatin	0.5	0.7	2.5	0.5	1.0	1.6	0.7	1.1	-0.2	0.6	0.0	0.4	0.9
Illnesses of father: High blood pressure	1.1	1.4	4.4	-2.1	-0.4	0.4	-0.9	-1.3	-1.2	-0.8	1.5	-1.3	-0.9
Alcohol drinker status: Never	0.1	0.2	0.5	-0.1	-0.5	-0.2	0.2	0.4	0.7	0.3	0.7	0.1	0.5
Ever smoked	1.4	2.4	8.6	-2.8	0.1	-0.8	-1.1	-0.8	0.0	0.2	2.9	-1.5	-1.6
Basal metabolic rate	4.4	24.6	72.6	0.6	-5.9	0.9	6.5	0.4	-0.7	8.5	1.5	6.4	7.2
Leg fat percentage (left)	0.4	1.5	5.2	-0.7	1.4	0.4	-1.6	0.0	-0.7	-0.9	0.3	-1.9	-2.3
Arm fat-free mass (left)	4.3	21.6	69.4	0.6	-5.2	1.2	6.1	0.7	-0.4	8.3	1.4	6.0	6.5
Number of operations (self-reported)	1.1	1.6	4.0	-1.9	-1.7	-1.7	1.0	-0.5	0.3	0.2	2.0	0.7	1.0
Average weekly beer plus cider intake	1.0	1.4	3.5	-0.5	0.9	0.4	-1.9	-1.0	-0.8	-1.5	-1.2	-1.9	-0.9
Irritability	1.3	2.3	6.0	-0.4	1.8	-0.7	-2.2	-0.3	0.1	-2.1	-0.0	-2.4	-1.8
Risk taking	0.4	0.6	2.5	-0.2	0.4	-0.3	-0.8	-0.1	-1.1	-0.7	-0.4	-0.5	1.6
Ever had prostate specific antigen (PSA) test	2.2	2.6	8.1	2.3	0.4	2.8	1.5	1.4	1.8	0.7	-1.2	1.6	0.6
Fractured/broken bones in last 5 years	1.4	1.9	3.8	-0.3	-1.8	-0.6	1.8	-0.1	-1.2	1.6	1.1	1.9	1.7
Age started oral contraceptive pill	1.7	2.2	5.4	0.4	-2.2	0.6	1.9	-0.0	-0.2	1.7	0.2	2.3	2.1
Diastolic blood pressure, automated reading	7.1	21.9	48.6	1.9	7.0	1.6	-5.5	1.5	1.9	-6.6	-3.4	-5.2	-6.8
Ever depressed for a whole week	2.1	2.6	8.2	-1.7	-0.6	-2.9	-1.1	-2.0	-2.0	-1.1	1.0	-1.5	-0.3
Unable to work because of sickness or disability	0.6	0.8	2.6	-0.8	0.4	-0.1	-1.0	-0.6	-1.6	-0.6	0.2	-1.2	-1.1
Commuting to job workplace: Cycle	0.3	0.4	1.3	0.5	-0.2	1.1	0.7	-0.5	-0.9	0.1	-0.2	0.7	0.3
Myopia	1.0	1.5	5.8	0.7	-2.0	0.0	0.8	-0.3	1.2	0.2	-1.0	1.1	2.4
Vascular/heart problems diagnosed by doctor	1.3	3.7	11.9	0.8	-1.8	-1.4	2.7	0.6	0.9	1.7	0.0	2.7	3.4
Cholesterol lowering medication	1.0	1.5	4.7	-1.0	-0.7	0.2	1.5	0.9	0.1	1.9	2.2	1.0	1.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	6.1	0.2	1.5	2.5	-0.5	0.7	0.6	-0.7	0.7	-1.1	-1.5
Pain experienced in last month	4.5	7.5	21.4	-2.6	-4.6	-2.4	1.7	-3.3	-2.4	2.5	2.8	1.4	2.0
Supplements: Calcium	0.8	0.9	2.9	-0.8	-1.7	-0.9	0.4	-0.0	0.6	1.1	1.6	0.4	0.6
Basal cell carcinoma (self-reported)	1.7	2.0	5.6	-1.9	-1.5	-0.1	-0.8	-2.1	-2.4	0.2	1.5	-1.2	-0.8
Heart attack/myocardial infarction (self-reported)	0.7	1.0	2.6	-1.1	0.8	-0.1	-1.6	-0.8	-1.0	-0.8	-0.6	-1.5	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.4	-1.2	-0.6	-0.3	0.5	0.5	-0.6	-0.0	1.1	0.4	0.2
Heart disease (siblings)	0.9	1.1	3.5	-1.2	0.1	0.4	-1.9	-0.8	-0.7	-0.3	-0.3	-1.9	-0.9
Alcohol drinker status: Previous	0.4	0.5	1.3	-0.9	0.7	-0.7	-0.2	0.8	0.6	0.7	1.1	-0.5	0.0
Pack years of smoking	1.1	1.5	6.4	-0.1	2.5	2.2	0.3	1.8	-0.5	-0.5	0.2	-0.3	-0.2
Impedance of whole body	2.5	12.8	34.1	-1.6	3.2	-1.2	-4.7	-1.6	0.4	-5.8	-0.4	-4.9	-5.6
Leg fat mass (left)	0.4	1.5	6.4	-0.1	-1.4	0.7	1.4	-0.1	-1.0	2.5	0.5	1.1	1.2
Arm predicted mass (left)	4.4	22.5	70.4	0.8	-5.2	1.3	6.3	0.8	-0.6	8.4	1.2	6.2	6.7