Hub : Genes

KRT8P33

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.205 0.067 0.0012 0.011 NA 0.004 NA 0.007 0.0380 NA 0.150 NA 0.08700
2 GTEx Artery Aorta 0.104 0.040 0.0021 0.042 NA 0.010 NA 0.050 0.0024 NA 0.083 NA 0.00091
3 GTEx Cells EBV-transformed lymphocytes 0.164 0.069 0.0050 -0.009 NA -0.002 NA 0.005 0.8300 NA 0.370 NA 0.21000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.9 1.4 3.7 0.5 1.9 0.5
Bipolar Disorder or Schizophrenia 0.9 2.1 4.7 1.2 2.2 -0.1
Depressed Affect (Nagel 2018) 1.4 2.8 6.5 2.5 -0.2 -1.4
Depression (Nagel 2018) 0.6 0.8 1.6 1.3 -0.4 -0.9
Intelligence (Savage-Jansen 2018) 0.4 1.3 2.3 0.7 1.0 -1.5
Neuroticism (Nagel 2018) 1.0 2.3 3.1 1.8 -1.0 -1.7
Schizophrenia (2018) 0.5 1.1 1.5 1.2 1.2 -0.5
Schizophrenia vs Biploar Disorder 0.3 0.3 0.7 -0.6 -0.8 0.1
Worry (Nagel 2018) 1.3 2.7 4.3 1.3 -1.4 -2.1
Alzheimer’s Disease (in mother) 0.6 0.7 1.1 1.1 -0.9 -0.2
Alzheimer’s Disease (in father) 3.1 3.4 5.8 0.9 1.9 2.4
Alzheimer’s Disease (including proxy) 1.1 1.5 3.3 1.8 0.4 1.1
Crohns Disease (2017) 0.3 0.6 1.6 -1.3 -0.4 0.1
Irritable Bowel Disease (IBD) 0.0 0.1 0.1 0.3 0.3 -0.1
Ulcerative Colitis (UC) 0.6 1.1 2.8 1.7 0.7 -0.2
Major Depression (MDD) 1.1 1.4 3.5 1.9 -0.7 -0.3
Reaction Time 1.2 2.4 4.6 -1.6 -0.3 -2.1
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.5 0.7 0.3 -0.2
Breast Cancer 1.5 3.5 4.1 -1.9 -1.7 -2.0
Ovarian Cancer 0.6 0.8 1.1 -1.0 -0.4 -1.0
Prostate Cancer 0.7 1.0 3.1 0.1 1.8 0.2
Age at First Birth 2.3 3.3 5.5 -1.6 1.4 2.3
Bipolar Disorder (2011) 1.8 1.7 2.7 1.1 1.1 1.6
Body Mass Index (BMI) (2010) 1.7 2.4 4.9 -0.5 2.2 1.4
Coronary Artery Disease (CAD) 0.5 0.6 0.6 -0.8 -0.8 -0.7
Crohns Disease (2012) 0.2 0.3 0.6 0.4 -0.3 0.7
Mean Putamen Volume 1.0 1.2 2.1 -0.9 0.8 1.4
Fasting Glucose 0.3 0.3 0.9 -1.0 -0.1 0.3
HbA1C 0.7 0.7 2.2 1.5 -0.1 0.2
HDL Cholesterol 1.3 2.2 3.7 -1.4 -1.9 -0.9
LDL Cholesterol 1.0 1.6 4.2 -0.5 -0.5 2.1
Lupus 0.2 0.2 0.3 -0.5 0.5 0.4
Neuroticism (2016) 0.8 1.2 2.0 0.8 -0.9 -1.4
Primary Biliary Cirrhosis 1.2 1.7 3.5 1.9 1.2 0.5
Rheumatoid Arthritis 0.8 1.1 3.0 0.2 1.7 0.6
Schizophrenia (2014) 0.4 0.9 2.1 0.6 1.4 0.4
Triglycerides 0.1 0.2 0.3 0.1 -0.5 0.4
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.6 -1.3 0.3 0.9
Ulcerative Colitis 0.8 1.1 2.1 1.1 1.4 0.2
Blood Eosinophil Count 0.1 0.7 1.3 0.6 -1.1 -0.7
Blood Platelet Count 0.9 10.6 30.7 -0.2 -5.5 -1.1
Blood Red Count 0.7 6.9 19.6 -0.7 -0.9 -4.4
Blood White Count 1.5 11.3 17.5 1.4 -3.8 -4.2
Heel T-Score 6.9 55.0 108.2 0.1 -7.5 -10.4
BMI 0.9 5.0 11.6 -1.0 3.4 1.6
Height 2.4 45.8 119.5 -0.7 10.9 4.2
Waist Hip Ratio (WHR) 0.1 0.7 1.4 0.7 0.2 -1.2
Systolic Blood Pressure 4.5 22.5 34.2 -1.3 -5.6 -5.8
Smoking Status 1.8 4.3 8.1 2.2 -0.5 -2.8
Allergy or Eczema 0.7 1.9 4.6 -2.1 0.7 0.7
Cardiovascular Disease 1.3 4.3 6.5 2.5 -2.1 -1.5
Hypothyroidism (self reported) 1.5 3.4 9.9 -0.4 3.1 0.1
Respiratory disease 1.6 3.5 8.1 -0.1 -2.9 -1.5
Type 2 Diabetes (T2D) (2018) 0.2 0.5 1.1 -1.0 -0.6 -0.1
Lung FEV1/FVC ratio 2.1 10.8 19.4 1.2 4.4 3.4
Lung FVC 1.0 5.1 7.5 -1.7 2.7 2.2
Neuroticism 1.0 2.3 3.6 1.8 -0.4 -1.9
Chronotype (morning person) 0.7 1.6 3.8 1.0 -0.1 1.9
Hair Pigment 0.2 4.3 7.5 -2.0 -2.7 -1.3
Tanning 0.1 1.1 1.6 0.9 -1.3 0.9
Hand grip strength (left) 0.6 1.6 3.8 -0.9 0.3 2.0
Number of treatments/medications taken 1.0 1.8 2.8 -0.7 -1.7 -1.4
Average weekly spirits intake 0.2 0.2 0.5 -0.3 -0.2 0.7
Sensitivity / hurt feelings 0.6 1.1 3.1 -0.1 1.8 0.4
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.4 1.0 0.8 -1.2
Hearing difficulty/problems: Yes 0.9 1.4 2.1 -0.5 -1.3 1.4
Relative age of first facial hair 0.8 1.6 2.6 1.4 1.6 0.5
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.0 -0.2 0.1 0.1
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.7 0.7 -0.8 -0.5
Ever had hysterectomy (womb removed) 1.2 1.3 2.2 1.5 -0.3 -1.3
Systolic blood pressure, automated reading 2.2 6.3 8.9 -2.1 -2.4 -3.0
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.1 -0.3 -0.8 -1.1
Angina 0.1 0.1 0.2 -0.3 0.2 -0.4
Medication for hormone replacement therapy 0.1 0.1 0.3 -0.3 -0.1 0.5
Vitamin and mineral supplements 0.3 0.4 1.0 1.0 0.4 -0.2
Supplements: Zinc 0.9 1.0 1.2 -1.1 -0.9 -0.9
Medication: Co-codamol 1.5 1.8 2.1 1.4 -1.2 -1.4
Medication: Metformin 0.4 0.6 1.0 -1.0 0.8 -0.3
Diabetes (father) 0.9 1.1 2.0 0.6 -1.0 -1.4
Diabetes (mother) 0.8 1.0 2.6 -1.6 -0.3 -0.7
Severe depression (siblings) 0.5 0.6 1.0 0.7 0.4 1.0
Pack years adult smoking proportion 1.4 2.1 6.0 2.4 0.6 0.4
Impedance of leg (right) 6.3 30.5 58.8 1.9 -7.7 -5.4
Leg fat-free mass (left) 5.8 30.8 69.4 -1.2 8.3 4.6
Trunk fat percentage 0.1 0.6 1.4 0.4 1.2 -0.4
Hand grip strength (right) 1.0 2.8 4.9 -0.5 1.8 2.2
Townsend deprivation index at recruitment 1.4 2.0 3.9 -0.5 1.4 -2.0
Current tobacco smoking 1.7 2.8 6.6 2.6 0.2 -1.3
Average weekly fortified wine intake 2.0 2.4 3.9 -1.8 2.0 0.3
Maternal smoking around birth 0.2 0.3 0.5 0.7 -0.6 -0.3
Fed-up feelings 1.5 2.7 7.7 2.8 -0.3 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.4 1.2 -0.2 -1.2
Relative age voice broke 0.0 0.0 0.1 0.2 0.3 0.0
Taking other prescription medications 0.7 1.1 2.2 -1.5 0.0 -1.0
Age when periods started (menarche) 0.3 0.8 2.1 0.2 -0.4 1.4
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.0 -0.0 -0.3 1.0
Heel bone mineral density (BMD) T-score, automated (left) 4.0 9.0 12.0 -1.7 -3.5 -3.5
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 0.3 -0.7 -0.1
Qualifications: CSEs or equivalent 0.4 0.5 1.0 0.1 0.7 -1.0
Serious illness, injury or assault to yourself 1.7 2.0 5.3 0.3 2.3 -0.8
High blood pressure 1.0 2.8 4.3 0.8 -1.9 -2.1
Hayfever, allergic rhinitis or eczema 1.2 2.6 7.7 -2.8 -0.3 -0.2
Multivitamins +/- minerals 0.3 0.4 1.0 -0.6 -0.2 1.0
Stomach or abdominal pain in last month 0.9 1.1 3.1 1.8 0.2 -0.5
Supplements: Glucosamine 0.4 0.5 1.6 0.0 -0.2 1.2
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.8 -0.2 -0.9 1.4
Medication: Atenolol 0.9 1.2 2.6 -0.9 -1.6 -0.3
Medication: Levothyroxine sodium 2.0 3.4 9.2 0.9 3.0 -0.5
Sitting height 2.6 18.5 54.9 -0.3 7.4 0.7
Chronic bronchitis/emphysema (father) 0.8 0.9 2.5 0.4 -1.6 0.1
High blood pressure (mother) 3.3 4.6 10.5 -0.9 -3.2 -1.5
Body mass index (BMI) 0.8 3.4 7.8 -0.5 2.8 1.5
Impedance of leg (left) 5.7 27.8 55.7 1.5 -7.5 -5.1
Leg predicted mass (left) 6.1 32.1 72.1 -1.2 8.5 4.8
Trunk fat mass 0.8 3.4 9.7 -0.0 3.1 0.8
Waist circumference 1.5 5.6 14.3 -0.0 3.8 1.6
Number of incorrect matches in round 1.4 2.4 5.1 -2.3 -1.0 1.0
Past tobacco smoking 1.6 3.0 7.4 -1.3 -0.0 2.7
Alcohol usually taken with meals 1.3 2.1 4.3 -0.9 -2.1 1.1
Nervous feelings 0.6 1.2 2.9 0.1 -1.7 -0.8
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 4.1 2.0 0.5 -1.0
Hearing difficulty/problems with background noise 1.0 1.7 3.7 0.3 -1.9 1.1
Hair/balding pattern: Pattern 2 0.4 0.5 1.0 0.5 1.0 0.6
Had menopause 0.7 0.8 1.4 1.0 1.2 0.4
Had other major operations 2.5 3.0 4.4 1.4 1.7 -2.1
Forced vital capacity (FVC) 1.6 6.3 14.6 -1.1 3.8 1.8
Heel bone mineral density (BMD) T-score, automated (right) 3.2 7.3 12.7 -1.4 -3.6 -2.7
Ever unenthusiastic/disinterested for a whole week 3.9 4.8 10.0 1.8 1.0 -3.2
Qualifications: None of the above 0.5 1.0 2.5 1.6 0.4 0.6
Financial difficulties in last 2 years 0.6 0.8 1.4 1.2 1.0 0.2
Mouth/teeth dental problems 0.8 1.2 2.0 -1.2 -1.4 0.2
Heart attack 1.3 1.7 4.7 2.2 0.6 -0.3
Allergy 0.7 1.6 3.3 1.8 1.2 0.0
Pain all over the body in last month 1.2 1.2 3.0 -1.7 -0.8 -0.1
Diabetes (self-reported) 0.3 0.5 0.9 -1.0 0.8 0.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.2 -1.1 -0.2 -0.0
Medication: Ramipril 1.8 2.3 6.9 2.6 0.2 -0.2
Medication: Simvastatin 0.7 1.0 2.0 1.4 0.8 -0.4
Fluid intelligence score 0.2 0.3 0.6 0.8 0.0 -0.6
Illnesses of siblings 1.0 1.4 3.5 -0.6 0.6 1.9
Neuroticism score 1.1 2.4 4.5 1.5 -0.7 -2.1
Weight 2.8 13.6 34.1 -0.5 5.8 2.5
Impedance of arm (right) 1.9 8.7 14.4 -0.1 -3.4 -3.8
Arm fat percentage (right) 0.2 0.8 2.3 -0.5 1.5 -0.1
Trunk fat-free mass 5.0 28.5 63.9 -1.2 8.0 4.5
Hip circumference 1.2 5.4 12.0 -0.6 3.5 1.9
Time employed in main current job 0.4 0.5 1.5 0.1 -0.0 1.2
Alcohol intake versus 10 years previously 1.1 1.6 2.0 1.4 -0.9 -1.4
Father’s age at death 0.2 0.3 0.6 0.0 0.5 -0.8
Worrier / anxious feelings 1.4 2.6 6.9 -0.3 -2.6 -0.9
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 3.9 1.2 -0.8 -2.0
Falls in the last year 0.5 0.7 1.6 0.5 1.3 0.6
Hair/balding pattern: Pattern 3 1.2 1.8 2.2 -1.1 -1.5 1.5
Number of live births 2.2 3.1 5.9 1.8 2.4 -0.2
Forced expiratory volume in 1-second (FEV1) 2.5 8.4 16.6 -0.6 4.1 2.9
Pulse rate 5.5 9.2 16.3 0.4 -3.4 -4.0
Happiness 1.5 1.8 2.3 1.5 1.5 0.9
Noisy workplace 0.2 0.3 0.5 -0.5 -0.7 0.2
Qualifications: A levels/AS levels or equivalent 1.1 2.4 4.4 -0.1 -1.7 -2.1
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.5 -0.6 1.2 0.4
Mouth/teeth dental problems: Dentures 0.3 0.5 1.2 -0.1 1.1 0.7
Asthma 0.7 1.4 3.2 -0.0 -1.8 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 3.1 0.1 -1.8 0.4
Medication: Cholesterol lowering 0.0 0.0 0.0 0.1 -0.0 -0.0
Depression (self-reported) 0.8 0.9 2.0 -0.2 1.4 -0.8
Medication: Lansoprazole 1.1 1.3 2.8 -1.7 -0.5 0.9
Prospective memory result 0.5 0.6 1.1 0.1 -1.1 0.8
Lung cancer (father) 0.6 0.8 1.7 -0.2 0.7 1.3
Illnesses of mother 0.9 1.2 2.9 0.7 1.7 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 2.7 8.5 18.1 -0.2 4.2 2.7
Pulse wave Arterial Stiffness index 1.7 2.0 3.1 -0.3 -1.7 -1.8
Impedance of arm (left) 1.7 8.1 12.9 0.7 -3.3 -3.6
Arm fat mass (right) 1.2 5.1 14.0 -0.4 3.7 1.1
Trunk predicted mass 5.0 28.5 64.2 -1.2 8.0 4.5
Standing height 1.8 18.3 47.8 -0.2 6.9 2.7
Length of working week for main job 0.7 0.7 1.0 -1.0 -0.7 0.9
Exposure to tobacco smoke at home 0.6 0.6 1.2 -0.8 1.1 -0.1
Breastfed as a baby 2.0 2.5 6.5 0.8 2.6 -0.4
Tense / ‘highly strung’ 0.6 1.1 1.7 1.3 -0.8 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 5.5 2.4 0.9 -1.5
Hair/balding pattern: Pattern 4 0.6 1.4 3.9 0.2 -2.0 -0.6
Birth weight of first child 0.9 1.6 2.5 1.1 -1.0 -1.6
Peak expiratory flow (PEF) 0.1 0.3 0.5 0.6 -0.3 0.7
Pulse wave reflection index 2.1 2.6 6.8 -1.0 0.1 2.6
Ever highly irritable/argumentative for 2 days 1.2 1.4 2.9 1.7 0.8 -0.9
Loud music exposure frequency 0.3 0.3 0.6 -0.8 -0.2 0.6
Qualifications: O levels/GCSEs or equivalent 2.8 4.5 11.2 -0.1 -1.5 -3.4
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 3.3 1.7 1.8 0.3
Blood clot in the leg (DVT) 1.4 1.8 2.7 1.6 1.6 0.0
Medication: Paracetamol 1.7 2.8 5.9 -0.2 -2.4 -1.6
Headache pain in last month 1.4 2.4 4.9 1.0 -2.2 1.2
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.8 -0.6 0.9 -0.0
Glaucoma (self-reported) 0.1 0.1 0.3 -0.1 0.0 0.5
Gout (self-reported) 1.0 1.4 2.9 -0.4 -1.1 -1.7
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 6.4 -0.7 2.5 0.1
Medication: Amlodipine 2.4 3.3 5.9 -0.6 -1.9 -2.4
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.6 0.8 -0.5 -0.8
Birth weight 3.0 6.5 13.0 2.0 3.6 1.5
Chronic bronchitis/emphysema (mother) 1.5 1.8 3.6 1.2 -0.6 -1.9
High blood pressure (siblings) 1.4 2.0 4.0 1.0 -1.1 -2.0
Forced vital capacity (FVC), Best measure 1.8 6.8 16.4 -0.3 4.1 1.9
Body fat percentage 0.0 0.2 0.3 0.3 0.5 -0.4
Leg fat percentage (right) 0.3 1.2 2.0 0.4 -1.4 -1.3
Arm fat-free mass (right) 4.2 21.6 49.0 -0.1 7.0 4.0
Exposure to tobacco smoke outside home 1.1 1.4 2.6 1.0 -0.7 -1.6
Comparative body size at age 10 1.0 2.7 6.7 0.5 2.6 1.1
Number of full brothers 1.3 1.7 3.7 0.1 -1.1 -1.9
Worry too long after embarrassment 0.6 1.1 1.5 0.6 -1.2 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 2.8 1.7 1.1 -0.6
Wheeze or whistling in the chest in last year 0.9 1.6 2.6 -0.3 -1.6 -1.4
Number of children fathered 1.3 1.5 2.3 0.6 -1.4 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.6 1.1 0.5 1.3
Age at first live birth 0.3 0.5 0.7 -0.6 0.7 0.9
Pulse wave peak to peak time 2.2 2.6 4.5 0.3 2.1 1.8
Health satisfaction 0.8 1.1 1.6 1.2 1.3 -0.5
Shortness of breath walking on level ground 0.5 0.5 0.9 0.6 -1.0 -0.6
Qualifications: College or University degree 1.1 3.4 10.0 -0.2 3.2 0.3
Eye problems/disorders: None of the above 0.9 1.0 1.6 -0.8 0.8 1.3
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.4 0.6 0.1 -0.0
Emphysema/chronic bronchitis 3.4 3.8 6.9 -0.6 -2.6 -2.0
Medication for pain relief, constipation, heartburn 2.1 3.7 6.9 -0.2 2.6 2.0
Neck or shoulder pain in last month 2.4 3.4 5.1 2.2 -2.2 0.6
Medication: Blood pressure 1.1 1.9 4.2 -0.3 -2.0 -1.2
Angina (self-reported) 0.1 0.1 0.3 -0.3 0.2 -0.6
Migraine (self-reported) 1.6 2.0 2.8 1.4 -1.7 1.1
Medication: Ibuprofen 0.7 0.8 1.7 0.6 -1.3 0.6
Medication: Allopurinol 0.4 0.6 1.0 -0.1 -0.8 -1.0
Medication: Omeprazole 0.9 1.1 3.0 0.3 -1.7 -0.6
Medication: Seretide 50 evohaler 0.1 0.1 0.1 -0.1 0.4 -0.4
Mean time to correctly identify matches 0.7 1.4 2.8 -1.1 0.1 -1.7
Heart disease (mother) 0.3 0.4 1.1 -0.3 1.0 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 2.5 1.1 0.7 1.6
Whole body fat mass 0.7 3.1 8.5 -0.2 2.9 0.9
Leg fat mass (right) 0.4 1.7 4.2 -0.2 2.0 0.9
Arm predicted mass (right) 4.6 23.4 52.4 -0.4 7.2 4.2
Pulse rate, automated reading 6.7 21.6 34.9 1.4 -5.3 -5.9
Alcohol intake frequency. 0.9 2.1 3.1 1.3 1.2 -1.8
Comparative height size at age 10 0.9 4.8 13.4 -0.4 3.7 0.9
Number of full sisters 1.0 1.2 2.0 1.0 0.7 1.4
Suffer from ‘nerves’ 0.9 1.4 3.1 1.0 0.4 -1.8
Overall health rating 0.9 1.9 3.2 1.3 -0.9 -1.8
Chest pain or discomfort 0.7 1.0 2.0 0.4 -1.0 -1.4
Had major operations 0.7 0.8 2.3 1.5 0.2 0.3
Age at last live birth 0.8 1.2 2.2 -0.4 1.5 1.1
Family relationship satisfaction 2.8 3.4 5.9 2.0 2.4 0.3
Leg pain on walking 1.7 2.1 4.5 1.4 2.1 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 2.2 -0.4 -1.5 0.1
Commuting to job workplace: Car/motor vehicle 0.5 0.6 0.9 -0.4 -0.9 -0.8
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.6 -1.1 -1.3 0.3
Medication: Aspirin 0.8 1.1 2.0 1.4 0.1 -1.2
Supplements: Vitamin C 0.8 0.9 1.5 -1.1 1.2 0.3
Knee pain experienced in last month 0.3 0.5 0.8 0.9 0.2 0.8
Hypertension (Self-reported) 1.1 3.2 4.7 0.6 -2.2 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.1 -0.7 -1.1 -0.4
Illnesses of father: Heart disease 0.4 0.6 1.4 1.2 0.3 0.4
Illnesses of siblings: Diabetes 0.6 0.7 1.1 -1.0 -1.1 -0.3
Smoking status: Previous 1.1 1.6 4.5 0.4 -0.4 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 2.3 4.8 11.8 0.9 3.4 1.4
Whole body fat-free mass 5.6 31.9 71.1 -1.3 8.4 4.8
Leg fat-free mass (right) 6.5 34.9 76.6 -1.4 8.8 5.1
Arm fat percentage (left) 0.2 0.8 2.2 -0.2 1.5 0.1
Average weekly red wine intake 0.6 0.9 1.7 0.5 1.3 0.9
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 -0.0 0.1 -0.2
Mood swings 1.8 3.3 8.8 3.0 -0.6 -0.9
Loneliness, isolation 0.1 0.2 0.4 0.2 0.6 -0.3
Long-standing illness, disability or infirmity 0.6 0.9 2.2 -0.2 0.7 -1.5
Ever had bowel cancer screening 0.7 0.8 1.8 -1.3 -0.8 0.3
Diabetes diagnosed by doctor 0.3 0.5 1.1 -1.0 0.7 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.9 -0.1 -1.4 0.3
Friendships satisfaction 2.6 3.2 4.0 2.0 2.0 -1.3
Qualifications: nursing, teaching 0.3 0.4 0.8 -0.9 0.4 -0.6
Commuting to job workplace: Walk 2.6 2.8 4.7 1.3 2.2 1.4
Eye problems/disorders: Cataract 1.3 1.5 3.4 1.8 -0.5 -0.9
Mouth/teeth dental problems: Mouth ulcers 1.3 2.1 4.4 -1.2 -2.1 -0.6
Medication for cholesterol 0.8 1.2 3.0 0.1 0.7 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.5 -0.7 0.1 -0.6
Back pain experienced in last month 1.2 1.8 4.9 -0.2 -2.2 -0.6
Mineral and other dietary supplements 0.1 0.1 0.1 0.2 0.4 -0.3
Breast cancer (self-reported) 0.7 0.8 1.3 1.1 1.1 -0.2
Asthma (self-reported) 0.9 1.7 4.3 -0.0 -2.1 -1.0
Osteoporosis (self-reported) 0.7 0.9 1.6 -0.5 1.0 1.2
Osteoarthritis (self-reported) 1.0 1.4 2.0 1.0 -1.4 -1.0
Medication: Aspirin 1.1 1.5 3.5 1.9 0.4 -0.9
Medication: Gliclazide 0.3 0.4 0.9 -0.4 0.4 -0.9
Illnesses of father: None of the above (group 1) 1.9 2.4 6.7 -2.6 -0.3 0.5
Smoking status: Current 1.7 2.8 6.6 2.6 0.4 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.1 6.5 10.2 -1.8 2.5 3.2
Whole body water mass 5.6 31.8 71.4 -1.1 8.4 4.8
Leg predicted mass (right) 6.7 35.7 77.6 -1.4 8.8 5.2
Arm fat mass (left) 1.4 5.6 14.8 -0.2 3.9 1.3
Number of self-reported non-cancer illnesses 0.7 1.2 3.0 -0.2 -0.8 -1.7
Average weekly champagne plus white wine intake 0.3 0.4 0.7 -0.8 0.1 0.7
Miserableness 1.1 1.8 2.4 1.6 0.9 -1.5
Guilty feelings 0.5 0.8 2.2 0.4 0.2 -1.5
Wears glasses or contact lenses 0.5 0.5 1.1 0.5 -1.1 0.5
Ever taken oral contraceptive pill 1.3 1.5 2.1 -1.3 1.4 0.7
Hearing aid user 1.0 1.1 2.9 0.0 1.7 0.6
Mother’s age at death 1.0 1.2 2.2 -1.5 0.9 0.8
Financial situation satisfaction 0.8 0.9 1.4 1.2 1.1 -0.3
Tinnitus: Yes, now most or all of the time 2.6 3.0 6.6 -1.2 -2.6 -1.0
Commuting to job workplace: Public transport 0.2 0.2 0.5 0.1 0.3 0.7
Eye problems/disorders: Glaucoma 0.1 0.1 0.1 -0.3 -0.2 0.3
Medication: Blood pressure 1.6 3.1 8.0 0.1 -1.1 -2.8
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.7 1.6 0.4 0.4
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.4 -0.2 -0.6 -0.6
High cholesterol (Self-reported) 0.6 1.1 3.2 1.8 0.1 0.3
Medication: Bendroflumethiazide 1.4 2.2 4.4 0.8 -1.3 -2.1
Medication: Paracetamol 1.1 1.6 3.3 0.9 -1.8 -0.9
Medication: Lisinopril 0.8 1.0 2.6 -0.2 0.6 -1.6
Medication: Atorvastatin 0.2 0.3 0.4 0.5 0.3 0.7
Illnesses of father: High blood pressure 0.4 0.5 1.0 1.0 -0.1 -0.7
Alcohol drinker status: Never 0.2 0.3 0.4 0.2 0.6 -0.6
Ever smoked 1.7 2.9 5.1 1.9 0.2 -2.3
Basal metabolic rate 5.0 27.4 62.9 -1.0 7.9 4.3
Leg fat percentage (left) 0.2 0.9 1.6 0.2 -1.3 -1.0
Arm fat-free mass (left) 4.5 22.6 53.0 -0.4 7.3 3.9
Number of operations (self-reported) 2.0 3.0 5.2 1.1 2.3 -1.6
Average weekly beer plus cider intake 1.1 1.5 4.3 2.1 -0.5 -0.2
Irritability 1.3 2.2 2.8 1.4 -1.7 -1.4
Risk taking 1.9 2.8 3.6 1.6 1.9 1.6
Ever had prostate specific antigen (PSA) test 0.9 1.1 2.6 -1.6 -0.4 0.7
Fractured/broken bones in last 5 years 1.2 1.5 3.9 0.7 2.0 0.3
Age started oral contraceptive pill 2.4 3.1 4.1 -2.0 1.3 1.8
Diastolic blood pressure, automated reading 7.5 23.1 52.7 1.9 -7.3 -3.6
Ever depressed for a whole week 1.2 1.5 3.2 0.7 0.8 -1.8
Unable to work because of sickness or disability 0.1 0.1 0.2 0.3 -0.1 -0.5
Commuting to job workplace: Cycle 0.7 0.8 2.0 -0.6 0.0 1.4
Myopia 1.0 1.5 3.0 -0.2 1.7 1.2
Vascular/heart problems diagnosed by doctor 1.1 3.1 4.6 -0.8 2.0 2.1
Cholesterol lowering medication 1.2 1.8 3.0 1.3 1.7 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 2.2 0.3 -1.5 -0.7
Pain experienced in last month 2.0 3.3 6.5 -1.6 2.6 -0.8
Supplements: Calcium 0.2 0.2 0.4 -0.6 0.5 -0.2
Basal cell carcinoma (self-reported) 0.9 1.1 1.6 -1.3 -0.4 -1.2
Heart attack/myocardial infarction (self-reported) 1.6 2.0 5.8 2.4 0.4 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 1.9 1.4 1.1 -0.1
Heart disease (siblings) 2.3 2.9 7.7 0.7 -0.6 -2.8
Alcohol drinker status: Previous 0.9 1.0 1.5 1.2 1.2 -0.4
Pack years of smoking 1.9 2.8 7.3 2.7 0.6 0.9
Impedance of whole body 3.7 18.9 31.0 1.6 -5.6 -4.8
Leg fat mass (left) 0.5 1.9 4.6 -0.3 2.1 1.0
Arm predicted mass (left) 4.7 23.9 55.7 -0.5 7.5 4.0