Best TWAS P=1.14e-12 · Best GWAS P=4.23e-20 conditioned to 8.32e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SRR | 0.16 | 0.16 | lasso | 9 | 0.18 | 1.9e-14 | -5.4 | 6.1 | 8.3e-10 | -0.07 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | SRR | 0.29 | 0.26 | lasso | 5 | 0.25 | 1.8e-13 | -4.9 | 5.2 | 1.9e-07 | -0.05 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adrenal Gland | SRR | 0.38 | 0.37 | lasso | 6 | 0.38 | 8.1e-15 | -4.9 | 5.5 | 3.8e-08 | -0.06 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Coronary | SRR | 0.44 | 0.28 | lasso | 8 | 0.26 | 2.5e-09 | -5.4 | 5.4 | 5.8e-08 | -0.06 | 0.99 | 0.00 | FALSE |
| 5 | GTEx | Artery Tibial | SRR | 0.22 | 0.23 | lasso | 4 | 0.24 | 3.9e-19 | -5.4 | 5.3 | 1.3e-07 | -0.06 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Brain Caudate basal ganglia | SRR | 0.26 | 0.03 | lasso | 3 | 0.02 | 8.6e-02 | -4.1 | 5.2 | 2.2e-07 | -0.03 | 0.13 | 0.08 | FALSE |
| 7 | GTEx | Brain Cerebellum | SRR | 0.26 | 0.20 | lasso | 3 | 0.21 | 8.7e-07 | -4.9 | 5.6 | 2.4e-08 | -0.03 | 0.38 | 0.04 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | SRR | 0.20 | 0.21 | lasso | 3 | 0.20 | 8.2e-11 | -5.3 | 5.5 | 3.1e-08 | -0.07 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | SRR | 0.24 | 0.25 | lasso | 3 | 0.21 | 6.3e-07 | -5.3 | 5.5 | 3.9e-08 | -0.07 | 0.78 | 0.02 | FALSE |
| 10 | GTEx | Cells EBV-transformed lymphocytes | SRR | 0.39 | 0.34 | lasso | 5 | 0.35 | 3.1e-12 | -4.9 | 5.4 | 7.3e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Colon Sigmoid | SRR | 0.32 | 0.35 | enet | 8 | 0.32 | 9.2e-12 | -4.9 | 5.2 | 2.4e-07 | -0.05 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Esophagus Mucosa | SRR | 0.23 | 0.24 | lasso | 5 | 0.24 | 2.0e-16 | -5.4 | 5.6 | 2.3e-08 | -0.06 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Heart Atrial Appendage | SRR | 0.35 | 0.30 | lasso | 7 | 0.29 | 1.4e-13 | -5.4 | 5.3 | 1.1e-07 | -0.05 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Liver | SRR | 0.31 | 0.00 | lasso | 7 | 0.00 | 3.0e-01 | -6.5 | 7.1 | 1.1e-12 | -0.40 | 0.06 | 0.14 | TRUE |
| 15 | GTEx | Muscle Skeletal | SRR | 0.27 | 0.27 | lasso | 6 | 0.27 | 7.1e-27 | -4.9 | 5.2 | 2.5e-07 | -0.04 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Nerve Tibial | SRR | 0.15 | 0.13 | lasso | 3 | 0.13 | 2.9e-09 | -5.4 | 5.3 | 1.3e-07 | -0.06 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Pancreas | SRR | 0.13 | 0.17 | lasso | 3 | 0.15 | 5.2e-07 | -5.4 | 5.3 | 1.2e-07 | -0.06 | 0.96 | 0.00 | FALSE |
| 18 | GTEx | Skin Not Sun Exposed Suprapubic | SRR | 0.18 | 0.16 | enet | 18 | 0.19 | 7.9e-11 | -4.9 | 5.3 | 1.3e-07 | -0.04 | 0.98 | 0.00 | FALSE |
| 19 | GTEx | Spleen | SRR | 0.21 | 0.10 | lasso | 4 | 0.04 | 3.1e-02 | -4.9 | 5.4 | 6.4e-08 | -0.04 | 0.13 | 0.06 | FALSE |
| 20 | GTEx | Stomach | SRR | 0.27 | 0.30 | lasso | 7 | 0.28 | 7.1e-14 | -5.4 | 5.3 | 1.1e-07 | -0.07 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Testis | SRR | 0.13 | 0.12 | lasso | 2 | 0.09 | 6.6e-05 | -5.4 | 5.4 | 6.7e-08 | -0.07 | 0.57 | 0.02 | FALSE |
| 22 | GTEx | Whole Blood | SRR | 0.09 | 0.03 | enet | 8 | 0.02 | 4.5e-03 | -4.9 | 5.2 | 2.2e-07 | -0.04 | 0.75 | 0.01 | FALSE |
| 23 | METSIM | Adipose | SRR | 0.07 | 0.07 | enet | 21 | 0.06 | 4.4e-09 | -4.9 | 5.2 | 2.6e-07 | -0.01 | 1.00 | 0.00 | FALSE |
| 24 | YFS | Blood | SRR | 0.17 | 0.22 | lasso | 7 | 0.23 | 2.5e-72 | -4.9 | 5.2 | 1.9e-07 | -0.04 | 1.00 | 0.00 | FALSE |
| 25 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SRR | 0.11 | 0.09 | lasso | 4 | 0.10 | 6.8e-09 | -4.9 | 5.4 | 5.5e-08 | -0.04 | 0.01 | 0.99 | FALSE |
| 26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SRR | 0.16 | 0.16 | lasso | 5 | 0.16 | 2.3e-32 | -5.4 | 5.4 | 5.5e-08 | -0.07 | 0.00 | 0.99 | FALSE |
| 27 | The Cancer Genome Atlas | Esophageal Carcinoma | SRR | 0.32 | 0.13 | lasso | 2 | 0.16 | 9.2e-06 | -5.4 | 5.4 | 5.7e-08 | -0.07 | 0.00 | 0.99 | FALSE |
| 28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SRR | 0.30 | 0.40 | lasso | 7 | 0.39 | 8.5e-47 | -5.4 | 5.6 | 2.7e-08 | -0.07 | 0.00 | 1.00 | FALSE |
| 29 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SRR | 0.29 | 0.26 | lasso | 2 | 0.27 | 1.9e-30 | -5.4 | 5.5 | 4.7e-08 | -0.07 | 0.00 | 1.00 | FALSE |
| 30 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SRR | 0.16 | 0.20 | lasso | 3 | 0.20 | 2.8e-13 | -5.4 | 5.5 | 5.1e-08 | -0.07 | 0.01 | 0.99 | FALSE |
| 31 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SRR | 0.34 | 0.30 | lasso | 4 | 0.30 | 2.9e-13 | -4.9 | 5.2 | 1.7e-07 | -0.04 | 0.01 | 0.99 | FALSE |
| 32 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SRR | 0.27 | 0.19 | enet | 5 | 0.21 | 8.9e-09 | -5.4 | 5.5 | 4.3e-08 | -0.07 | 0.00 | 1.00 | FALSE |
| 33 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SRR | 0.30 | 0.35 | lasso | 3 | 0.36 | 7.5e-39 | -4.9 | 5.2 | 1.9e-07 | -0.04 | 0.02 | 0.98 | FALSE |
| 34 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SRR | 0.20 | 0.18 | lasso | 2 | 0.20 | 8.8e-12 | -4.9 | 5.2 | 2.1e-07 | -0.05 | 0.01 | 0.99 | FALSE |
| 35 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | SRR | 0.16 | 0.03 | blup | 61 | 0.02 | 8.7e-02 | -5.4 | 5.3 | 1.4e-07 | -0.07 | 0.01 | 0.70 | FALSE |
| 36 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SGSM2 | 0.13 | 0.01 | blup | 81 | 0.01 | 1.1e-01 | 4.2 | -5.9 | 3.1e-09 | 0.08 | 0.02 | 0.39 | TRUE |