Best TWAS P=3.97e-09 · Best GWAS P=2.49e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | PIK3C3 | 0.16 | 0.12 | enet | 13 | 0.15 | 1.2e-10 | 4.8 | -5.6 | 2.3e-08 | -0.60 | 0.58 | 0.42 | FALSE |
| 2 | GTEx | Testis | PIK3C3 | 0.10 | 0.01 | enet | 24 | 0.02 | 4.8e-02 | 5.1 | -5.9 | 4.0e-09 | -0.39 | 0.14 | 0.13 | TRUE |
| 3 | METSIM | Adipose | PIK3C3 | 0.10 | 0.08 | enet | 28 | 0.08 | 1.8e-12 | 5.4 | -5.3 | 1.1e-07 | -0.58 | 0.24 | 0.76 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | PIK3C3 | 0.09 | 0.04 | lasso | 8 | 0.03 | 6.0e-03 | 5.8 | -5.4 | 5.2e-08 | -0.98 | 0.01 | 0.91 | TRUE |