[Hub]/) : Traits : Arm fat percentage (left) :

chr18:20,393,480-21,863,589

Best TWAS P=2.7e-15 · Best GWAS P=2.73e-12 conditioned to 0.234

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C18orf8 0.26 0.35 lasso 6 0.40 1.9e-52 -6.8 -7.2 4.7e-13 0.86 0.02 0.98 FALSE
2 CommonMind Brain Pre-frontal Cortex NPC1 0.08 0.07 lasso 3 0.08 5.2e-10 6.5 -6.7 2.0e-11 0.67 0.31 0.69 FALSE
3 GTEx Adipose Subcutaneous C18orf8 0.17 0.16 enet 13 0.16 2.6e-13 -6.7 -7.2 4.2e-13 0.92 0.02 0.98 FALSE
4 GTEx Adipose Subcutaneous NPC1 0.27 0.27 enet 12 0.30 2.4e-25 -6.9 -7.0 1.9e-12 0.88 0.01 0.99 FALSE
5 GTEx Adipose Visceral Omentum C18orf8 0.18 0.11 enet 10 0.04 4.5e-03 -7.0 -5.8 5.0e-09 0.88 0.01 0.98 FALSE
6 GTEx Adipose Visceral Omentum NPC1 0.20 0.19 lasso 3 0.17 2.9e-09 -6.9 -7.2 7.6e-13 0.85 0.01 0.99 FALSE
7 GTEx Artery Tibial C18orf8 0.18 0.12 lasso 3 0.10 1.5e-08 6.3 -6.3 3.3e-10 0.64 0.36 0.64 FALSE
8 GTEx Artery Tibial NPC1 0.26 0.07 enet 31 0.11 3.7e-09 6.3 -7.9 2.7e-15 0.79 0.06 0.94 TRUE
9 GTEx Brain Caudate basal ganglia C18orf8 0.15 0.16 enet 11 0.11 5.9e-04 -6.9 -7.3 3.3e-13 0.89 0.03 0.94 FALSE
10 GTEx Brain Cerebellar Hemisphere C18orf8 0.27 0.34 enet 19 0.34 1.3e-09 -6.8 -7.1 1.4e-12 0.91 0.02 0.98 FALSE
11 GTEx Brain Cerebellum C18orf8 0.23 0.18 enet 13 0.21 9.9e-07 -6.7 -7.2 7.4e-13 0.85 0.03 0.97 FALSE
12 GTEx Brain Cerebellum NPC1 0.20 0.10 enet 9 0.12 1.9e-04 -6.7 -6.8 9.0e-12 0.89 0.03 0.94 FALSE
13 GTEx Brain Cortex C18orf8 0.19 0.18 lasso 5 0.13 1.8e-04 -6.9 -6.9 3.8e-12 0.93 0.02 0.95 FALSE
14 GTEx Brain Frontal Cortex BA9 C18orf8 0.42 0.30 enet 12 0.08 3.4e-03 -6.7 -6.4 2.0e-10 0.83 0.02 0.97 FALSE
15 GTEx Breast Mammary Tissue NPC1 0.27 0.13 enet 27 0.19 5.0e-10 -6.9 -7.5 8.1e-14 0.86 0.02 0.98 FALSE
16 GTEx Breast Mammary Tissue (Male) NPC1 0.15 0.12 lasso 7 0.16 2.0e-04 -2.9 -5.5 3.9e-08 0.51 0.04 0.60 FALSE
17 GTEx Breast Mammary Tissue (Female) NPC1 0.43 0.24 lasso 3 0.27 1.1e-08 -6.3 -6.8 1.2e-11 0.90 0.03 0.97 FALSE
18 GTEx Colon Transverse NPC1 0.21 0.03 enet 23 0.05 3.0e-03 -4.3 -6.0 1.8e-09 0.58 0.08 0.55 FALSE
19 GTEx Esophagus Mucosa NPC1 0.09 0.04 lasso 3 0.05 1.5e-04 -6.9 -6.8 1.3e-11 0.87 0.02 0.96 FALSE
20 GTEx Esophagus Muscularis C18orf8 0.14 0.13 lasso 3 0.10 8.0e-07 6.4 -7.0 3.6e-12 0.76 0.08 0.92 FALSE
21 GTEx Esophagus Muscularis NPC1 0.11 0.07 enet 4 0.09 7.3e-06 -7.0 -7.2 4.2e-13 0.98 0.01 0.98 FALSE
22 GTEx Heart Left Ventricle NPC1 0.19 0.15 enet 12 0.17 1.6e-09 -6.7 -7.1 1.7e-12 0.91 0.03 0.97 FALSE
23 GTEx Lung NPC1 0.11 0.06 enet 11 0.04 2.3e-04 -6.9 -6.8 9.1e-12 0.93 0.02 0.98 FALSE
24 GTEx Nerve Tibial C18orf8 0.16 0.07 enet 21 0.09 3.9e-07 -6.3 -7.6 2.8e-14 0.83 0.03 0.97 FALSE
25 GTEx Nerve Tibial NPC1 0.19 0.12 lasso 6 0.16 1.1e-11 6.4 -7.2 4.3e-13 0.83 0.05 0.95 FALSE
26 GTEx Pancreas NPC1 0.33 0.14 lasso 7 0.12 1.1e-05 -6.7 -6.8 8.8e-12 0.91 0.03 0.97 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic C18orf8 0.21 0.27 enet 6 0.23 6.9e-13 -6.8 -6.9 6.2e-12 0.92 0.03 0.97 FALSE
28 GTEx Skin Not Sun Exposed Suprapubic NPC1 0.15 0.08 lasso 4 0.12 2.3e-07 -6.8 -7.3 3.5e-13 0.87 0.03 0.97 FALSE
29 GTEx Skin Sun Exposed Lower leg C18orf8 0.35 0.33 enet 23 0.36 1.7e-30 -6.9 -7.1 1.2e-12 0.91 0.03 0.97 FALSE
30 GTEx Skin Sun Exposed Lower leg NPC1 0.23 0.18 lasso 3 0.27 1.8e-22 -6.9 -7.4 1.4e-13 0.84 0.02 0.98 FALSE
31 GTEx Testis C18orf8 0.12 0.07 lasso 6 0.08 1.9e-04 -6.8 -6.4 1.8e-10 0.86 0.03 0.90 FALSE
32 GTEx Thyroid NPC1 0.20 0.10 enet 25 0.13 2.3e-10 -6.9 -7.6 2.2e-14 0.87 0.02 0.98 FALSE
33 METSIM Adipose NPC1 0.06 0.05 enet 18 0.05 6.4e-08 -6.9 -6.3 2.1e-10 0.82 0.02 0.98 FALSE
34 The Cancer Genome Atlas Breast Invasive Carcinoma NPC1 0.03 0.03 blup 69 0.04 2.9e-09 -6.7 -7.3 2.5e-13 0.84 0.03 0.97 FALSE
35 The Cancer Genome Atlas Esophageal Carcinoma NPC1 0.16 0.10 lasso 3 0.10 3.7e-04 6.4 -7.2 8.3e-13 0.77 0.04 0.73 FALSE
36 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NPC1 0.05 0.02 blup 66 0.03 1.4e-04 -7.0 -6.6 4.5e-11 0.76 0.02 0.96 FALSE
37 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NPC1 0.03 0.04 lasso 2 0.05 4.2e-06 -7.0 -7.1 1.4e-12 0.92 0.02 0.98 FALSE
38 The Cancer Genome Atlas Brain Lower Grade Glioma C18orf8 0.07 0.05 lasso 5 0.03 9.5e-05 6.3 -6.3 2.1e-10 0.66 0.18 0.80 FALSE
39 The Cancer Genome Atlas Brain Lower Grade Glioma NPC1 0.07 0.08 lasso 3 0.10 1.6e-11 6.3 -7.3 3.7e-13 0.87 0.05 0.95 FALSE
40 The Cancer Genome Atlas Pancreatic Adenocarcinoma NPC1 0.14 0.01 enet 14 0.08 3.3e-04 -7.0 -5.4 8.2e-08 0.74 0.03 0.82 FALSE
41 The Cancer Genome Atlas Prostate Adenocarcinoma NPC1 0.05 0.02 blup 65 0.03 9.9e-04 -7.0 -6.9 4.5e-12 0.80 0.02 0.80 FALSE
42 The Cancer Genome Atlas Thyroid Carcinoma NPC1 0.04 0.03 blup 70 0.05 9.4e-06 -6.8 -7.0 3.6e-12 0.86 0.03 0.96 FALSE