Best TWAS P=4.27e-10 · Best GWAS P=1.59e-08 conditioned to 0.83
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | GFPT1 | 0.09 | 0.05 | lasso | 4 | 0.02 | 1.1e-02 | -5.6 | 5.6 | 1.9e-08 | -0.97 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | AAK1 | 0.08 | 0.05 | lasso | 5 | 0.03 | 1.4e-03 | -5.5 | -5.6 | 2.1e-08 | 0.93 | 0.02 | 0.97 | FALSE |
| 3 | GTEx | Muscle Skeletal | GFPT1 | 0.08 | 0.00 | lasso | 8 | 0.00 | 2.2e-01 | -5.5 | 5.2 | 2.4e-07 | -0.85 | 0.03 | 0.95 | FALSE |
| 4 | GTEx | Nerve Tibial | GFPT1 | 0.13 | 0.01 | lasso | 4 | 0.02 | 1.8e-02 | -5.5 | 6.2 | 4.3e-10 | -0.89 | 0.02 | 0.91 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GFPT1 | 0.05 | 0.00 | blup | 67 | 0.02 | 5.9e-03 | -5.5 | 5.9 | 4.5e-09 | -0.89 | 0.01 | 0.77 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GFPT1 | 0.12 | 0.05 | blup | 67 | 0.04 | 3.9e-05 | -5.5 | 5.5 | 3.0e-08 | -0.93 | 0.01 | 0.99 | FALSE |