Best TWAS P=1.18e-10 · Best GWAS P=3.89e-26 conditioned to 9.96e-17
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | PTGFR | 0.12 | 0.04 | enet | 17 | 0.04 | 4.7e-04 | 5.2 | -5.8 | 6.6e-09 | -0.26 | 0.97 | 0.00 | FALSE |
| 2 | GTEx | Spleen | GIPC2 | 0.43 | 0.07 | enet | 19 | 0.22 | 2.9e-06 | -5.6 | 5.9 | 3.3e-09 | 0.22 | 0.83 | 0.02 | FALSE |
| 3 | METSIM | Adipose | DNAJB4 | 0.04 | 0.04 | lasso | 4 | 0.03 | 2.1e-05 | -4.9 | -5.4 | 7.7e-08 | -0.26 | 0.70 | 0.01 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | DNAJB4 | 0.08 | 0.09 | lasso | 2 | 0.09 | 1.3e-11 | -5.1 | -5.2 | 2.5e-07 | -0.18 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | GIPC2 | 0.04 | 0.01 | blup | 65 | 0.00 | 2.5e-01 | -5.0 | 6.3 | 2.6e-10 | 0.28 | 0.07 | 0.06 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GIPC2 | 0.10 | 0.06 | enet | 13 | 0.06 | 1.5e-07 | -3.3 | 5.4 | 5.3e-08 | 0.37 | 0.96 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GIPC2 | 0.02 | 0.02 | lasso | 3 | 0.02 | 1.0e-03 | -5.6 | 5.7 | 1.3e-08 | 0.22 | 0.37 | 0.02 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | DNAJB4 | 0.04 | 0.04 | lasso | 2 | 0.04 | 1.2e-05 | 6.4 | -6.4 | 1.2e-10 | -0.45 | 0.00 | 1.00 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | GIPC2 | 0.07 | 0.05 | blup | 64 | 0.06 | 1.5e-06 | -5.0 | 5.3 | 1.0e-07 | 0.28 | 0.67 | 0.02 | FALSE |