TWAS
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Traits
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Traits
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Arm fat mass (left)
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chr14:90,643,934-92,390,620
Best TWAS P=7.27e-09 · Best GWAS P=9.36e-10 conditioned to 0.0143
90.6M
90.8M
91M
91.2M
91.4M
91.6M
91.8M
92M
92.2M
92.4M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
GTEx
Spleen
C14orf159
0.30
0.21
lasso
5
0.21
3.6e-06
-5.3
5.8
7.3e-09
-0.81
0.07
0.46
TRUE
1
GTEx
Cells Transformed fibroblasts
RPS6KA5
0.08
0.07
lasso
2
0.06
5.3e-05
-5.5
5.8
8.8e-09
-0.89
0.03
0.96
FALSE
2
GTEx
Colon Sigmoid
RPS6KA5
0.16
0.09
lasso
5
0.08
7.1e-04
-5.3
-5.2
1.7e-07
0.81
0.04
0.89
FALSE