Best TWAS P=5.96e-08 · Best GWAS P=7.53e-08 conditioned to 0.0305
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | TRIM47 | 0.04 | 0.01 | blup | 30 | 0.03 | 2.7e-04 | 5.1 | -5.4 | 6.0e-08 | -0.71 | 0.01 | 0.68 | TRUE |
| 2 | GTEx | Lung | RP11-552F3.10 | 0.12 | 0.02 | lasso | 2 | 0.03 | 4.4e-03 | 5.2 | -5.4 | 6.1e-08 | -0.70 | 0.02 | 0.44 | FALSE |
| 4 | YFS | Blood | GALK1 | 0.05 | 0.04 | enet | 26 | 0.04 | 2.4e-13 | 4.9 | -5.4 | 6.3e-08 | -0.55 | 0.04 | 0.95 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | TRIM47 | 0.06 | 0.06 | blup | 30 | 0.06 | 1.6e-06 | 5.2 | -5.3 | 9.1e-08 | -0.91 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Glioblastoma Multiforme | TRIM65 | 0.08 | 0.02 | enet | 7 | 0.04 | 1.9e-02 | 4.4 | 5.2 | 2.4e-07 | 0.90 | 0.01 | 0.71 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | TRIM47 | 0.09 | 0.03 | lasso | 3 | 0.03 | 1.5e-03 | 5.0 | -5.2 | 2.5e-07 | -0.97 | 0.01 | 0.99 | FALSE |
| 1 | GTEx | Cells Transformed fibroblasts | TRIM65 | 0.18 | 0.13 | lasso | 8 | 0.12 | 4.0e-09 | 5.2 | 5.1 | 3.1e-07 | 0.66 | 0.01 | 0.99 | FALSE |