Hub : Genes

GALK1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Liver 0.3470 0.1060 9.9e-05 0.159 NA 0.206 NA 0.239 3.3e-05 NA 2.1e-06 NA 2.6e-07
2 YFS Blood 0.0529 0.0145 3.7e-10 0.038 0.038 0.041 0.04 0.039 2.2e-12 1.3e-12 2.4e-13 4.6e-13 8.6e-13
3 TCGA Glioblastoma Multiforme 0.1490 0.0730 4.2e-03 0.037 0.062 0.010 NA 0.011 2.8e-02 5.9e-03 1.5e-01 NA 1.5e-01
4 TCGA Pheochromocytoma and Paraganglioma 0.1340 0.0650 7.7e-03 -0.003 0.002 0.000 NA 0.000 4.6e-01 2.6e-01 3.1e-01 NA 3.2e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.2 1.9 3.4 1.8 -1.2 1.2 1.0
Bipolar Disorder or Schizophrenia 1.2 3.0 5.4 2.3 -1.8 1.0 1.5
Depressed Affect (Nagel 2018) 0.8 1.8 2.6 -0.9 1.5 -1.6 -1.2
Depression (Nagel 2018) 1.4 2.1 5.3 1.4 -2.3 1.0 0.2
Intelligence (Savage-Jansen 2018) 0.8 2.3 4.6 0.8 -1.4 2.1 -1.5
Neuroticism (Nagel 2018) 1.0 2.2 5.7 -1.2 2.4 -1.4 -0.1
Schizophrenia (2018) 0.5 1.0 2.3 1.5 -1.3 0.0 0.0
Schizophrenia vs Biploar Disorder 0.1 0.1 0.3 -0.3 0.5 0.0 0.0
Worry (Nagel 2018) 3.0 6.3 14.1 -2.7 3.8 -1.9 -0.4
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 0.1 -0.4 -0.2 0.4
Alzheimer’s Disease (in father) 0.7 0.8 1.2 1.0 -1.1 0.7 0.7
Alzheimer’s Disease (including proxy) 0.5 0.8 1.7 0.5 -1.0 -0.4 1.3
Crohns Disease (2017) 1.4 3.0 7.4 -1.6 1.4 -2.7 -0.2
Irritable Bowel Disease (IBD) 2.1 5.1 10.0 -2.3 2.2 -3.2 0.5
Ulcerative Colitis (UC) 1.9 3.5 6.1 -1.9 1.9 -2.5 0.8
Major Depression (MDD) 0.1 0.2 0.7 0.1 0.8 0.0 0.0
Reaction Time 1.7 3.3 3.7 1.9 -1.9 1.6 1.9
Verbal and Numeric Reasoning (VNR) 0.7 1.6 2.8 1.0 -1.7 1.6 -0.3
Breast Cancer 3.0 7.3 10.7 -2.4 3.3 -2.6 -2.5
Ovarian Cancer 0.6 0.7 2.7 -0.4 1.6 -0.3 0.1
Prostate Cancer 1.7 2.3 5.5 -0.9 1.6 -2.3 -0.7
Age at First Birth 0.6 0.9 1.3 -1.0 1.1 -0.8 -0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.9 2.6 5.3 2.3 -2.3 0.0 0.0
Coronary Artery Disease (CAD) 0.1 0.1 0.5 0.0 0.7 0.0 0.0
Crohns Disease (2012) 1.3 2.1 5.2 -0.8 1.6 -2.3 -0.1
Mean Putamen Volume 0.2 0.2 0.5 -0.5 0.4 -0.7 -0.1
Fasting Glucose 0.3 0.3 0.5 -0.6 -0.3 -0.7 0.6
HbA1C 1.0 1.1 2.7 0.8 -1.6 0.8 -0.6
HDL Cholesterol 1.7 2.8 5.5 2.4 -0.9 1.7 1.4
LDL Cholesterol 8.6 13.6 18.6 -4.3 3.7 -3.9 -2.7
Lupus 0.8 1.2 2.9 1.1 -1.7 0.6 -0.6
Neuroticism (2016) 1.1 1.6 3.1 -1.2 1.8 -1.2 0.8
Primary Biliary Cirrhosis 0.6 0.8 1.9 -0.8 0.8 -1.4 0.1
Rheumatoid Arthritis 0.1 0.2 0.8 0.9 -0.0 0.0 0.0
Schizophrenia (2014) 0.8 1.7 3.9 2.0 -1.6 0.0 0.0
Triglycerides 1.6 2.6 5.8 -2.4 1.0 -1.5 -1.0
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.6 -1.3 0.6 0.0 0.0
Ulcerative Colitis 0.4 0.6 1.5 -1.0 1.2 0.0 0.0
Blood Eosinophil Count 2.6 20.3 36.7 -5.5 3.7 -6.1 -0.0
Blood Platelet Count 1.5 17.8 34.9 -5.9 3.4 -1.7 -4.6
Blood Red Count 0.1 1.3 3.2 1.3 -0.3 1.8 0.7
Blood White Count 1.4 10.7 19.4 -4.4 2.9 -3.8 -0.8
Heel T-Score 0.1 0.8 2.4 0.0 -1.5 -0.3 -0.8
BMI 3.2 18.5 28.7 4.8 -5.4 2.8 3.8
Height 0.4 8.1 15.9 1.8 -3.6 0.6 4.0
Waist Hip Ratio (WHR) 0.5 2.3 5.7 -1.9 -0.3 -2.4 -0.3
Systolic Blood Pressure 2.5 12.4 21.4 -4.6 3.1 -2.8 -3.3
Smoking Status 0.9 2.2 4.2 2.1 -1.9 0.8 0.7
Allergy or Eczema 0.5 1.3 2.7 1.6 -0.8 0.7 1.2
Cardiovascular Disease 3.5 11.6 21.4 -4.6 2.1 -4.3 -1.4
Hypothyroidism (self reported) 2.8 6.5 14.2 3.8 -2.6 1.8 1.3
Respiratory disease 4.5 10.0 18.3 4.3 -3.5 2.1 2.2
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.9 0.5 -1.7 -0.5 0.3
Lung FEV1/FVC ratio 0.1 0.5 1.3 0.3 0.6 -1.1 0.4
Lung FVC 0.9 4.6 8.1 2.8 -0.2 2.6 -1.8
Neuroticism 1.7 4.1 9.4 -1.9 3.1 -1.8 -0.4
Chronotype (morning person) 0.2 0.6 1.3 -1.1 -0.7 -0.5 0.5
Hair Pigment 0.2 6.9 15.2 -3.9 2.4 -2.6 -0.2
Tanning 0.3 3.8 5.0 1.8 -1.9 2.2 -1.8
Hand grip strength (left) 0.5 1.3 3.3 -1.2 -0.2 -1.8 -0.8
Number of treatments/medications taken 0.3 0.5 1.2 -0.1 -1.1 0.4 0.6
Average weekly spirits intake 0.6 0.8 1.5 -0.6 1.2 -0.9 -0.7
Sensitivity / hurt feelings 0.5 0.9 1.9 -1.1 1.4 -0.6 0.3
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.1 -0.1 0.1 0.3 0.1
Hearing difficulty/problems: Yes 0.4 0.7 1.6 0.4 -0.7 1.3 0.7
Relative age of first facial hair 0.7 1.4 2.2 -1.5 1.3 -1.3 -0.3
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 2.3 1.1 -1.5 0.7 1.4
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.0 -1.4 0.7 0.3 -1.2
Ever had hysterectomy (womb removed) 0.5 0.5 0.8 0.9 0.9 0.6 -0.1
Systolic blood pressure, automated reading 1.5 4.2 6.1 -2.3 1.8 -2.5 -1.5
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 0.4 0.2 -0.5 0.5
Angina 0.5 0.6 0.9 0.9 -0.9 1.0 0.0
Medication for hormone replacement therapy 0.8 0.9 2.6 -0.7 -0.5 -0.5 1.6
Vitamin and mineral supplements 0.4 0.5 0.9 -0.1 0.5 -0.9 -0.9
Supplements: Zinc 0.3 0.3 1.2 0.4 0.1 0.0 1.1
Medication: Co-codamol 0.3 0.3 1.1 1.0 -0.2 0.0 -0.5
Medication: Metformin 0.2 0.3 1.1 0.1 -1.0 -0.5 -0.1
Diabetes (father) 0.3 0.3 0.9 0.5 -0.9 -0.5 -0.0
Diabetes (mother) 0.5 0.6 1.5 -0.6 0.3 -0.7 1.2
Severe depression (siblings) 0.9 1.1 1.9 1.3 -1.4 0.7 0.5
Pack years adult smoking proportion 2.5 3.9 6.5 2.5 -2.3 0.8 1.7
Impedance of leg (right) 1.4 6.8 12.5 -2.7 2.6 1.0 -3.5
Leg fat-free mass (left) 2.7 14.3 25.6 3.9 -5.1 0.8 4.0
Trunk fat percentage 4.3 17.1 26.6 4.8 -5.2 2.5 3.4
Hand grip strength (right) 0.3 0.8 1.4 -0.4 -1.2 -1.2 0.5
Townsend deprivation index at recruitment 1.7 2.4 5.2 -1.1 2.3 -1.3 1.1
Current tobacco smoking 1.0 1.7 2.0 1.2 -1.3 -1.3 1.4
Average weekly fortified wine intake 1.5 1.7 3.3 1.8 -0.8 1.7 0.5
Maternal smoking around birth 2.8 4.0 6.8 1.9 -2.6 2.3 0.4
Fed-up feelings 0.8 1.5 2.2 -1.3 1.3 -1.5 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.0 0.7 -1.4 0.3 0.7
Relative age voice broke 1.0 1.5 4.5 -0.6 0.6 -0.7 2.1
Taking other prescription medications 3.1 4.8 7.0 2.3 -2.6 1.9 1.8
Age when periods started (menarche) 0.6 1.4 2.7 0.1 0.4 1.6 -1.6
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.4 1.3 -1.2 1.6 0.0
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.6 7.6 1.5 -2.8 0.7 -0.1
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.4 0.6 -0.1 0.1 0.3
Qualifications: CSEs or equivalent 1.1 1.5 2.5 -1.6 1.3 -1.2 -0.6
Serious illness, injury or assault to yourself 0.4 0.5 0.7 0.9 -0.8 0.4 0.5
High blood pressure 3.3 9.1 18.6 -4.3 1.9 -3.6 -1.3
Hayfever, allergic rhinitis or eczema 2.0 4.4 7.3 2.7 -1.8 2.2 1.4
Multivitamins +/- minerals 0.3 0.4 0.9 0.0 -0.6 0.4 0.9
Stomach or abdominal pain in last month 0.4 0.5 0.6 0.8 -0.8 -0.3 0.8
Supplements: Glucosamine 0.2 0.3 0.8 -0.2 0.6 0.1 0.9
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.2 0.5 -1.0 0.4 1.1
Medication: Atenolol 2.2 2.8 6.2 -2.5 1.1 -1.4 -1.4
Medication: Levothyroxine sodium 2.0 3.4 6.8 2.6 -2.4 1.1 0.4
Sitting height 0.4 2.9 9.7 0.4 -1.3 -0.2 3.1
Chronic bronchitis/emphysema (father) 0.7 0.8 1.5 1.2 -0.8 0.9 0.7
High blood pressure (mother) 1.3 1.9 3.3 -1.5 0.8 -1.1 -1.8
Body mass index (BMI) 2.8 12.0 19.3 4.1 -4.4 1.9 2.9
Impedance of leg (left) 1.1 5.6 9.1 -2.6 2.5 0.4 -3.0
Leg predicted mass (left) 2.7 14.5 26.0 3.9 -5.1 0.9 4.0
Trunk fat mass 4.6 19.9 32.9 5.0 -5.7 2.3 4.0
Waist circumference 3.8 13.9 28.6 3.9 -5.3 1.4 3.1
Number of incorrect matches in round 2.9 4.7 7.1 -2.4 2.4 -2.7 -0.1
Past tobacco smoking 0.4 0.8 2.1 -0.9 0.5 -1.4 -0.2
Alcohol usually taken with meals 1.0 1.6 2.8 -1.3 1.7 -1.4 -0.2
Nervous feelings 1.4 2.5 5.6 -1.9 2.4 -0.7 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.5 -0.6 0.1 0.5 -0.7
Hearing difficulty/problems with background noise 1.5 2.5 4.4 2.0 -1.0 0.6 2.1
Hair/balding pattern: Pattern 2 0.1 0.2 0.3 -0.5 0.5 0.0 -0.2
Had menopause 0.3 0.4 0.6 0.5 -0.5 0.7 0.8
Had other major operations 2.5 3.0 6.2 1.4 -2.5 1.6 -1.0
Forced vital capacity (FVC) 0.9 3.4 7.7 2.8 -1.3 2.0 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 5.4 1.2 -2.3 0.1 0.6
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.9 -1.4 0.7 -0.5 0.1
Qualifications: None of the above 0.0 0.1 0.1 0.3 -0.1 0.4 -0.0
Financial difficulties in last 2 years 0.7 0.9 1.3 0.5 -1.1 1.0 1.1
Mouth/teeth dental problems 0.2 0.3 0.7 0.1 0.1 0.9 -0.5
Heart attack 1.7 2.2 3.2 -1.8 1.7 -0.6 -1.5
Allergy 3.7 8.4 16.9 -4.1 2.9 -2.0 -2.1
Pain all over the body in last month 0.6 0.7 2.0 0.7 -0.0 0.6 -1.4
Diabetes (self-reported) 0.7 1.1 2.9 0.6 -1.7 -0.7 0.7
Hayfever/allergic rhinitis (self-reported) 1.4 1.8 4.7 1.2 -1.1 0.0 2.2
Medication: Ramipril 0.5 0.6 1.2 -0.4 1.1 0.3 -1.0
Medication: Simvastatin 5.2 7.7 13.9 -3.1 2.5 -3.7 -0.8
Fluid intelligence score 0.3 0.6 0.7 0.9 -0.7 0.8 0.8
Illnesses of siblings 0.4 0.5 1.3 0.8 0.2 1.2 0.3
Neuroticism score 2.3 4.8 11.4 -2.1 3.4 -1.8 -0.4
Weight 3.4 16.6 29.4 4.3 -5.4 1.5 4.1
Impedance of arm (right) 0.1 0.4 0.8 0.5 0.4 0.9 -0.5
Arm fat percentage (right) 4.2 16.5 25.6 5.1 -4.9 2.3 3.4
Trunk fat-free mass 0.8 4.4 8.1 1.2 -2.9 -0.5 2.8
Hip circumference 5.1 21.8 32.3 5.7 -5.7 3.7 2.9
Time employed in main current job 0.1 0.2 0.6 0.2 0.1 -0.0 -0.8
Alcohol intake versus 10 years previously 2.4 3.6 5.1 -2.2 2.0 -2.3 -0.7
Father’s age at death 0.6 0.8 1.7 1.3 -0.3 0.1 1.1
Worrier / anxious feelings 4.6 8.8 15.4 -2.7 3.9 -3.2 1.5
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 2.3 1.2 -1.5 1.2 -0.2
Falls in the last year 0.7 0.9 2.6 0.6 -0.8 0.0 1.6
Hair/balding pattern: Pattern 3 0.0 0.1 0.1 -0.1 0.2 0.3 0.2
Number of live births 0.7 1.0 1.7 1.3 -1.1 0.3 1.1
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 6.9 2.6 -0.8 1.9 -0.2
Pulse rate 1.6 2.7 5.0 -1.7 1.0 -2.2 1.4
Happiness 0.4 0.5 1.8 0.4 -1.3 -0.0 0.2
Noisy workplace 0.4 0.5 1.3 -0.6 0.3 -1.1 0.6
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.4 -0.3 -0.1 -0.5 0.6
Serious illness, injury or assault of a close relative in last 2 years 2.6 3.0 4.4 2.1 -1.8 1.7 1.1
Mouth/teeth dental problems: Dentures 0.5 0.8 1.5 1.2 -0.9 1.0 -0.1
Asthma 3.2 6.3 11.2 3.3 -2.7 2.0 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.0 0.5 -1.0 -0.1 0.9
Medication: Cholesterol lowering 2.6 4.1 6.9 -2.6 1.9 -2.0 -1.2
Depression (self-reported) 0.8 0.9 3.2 -0.3 0.6 0.3 -1.8
Medication: Lansoprazole 1.2 1.4 2.3 1.5 -1.3 0.9 0.8
Prospective memory result 1.8 2.2 4.8 -1.4 -0.3 -2.2 1.4
Lung cancer (father) 0.3 0.4 1.0 0.0 1.0 0.3 -0.6
Illnesses of mother 0.8 1.0 1.6 1.1 -1.3 0.9 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.2 8.9 3.0 -1.1 2.5 0.0
Pulse wave Arterial Stiffness index 0.1 0.2 0.3 -0.6 -0.2 -0.5 -0.0
Impedance of arm (left) 0.2 0.7 2.1 0.7 0.1 1.4 -0.5
Arm fat mass (right) 3.7 15.4 24.9 4.5 -5.0 2.1 3.4
Trunk predicted mass 0.7 4.2 7.7 1.2 -2.8 -0.5 2.8
Standing height 0.4 3.5 7.2 0.6 -2.5 -0.4 2.7
Length of working week for main job 0.7 0.8 1.7 1.3 -0.4 0.7 -0.9
Exposure to tobacco smoke at home 1.4 1.6 5.5 -0.5 -0.0 0.8 -2.3
Breastfed as a baby 0.1 0.1 0.3 -0.0 -0.6 -0.3 -0.3
Tense / ‘highly strung’ 0.6 0.9 2.1 -0.3 0.6 1.1 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.1 0.6 0.7 0.8 -1.0
Hair/balding pattern: Pattern 4 2.1 5.1 7.3 -2.7 1.9 -2.6 -1.6
Birth weight of first child 0.6 1.1 2.4 -0.7 0.2 -1.5 1.2
Peak expiratory flow (PEF) 1.7 3.9 8.9 3.0 -1.9 1.7 -0.0
Pulse wave reflection index 0.5 0.6 0.8 0.9 -0.9 0.4 -0.7
Ever highly irritable/argumentative for 2 days 2.4 2.9 5.5 1.7 -1.7 2.3 0.8
Loud music exposure frequency 0.7 0.8 1.3 -0.4 -0.9 -1.0 1.1
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.9 -0.4 1.0 0.2 0.6
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.1 0.3 -0.1 -0.9 1.0
Blood clot in the leg (DVT) 2.2 2.9 5.2 2.3 -1.9 -0.9 1.4
Medication: Paracetamol 0.1 0.1 0.3 -0.4 0.0 0.2 -0.5
Headache pain in last month 0.3 0.6 1.4 -1.2 0.8 -0.0 -0.6
Medication for cholesterol, blood pressure or diabetes 2.4 4.0 7.2 2.7 -1.4 2.4 0.8
Glaucoma (self-reported) 2.5 2.9 4.3 -1.9 1.6 -2.1 -1.0
Gout (self-reported) 0.2 0.3 0.6 0.3 0.5 -0.7 0.7
Hypothyroidism/myxoedema (self-reported) 1.9 3.8 7.6 2.7 -2.2 1.4 0.7
Medication: Amlodipine 2.3 3.2 4.5 -1.8 1.0 -2.1 -2.0
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.5 1.2 -1.0 0.7 -0.1
Birth weight 0.2 0.5 1.0 0.8 -0.6 -0.3 1.0
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.8 0.2 -0.6 0.9 -0.3
High blood pressure (siblings) 0.9 1.3 4.0 -0.9 0.3 -2.0 0.6
Forced vital capacity (FVC), Best measure 1.1 4.0 8.5 2.9 -1.3 2.4 0.1
Body fat percentage 4.3 16.9 26.0 4.9 -5.1 2.6 3.3
Leg fat percentage (right) 3.5 12.6 19.6 4.2 -4.4 2.8 2.3
Arm fat-free mass (right) 1.4 7.4 15.1 2.3 -3.9 0.4 3.0
Exposure to tobacco smoke outside home 0.6 0.9 1.7 1.2 -0.2 -0.5 1.3
Comparative body size at age 10 0.4 1.1 2.0 1.1 -1.4 -0.7 0.8
Number of full brothers 1.4 1.8 3.5 0.9 -1.7 1.9 -0.1
Worry too long after embarrassment 0.2 0.4 0.8 0.2 0.7 0.9 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.3 0.6 0.2 0.2 0.1
Wheeze or whistling in the chest in last year 1.9 3.4 7.8 2.8 -2.0 1.4 -0.1
Number of children fathered 3.2 3.6 6.7 2.4 -2.6 1.2 0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 2.2 -1.1 1.5 -1.4 0.6
Age at first live birth 0.4 0.6 2.1 -0.2 -0.4 0.5 -1.4
Pulse wave peak to peak time 0.1 0.1 0.2 0.4 0.1 0.5 0.1
Health satisfaction 4.5 5.9 10.1 2.0 -3.2 3.0 -0.5
Shortness of breath walking on level ground 5.6 6.7 12.6 2.8 -3.5 2.3 0.9
Qualifications: College or University degree 0.1 0.2 0.5 0.7 -0.2 0.2 -0.4
Eye problems/disorders: None of the above 0.7 0.8 2.9 0.4 -0.4 1.7 0.4
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.7 -0.8 0.8 -0.4 -0.6
Emphysema/chronic bronchitis 1.2 1.3 3.8 1.9 -0.6 1.0 0.3
Medication for pain relief, constipation, heartburn 0.1 0.2 0.4 0.4 0.6 -0.1 -0.1
Neck or shoulder pain in last month 0.7 1.0 2.4 -0.4 0.7 -1.6 0.9
Medication: Blood pressure 2.4 4.3 8.0 -2.8 1.7 -2.4 -0.7
Angina (self-reported) 0.5 0.6 1.0 0.8 -0.9 1.0 0.1
Migraine (self-reported) 0.7 0.9 2.9 -0.4 0.5 1.7 0.3
Medication: Ibuprofen 1.3 1.6 3.2 1.3 -1.8 0.6 1.0
Medication: Allopurinol 1.4 1.9 5.6 -0.3 0.3 -1.3 2.4
Medication: Omeprazole 2.3 2.7 7.2 0.9 -1.7 -0.5 2.7
Medication: Seretide 50 evohaler 2.8 3.2 5.7 2.4 -2.1 0.8 1.5
Mean time to correctly identify matches 0.8 1.5 3.8 0.7 -1.1 0.6 1.9
Heart disease (mother) 0.6 0.7 1.7 -0.4 -0.7 1.3 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 2.7 0.8 -1.1 1.6 -0.4
Whole body fat mass 4.3 17.9 30.5 4.7 -5.5 2.3 3.6
Leg fat mass (right) 4.7 18.3 31.5 4.8 -5.6 2.7 3.3
Arm predicted mass (right) 1.5 7.6 16.5 2.4 -4.1 0.7 2.8
Pulse rate, automated reading 1.3 4.0 7.3 -1.6 0.1 -2.7 2.5
Alcohol intake frequency. 0.5 1.2 3.5 -1.9 0.7 -0.2 -0.9
Comparative height size at age 10 0.5 2.7 5.8 1.0 -2.4 0.0 2.0
Number of full sisters 5.1 6.3 11.0 1.9 -3.0 3.3 1.2
Suffer from ‘nerves’ 4.5 7.1 11.7 -3.1 3.4 -2.0 -1.6
Overall health rating 0.2 0.4 1.1 0.1 -1.0 -0.4 0.5
Chest pain or discomfort 0.7 1.0 3.4 0.7 -0.3 1.8 -0.5
Had major operations 1.1 1.3 3.1 -0.8 1.8 -1.2 -0.1
Age at last live birth 1.0 1.4 2.5 0.4 -1.1 1.4 -1.6
Family relationship satisfaction 0.6 0.7 2.1 -0.8 0.2 -1.5 -0.3
Leg pain on walking 0.9 1.1 2.1 -1.4 0.6 -1.4 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 -0.4 -0.1 -0.1 -0.2
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.2 -0.1 -1.1 -0.6 -0.5
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 1.3 -1.1 1.1 -0.7 -1.0
Medication: Aspirin 0.5 0.6 1.0 -0.9 -0.1 -0.8 -1.0
Supplements: Vitamin C 0.8 1.0 3.2 0.1 -0.6 0.6 1.8
Knee pain experienced in last month 1.8 2.8 7.7 -1.6 0.6 -2.8 0.9
Hypertension (Self-reported) 3.0 8.4 16.2 -4.0 1.7 -3.6 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 7.2 0.5 -0.8 0.0 2.7
Illnesses of father: Heart disease 0.8 1.2 2.4 -1.2 0.9 -1.6 0.0
Illnesses of siblings: Diabetes 0.6 0.7 2.2 0.2 -1.5 0.8 -0.1
Smoking status: Previous 0.2 0.3 1.1 -0.0 0.2 1.1 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 3.9 -0.2 -0.6 0.1 2.0
Whole body fat-free mass 1.4 7.9 15.0 2.4 -3.9 0.1 3.3
Leg fat-free mass (right) 2.6 13.8 24.7 3.8 -5.0 0.5 4.0
Arm fat percentage (left) 4.6 18.3 27.9 5.3 -5.1 2.8 3.3
Average weekly red wine intake 0.1 0.2 0.4 0.6 0.3 -0.2 0.5
Handedness (chirality/laterality): Left-handed 0.5 0.6 0.7 -0.8 0.8 -0.9 -0.5
Mood swings 0.9 1.6 3.0 -1.0 1.7 -1.5 -0.0
Loneliness, isolation 4.2 5.8 7.5 -2.7 2.7 -1.8 -2.3
Long-standing illness, disability or infirmity 2.6 3.9 7.6 1.9 -2.8 1.3 1.6
Ever had bowel cancer screening 1.0 1.1 2.2 -1.4 0.6 -1.5 0.3
Diabetes diagnosed by doctor 0.3 0.5 0.8 -0.3 -0.9 -0.8 0.6
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 2.0 1.4 -1.3 1.3 -0.7
Friendships satisfaction 0.1 0.2 0.5 0.1 -0.7 -0.0 0.3
Qualifications: nursing, teaching 0.7 1.0 2.6 0.7 -1.6 1.1 -0.1
Commuting to job workplace: Walk 1.4 1.5 2.4 -0.7 1.3 -1.6 1.2
Eye problems/disorders: Cataract 0.5 0.6 2.1 -0.3 0.1 -0.4 -1.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.1 -0.0 -0.2 0.4 1.1
Medication for cholesterol 3.4 5.2 10.7 2.8 -1.4 3.3 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.7 5.9 0.8 -0.3 -0.5 2.4
Back pain experienced in last month 1.0 1.4 3.8 0.5 -1.9 0.2 1.3
Mineral and other dietary supplements 1.3 1.7 3.3 1.6 -1.8 0.6 0.8
Breast cancer (self-reported) 0.3 0.3 0.8 -0.4 0.5 0.9 -0.1
Asthma (self-reported) 3.8 7.6 13.6 3.7 -2.8 2.4 1.8
Osteoporosis (self-reported) 0.8 0.9 2.8 0.7 -0.1 1.7 0.7
Osteoarthritis (self-reported) 0.8 1.0 2.8 -1.0 -0.1 -1.7 -0.3
Medication: Aspirin 0.3 0.4 0.7 -0.7 -0.2 -0.5 -0.8
Medication: Gliclazide 0.2 0.3 0.7 -0.9 0.2 -0.2 -0.4
Illnesses of father: None of the above (group 1) 2.9 3.6 8.1 0.2 0.6 2.8 -2.4
Smoking status: Current 0.8 1.3 1.6 1.1 -0.9 -1.2 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.8 3.8 8.3 2.6 -0.2 2.9 -0.6
Whole body water mass 1.3 7.6 14.5 2.3 -3.8 0.0 3.2
Leg predicted mass (right) 2.6 13.9 24.6 3.8 -5.0 0.5 4.0
Arm fat mass (left) 4.3 17.8 29.3 4.9 -5.4 2.6 3.4
Number of self-reported non-cancer illnesses 0.4 0.7 1.7 -1.0 -0.3 -1.3 0.1
Average weekly champagne plus white wine intake 2.3 3.2 5.6 -1.7 1.9 -2.4 0.6
Miserableness 0.4 0.8 1.6 -0.3 1.2 -1.2 0.2
Guilty feelings 0.4 0.6 1.8 0.3 0.7 -0.0 1.3
Wears glasses or contact lenses 0.5 0.6 1.2 -1.0 0.6 -1.1 0.1
Ever taken oral contraceptive pill 0.2 0.3 0.4 -0.6 0.5 0.7 -0.1
Hearing aid user 0.6 0.7 1.1 0.8 -0.3 1.0 1.0
Mother’s age at death 0.6 0.8 1.9 0.4 0.8 -0.7 -1.4
Financial situation satisfaction 1.5 1.9 5.0 0.8 -2.2 0.9 1.1
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.2 0.9 -0.6 1.5 -0.5
Commuting to job workplace: Public transport 0.1 0.1 0.3 0.2 0.1 -0.6 0.1
Eye problems/disorders: Glaucoma 3.5 4.1 4.5 -2.0 2.1 -1.9 -2.1
Medication: Blood pressure 0.9 1.6 3.6 -1.5 0.1 -0.8 -1.9
Pain type(s) experienced in last month: Hip pain 2.0 2.5 5.6 -1.6 1.4 -2.4 0.0
Supplements: Fish oil (including cod liver oil) 2.6 3.4 6.2 -1.9 2.5 -1.8 -0.7
High cholesterol (Self-reported) 12.1 21.4 33.6 -5.8 4.3 -5.8 -0.6
Medication: Bendroflumethiazide 0.4 0.7 1.9 -1.4 -0.3 -0.6 -0.5
Medication: Paracetamol 0.1 0.2 0.7 -0.1 -0.2 0.8 -0.2
Medication: Lisinopril 1.3 1.7 2.7 -1.6 1.1 -1.6 -0.5
Medication: Atorvastatin 3.1 3.8 6.5 -2.5 1.7 -2.4 -0.2
Illnesses of father: High blood pressure 0.2 0.2 0.3 -0.2 -0.6 -0.5 0.3
Alcohol drinker status: Never 1.1 1.4 3.4 1.1 -0.5 1.8 -0.8
Ever smoked 0.6 1.0 1.3 1.1 -0.9 0.8 1.2
Basal metabolic rate 1.8 10.1 19.4 3.0 -4.4 0.6 3.4
Leg fat percentage (left) 3.6 12.9 20.4 4.3 -4.5 2.4 2.6
Arm fat-free mass (left) 1.2 6.3 12.6 2.0 -3.5 0.1 2.9
Number of operations (self-reported) 1.3 2.0 3.7 1.5 -1.9 0.6 1.2
Average weekly beer plus cider intake 0.5 0.7 1.9 0.1 -0.7 0.5 1.4
Irritability 0.3 0.5 0.9 0.5 -0.6 0.6 0.9
Risk taking 1.3 1.9 3.5 1.2 -1.9 -0.3 1.6
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.3 1.1 0.4 0.6 -0.1
Fractured/broken bones in last 5 years 0.3 0.4 0.8 0.6 -0.1 -0.5 0.9
Age started oral contraceptive pill 0.1 0.1 0.2 -0.5 0.2 -0.5 -0.2
Diastolic blood pressure, automated reading 0.6 1.8 5.2 -1.1 0.1 -2.3 -0.8
Ever depressed for a whole week 0.1 0.2 0.5 -0.7 0.2 -0.3 0.3
Unable to work because of sickness or disability 3.3 4.2 6.2 2.5 -2.4 1.6 1.5
Commuting to job workplace: Cycle 0.9 1.1 2.7 0.9 0.3 1.6 -1.0
Myopia 0.3 0.5 1.3 -1.1 -0.6 -0.5 -0.1
Vascular/heart problems diagnosed by doctor 2.5 6.9 14.3 3.8 -1.5 3.2 1.1
Cholesterol lowering medication 6.1 9.0 19.8 -3.2 2.5 -4.5 -0.4
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 4.1 1.0 -1.4 0.1 2.0
Pain experienced in last month 0.7 1.2 2.6 1.4 -0.0 1.6 -0.1
Supplements: Calcium 0.4 0.5 1.5 0.3 -0.2 0.6 1.2
Basal cell carcinoma (self-reported) 0.2 0.2 0.5 -0.7 0.7 -0.3 0.1
Heart attack/myocardial infarction (self-reported) 2.6 3.4 5.2 -2.3 2.1 -1.1 -1.6
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 5.5 2.4 -1.9 -0.7 1.1
Heart disease (siblings) 2.1 2.5 5.4 -2.3 1.1 -1.4 -1.3
Alcohol drinker status: Previous 0.8 1.0 2.5 -0.3 -0.5 -1.0 1.6
Pack years of smoking 2.4 3.5 6.3 2.5 -2.2 0.9 1.4
Impedance of whole body 0.3 1.5 2.5 -0.8 1.3 1.1 -1.6
Leg fat mass (left) 4.6 18.1 31.4 4.9 -5.6 2.4 3.4
Arm predicted mass (left) 1.1 5.8 12.2 1.8 -3.5 -0.1 2.8