TWAS
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Traits
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Traits
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Arm fat mass (left)
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chr2:26,223,547-27,689,899
Best TWAS P=1.68e-13 · Best GWAS P=8.68e-13 conditioned to 1
26.2M
26.4M
26.6M
26.8M
27M
27.2M
27.4M
27.6M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
KCNK3
0.24
0.15
lasso
3
0.15
6.5e-19
7.2
-7.4
1.7e-13
-0.99
0.00
1.00
TRUE
3
ROSMAP
Brain Pre-frontal Cortex
SLC35F6
0.05
0.04
enet
11
0.04
8.0e-06
-5.2
5.6
2.5e-08
0.73
0.24
0.75
FALSE
1
GTEx
Skin Sun Exposed Lower leg
SLC35F6
0.10
0.04
lasso
4
0.05
4.2e-05
-5.2
5.3
1.2e-07
0.76
0.39
0.20
FALSE
4
The Cancer Genome Atlas
Esophageal Carcinoma
C2orf18
0.20
0.02
blup
30
0.06
6.7e-03
3.5
5.2
1.7e-07
0.75
0.01
0.38
FALSE