Best TWAS P=1.68e-13 · Best GWAS P=8.68e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Skin Sun Exposed Lower leg | SLC35F6 | 0.10 | 0.04 | lasso | 4 | 0.05 | 4.2e-05 | -5.2 | 5.3 | 1.2e-07 | 0.76 | 0.39 | 0.20 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | KCNK3 | 0.24 | 0.15 | lasso | 3 | 0.15 | 6.5e-19 | 7.2 | -7.4 | 1.7e-13 | -0.99 | 0.00 | 1.00 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | SLC35F6 | 0.05 | 0.04 | enet | 11 | 0.04 | 8.0e-06 | -5.2 | 5.6 | 2.5e-08 | 0.73 | 0.24 | 0.75 | FALSE |
| 4 | The Cancer Genome Atlas | Esophageal Carcinoma | C2orf18 | 0.20 | 0.02 | blup | 30 | 0.06 | 6.7e-03 | 3.5 | 5.2 | 1.7e-07 | 0.75 | 0.01 | 0.38 | FALSE |