Best TWAS P=1.95e-09 · Best GWAS P=1.93e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C3orf38 | 0.08 | 0.00 | enet | 14 | 0.04 | 2.3e-05 | -5.2 | -5.3 | 1.2e-07 | 0.63 | 0.05 | 0.91 | FALSE |
2 | GTEx | Artery Aorta | C3orf38 | 0.06 | 0.06 | lasso | 7 | 0.05 | 6.0e-04 | -5.3 | 5.3 | 1.2e-07 | -0.80 | 0.21 | 0.69 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | ZNF654 | 0.08 | 0.09 | enet | 6 | 0.10 | 3.1e-08 | -5.9 | -6.0 | 2.0e-09 | 0.99 | 0.01 | 0.99 | TRUE |
4 | GTEx | Esophagus Mucosa | C3orf38 | 0.11 | 0.06 | lasso | 7 | 0.07 | 1.5e-05 | -5.2 | 5.7 | 1.0e-08 | -0.91 | 0.08 | 0.91 | FALSE |
5 | GTEx | Nerve Tibial | C3orf38 | 0.09 | 0.05 | lasso | 4 | 0.04 | 6.3e-04 | -5.2 | 5.3 | 1.3e-07 | -0.80 | 0.23 | 0.69 | FALSE |
6 | GTEx | Thyroid | C3orf38 | 0.12 | 0.08 | lasso | 18 | 0.07 | 1.0e-05 | -5.2 | 5.2 | 2.1e-07 | -0.80 | 0.29 | 0.70 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf38 | 0.02 | 0.03 | lasso | 1 | 0.03 | 1.9e-04 | -5.2 | 5.2 | 1.7e-07 | -0.79 | 0.03 | 0.60 | FALSE |
8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C3orf38 | 0.03 | 0.05 | lasso | 1 | 0.05 | 8.1e-06 | -5.2 | 5.2 | 1.7e-07 | -0.79 | 0.08 | 0.90 | FALSE |
9 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF654 | 0.03 | 0.04 | lasso | 3 | 0.03 | 4.6e-04 | -5.2 | -5.3 | 1.2e-07 | 0.80 | 0.03 | 0.90 | FALSE |