Best TWAS P=1.15e-10 · Best GWAS P=6.93e-19 conditioned to 1.47e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | PROS1 | 0.31 | 0.16 | enet | 7 | 0.19 | 8.4e-09 | 6.4 | -6.1 | 1.1e-09 | -0.68 | 0.96 | 0.02 | FALSE |
| 2 | METSIM | Adipose | STX19 | 0.06 | 0.09 | lasso | 3 | 0.08 | 1.8e-11 | 5.6 | 6.1 | 1.3e-09 | 0.50 | 1.00 | 0.00 | FALSE |
| 3 | YFS | Blood | DHFRL1 | 0.07 | 0.04 | lasso | 9 | 0.04 | 4.1e-14 | 6.6 | 6.3 | 3.6e-10 | 0.54 | 1.00 | 0.00 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DHFRL1 | 0.07 | 0.05 | lasso | 1 | 0.05 | 3.4e-11 | 5.6 | -5.6 | 2.8e-08 | -0.43 | 0.81 | 0.19 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STX19 | 0.04 | 0.02 | lasso | 1 | 0.01 | 5.5e-04 | 6.4 | 6.4 | 1.8e-10 | 0.64 | 0.01 | 0.83 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | DHFRL1 | 0.20 | 0.12 | lasso | 8 | 0.11 | 3.7e-04 | 5.6 | -5.7 | 1.5e-08 | -0.44 | 0.01 | 0.09 | FALSE |
| 7 | The Cancer Genome Atlas | Glioblastoma Multiforme | STX19 | 0.52 | -0.01 | enet | 15 | 0.17 | 5.6e-06 | 6.4 | 5.2 | 2.4e-07 | 0.30 | 0.00 | 0.16 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DHFRL1 | 0.07 | 0.05 | enet | 17 | 0.05 | 2.5e-06 | 5.6 | -6.3 | 3.7e-10 | -0.54 | 0.05 | 0.91 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DHFRL1 | 0.13 | 0.07 | lasso | 2 | 0.07 | 5.7e-08 | 5.6 | -5.6 | 2.8e-08 | -0.43 | 0.79 | 0.20 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | STX19 | 0.35 | 0.11 | enet | 12 | 0.20 | 2.4e-22 | 6.4 | 6.2 | 4.4e-10 | 0.49 | 0.02 | 0.98 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DHFRL1 | 0.10 | 0.06 | lasso | 2 | 0.05 | 5.2e-06 | 5.6 | -5.6 | 2.8e-08 | -0.43 | 0.77 | 0.20 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | STX19 | 0.51 | 0.13 | enet | 19 | 0.34 | 3.9e-40 | 6.4 | 5.4 | 7.3e-08 | 0.40 | 0.04 | 0.96 | FALSE |
| 13 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | STX19 | 0.15 | 0.08 | lasso | 1 | 0.05 | 1.8e-03 | 6.4 | 6.4 | 1.8e-10 | 0.64 | 0.02 | 0.67 | FALSE |
| 14 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | STX19 | 0.28 | -0.01 | enet | 15 | 0.08 | 6.4e-04 | 6.4 | 5.6 | 1.9e-08 | 0.44 | 0.00 | 0.28 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | ARL13B | 0.03 | 0.00 | blup | 39 | 0.00 | 2.1e-01 | -6.7 | 6.5 | 1.2e-10 | 0.66 | 0.01 | 0.68 | TRUE |