TWAS
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Models
Genes
Traits
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Traits
:
Arm fat mass (left)
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chr6:160,071,844-161,571,560
Best TWAS P=2.36e-08 · Best GWAS P=2.06e-08 conditioned to 0.00772
160M
160.2M
160.4M
160.6M
160.8M
161M
161.2M
161.4M
161.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Brain Caudate basal ganglia
SLC22A3
0.15
0.10
enet
39
0.11
0.00056
-4.7
-5.6
2.4e-08
0.64
0.18
0.55
TRUE
2
GTEx
Skin Not Sun Exposed Suprapubic
SLC22A3
0.15
0.05
lasso
9
0.05
0.00099
-3.8
-5.2
2.2e-07
0.82
0.02
0.98
FALSE