Hub : Genes

SLC22A3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1000 0.0330 3.5e-06 0.021 0.053 0.044 0.053 0.032 1.3e-03 4.4e-07 3.9e-06 4.9e-07 8.3e-05
2 GTEx Adipose Visceral Omentum 0.1350 0.0500 8.4e-05 0.055 NA 0.095 NA 0.087 7.9e-04 NA 1.3e-05 NA 2.9e-05
3 GTEx Artery Tibial 0.1057 0.0423 1.5e-03 -0.003 NA 0.012 NA 0.001 6.8e-01 NA 3.7e-02 NA 2.3e-01
4 GTEx Brain Caudate basal ganglia 0.1530 0.0600 1.8e-03 0.096 NA 0.107 NA 0.011 1.1e-03 NA 5.6e-04 NA 1.5e-01
5 GTEx Brain Frontal Cortex BA9 0.2613 0.0811 2.1e-04 0.078 NA 0.036 NA 0.054 4.1e-03 NA 3.9e-02 NA 1.5e-02
6 GTEx Colon Transverse 0.1840 0.0780 3.4e-03 -0.004 NA -0.004 NA -0.004 5.8e-01 NA 5.2e-01 NA 5.3e-01
7 GTEx Esophagus Mucosa 0.1900 0.0540 1.6e-07 0.078 NA 0.122 NA 0.091 6.8e-06 NA 1.7e-08 NA 1.1e-06
8 GTEx Nerve Tibial 0.2041 0.0573 4.1e-07 0.098 NA 0.114 NA 0.126 2.1e-07 NA 2.0e-08 NA 3.2e-09
9 GTEx Ovary 0.3300 0.0910 4.2e-05 0.287 NA 0.193 NA 0.226 9.3e-08 NA 1.7e-05 NA 2.8e-06
10 GTEx Pancreas 0.1660 0.0730 3.6e-03 0.037 NA 0.040 NA 0.033 1.1e-02 NA 8.7e-03 NA 1.5e-02
11 GTEx Skin Not Sun Exposed Suprapubic 0.1510 0.0520 3.0e-05 0.050 NA 0.048 NA 0.050 1.0e-03 NA 1.2e-03 NA 9.9e-04
12 GTEx Skin Sun Exposed Lower leg 0.2930 0.0630 8.4e-15 0.135 NA 0.162 NA 0.197 2.9e-11 NA 2.1e-13 NA 3.7e-16
13 GTEx Small Intestine Terminal Ileum 0.2390 0.0980 5.2e-03 0.127 NA 0.084 NA 0.099 9.2e-04 NA 6.4e-03 NA 3.3e-03
14 GTEx Testis 0.1870 0.0600 6.9e-06 0.011 NA 0.049 NA 0.051 9.8e-02 NA 3.2e-03 NA 2.6e-03
15 METSIM Adipose 0.0362 0.0165 5.5e-03 0.012 0.014 0.008 0.013 0.015 4.7e-03 2.7e-03 1.8e-02 4.4e-03 2.3e-03
16 ROSMAP Brain Pre-frontal Cortex 0.1448 0.0308 0.0e+00 0.199 0.149 0.191 0.174 0.194 5.0e-25 1.1e-18 5.8e-24 7.2e-22 2.4e-24
17 TCGA Colon Adenocarcinoma 0.1740 0.1170 6.3e-03 0.062 0.010 0.003 NA 0.038 1.7e-04 8.6e-02 2.0e-01 NA 2.8e-03
18 TCGA Brain Lower Grade Glioma 0.1215 0.0485 1.0e-06 0.071 0.058 0.067 NA 0.067 1.7e-08 3.3e-07 4.0e-08 NA 4.3e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Bipolar Disorder (2018) 1.0 1.6 3.6 1.6 1.6 1.3 1.1 0.9 0.4 -0.3 1.8 1.8 -0.6 1.9 1.4 -0.7 1.1 0.8 1.6 -1.9 -0.4
Bipolar Disorder or Schizophrenia 0.3 0.8 4.9 1.0 0.9 0.6 0.2 0.3 0.5 0.4 1.3 0.7 -1.2 1.1 0.1 -0.8 0.3 0.2 1.0 -0.9 -2.2
Depressed Affect (Nagel 2018) 1.1 2.3 4.7 -0.8 -1.6 -1.2 -1.6 -1.7 -0.9 -1.9 -2.0 -2.0 -1.1 -2.2 -1.6 -0.5 -1.8 -1.2 -1.6 1.7 0.8
Depression (Nagel 2018) 0.4 0.7 2.5 -0.2 -1.1 -0.3 -0.7 -0.1 -0.6 -0.7 -1.1 -1.0 -0.7 -0.4 -0.6 -0.4 -1.6 -0.0 -0.9 0.3 1.6
Intelligence (Savage-Jansen 2018) 0.2 0.7 3.8 -0.1 -0.4 -0.3 -0.7 -1.4 1.9 -0.2 -0.1 0.2 -0.0 0.3 0.3 0.9 0.7 1.0 -0.5 1.7 -0.3
Neuroticism (Nagel 2018) 0.3 0.7 4.2 0.7 -0.5 -0.8 -0.6 -1.2 0.1 -0.8 -0.8 -1.0 -0.7 -1.1 -0.7 0.1 -0.4 -0.5 -0.4 2.0 -0.8
Schizophrenia (2018) 0.3 0.6 7.1 0.1 -0.2 0.0 -0.4 -0.4 0.6 0.7 0.3 -0.5 -1.1 -0.2 -0.9 -0.5 -0.5 -0.3 -0.0 0.3 -2.7
Schizophrenia vs Biploar Disorder 0.9 1.2 2.5 -0.9 -0.8 -0.8 -0.9 -1.1 -1.0 -0.7 -1.1 -1.2 -1.3 -1.0 -1.6 -1.6 -1.5 -1.5 -0.9 0.6 -0.7
Worry (Nagel 2018) 0.5 1.0 4.6 2.1 0.6 -0.0 0.5 -0.1 1.3 0.9 0.6 0.3 -0.4 0.8 0.7 0.9 0.7 0.4 0.8 1.4 -2.0
Alzheimer’s Disease (in mother) 0.2 0.3 1.0 0.3 -0.7 -0.4 -0.4 -0.6 0.8 -0.3 0.2 0.4 0.4 0.8 0.1 -0.1 0.1 0.0 -0.7 0.5 -1.0
Alzheimer’s Disease (in father) 1.8 2.0 3.8 -1.8 -1.9 -1.5 -1.4 -1.2 -1.5 -0.4 -1.7 -1.2 -1.2 -1.3 -1.9 -0.3 -1.5 -1.2 -1.9 1.5 0.5
Alzheimer’s Disease (including proxy) 0.8 1.2 4.9 -1.1 -1.4 -0.9 -1.4 -2.2 0.0 -0.7 -0.8 -0.7 0.0 -0.5 -0.9 0.1 -0.6 -0.7 -1.6 1.7 -1.0
Crohns Disease (2017) 0.2 0.5 3.5 0.1 -0.2 -0.5 -0.2 -0.7 -0.1 0.2 -0.5 -1.2 0.1 0.1 -0.5 -0.3 -0.6 -0.5 -0.0 1.3 -1.9
Irritable Bowel Disease (IBD) 0.9 2.1 5.5 -0.8 -0.8 -1.7 -0.9 -1.4 -1.4 -0.8 -1.2 -1.3 -0.8 -2.2 -2.2 -2.4 -1.4 -1.6 -0.7 1.7 -1.1
Ulcerative Colitis (UC) 1.4 2.7 8.4 -1.4 -0.9 -1.8 -1.0 -1.8 -1.6 -1.3 -1.0 -1.0 -1.5 -2.7 -2.4 -2.9 -1.6 -1.5 -0.8 1.8 -0.7
Major Depression (MDD) 0.5 0.6 3.5 0.5 0.0 0.0 -0.8 0.9 -1.0 -0.7 0.3 1.2 -0.6 -0.0 -0.7 -1.5 -0.2 -0.3 0.2 -0.6 1.9
Reaction Time 0.3 0.6 2.4 1.1 0.8 0.5 1.1 0.6 -0.1 1.2 0.6 0.2 0.1 1.4 0.6 0.6 0.4 -0.2 0.7 -0.3 -1.5
Verbal and Numeric Reasoning (VNR) 0.4 0.9 4.4 -0.5 -0.5 -0.1 -0.6 -1.5 2.0 -0.6 -0.2 0.2 -0.1 -0.0 0.1 1.2 0.8 0.6 -0.6 2.1 -1.0
Breast Cancer 0.2 0.5 2.4 0.5 -0.5 -1.0 0.2 0.1 -0.1 1.1 0.1 -1.0 -1.0 0.1 -0.5 -0.1 -1.2 -0.3 -0.1 -0.7 -1.5
Ovarian Cancer 0.2 0.3 1.1 0.4 0.6 0.0 0.5 -0.2 -0.1 -0.3 1.0 1.0 -0.7 0.4 0.1 0.5 0.8 -0.1 0.6 -0.2 -0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.8 1.2 5.9 -1.1 -1.3 -1.5 -1.7 -0.1 0.3 -0.6 -0.8 -0.6 -2.4 0.3 -1.1 0.1 -1.0 -1.4 -1.1 -0.4 -0.5
Bipolar Disorder (2011) 0.7 0.7 2.1 -0.1 0.9 0.6 1.0 1.0 -0.1 -0.1 0.5 1.4 1.2 1.3 0.9 -0.6 0.5 0.4 0.9 -1.2 0.3
Body Mass Index (BMI) (2010) 3.4 4.7 12.3 -2.2 -2.9 -0.9 -3.5 -2.5 -1.1 -2.1 -2.0 -2.8 -2.2 -2.0 -2.2 -0.9 -2.3 -1.6 -2.9 1.6 0.9
Coronary Artery Disease (CAD) 8.7 10.4 20.5 4.1 2.8 1.7 3.6 4.3 1.7 3.8 2.7 3.0 2.8 2.9 4.2 2.5 3.0 4.5 3.5 -3.7 0.3
Crohns Disease (2012) 0.4 0.7 5.1 0.2 -0.4 -0.3 -0.2 -1.2 1.3 0.4 -0.4 -0.9 -0.0 0.5 -0.3 -0.3 -0.4 -0.0 -0.2 1.1 -2.3
Mean Putamen Volume 1.3 1.5 4.0 -1.4 -1.9 -2.0 -0.9 0.2 -0.4 -0.2 -1.2 -1.1 -1.0 -0.5 -1.5 -0.6 -1.5 -1.9 -1.9 0.6 0.5
Fasting Glucose 1.3 1.6 5.8 1.0 0.9 0.7 2.4 1.6 1.4 1.9 0.9 0.1 2.0 0.3 1.2 1.0 0.1 1.3 1.0 -1.5 -0.5
HbA1C 0.8 0.8 2.7 0.5 1.3 1.4 0.4 0.2 1.6 0.8 1.4 0.6 0.9 0.8 0.3 0.4 0.8 0.4 1.3 -0.4 -1.1
HDL Cholesterol 1.1 1.9 11.7 0.4 0.0 1.9 0.8 -1.5 1.8 0.8 -0.6 0.0 3.4 0.4 1.8 1.0 0.8 2.2 -0.2 1.3 0.8
LDL Cholesterol 2.5 4.0 20.3 1.5 1.0 -1.1 3.1 4.5 -0.6 3.8 -0.2 1.8 1.4 1.6 1.6 1.3 0.8 1.4 1.9 -2.1 0.9
Lupus 0.8 1.1 3.4 1.5 0.7 -1.1 0.7 1.5 -0.3 0.7 -0.2 1.2 -1.5 1.2 -0.7 -0.0 1.0 -1.9 0.9 -1.0 -1.0
Neuroticism (2016) 1.1 1.6 7.2 -0.2 -0.9 -1.1 -1.2 -2.0 1.5 0.9 -0.8 -1.9 -0.8 -1.0 -1.1 0.9 -0.4 -0.6 -1.0 2.7 -1.5
Primary Biliary Cirrhosis 1.4 1.9 6.7 -1.3 -0.9 -1.0 -1.2 -0.9 -1.8 -2.6 -1.0 -0.4 -1.1 -1.6 -1.5 -1.8 -1.0 -1.3 -0.8 -0.2 2.3
Rheumatoid Arthritis 0.3 0.5 1.1 -0.6 0.3 0.9 0.1 -0.0 0.8 1.0 0.8 -0.5 0.9 -0.3 0.8 0.9 0.4 1.0 0.2 0.7 -0.6
Schizophrenia (2014) 0.2 0.5 4.2 -0.2 0.1 0.8 -0.7 -0.0 0.3 0.4 0.5 0.1 -1.2 0.3 -0.7 -0.5 -0.3 -0.3 0.3 -0.5 -2.0
Triglycerides 4.0 6.5 25.7 2.4 3.0 -0.5 3.5 5.1 1.2 3.1 2.4 3.3 0.9 2.5 1.5 1.0 2.4 -0.1 3.5 -2.9 -0.2
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.9 0.7 -0.2 -1.0 -0.3 -0.1 -0.1 -0.0 -0.6 -0.1 -0.6 0.2 -0.7 -0.9 -0.4 -0.8 -0.5 0.1 0.7
Ulcerative Colitis 2.5 3.7 8.9 -1.2 -1.9 -2.5 -1.7 -1.8 -1.2 -1.4 -2.1 -1.6 -1.9 -2.3 -3.0 -2.3 -2.2 -2.4 -1.7 1.4 -0.2
Blood Eosinophil Count 0.0 0.4 2.4 0.5 -0.2 -0.5 -0.1 -0.7 0.5 0.2 -0.5 -0.3 -1.5 0.8 0.1 1.0 -0.1 -0.6 -0.3 -0.1 0.0
Blood Platelet Count 1.0 11.8 29.7 3.9 4.8 1.9 4.2 1.0 2.7 2.4 4.3 3.8 3.1 2.6 3.5 2.0 5.5 2.4 4.8 -0.3 -3.7
Blood Red Count 0.1 0.6 1.6 -0.9 0.3 0.9 0.2 -0.1 0.9 -0.3 0.5 0.7 -1.1 1.3 0.4 1.2 1.0 -0.2 0.4 0.7 -1.0
Blood White Count 0.2 1.2 6.0 0.1 0.5 -0.1 0.9 0.2 1.7 1.8 0.4 0.1 0.6 2.0 1.2 2.5 0.7 0.9 0.6 0.3 -0.8
Heel T-Score 0.1 0.7 4.0 0.5 0.2 1.5 0.5 -1.1 0.8 -0.0 0.4 0.1 -1.1 0.4 0.3 0.3 0.8 0.4 0.4 0.8 -2.0
BMI 3.8 22.0 38.4 -5.0 -5.2 -2.5 -6.2 -5.0 -3.5 -3.5 -5.5 -4.8 -5.7 -4.9 -6.1 -3.1 -5.4 -4.3 -5.2 4.5 1.0
Height 2.9 56.5 139.2 -7.0 -8.7 0.1 -10.8 -8.5 -6.3 -11.8 -8.1 -7.4 -5.2 -8.3 -7.0 -5.2 -7.5 -4.7 -9.3 5.6 6.0
Waist Hip Ratio (WHR) 10.6 47.5 76.9 8.2 7.7 3.6 8.8 8.5 5.7 6.4 7.4 8.3 4.4 8.3 7.8 4.9 8.3 4.5 8.0 -5.9 -2.5
Systolic Blood Pressure 1.5 7.7 16.8 4.1 2.3 0.6 3.2 0.9 4.1 3.8 2.7 1.4 1.7 3.2 3.2 2.8 2.7 2.8 2.7 -0.9 -3.4
Smoking Status 0.5 1.2 3.2 -0.8 -1.2 -0.9 -1.4 -1.1 -0.9 -1.8 -1.0 -0.9 -1.5 -1.3 -1.3 -0.6 -1.1 -0.2 -1.2 1.0 0.6
Allergy or Eczema 2.7 7.0 12.3 3.0 3.1 2.1 2.2 1.9 2.6 2.7 3.5 1.8 2.2 2.5 3.4 2.7 2.9 3.5 2.9 -2.1 -0.6
Cardiovascular Disease 3.1 10.4 27.6 4.7 2.9 0.6 3.3 4.1 2.5 4.4 2.8 2.3 -0.3 5.2 3.8 2.6 1.9 2.7 3.7 -3.9 -1.3
Hypothyroidism (self reported) 0.2 0.5 3.1 -1.2 -0.5 1.8 -1.2 -0.4 0.1 -0.1 -0.6 -0.7 0.1 0.4 0.1 0.7 -0.7 -0.1 -0.4 0.5 -0.5
Respiratory disease 0.4 0.8 2.2 -1.4 -0.4 0.2 -1.3 -1.5 -0.8 -0.1 -1.1 -1.3 0.6 -1.3 -0.5 -0.5 -1.2 0.3 -0.7 0.6 0.7
Type 2 Diabetes (T2D) (2018) 3.8 7.1 14.9 3.3 3.6 1.9 3.9 2.5 1.3 2.7 3.2 3.0 -0.2 3.2 2.6 1.8 3.0 1.4 3.5 -2.0 -1.7
Lung FEV1/FVC ratio 0.6 3.1 8.1 2.1 2.3 1.1 2.5 2.8 -0.3 1.0 2.7 1.4 -1.3 1.6 1.2 0.5 2.0 0.3 2.5 -1.6 -1.0
Lung FVC 0.5 2.5 5.9 1.6 1.3 0.2 2.3 2.4 1.0 2.4 1.7 1.9 2.2 1.0 1.2 0.2 1.3 1.2 1.2 -2.1 0.4
Neuroticism 0.6 1.4 3.1 0.3 -1.1 -1.0 -1.2 -1.4 -0.3 -1.4 -1.5 -1.1 -1.7 -1.0 -1.5 -0.4 -0.9 -1.8 -0.8 1.8 -0.7
Chronotype (morning person) 1.0 2.4 6.3 2.2 1.7 -1.4 2.5 1.2 -0.2 2.1 1.9 1.3 1.7 0.1 1.6 -0.9 0.9 2.0 1.8 -0.5 -1.3
Hair Pigment 0.1 1.5 6.6 0.4 -0.4 -1.0 -0.3 1.5 -2.1 -1.4 -0.8 0.4 -0.4 -0.4 -0.9 -1.7 -0.6 -0.9 -0.4 -2.2 2.6
Tanning 0.1 1.1 2.8 -0.1 -1.5 -0.2 -0.5 -0.9 -1.0 -1.0 -1.5 -0.7 -0.3 -0.7 -1.2 -1.3 -1.5 -1.0 -1.7 1.1 -0.1
Hand grip strength (left) 0.9 2.3 11.1 -1.3 -2.0 -0.3 -2.4 -1.7 -1.5 -3.3 -1.7 -1.3 -0.8 -0.7 -0.5 -0.4 -1.3 -1.0 -1.8 1.1 0.2
Number of treatments/medications taken 2.0 3.6 7.1 2.2 1.7 0.9 1.4 2.6 2.6 2.7 1.6 1.0 0.1 2.6 2.4 1.9 0.9 1.6 2.1 -2.1 -1.3
Average weekly spirits intake 1.1 1.4 4.7 1.5 -1.1 1.3 -0.4 -0.7 1.4 1.6 0.1 -0.7 1.3 -0.4 1.0 1.8 0.2 2.2 -1.0 1.1 0.8
Sensitivity / hurt feelings 1.2 2.0 6.5 -0.9 -1.3 -1.9 0.0 -2.0 0.8 -0.1 -1.6 -1.8 0.1 -1.1 -1.4 -0.3 -1.2 -1.4 -1.0 2.5 -2.5
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.2 -0.8 -0.9 -1.0 -0.9 -0.0 -0.9 -0.8 -1.0 -1.1 -1.1 -0.0 -0.9 -0.6 -1.5 -0.6 -0.7 0.0 0.5
Hearing difficulty/problems: Yes 0.6 0.9 6.4 0.2 -0.8 -0.9 -1.5 -0.2 -0.4 0.3 -0.5 -0.4 -2.5 -0.0 -1.5 -0.2 -0.9 -1.4 -0.6 0.2 -0.2
Relative age of first facial hair 0.7 1.5 4.0 -1.7 -0.4 -0.9 -1.9 -1.3 -2.0 -1.4 -0.7 -0.1 -1.1 -1.8 -1.6 -1.7 -0.6 -1.2 -0.2 0.5 -0.6
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 3.2 -0.6 -0.8 1.7 -0.5 -0.3 1.8 -0.0 -0.9 -0.8 -0.2 1.4 0.1 1.0 -0.5 -0.1 -0.6 0.4 -1.1
Ever used hormone-replacement therapy (HRT) 0.2 0.2 1.8 0.4 0.4 -0.3 0.3 -0.1 -0.1 0.2 0.6 0.3 0.1 -0.8 -0.3 -1.3 0.1 0.2 0.5 0.4 -0.4
Ever had hysterectomy (womb removed) 1.5 1.7 6.0 1.0 1.6 0.9 1.2 2.4 0.6 0.6 1.0 1.0 0.2 2.1 1.0 -0.0 0.6 0.0 1.9 -2.5 0.0
Systolic blood pressure, automated reading 0.4 1.1 7.5 1.2 0.3 0.1 0.7 -1.1 1.8 1.2 0.2 -0.5 0.0 1.0 0.6 1.0 0.7 -0.0 0.2 0.7 -2.7
Eye problems/disorders: Diabetes related eye disease 3.4 3.7 7.6 1.7 2.3 2.3 1.8 0.1 1.8 1.7 2.4 1.8 2.1 1.4 2.3 2.0 2.8 2.5 2.1 0.6 -1.3
Angina 8.8 11.6 28.6 5.3 2.6 3.0 3.6 4.6 1.9 3.7 2.7 3.0 1.2 4.3 4.2 3.1 2.7 3.8 3.2 -4.2 0.1
Medication for hormone replacement therapy 0.4 0.4 1.0 0.8 0.9 0.4 0.4 0.2 -0.2 0.5 0.8 0.2 1.0 -0.2 0.6 -0.9 -0.1 1.0 0.8 -0.7 -0.3
Vitamin and mineral supplements 1.3 1.8 10.2 -1.5 0.3 1.4 -0.9 -1.4 -1.9 -2.2 0.4 -0.2 -0.3 -3.2 -0.8 -1.6 -0.3 0.4 0.0 0.6 1.6
Supplements: Zinc 0.6 0.6 3.3 -0.8 -0.2 1.0 0.4 0.8 0.1 -0.3 0.4 0.5 1.4 1.8 1.0 0.9 0.3 -0.4 -0.3 -0.8 0.1
Medication: Co-codamol 0.7 0.8 2.2 -1.5 -0.3 0.7 -0.5 -0.7 -0.8 -1.4 -0.8 -1.2 -0.1 -1.3 -0.6 -1.4 -1.4 0.1 -0.2 -0.2 1.0
Medication: Metformin 2.0 2.9 5.9 2.4 2.3 1.5 2.0 1.0 0.0 2.1 2.1 2.4 0.6 1.0 1.7 0.9 2.4 1.6 2.3 -0.7 0.0
Diabetes (father) 1.9 2.4 6.2 1.7 2.5 0.5 1.3 2.0 1.1 0.4 2.4 2.3 -0.9 1.1 0.9 0.0 2.0 0.4 2.1 -2.0 0.4
Diabetes (mother) 1.5 1.9 5.6 1.3 1.6 -1.5 2.1 0.9 0.1 1.8 1.6 1.9 0.3 0.7 0.5 -0.8 1.7 -0.0 1.8 0.7 -2.4
Severe depression (siblings) 0.4 0.4 1.4 -0.8 0.2 -0.2 -0.2 -0.8 0.4 -0.2 0.6 0.9 -0.5 -1.2 -1.0 -0.4 1.1 -0.3 0.4 0.9 -0.0
Pack years adult smoking proportion 0.3 0.5 3.1 -0.6 -0.6 -1.8 0.1 0.5 -0.7 0.2 -0.1 0.5 -1.3 0.6 -0.6 -0.1 -0.1 -1.2 -0.3 0.0 -0.4
Impedance of leg (right) 1.0 5.0 9.5 0.7 2.5 0.7 3.1 2.3 3.0 2.6 2.8 2.5 1.5 2.8 2.1 1.4 2.4 1.1 2.7 -2.1 -2.0
Leg fat-free mass (left) 5.6 29.7 58.2 -4.7 -6.1 -2.1 -7.6 -6.3 -5.5 -6.6 -6.3 -5.8 -4.1 -6.4 -5.7 -3.6 -5.8 -3.7 -6.2 5.1 3.3
Trunk fat percentage 3.5 13.8 27.2 -4.4 -3.8 -1.9 -4.9 -4.1 -2.8 -3.1 -4.0 -3.8 -2.9 -5.2 -4.7 -3.0 -4.0 -2.9 -3.9 4.0 1.2
Hand grip strength (right) 2.4 6.7 24.5 -1.9 -3.4 -0.4 -3.8 -2.7 -2.1 -4.9 -2.7 -2.4 -2.0 -2.3 -1.8 -0.8 -2.5 -1.6 -3.3 2.3 1.4
Townsend deprivation index at recruitment 0.1 0.2 1.3 -0.9 0.5 0.4 -0.1 -0.1 0.1 0.1 0.3 0.6 1.1 -0.0 0.0 -0.4 0.2 0.4 0.3 -0.5 0.2
Current tobacco smoking 0.5 0.9 2.0 -1.1 -1.3 -1.2 -1.1 -0.5 -0.5 -0.9 -0.6 -0.6 -1.1 -1.2 -0.9 -0.1 -0.8 -0.1 -1.4 0.6 1.3
Average weekly fortified wine intake 0.4 0.5 1.7 0.3 0.1 0.2 -0.8 0.8 0.5 -0.5 0.2 -0.3 -1.2 1.0 -0.1 0.9 0.2 -1.3 -0.2 -0.5 0.8
Maternal smoking around birth 0.8 1.2 4.1 -0.1 -0.8 0.4 -1.8 0.4 -1.7 -2.0 -0.9 0.4 -1.5 -0.7 -1.0 -1.4 -0.4 -1.1 -0.9 -0.6 1.2
Fed-up feelings 1.1 1.9 4.5 -1.9 -1.6 -1.6 -1.8 -1.2 -0.3 -1.5 -1.5 -2.1 -0.8 -1.4 -1.3 0.4 -1.7 -1.1 -1.6 1.2 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 3.6 -1.1 -1.3 -1.0 -1.5 -1.2 -0.8 -0.7 -1.4 -1.8 -1.2 -0.9 -1.4 -0.5 -1.9 -0.8 -1.1 0.8 0.6
Relative age voice broke 0.2 0.3 1.1 -0.7 0.1 0.9 -0.8 0.0 0.1 -1.1 0.2 0.2 -0.5 -1.0 -0.8 -0.6 -0.1 -0.6 -0.1 -0.5 0.1
Taking other prescription medications 0.8 1.3 5.2 1.0 0.5 0.7 0.9 0.9 2.3 1.9 0.5 0.1 -1.1 1.4 0.9 1.8 0.6 0.3 0.6 -0.1 -1.5
Age when periods started (menarche) 0.2 0.4 1.4 -0.5 -1.1 -0.7 -0.9 -0.1 0.7 0.7 -0.2 -0.7 -1.2 0.3 -0.3 0.4 -0.9 0.3 -0.9 0.0 -0.3
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 5.0 2.2 0.9 0.4 0.9 1.6 -0.5 -0.4 1.3 0.9 0.1 1.5 1.2 -0.7 0.6 0.5 1.0 -1.3 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 2.9 -1.3 0.2 0.3 -0.3 -1.3 0.1 -1.7 0.5 0.2 -0.5 -0.3 0.3 -0.9 0.4 0.7 0.3 0.3 -0.9
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 3.4 0.9 0.7 1.4 0.3 0.8 -0.1 0.2 0.3 0.7 1.8 1.1 1.2 0.7 0.8 0.6 0.6 0.0 0.6
Qualifications: CSEs or equivalent 0.3 0.4 2.0 0.9 0.3 -0.8 0.3 1.0 -0.5 0.2 -0.0 -0.1 -0.9 0.9 0.0 -0.5 -0.9 -0.7 0.3 -1.4 0.2
Serious illness, injury or assault to yourself 1.9 2.3 5.2 1.2 2.1 1.2 1.1 1.4 0.9 2.0 1.5 1.1 1.1 2.0 2.0 1.1 1.3 1.0 2.0 -2.3 0.3
High blood pressure 0.8 2.2 8.9 3.0 1.7 0.7 1.1 1.0 1.4 1.2 1.3 1.2 -0.8 2.5 1.2 0.6 1.2 0.4 1.6 -1.7 -1.8
Hayfever, allergic rhinitis or eczema 2.0 4.3 8.2 2.9 2.7 1.1 2.2 1.6 1.2 1.8 2.5 1.5 2.5 1.7 2.5 1.5 2.5 2.6 2.6 -1.6 -0.3
Multivitamins +/- minerals 1.9 2.4 10.2 2.7 0.5 -1.4 1.9 2.3 0.7 2.3 0.4 0.8 0.8 3.2 1.7 1.5 0.8 0.2 0.7 -0.6 -1.1
Stomach or abdominal pain in last month 1.3 1.6 6.5 0.4 0.8 0.4 0.9 0.3 2.5 1.5 1.3 1.0 0.2 1.2 1.5 2.6 1.8 1.1 0.8 0.3 -0.8
Supplements: Glucosamine 1.1 1.4 4.6 1.6 0.9 1.4 1.7 1.1 -0.0 0.5 1.3 1.4 2.1 0.2 1.0 0.5 2.0 0.8 0.9 -0.1 0.9
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 7.7 0.0 0.9 -1.3 -0.2 1.8 -2.0 -0.4 -0.1 1.5 -2.4 0.1 -1.5 -1.8 0.5 -2.8 0.9 -1.7 0.7
Medication: Atenolol 0.9 1.1 6.4 2.5 0.2 1.1 0.3 1.1 0.9 1.9 0.3 0.2 -0.3 1.2 0.8 0.3 -0.1 1.4 0.4 -0.8 -1.0
Medication: Levothyroxine sodium 0.4 0.7 3.8 0.3 0.2 1.9 -0.1 0.5 0.7 0.9 -0.3 -0.1 0.5 1.6 0.6 1.5 0.2 -0.2 0.4 0.1 -0.9
Sitting height 3.1 22.1 50.3 -4.6 -5.5 -1.7 -6.5 -5.0 -3.8 -7.1 -5.1 -4.7 -2.7 -5.5 -4.6 -4.1 -5.2 -2.9 -5.5 3.6 3.2
Chronic bronchitis/emphysema (father) 3.1 3.6 9.4 -2.9 -1.5 -0.3 -2.8 -3.1 0.1 -1.9 -1.9 -1.9 -0.7 -2.3 -1.8 -0.9 -1.6 -0.9 -1.9 2.2 -2.0
High blood pressure (mother) 0.9 1.3 4.4 -1.2 -0.4 -1.9 -0.6 -1.2 -0.2 -1.2 -0.4 -0.9 -0.9 0.0 -0.6 -1.7 -1.3 -0.9 -0.5 1.2 -2.1
Body mass index (BMI) 1.8 7.7 16.0 -2.5 -2.5 -1.6 -3.5 -3.3 -2.9 -2.3 -3.3 -2.7 -2.6 -4.0 -3.6 -2.1 -2.5 -2.4 -2.6 3.2 0.7
Impedance of leg (left) 0.7 3.4 8.4 0.6 1.8 0.6 2.5 2.1 2.9 1.9 2.4 2.0 1.6 2.1 1.7 0.7 1.8 0.9 1.9 -2.0 -1.4
Leg predicted mass (left) 5.7 30.3 59.7 -4.8 -6.1 -2.3 -7.7 -6.4 -5.4 -6.6 -6.4 -5.9 -4.2 -6.4 -5.7 -3.7 -5.9 -3.8 -6.3 5.1 3.3
Trunk fat mass 5.1 21.9 40.4 -5.0 -5.0 -2.0 -6.4 -5.3 -3.6 -4.6 -5.3 -4.9 -3.7 -6.1 -5.5 -3.3 -5.0 -3.5 -5.2 4.7 1.9
Waist circumference 0.3 1.2 3.5 -0.8 -0.7 0.2 -1.9 -1.2 -0.7 -1.2 -1.4 -0.4 -1.2 -1.8 -1.2 -0.6 -0.4 -0.7 -0.8 1.2 1.2
Number of incorrect matches in round 0.4 0.7 2.7 0.8 0.9 0.3 1.2 1.0 0.3 1.5 0.3 1.6 0.4 0.2 0.6 0.7 0.9 0.3 0.5 -1.3 0.3
Past tobacco smoking 0.4 0.7 1.6 0.2 1.1 -0.2 1.1 1.1 0.8 1.3 1.1 0.6 0.4 0.7 1.0 0.9 1.1 0.3 1.0 -0.7 -0.5
Alcohol usually taken with meals 0.2 0.4 1.7 1.3 -0.1 -0.3 0.4 -0.2 0.6 0.6 -0.3 0.2 0.6 0.2 1.0 0.9 0.4 1.2 0.0 0.4 0.1
Nervous feelings 0.5 0.9 7.2 0.9 -0.3 -1.0 -0.2 -0.8 1.6 0.7 -0.6 -0.4 0.0 0.6 -0.1 0.4 -0.0 -0.7 -0.4 1.0 -2.7
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.3 5.8 -1.2 -1.6 -2.0 -1.5 -2.4 -1.1 -1.2 -1.8 -2.2 -0.6 -1.1 -1.3 -0.6 -2.1 -0.3 -1.5 1.9 -0.9
Hearing difficulty/problems with background noise 0.1 0.2 0.9 0.4 -0.0 -0.3 -1.0 -0.6 -0.5 -0.7 0.1 0.5 -0.3 -0.3 -0.5 -0.1 0.2 -0.0 -0.0 0.4 0.6
Hair/balding pattern: Pattern 2 1.5 1.9 6.6 1.8 1.0 0.0 1.6 2.5 0.3 0.6 1.8 1.2 1.0 1.3 1.5 0.1 0.8 0.6 0.9 -2.6 1.7
Had menopause 1.5 1.8 6.3 0.8 1.6 0.9 0.8 0.9 1.6 2.0 1.5 0.8 2.5 -0.3 1.3 0.8 1.3 2.2 1.5 -0.9 0.1
Had other major operations 0.3 0.4 2.9 -0.0 0.5 -1.7 -0.5 0.5 -0.1 0.5 0.4 -0.2 -1.3 0.7 -0.1 -0.1 -0.2 -0.6 0.5 -0.4 -0.2
Forced vital capacity (FVC) 0.5 1.8 6.0 -1.2 -1.7 0.4 -1.5 -1.1 -1.5 -2.4 -1.0 -0.8 -0.5 -1.2 -1.1 -1.8 -1.3 -1.1 -1.7 -0.5 1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 2.5 -1.3 -0.7 -0.2 -1.1 -1.5 0.0 -1.6 -0.4 -0.4 -1.2 -1.2 -0.7 -1.3 -0.4 0.4 -0.5 0.7 -0.4
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 3.9 1.4 0.7 -0.4 0.8 0.5 0.6 1.5 0.4 1.3 -0.8 1.8 0.5 1.0 1.4 0.2 1.0 0.1 -2.0
Qualifications: None of the above 0.3 0.7 2.5 0.1 1.0 -0.9 -0.1 1.5 -1.3 0.7 0.3 1.2 -0.9 0.6 -0.3 -0.5 0.1 -0.4 1.0 -1.6 0.8
Financial difficulties in last 2 years 0.6 0.9 3.4 0.4 1.2 -1.6 0.2 0.1 -0.6 1.0 1.4 0.1 0.6 -1.3 0.8 -0.6 0.5 1.9 1.1 -0.2 0.5
Mouth/teeth dental problems 0.3 0.5 1.9 -0.7 -1.2 -0.3 -0.6 -0.1 -0.9 -0.6 -1.4 -0.3 -0.5 0.1 -0.6 0.4 -0.5 -0.8 -1.4 0.4 0.5
Heart attack 7.2 9.2 34.2 5.8 2.2 1.8 4.0 4.9 0.1 3.1 2.0 2.7 1.1 4.0 3.1 1.7 1.7 2.7 2.8 -3.8 1.0
Allergy 1.2 2.8 6.2 -2.1 -2.5 -0.6 -1.5 -0.8 -0.3 -1.6 -2.2 -1.2 -2.2 -1.0 -2.0 -0.6 -1.9 -2.4 -2.3 1.2 0.6
Pain all over the body in last month 0.6 0.6 3.6 0.9 0.4 -1.4 0.8 -0.3 1.1 1.0 0.3 -0.8 -0.1 0.1 -0.1 0.5 0.0 -0.4 0.2 0.1 -1.9
Diabetes (self-reported) 3.5 5.4 8.6 2.8 2.7 2.6 2.9 1.3 2.0 2.0 2.7 2.6 0.8 2.5 2.9 1.9 2.8 2.5 2.8 -0.7 -1.1
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 5.3 2.0 1.8 0.5 2.3 1.9 -0.9 1.4 1.6 1.4 -0.3 0.7 0.1 -0.1 1.4 -0.2 1.8 -0.7 0.1
Medication: Ramipril 5.3 6.8 18.1 3.3 2.6 2.7 2.4 3.8 1.0 0.9 2.3 3.2 -0.2 4.3 2.7 1.9 2.0 2.0 2.9 -3.5 1.2
Medication: Simvastatin 4.7 7.0 18.8 4.1 2.6 0.2 2.9 4.3 0.8 2.9 1.6 2.9 1.7 3.5 3.0 0.4 1.3 1.9 3.1 -3.8 0.6
Fluid intelligence score 1.0 2.1 11.7 -1.6 -2.1 -0.6 -1.5 -2.0 0.9 -0.7 -1.7 -0.7 0.2 -1.1 -0.7 0.9 -0.4 -0.1 -2.0 3.4 -0.3
Illnesses of siblings 2.8 3.9 9.4 -2.9 -2.1 -1.2 -2.7 -2.7 -0.8 -1.1 -1.9 -1.9 -1.4 -2.6 -2.1 -0.4 -0.7 -2.1 -2.2 3.1 -0.2
Neuroticism score 1.0 2.0 3.9 -0.5 -1.5 -1.6 -1.7 -1.4 0.0 -1.6 -1.8 -1.6 -1.5 -0.9 -1.5 -0.1 -1.4 -1.9 -1.3 2.0 -0.7
Weight 5.2 25.6 49.0 -4.8 -5.4 -1.9 -7.0 -5.9 -4.5 -5.8 -5.9 -5.1 -4.0 -6.5 -5.7 -3.6 -5.1 -3.8 -5.6 4.9 2.7
Impedance of arm (right) 0.3 1.3 3.1 -0.9 1.1 0.9 1.1 1.1 1.8 1.2 1.4 1.5 1.4 1.2 0.7 0.5 1.2 0.4 1.2 -1.0 -0.5
Arm fat percentage (right) 1.9 7.4 13.7 -3.3 -2.5 -1.4 -3.5 -3.3 -2.0 -1.8 -3.2 -2.5 -2.3 -3.6 -3.7 -1.8 -2.4 -2.6 -2.6 3.4 0.2
Trunk fat-free mass 4.4 25.1 51.1 -3.9 -6.1 -1.3 -7.2 -5.9 -4.2 -6.8 -6.1 -5.3 -4.2 -5.1 -4.9 -2.9 -5.3 -3.5 -6.2 4.1 2.9
Hip circumference 5.2 22.2 40.7 -5.4 -4.7 -1.8 -6.4 -6.0 -3.9 -4.8 -5.5 -4.7 -3.4 -6.2 -5.6 -3.3 -4.7 -3.4 -5.0 4.7 2.4
Time employed in main current job 0.7 0.8 2.7 0.5 1.0 0.9 0.9 1.2 0.3 0.5 0.9 1.7 1.0 0.0 0.5 0.1 0.9 0.6 0.7 -1.4 1.3
Alcohol intake versus 10 years previously 1.2 1.9 4.4 0.6 1.8 -0.2 2.1 1.8 0.5 1.6 1.6 1.4 1.4 1.1 1.4 0.7 1.0 1.0 1.8 -1.9 -0.5
Father’s age at death 1.3 1.8 5.6 -1.6 -2.0 1.2 -1.2 -1.4 1.0 -1.5 -1.8 -1.0 0.6 -0.4 -1.3 -0.2 -0.7 -1.5 -2.4 1.8 -0.1
Worrier / anxious feelings 0.2 0.3 1.9 0.9 -0.3 -0.8 -0.3 0.2 -0.3 -1.4 -0.5 0.3 -0.5 0.4 -0.3 0.1 -0.3 -0.9 -0.1 0.6 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.0 -0.7 -0.2 -0.5 -0.7 -0.5 -0.0 -0.6 -0.5 -0.4 -0.2 -1.0 -0.6 -0.3 -0.7 -0.2 -0.2 0.6 -0.3
Falls in the last year 1.0 1.3 6.2 -0.8 -0.7 -0.7 -0.7 -0.8 -2.2 -0.4 -0.7 -1.2 -0.5 -0.9 -1.3 -2.5 -1.6 -1.3 -0.7 0.1 -0.8
Hair/balding pattern: Pattern 3 0.3 0.4 3.4 -0.4 0.2 0.7 0.0 -1.8 0.3 0.1 0.2 0.5 -0.1 -0.6 -0.4 -0.3 0.7 0.9 0.4 0.8 -0.7
Number of live births 0.4 0.6 1.9 -0.4 1.0 -0.6 0.3 0.6 -0.4 0.1 1.2 1.2 -0.4 1.1 0.4 -0.6 0.7 0.1 1.4 -1.4 0.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 2.8 -0.8 -1.3 0.1 -0.8 -0.3 -1.5 -1.6 -0.7 -0.7 -0.6 -0.8 -1.1 -1.7 -1.0 -1.3 -1.2 -0.5 1.2
Pulse rate 1.2 2.0 5.1 0.8 2.3 0.3 2.0 1.7 0.1 1.1 1.6 1.8 2.0 0.1 0.8 0.4 2.1 0.6 1.9 -1.3 1.0
Happiness 0.2 0.2 1.0 1.0 0.2 0.6 -0.5 0.3 0.8 -0.1 0.6 -0.1 -0.3 0.5 -0.0 0.5 0.0 -0.0 -0.2 -0.4 0.6
Noisy workplace 0.8 1.0 4.0 1.5 2.0 -0.0 1.2 0.5 -1.2 0.6 1.2 0.8 -0.6 -0.2 -0.2 -0.0 1.1 -0.7 1.7 -0.0 -0.7
Qualifications: A levels/AS levels or equivalent 0.6 1.2 4.5 0.4 -0.1 1.8 0.4 -1.3 2.1 0.3 1.0 0.1 1.2 0.4 0.9 1.5 1.4 1.5 -0.0 1.5 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.9 3.4 -1.9 -1.2 0.9 -0.4 -0.5 -0.3 -1.6 -1.1 -1.0 -0.4 0.2 -0.7 -0.6 -1.1 -0.7 -1.2 0.3 -0.2
Mouth/teeth dental problems: Dentures 0.1 0.2 1.1 0.4 0.6 0.7 -0.0 -0.0 -0.3 0.3 0.4 0.1 1.0 -0.4 -0.1 -1.0 0.1 0.1 0.5 -0.0 0.0
Asthma 0.2 0.3 1.1 -0.9 0.6 -0.3 -0.5 -1.1 -0.7 0.7 -0.4 -0.4 0.8 -0.4 0.2 -0.3 -0.1 0.4 0.3 -0.2 -0.5
Medication: Ibuprofen (e.g. Nurofen) 3.1 4.0 11.9 -3.4 -2.1 -0.4 -2.1 -2.8 -1.0 -2.1 -2.4 -2.1 0.6 -2.6 -1.8 -1.3 -1.8 -1.3 -2.2 2.4 0.2
Medication: Cholesterol lowering 4.2 6.5 18.8 4.1 1.6 0.1 2.7 4.3 0.4 3.1 0.8 2.6 0.9 3.7 2.9 1.1 0.7 2.8 2.3 -4.0 1.2
Depression (self-reported) 0.5 0.6 2.0 0.5 1.1 0.1 0.2 -0.1 0.3 -0.0 1.3 0.1 -0.5 0.8 0.7 -0.6 -0.3 1.1 1.4 -1.0 -1.1
Medication: Lansoprazole 3.7 4.2 9.0 3.0 3.0 0.9 2.5 2.8 0.9 1.8 2.1 2.0 1.0 2.4 1.5 0.7 2.0 1.4 3.0 -2.4 -0.5
Prospective memory result 0.9 1.1 3.5 0.5 0.4 -0.8 0.2 1.8 -1.7 0.0 -0.4 -0.3 0.7 0.3 -0.5 -1.8 -1.3 -0.8 0.3 -1.9 1.4
Lung cancer (father) 3.7 4.3 11.1 -2.2 -2.4 -0.3 -3.3 -2.9 0.3 -2.2 -1.5 -2.9 -1.4 -2.7 -1.6 -0.4 -2.3 -0.4 -2.6 2.8 0.5
Illnesses of mother 1.2 1.4 5.0 -1.3 -1.5 0.6 -1.2 -0.6 -1.2 -0.8 -1.5 -0.8 0.0 -1.7 -1.5 0.0 -0.5 -1.1 -1.6 0.7 2.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.7 -0.5 -0.7 0.2 -0.3 0.0 -0.1 -0.8 -0.2 -0.5 -0.6 -0.1 -0.4 -0.3 -0.5 -0.9 -0.7 -0.4 0.3
Pulse wave Arterial Stiffness index 1.4 1.6 4.6 -0.1 -1.0 -0.4 -0.7 -0.8 -1.1 -1.9 -0.6 -0.8 -1.4 -2.1 -2.1 -1.2 -0.7 -1.2 -1.0 1.8 1.2
Impedance of arm (left) 0.3 1.5 4.9 -0.6 1.2 1.0 1.1 1.4 2.2 1.4 1.9 1.3 1.2 1.3 0.9 0.6 1.0 0.8 1.2 -1.3 -0.3
Arm fat mass (right) 4.0 16.4 29.9 -4.3 -4.2 -1.9 -5.5 -4.8 -3.5 -4.0 -4.8 -4.0 -3.2 -5.1 -4.9 -2.9 -3.9 -3.5 -4.3 4.3 1.3
Trunk predicted mass 4.3 24.4 50.4 -3.8 -6.0 -1.2 -7.1 -5.8 -4.2 -6.8 -6.0 -5.2 -4.1 -5.1 -4.8 -2.9 -5.3 -3.4 -6.2 4.1 2.9
Standing height 3.3 33.0 70.9 -5.7 -7.2 -0.9 -8.4 -6.6 -4.0 -8.4 -6.5 -6.0 -3.6 -6.0 -5.3 -3.6 -6.1 -3.5 -7.3 4.5 4.2
Length of working week for main job 0.2 0.3 1.0 0.4 0.0 0.1 0.7 -0.4 -0.7 -0.4 0.8 -0.4 -0.4 -0.4 0.0 0.6 0.0 0.4 0.3 0.6 -1.0
Exposure to tobacco smoke at home 0.7 0.8 3.2 0.3 -0.2 0.3 0.8 0.2 1.1 1.8 0.3 0.3 1.7 1.3 1.1 1.3 0.5 1.0 -0.0 -0.4 -0.4
Breastfed as a baby 1.8 2.2 11.3 0.0 -1.7 -0.3 -1.1 -3.4 0.7 -0.2 -1.2 -2.2 0.1 -1.7 -1.1 1.2 -0.7 -0.0 -1.8 2.7 -0.9
Tense / ‘highly strung’ 0.2 0.3 0.8 0.4 0.7 -0.1 0.4 0.1 0.6 0.5 0.9 0.2 -0.1 0.0 0.4 0.5 0.4 0.4 0.7 0.7 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 2.4 -0.4 -1.3 -0.8 -1.3 -0.6 -0.2 -1.5 -0.5 -0.4 -0.9 -0.5 -0.6 -0.7 -0.9 -0.6 -1.3 0.6 0.7
Hair/balding pattern: Pattern 4 0.9 2.2 5.0 -1.2 -2.0 -0.7 -2.2 -0.7 -0.6 -1.3 -1.9 -2.1 -1.9 -1.0 -1.1 -0.3 -2.1 -1.4 -2.0 1.2 0.9
Birth weight of first child 0.8 1.5 7.3 -0.7 -0.8 1.4 -0.9 -1.1 -1.2 -0.9 -0.6 -0.6 -0.2 -2.7 -0.7 -0.1 -0.7 0.6 -1.0 1.3 2.6
Peak expiratory flow (PEF) 0.2 0.4 1.0 0.4 -0.8 0.1 -0.1 0.7 -1.0 -0.2 -0.6 -0.6 -0.4 -0.1 -0.7 -0.6 -0.7 -0.9 -0.5 -0.0 0.9
Pulse wave reflection index 9.3 11.5 19.7 -3.0 -3.6 -2.4 -3.1 -3.4 -3.6 -4.4 -3.5 -3.0 -3.7 -3.1 -4.4 -3.2 -3.6 -3.7 -3.5 3.5 0.6
Ever highly irritable/argumentative for 2 days 2.4 2.9 7.1 -0.9 -2.6 -2.5 -2.0 -0.8 0.2 0.6 -1.8 -2.2 -1.9 -1.3 -1.9 -0.4 -2.4 -1.2 -2.7 1.5 -0.1
Loud music exposure frequency 0.9 0.9 3.5 1.0 0.3 0.9 0.7 0.5 0.6 0.8 1.2 0.6 1.1 1.8 1.7 0.2 0.5 1.9 0.3 -0.3 -0.1
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 4.5 -0.9 -1.7 0.4 -1.0 -2.1 1.0 -0.3 -1.1 -1.9 1.1 -0.1 -0.4 0.6 -0.7 0.1 -1.8 1.8 -1.1
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 5.0 1.1 1.3 1.0 0.5 0.0 1.8 -0.0 2.2 0.5 0.7 0.4 1.6 0.5 0.9 1.9 1.6 -0.7 -0.3
Blood clot in the leg (DVT) 0.3 0.3 1.2 0.3 -0.4 -0.2 0.3 -0.2 -0.2 1.0 -0.2 -0.9 0.7 -0.7 0.0 -0.4 -0.4 1.1 -0.5 0.9 -0.1
Medication: Paracetamol 0.5 0.9 6.0 -1.3 -0.4 -1.9 0.1 -1.0 1.1 0.5 0.0 -0.5 -0.0 0.1 0.0 0.4 0.2 -0.1 -0.2 1.2 -2.4
Headache pain in last month 1.5 2.6 8.1 -2.8 -2.8 -0.8 -1.2 -2.0 0.4 -0.8 -1.7 -2.1 0.0 -1.0 -0.5 0.3 -2.0 -0.1 -2.6 2.3 -0.4
Medication for cholesterol, blood pressure or diabetes 1.2 1.9 8.5 -1.7 -0.5 0.1 -0.9 -1.9 -1.2 -1.8 -0.1 -1.4 0.3 -2.9 -1.6 -1.6 -0.3 -1.4 -1.0 1.9 -0.2
Glaucoma (self-reported) 0.4 0.5 1.7 -1.0 0.3 -0.0 0.3 -0.3 0.5 0.3 0.3 -0.2 1.3 -1.2 0.6 1.1 0.3 0.8 0.2 0.5 1.0
Gout (self-reported) 0.5 0.7 2.2 0.4 0.1 -1.0 1.4 1.3 0.7 1.0 -0.2 0.6 -0.2 1.3 0.3 1.5 0.8 -0.9 0.2 -0.9 -0.6
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 7.2 0.1 0.6 2.7 0.1 0.8 0.4 0.5 0.4 0.2 1.0 1.6 1.4 1.2 0.3 0.8 0.6 -0.7 -0.5
Medication: Amlodipine 0.3 0.4 1.8 0.7 0.7 -1.2 0.4 -0.5 0.2 0.7 0.0 0.3 1.3 0.3 0.5 -0.3 0.3 0.3 0.7 -0.2 -0.7
Medication: Ventolin 100micrograms inhaler 0.3 0.3 1.8 0.1 0.7 -0.3 1.0 -0.3 0.5 1.3 0.1 -0.1 1.0 0.1 0.5 0.7 0.4 0.4 0.6 -0.1 -0.2
Birth weight 0.9 1.9 13.0 0.5 -0.8 2.0 -0.8 -1.0 -1.3 -2.8 -0.5 0.0 -0.5 -1.5 0.4 -0.3 -0.4 1.1 -0.8 0.8 3.6
Chronic bronchitis/emphysema (mother) 0.5 0.6 3.0 -1.1 -0.9 -0.0 -1.1 -1.7 0.6 0.2 -0.3 -0.9 0.4 -1.0 -0.2 0.1 -0.5 0.4 -1.0 0.6 -0.5
High blood pressure (siblings) 0.6 0.9 2.2 1.5 1.2 -0.0 1.0 0.7 -0.1 -0.7 0.6 1.4 -0.7 1.4 0.4 -1.2 0.1 0.1 1.3 -1.2 -1.0
Forced vital capacity (FVC), Best measure 0.3 0.9 2.6 -1.2 -1.4 0.3 -1.2 -1.1 -0.2 -1.6 -1.0 -0.9 -0.6 -0.7 -0.7 -0.6 -1.1 -1.0 -1.5 -0.2 0.6
Body fat percentage 2.5 9.8 20.7 -3.7 -3.2 -1.7 -3.9 -3.5 -2.1 -2.1 -3.6 -3.3 -2.4 -4.5 -4.1 -2.2 -3.2 -2.5 -3.3 3.7 0.7
Leg fat percentage (right) 0.7 2.7 7.1 -1.7 -1.2 -1.3 -1.8 -2.2 -0.9 -0.1 -2.0 -1.6 -1.6 -2.7 -2.4 -0.6 -1.1 -1.6 -1.3 2.5 -0.4
Arm fat-free mass (right) 4.6 23.6 46.4 -3.4 -5.5 -2.0 -6.8 -5.5 -4.9 -6.3 -5.6 -5.3 -4.1 -5.6 -4.7 -3.5 -5.4 -3.0 -5.7 4.1 3.0
Exposure to tobacco smoke outside home 0.8 1.1 4.8 0.7 -0.2 -0.5 -0.7 -1.5 -1.5 -0.5 -0.3 -0.7 0.2 -1.9 -0.8 -2.2 -0.9 1.3 -0.2 1.1 0.7
Comparative body size at age 10 1.3 3.5 7.6 -1.6 -1.9 -1.6 -1.9 -1.1 -2.1 -2.8 -2.6 -1.9 -1.5 -1.6 -2.0 -0.8 -2.5 -2.3 -2.1 0.3 1.3
Number of full brothers 0.3 0.4 1.8 -0.2 -0.2 -1.4 -0.8 0.3 0.6 0.5 -0.2 -0.5 -1.1 0.1 -0.5 0.5 -0.7 -0.8 -0.0 -0.3 -0.4
Worry too long after embarrassment 0.8 1.3 3.9 -0.2 -1.3 -2.0 -1.2 -0.0 0.1 -0.9 -1.6 -1.0 -1.7 -0.3 -1.5 -0.4 -1.1 -1.8 -1.1 1.0 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 3.2 0.9 -0.3 0.1 -0.7 -0.5 0.8 1.2 0.2 0.4 -0.9 1.6 0.7 1.8 0.9 0.2 -0.2 1.1 -1.7
Wheeze or whistling in the chest in last year 0.3 0.6 1.9 -1.4 -0.7 0.1 -0.8 -1.0 -0.2 0.8 -1.1 -0.9 0.6 -0.8 -0.4 0.8 -0.3 -0.5 -0.9 1.1 -0.0
Number of children fathered 1.1 1.2 3.8 -1.9 -1.2 -0.8 -0.5 -0.3 -1.9 -1.0 -1.0 -0.6 -0.5 -0.8 -1.4 -1.6 -1.1 -1.3 -1.0 0.8 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 2.2 -0.3 0.2 0.2 -0.5 -0.2 -1.2 -1.5 -0.4 -0.6 0.7 -0.3 -0.0 -1.1 -0.8 -0.3 0.5 -0.0 0.1
Age at first live birth 0.2 0.3 1.5 -0.2 -0.4 -0.5 -1.0 -0.2 -0.0 0.9 -0.3 -0.3 -1.1 0.5 -0.1 1.2 -0.1 -0.4 -0.3 0.1 -0.5
Pulse wave peak to peak time 0.9 1.1 3.8 -0.3 0.6 0.3 0.3 0.5 1.0 1.6 0.3 0.4 1.1 2.0 1.8 1.2 0.4 0.9 0.6 -1.5 -1.2
Health satisfaction 2.0 2.7 5.8 1.7 2.3 1.4 1.6 2.4 0.8 1.4 2.3 1.9 -0.9 1.7 1.2 0.2 1.1 1.1 2.2 -2.4 0.0
Shortness of breath walking on level ground 0.8 0.9 3.5 0.0 0.6 0.8 0.3 1.1 0.1 1.5 0.1 -0.9 1.4 0.6 1.2 0.5 -0.7 1.1 0.7 -1.9 1.2
Qualifications: College or University degree 0.3 0.8 2.9 0.2 0.2 1.4 -0.3 -1.1 0.8 1.0 0.6 0.4 0.5 0.2 1.2 1.7 1.1 1.6 0.5 0.8 -0.5
Eye problems/disorders: None of the above 2.2 2.6 5.7 -2.4 -2.0 -0.8 -2.4 -2.0 -0.7 -2.0 -1.9 -1.7 -1.3 -1.2 -1.6 -0.7 -1.4 -1.1 -2.0 1.4 0.4
Mouth/teeth dental problems: Loose teeth 1.4 1.7 5.1 0.8 1.0 -0.7 0.3 1.2 1.4 2.3 1.2 0.6 1.0 1.6 1.9 2.2 1.4 1.0 1.2 -1.3 -0.1
Emphysema/chronic bronchitis 1.2 1.3 3.8 -0.5 -0.8 -0.5 -1.2 -0.5 -2.0 -1.8 -1.0 -0.5 -1.6 -0.5 -1.6 -1.7 -1.4 -1.5 -0.7 -0.0 -0.2
Medication for pain relief, constipation, heartburn 0.6 1.0 2.9 -1.6 -0.2 -0.0 -1.0 -0.7 -1.7 -1.0 -0.5 -0.3 -0.4 -1.1 -1.4 -1.3 -0.7 -1.3 -0.5 -0.0 1.4
Neck or shoulder pain in last month 0.3 0.4 1.8 -0.2 -0.8 -0.1 0.5 -0.4 -0.0 1.1 -0.1 -0.8 0.7 0.2 0.7 0.4 -0.7 0.6 -0.4 1.1 -1.3
Medication: Blood pressure 0.5 0.8 3.7 1.9 0.5 -0.0 0.7 0.6 1.3 0.6 0.6 0.5 -0.4 1.6 1.0 1.4 0.5 1.0 0.6 -0.6 -0.4
Angina (self-reported) 10.0 13.1 33.6 5.8 2.9 3.1 3.9 5.0 1.8 4.0 2.9 3.2 1.2 4.5 4.4 3.1 2.8 4.0 3.5 -4.5 0.1
Migraine (self-reported) 2.5 3.1 11.0 -2.2 -1.5 -0.9 -1.6 -2.7 -1.8 -1.8 -1.5 -1.6 -0.6 -3.3 -1.5 -1.6 -1.4 -0.5 -1.7 2.2 0.5
Medication: Ibuprofen 3.4 4.0 12.6 -3.5 -2.0 0.0 -2.4 -3.1 -0.8 -2.6 -2.5 -1.7 0.4 -2.3 -1.8 -1.0 -1.5 -1.8 -2.1 2.1 0.1
Medication: Allopurinol 1.2 1.6 4.5 1.2 1.2 -0.7 2.1 1.3 1.1 1.6 0.7 0.8 1.5 1.5 1.6 1.8 1.3 0.5 1.1 -0.9 -0.9
Medication: Omeprazole 0.5 0.5 1.4 0.4 0.0 -0.3 0.8 1.2 1.2 1.0 0.0 -0.1 -1.0 1.0 0.4 0.8 0.3 -1.2 0.1 -0.6 -0.7
Medication: Seretide 50 evohaler 0.6 0.7 3.0 -1.7 -0.0 -1.0 -0.8 -1.7 -0.1 0.2 -0.2 -0.7 0.9 -0.4 0.2 0.7 0.0 0.5 -0.1 0.9 -1.5
Mean time to correctly identify matches 0.5 0.9 1.8 1.3 1.2 1.0 1.2 1.0 0.6 0.8 0.9 0.9 0.4 1.3 0.9 0.6 1.0 0.4 1.1 -0.9 -1.2
Heart disease (mother) 11.9 14.5 37.6 6.1 4.2 2.3 4.2 4.8 1.9 4.8 4.1 3.0 1.0 3.2 4.5 2.0 3.0 4.8 5.1 -3.7 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 6.2 0.9 1.7 0.7 1.3 2.2 0.6 0.7 2.0 2.0 -1.8 2.5 0.6 1.4 1.8 -0.5 1.8 -1.8 -0.6
Whole body fat mass 4.8 20.1 36.0 -4.9 -5.0 -2.0 -6.0 -5.2 -3.2 -4.0 -5.3 -4.9 -3.5 -5.8 -5.3 -2.8 -4.8 -3.3 -5.1 4.8 1.7
Leg fat mass (right) 3.4 13.1 24.0 -3.7 -3.9 -1.9 -4.9 -4.5 -2.9 -3.0 -4.4 -3.9 -3.1 -4.7 -4.3 -2.0 -3.6 -2.8 -3.9 4.1 1.1
Arm predicted mass (right) 5.0 25.7 50.3 -3.6 -5.8 -2.1 -7.1 -5.8 -5.0 -6.6 -5.9 -5.5 -4.1 -5.8 -5.0 -3.6 -5.6 -3.2 -6.0 4.2 3.2
Pulse rate, automated reading 0.2 0.5 3.4 -1.0 0.2 -1.9 -0.9 0.4 -0.7 -0.0 -0.1 0.0 -0.5 -0.5 -0.8 -0.3 0.0 -1.3 0.0 -0.2 0.6
Alcohol intake frequency. 2.2 5.2 13.8 2.5 3.0 0.6 3.7 3.0 1.4 1.4 2.4 2.5 1.8 2.6 2.3 1.3 2.3 1.1 3.2 -2.0 -1.0
Comparative height size at age 10 3.0 16.5 34.1 -3.7 -5.2 -0.3 -5.7 -4.8 -3.1 -5.8 -4.5 -4.7 -2.3 -4.0 -3.7 -2.5 -4.5 -2.6 -5.5 3.3 2.5
Number of full sisters 0.7 0.8 4.2 0.1 0.5 -1.1 0.4 1.1 -0.9 -0.4 -0.1 1.2 -0.0 2.0 0.2 -1.3 0.6 -1.2 0.6 -1.4 0.0
Suffer from ‘nerves’ 1.0 1.6 8.2 -0.7 -0.9 -1.5 -1.1 -1.5 1.0 0.3 -0.4 -1.9 -0.2 0.3 0.1 1.5 -0.9 -0.1 -0.7 2.4 -2.9
Overall health rating 0.4 0.8 4.5 0.9 1.2 0.1 0.1 1.2 0.2 0.8 0.5 0.6 -1.2 1.1 0.2 -0.5 -0.3 0.0 1.3 -2.1 0.1
Chest pain or discomfort 2.2 3.2 6.8 2.2 2.1 1.3 1.6 0.8 1.5 2.6 1.4 1.0 0.8 2.5 2.5 1.7 1.4 2.3 2.2 -0.4 -1.5
Had major operations 1.1 1.3 3.2 0.4 1.4 1.8 1.1 0.7 -0.1 0.9 1.2 1.8 -0.1 1.8 1.3 0.0 0.9 1.0 1.7 -1.0 -0.9
Age at last live birth 0.5 0.7 1.9 0.5 1.0 -0.2 -0.2 1.1 -1.1 0.8 0.7 1.4 -0.7 1.0 0.9 0.7 1.0 0.0 1.3 -1.1 0.0
Family relationship satisfaction 1.0 1.2 4.5 1.8 0.5 -0.3 0.9 0.6 1.6 2.1 1.4 0.0 0.7 0.9 1.1 1.4 0.6 1.6 0.5 -0.1 0.1
Leg pain on walking 1.2 1.5 7.1 1.5 0.8 1.0 0.5 2.5 -1.0 0.4 0.5 0.8 -0.3 0.9 0.4 0.2 -0.1 -0.0 0.6 -2.3 2.7
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.1 0.2 1.2 -0.2 0.8 0.1 0.5 -0.2 0.6 0.5 0.5 0.3 0.2 0.7 1.5 -0.9 1.1 0.1 -1.2
Commuting to job workplace: Car/motor vehicle 0.5 0.6 2.2 -0.3 -0.3 -0.2 -0.5 0.6 -1.5 -1.4 -0.6 0.8 -0.8 0.0 -0.5 -1.1 -0.0 -1.3 -0.1 -0.5 1.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.5 -0.3 -0.9 -1.2 -0.9 -0.4 -0.0 -0.2 -0.9 0.3 -1.5 -0.4 -1.3 -0.4 -0.3 -1.6 -0.8 0.6 -0.7
Medication: Aspirin 7.0 9.2 32.0 5.7 2.5 2.2 3.4 4.5 1.3 2.5 2.7 3.1 1.6 3.2 3.7 1.2 1.9 3.3 3.0 -3.7 1.0
Supplements: Vitamin C 0.9 1.1 7.4 -1.2 -0.8 0.2 -0.3 -0.7 2.7 0.7 -1.0 -0.3 0.6 0.9 0.1 1.9 -0.0 -0.1 -0.7 0.2 -1.5
Knee pain experienced in last month 0.4 0.7 1.7 0.6 1.2 -0.7 0.5 0.3 -0.6 1.3 0.7 1.2 1.2 0.3 0.3 -0.4 1.1 0.7 1.3 -0.0 -0.6
Hypertension (Self-reported) 1.1 3.1 11.3 3.4 1.8 1.3 1.2 1.2 1.8 1.4 1.4 1.4 -1.0 3.0 1.5 1.2 1.6 0.5 1.8 -1.8 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 2.1 0.0 -0.1 0.2 0.2 -0.4 0.6 0.3 -0.3 -0.6 0.1 -0.7 -0.3 0.5 0.2 0.2 -0.2 1.4 -0.1
Illnesses of father: Heart disease 13.9 19.3 51.4 7.2 4.7 2.6 5.1 5.5 1.6 4.4 4.0 3.2 3.3 3.8 5.4 2.2 2.6 5.9 5.3 -5.5 1.8
Illnesses of siblings: Diabetes 1.3 1.6 7.0 1.2 0.9 0.2 1.5 2.5 -0.6 -1.0 1.2 0.9 0.1 0.6 0.3 -0.9 -0.5 0.4 1.1 -2.6 2.0
Smoking status: Previous 0.1 0.2 1.0 0.8 0.4 1.0 0.4 0.0 0.1 -0.4 0.2 0.6 0.4 0.6 0.3 -0.1 0.3 0.5 0.6 -0.3 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.6 8.6 -2.0 -1.7 0.1 -2.2 -2.9 -0.5 -2.1 -1.6 -1.9 -0.4 -1.9 -0.9 -0.2 -1.0 -0.5 -1.9 2.4 0.9
Whole body fat-free mass 5.0 28.5 57.0 -4.2 -6.2 -1.8 -7.5 -6.2 -5.0 -7.0 -6.3 -5.7 -4.3 -5.8 -5.3 -3.4 -5.7 -3.6 -6.4 4.6 3.2
Leg fat-free mass (right) 5.7 30.4 58.4 -4.5 -6.2 -2.1 -7.6 -6.3 -5.4 -6.9 -6.4 -5.9 -3.9 -6.6 -5.7 -3.9 -5.9 -3.7 -6.5 5.1 3.5
Arm fat percentage (left) 1.8 7.3 13.6 -3.1 -2.5 -1.5 -3.5 -3.1 -2.0 -1.7 -3.1 -2.7 -2.5 -3.7 -3.6 -1.9 -2.7 -2.5 -2.6 3.1 0.4
Average weekly red wine intake 0.9 1.3 9.4 3.1 0.1 0.8 0.8 1.0 0.6 0.9 0.4 0.3 -0.2 1.1 1.2 1.6 0.6 1.7 0.2 -0.4 1.0
Handedness (chirality/laterality): Left-handed 1.5 1.8 5.6 0.1 1.8 0.6 1.0 1.1 0.4 1.2 1.8 2.4 -0.3 2.0 1.1 0.6 1.8 1.0 1.8 -1.5 -0.2
Mood swings 1.2 2.2 7.2 -0.8 -1.8 -1.9 -1.2 -2.1 0.6 -0.5 -1.7 -2.3 0.3 -1.6 -1.1 0.5 -1.5 -0.6 -1.6 2.7 -0.8
Loneliness, isolation 1.2 1.6 4.6 -0.2 -1.2 -1.2 -1.4 0.3 -1.2 -1.8 -1.3 -1.2 -1.9 0.5 -1.2 -0.9 -1.7 -2.1 -1.2 -0.6 0.8
Long-standing illness, disability or infirmity 2.6 3.9 12.1 1.4 2.1 1.7 2.2 0.8 2.5 3.5 2.0 0.9 1.3 2.1 1.9 1.7 1.8 1.6 2.3 -0.2 -2.9
Ever had bowel cancer screening 0.9 1.1 4.0 -0.6 -1.2 -0.9 -1.2 -1.0 0.7 -0.3 -1.5 -0.7 -2.0 -0.5 -1.1 0.1 -0.6 -1.3 -1.5 1.3 -0.2
Diabetes diagnosed by doctor 4.0 6.5 11.2 3.3 2.8 2.6 3.1 1.8 2.4 2.7 2.8 2.3 0.6 3.2 3.0 2.6 2.8 2.4 2.9 -0.9 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 2.0 0.2 0.2 -0.3 0.5 0.1 0.4 1.4 0.7 0.4 1.2 -0.0 0.4 0.5 0.4 1.0 0.5 -0.3 -0.3
Friendships satisfaction 0.3 0.4 1.8 0.6 -0.8 -0.5 0.1 -0.3 0.7 1.0 -0.2 -1.4 0.2 0.2 -0.3 -0.3 -1.1 0.3 -0.9 0.7 0.1
Qualifications: nursing, teaching 0.7 1.2 1.9 1.1 0.9 1.3 0.8 1.1 1.1 1.3 0.8 1.3 0.7 1.0 1.3 1.4 1.3 1.1 0.9 -1.0 0.2
Commuting to job workplace: Walk 0.5 0.6 1.6 0.5 -0.2 -0.6 1.1 -0.8 0.6 1.2 0.3 -0.8 0.7 0.3 -0.2 1.0 0.4 -0.6 -0.3 1.0 -1.3
Eye problems/disorders: Cataract 1.1 1.2 3.6 1.3 1.3 0.2 1.8 1.8 -0.3 1.7 1.0 1.1 -0.0 0.7 0.2 -1.1 0.3 -0.1 1.4 -1.9 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.1 0.3 0.8 -1.0 0.0 -0.1 0.7 0.6 0.7 0.7 -0.3 -0.0 -0.2 -0.7 0.5 0.1 0.8 -0.1 -1.0
Medication for cholesterol 7.4 11.3 29.2 -5.4 -4.2 -3.5 -3.5 -3.6 -1.4 -3.8 -3.5 -3.2 -1.9 -3.2 -3.9 -1.0 -3.1 -3.3 -4.1 3.4 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.8 0.4 1.0 0.1 0.6 1.3 0.9 1.1 0.8 0.5 1.3 -0.5 0.7 0.7 1.2 1.0 0.9 -0.6 0.6
Back pain experienced in last month 0.3 0.5 1.2 -1.1 -0.7 0.2 -0.9 0.3 -0.7 -0.3 -0.7 0.2 -1.0 -0.5 -1.0 -1.0 -0.8 -0.7 -0.6 -0.2 0.7
Mineral and other dietary supplements 4.7 6.3 11.5 -3.1 -2.7 -1.6 -3.1 -3.4 -1.4 -1.2 -2.4 -2.5 -3.3 -3.0 -3.1 -1.3 -2.9 -1.5 -2.7 2.7 -0.8
Breast cancer (self-reported) 0.3 0.3 1.5 -0.9 -0.1 -0.2 -0.3 -1.1 -0.3 0.3 -0.0 -0.7 -0.9 -1.2 -0.4 0.2 -0.4 0.2 -0.3 0.7 0.3
Asthma (self-reported) 0.1 0.2 0.9 -0.7 0.9 -0.1 -0.2 -0.4 -0.5 0.6 -0.0 -0.1 0.5 -0.0 0.4 -0.2 0.1 0.3 0.6 -0.8 -0.1
Osteoporosis (self-reported) 1.4 1.8 9.3 3.0 1.4 0.8 1.8 1.7 -0.5 1.1 1.1 1.6 -0.6 1.6 0.9 0.2 1.2 0.5 1.5 -0.3 -0.2
Osteoarthritis (self-reported) 0.2 0.2 1.7 -0.0 -0.3 0.2 -0.3 0.4 -0.3 0.3 -0.4 0.3 0.7 0.3 -0.8 -0.4 0.1 -1.3 -0.1 0.2 -0.3
Medication: Aspirin 6.1 8.0 30.1 5.5 2.5 2.0 3.2 4.0 0.9 2.2 2.4 2.9 1.6 2.8 3.4 0.9 1.8 3.3 3.0 -3.3 0.8
Medication: Gliclazide 2.0 2.2 6.6 1.0 1.7 0.7 1.3 0.8 1.0 1.4 1.8 1.2 1.7 0.9 2.4 1.8 1.7 2.6 1.6 -0.9 -0.1
Illnesses of father: None of the above (group 1) 6.0 7.4 18.3 -4.3 -2.8 -1.9 -3.0 -2.8 -1.2 -2.9 -2.7 -2.5 -2.0 -2.3 -3.4 -1.2 -2.0 -4.1 -3.0 3.3 -0.6
Smoking status: Current 0.8 1.2 2.6 -1.1 -1.4 -1.2 -1.4 -0.6 -0.8 -1.2 -0.8 -0.8 -1.5 -1.4 -1.1 -0.1 -1.0 -0.2 -1.6 0.7 1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.7 0.8 -0.4 0.5 1.5 1.4 1.7 1.3 -0.0 -0.0 0.3 1.7 0.6 0.9 -0.1 -0.4 -0.3 -0.6 -0.8
Whole body water mass 4.9 27.8 55.4 -4.1 -6.2 -1.8 -7.4 -6.1 -5.1 -6.9 -6.3 -5.6 -4.2 -5.8 -5.2 -3.4 -5.6 -3.6 -6.4 4.5 3.2
Leg predicted mass (right) 5.6 30.1 58.4 -4.5 -6.2 -2.1 -7.6 -6.3 -5.4 -6.9 -6.3 -5.8 -3.9 -6.5 -5.6 -3.9 -5.9 -3.6 -6.4 5.0 3.5
Arm fat mass (left) 4.1 16.7 31.1 -4.3 -4.2 -2.2 -5.6 -4.7 -3.5 -3.8 -4.8 -4.2 -3.5 -5.2 -5.0 -2.9 -4.1 -3.4 -4.3 4.2 1.4
Number of self-reported non-cancer illnesses 2.7 4.7 9.0 3.0 2.8 1.1 1.8 2.9 1.2 2.4 2.1 2.7 -0.1 2.9 2.0 0.8 2.3 0.9 3.0 -2.3 -1.2
Average weekly champagne plus white wine intake 0.4 0.6 3.5 0.2 -0.1 0.4 -0.8 -1.7 -0.2 -0.2 -0.2 -0.5 -0.5 -1.9 0.2 0.4 0.0 1.1 -0.2 1.3 -0.0
Miserableness 1.6 2.8 7.7 -1.1 -1.5 -1.2 -2.2 -2.0 -1.5 -2.8 -2.1 -1.8 -1.6 -1.2 -1.8 -1.1 -1.9 -1.7 -1.2 1.6 0.1
Guilty feelings 0.4 0.6 3.1 0.3 -0.5 0.7 -0.9 -0.0 0.2 -1.8 -0.6 -0.4 -1.6 -0.4 -0.7 0.0 -0.4 -0.7 -0.2 0.4 0.9
Wears glasses or contact lenses 1.1 1.3 4.6 1.0 0.8 2.1 0.7 0.6 1.9 0.3 1.1 1.4 0.2 0.8 1.0 1.8 1.5 1.2 0.7 -0.2 0.2
Ever taken oral contraceptive pill 1.0 1.1 3.7 -1.5 -1.5 -0.5 -1.4 -0.7 -0.0 0.3 -1.6 -1.9 -0.0 0.3 -0.5 0.3 -1.6 -0.9 -1.7 -0.0 -0.8
Hearing aid user 0.5 0.5 3.1 0.7 0.6 0.9 0.3 -0.9 0.3 1.1 0.9 0.2 0.0 -0.8 0.4 -0.6 -0.4 1.8 0.7 0.0 -0.3
Mother’s age at death 1.1 1.4 7.0 -2.4 -0.7 0.2 -0.3 -1.8 1.1 -0.0 -0.0 -0.9 1.5 -1.4 -0.4 0.2 -0.3 0.2 -0.9 2.6 -0.8
Financial situation satisfaction 0.4 0.5 2.5 -0.4 -0.4 -1.6 -1.5 -0.5 -0.3 0.1 -0.3 -1.1 0.0 -0.4 -0.2 -0.6 -1.1 -0.3 -0.8 -0.2 0.4
Tinnitus: Yes, now most or all of the time 0.5 0.6 3.4 -0.8 0.4 0.9 -0.2 -0.2 1.8 0.1 0.3 -0.1 0.8 1.0 0.7 1.4 0.4 0.7 0.2 -0.6 -0.7
Commuting to job workplace: Public transport 0.5 0.6 2.4 -0.8 -0.6 0.7 -0.7 -0.9 0.9 -0.2 -0.5 -0.3 -1.5 0.7 -0.3 1.4 -0.0 -0.1 -0.5 1.1 -0.9
Eye problems/disorders: Glaucoma 0.3 0.4 2.4 -0.8 0.1 0.1 0.1 -0.8 1.1 -0.1 0.1 -0.3 0.5 -0.7 0.6 1.6 0.4 0.6 0.1 0.7 -0.2
Medication: Blood pressure 2.5 4.7 18.8 4.3 3.1 2.7 1.9 1.6 0.7 1.6 2.6 1.9 0.2 1.5 2.3 0.2 2.1 2.0 2.8 -1.8 -1.6
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.8 0.0 -0.0 0.1 -1.1 0.2 -1.1 -0.6 -0.3 0.2 -1.1 0.2 -0.1 0.1 -0.5 0.3 -0.0 -0.6 1.3
Supplements: Fish oil (including cod liver oil) 5.0 6.6 13.5 3.5 2.8 1.7 3.7 3.6 1.0 1.4 2.3 2.9 2.7 2.9 2.8 0.9 2.9 1.4 2.8 -2.9 1.0
High cholesterol (Self-reported) 15.1 26.7 56.6 7.1 5.4 2.4 5.5 7.5 1.2 5.6 4.3 5.6 2.7 6.9 6.3 2.0 3.7 5.2 6.5 -6.7 0.6
Medication: Bendroflumethiazide 0.3 0.5 2.5 0.9 0.3 0.3 -0.0 0.2 -0.7 -0.7 -0.5 0.9 -0.8 0.1 -0.8 -1.0 0.4 -1.6 0.2 0.4 -0.9
Medication: Paracetamol 0.9 1.4 6.2 -1.6 -0.8 -2.3 -0.4 -1.5 0.5 0.2 -1.0 -0.6 -0.8 -0.1 -1.0 -0.4 -0.2 -1.4 -0.7 1.4 -2.5
Medication: Lisinopril 2.1 2.7 6.7 1.5 2.2 1.1 2.0 0.8 1.5 1.6 1.8 1.3 1.6 1.0 2.6 1.3 1.9 2.2 2.2 -1.1 -0.4
Medication: Atorvastatin 8.5 10.6 24.1 4.9 3.2 2.8 3.4 4.6 1.0 3.1 2.7 3.3 0.4 4.5 3.8 0.9 1.8 4.1 3.9 -4.0 -0.4
Illnesses of father: High blood pressure 0.7 0.9 2.9 0.7 0.8 0.2 0.2 -0.1 0.9 1.0 1.3 0.7 0.7 1.7 1.3 0.7 1.0 0.9 0.9 -0.8 -1.1
Alcohol drinker status: Never 0.5 0.5 1.8 0.1 0.5 -0.4 0.9 1.1 0.7 1.3 0.6 0.7 0.5 0.9 0.4 1.3 0.6 0.6 0.8 -0.3 0.1
Ever smoked 0.4 0.7 1.7 -0.6 -1.2 0.1 -1.0 -1.3 -1.0 -1.1 -0.8 -0.6 -0.4 -0.9 -0.9 -0.8 -0.9 -0.0 -1.1 0.7 0.8
Basal metabolic rate 5.4 30.0 59.0 -4.6 -6.3 -2.0 -7.7 -6.4 -5.1 -6.8 -6.5 -5.8 -4.4 -6.3 -5.7 -3.6 -5.8 -3.9 -6.5 4.9 3.1
Leg fat percentage (left) 0.9 3.2 8.7 -1.6 -1.6 -1.3 -2.1 -2.1 -0.9 -0.5 -2.2 -1.9 -1.5 -3.0 -2.5 -0.9 -1.5 -1.6 -1.8 2.5 0.0
Arm fat-free mass (left) 4.5 22.7 44.6 -3.6 -5.3 -1.9 -6.7 -5.6 -4.8 -6.3 -5.7 -4.9 -3.5 -5.5 -4.8 -3.2 -4.9 -3.2 -5.6 4.2 3.0
Number of operations (self-reported) 0.9 1.3 4.7 -0.3 0.7 0.5 0.3 2.2 0.8 1.2 0.9 1.1 -1.6 2.1 0.7 0.8 0.1 -0.1 1.0 -2.2 0.6
Average weekly beer plus cider intake 0.6 0.9 3.8 0.2 -0.0 -2.0 -0.3 -0.6 -1.0 0.9 0.5 -1.2 1.2 -1.1 -0.2 -1.6 -0.8 0.1 -0.0 0.4 -1.3
Irritability 1.3 2.2 6.6 -1.4 -1.8 -0.9 -2.0 -2.6 0.6 -0.6 -1.5 -1.7 -0.1 -2.0 -1.5 0.1 -1.1 -0.5 -1.7 2.5 -0.2
Risk taking 1.1 1.6 6.7 -0.5 -0.9 -0.6 -1.4 -2.1 -1.4 0.5 -0.7 -1.8 0.2 -2.6 -0.3 0.0 -1.1 1.8 -0.7 1.5 1.0
Ever had prostate specific antigen (PSA) test 0.5 0.5 3.4 -0.2 -0.5 1.3 1.0 0.5 1.8 0.2 0.2 -0.4 -1.0 0.6 -0.3 0.8 0.0 -0.5 -0.4 -0.0 -0.2
Fractured/broken bones in last 5 years 0.5 0.7 2.9 0.5 1.0 -1.4 0.4 -0.8 -1.7 -0.4 -0.2 0.3 1.5 -0.5 0.3 -0.3 0.9 -0.1 0.8 0.7 1.0
Age started oral contraceptive pill 0.2 0.2 0.9 0.9 0.1 -0.3 -0.4 0.3 -0.1 0.7 0.3 -0.1 -0.5 -0.5 -0.9 -0.3 -0.1 -0.6 -0.0 0.2 -0.2
Diastolic blood pressure, automated reading 2.6 7.9 14.5 -2.9 -2.7 -2.7 -3.2 -3.4 -1.9 -2.8 -3.3 -3.1 -3.2 -1.8 -3.4 -2.3 -2.7 -3.8 -2.8 2.2 -1.0
Ever depressed for a whole week 0.4 0.5 1.6 0.9 -0.6 -0.7 -0.3 -0.3 1.0 0.9 -0.1 -0.3 -1.2 0.6 -0.0 0.8 0.0 0.4 -0.5 1.1 -1.2
Unable to work because of sickness or disability 1.3 1.7 4.5 1.0 0.9 1.4 1.6 1.3 0.4 1.3 1.5 0.5 1.5 1.9 2.1 1.2 0.6 2.1 0.9 -1.3 0.1
Commuting to job workplace: Cycle 0.7 0.9 4.0 0.3 0.3 -0.3 1.0 0.3 1.0 2.0 1.0 0.1 0.6 1.0 0.7 1.7 1.0 0.4 0.5 -0.0 -1.6
Myopia 0.3 0.4 3.1 -0.5 0.3 0.6 -0.0 -0.5 1.8 0.8 0.6 -0.4 -0.0 -0.5 0.2 0.4 0.5 1.1 0.1 0.3 -0.2
Vascular/heart problems diagnosed by doctor 1.2 3.4 15.6 -3.9 -1.6 -1.0 -1.4 -2.0 -1.3 -1.9 -1.3 -1.5 1.1 -2.9 -1.6 -1.1 -1.2 -0.9 -1.8 2.3 1.1
Cholesterol lowering medication 17.1 25.2 48.6 6.6 6.0 3.1 5.6 7.0 1.8 5.4 5.0 5.1 3.3 5.7 6.0 1.6 4.1 4.6 6.5 -6.2 0.0
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.9 0.5 0.4 -0.8 0.6 1.0 1.4 0.8 0.3 0.3 -1.0 1.0 0.3 0.7 0.7 -1.0 0.4 -0.5 -1.0
Pain experienced in last month 0.8 1.4 4.8 0.9 1.3 2.2 0.9 0.3 1.1 0.4 1.4 0.9 1.1 1.0 1.6 0.7 1.4 1.3 1.1 -1.2 0.4
Supplements: Calcium 0.7 0.8 3.3 -0.7 0.5 -0.5 0.8 -0.0 1.3 1.5 -0.3 0.4 1.5 0.9 0.5 0.7 0.7 0.5 0.7 0.7 -1.8
Basal cell carcinoma (self-reported) 0.7 0.8 3.5 0.0 0.1 -0.1 1.2 0.2 1.9 1.1 0.0 -0.0 0.8 0.8 0.3 1.9 0.8 -0.6 0.2 1.0 -1.4
Heart attack/myocardial infarction (self-reported) 7.4 9.5 34.1 5.8 2.2 1.7 4.0 4.9 0.2 3.3 2.1 2.8 1.2 4.1 3.2 1.8 1.8 2.7 2.8 -3.8 1.0
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.6 -0.2 -0.9 -0.4 -0.1 -0.4 -0.2 0.7 -0.6 -1.3 0.6 -1.0 -0.4 -0.4 -0.8 0.6 -1.0 1.1 -0.0
Heart disease (siblings) 9.5 11.6 29.2 5.0 3.6 2.8 3.0 5.4 0.7 3.2 3.2 2.8 1.8 3.4 4.1 1.1 1.5 4.6 3.8 -4.8 2.1
Alcohol drinker status: Previous 1.0 1.1 4.2 2.0 1.1 0.8 0.7 0.8 0.7 0.4 1.2 0.7 -0.5 2.0 1.0 0.6 0.9 0.7 1.1 -0.9 -1.1
Pack years of smoking 0.6 0.8 3.6 -0.8 -1.0 -1.9 -0.4 0.5 -0.7 -0.2 -0.6 0.3 -1.9 0.4 -1.2 -0.2 -0.4 -1.7 -0.7 0.1 -0.2
Impedance of whole body 0.5 2.8 6.5 -0.1 1.8 0.8 1.9 2.0 2.5 1.7 2.4 1.9 1.8 1.9 1.5 0.6 1.6 1.0 1.9 -1.8 -0.9
Leg fat mass (left) 3.6 14.0 26.1 -3.7 -4.0 -2.0 -5.1 -4.5 -2.9 -3.3 -4.5 -4.0 -3.1 -4.9 -4.4 -2.3 -3.8 -2.8 -4.2 4.1 1.3
Arm predicted mass (left) 4.8 24.3 48.2 -3.9 -5.5 -2.0 -6.9 -5.8 -4.8 -6.2 -5.9 -5.2 -3.8 -5.7 -5.0 -3.4 -5.1 -3.4 -5.7 4.5 2.7