Hub : Genes

SLC22A3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1000	0.0330	3.5e-06	0.021	0.053	0.044	0.053	0.032	1.3e-03	4.4e-07	3.9e-06	4.9e-07	8.3e-05
2	GTEx	Adipose Visceral Omentum	0.1350	0.0500	8.4e-05	0.055	NA	0.095	NA	0.087	7.9e-04	NA	1.3e-05	NA	2.9e-05
3	GTEx	Artery Tibial	0.1057	0.0423	1.5e-03	-0.003	NA	0.012	NA	0.001	6.8e-01	NA	3.7e-02	NA	2.3e-01
4	GTEx	Brain Caudate basal ganglia	0.1530	0.0600	1.8e-03	0.096	NA	0.107	NA	0.011	1.1e-03	NA	5.6e-04	NA	1.5e-01
5	GTEx	Brain Frontal Cortex BA9	0.2613	0.0811	2.1e-04	0.078	NA	0.036	NA	0.054	4.1e-03	NA	3.9e-02	NA	1.5e-02
6	GTEx	Colon Transverse	0.1840	0.0780	3.4e-03	-0.004	NA	-0.004	NA	-0.004	5.8e-01	NA	5.2e-01	NA	5.3e-01
7	GTEx	Esophagus Mucosa	0.1900	0.0540	1.6e-07	0.078	NA	0.122	NA	0.091	6.8e-06	NA	1.7e-08	NA	1.1e-06
8	GTEx	Nerve Tibial	0.2041	0.0573	4.1e-07	0.098	NA	0.114	NA	0.126	2.1e-07	NA	2.0e-08	NA	3.2e-09
9	GTEx	Ovary	0.3300	0.0910	4.2e-05	0.287	NA	0.193	NA	0.226	9.3e-08	NA	1.7e-05	NA	2.8e-06
10	GTEx	Pancreas	0.1660	0.0730	3.6e-03	0.037	NA	0.040	NA	0.033	1.1e-02	NA	8.7e-03	NA	1.5e-02
11	GTEx	Skin Not Sun Exposed Suprapubic	0.1510	0.0520	3.0e-05	0.050	NA	0.048	NA	0.050	1.0e-03	NA	1.2e-03	NA	9.9e-04
12	GTEx	Skin Sun Exposed Lower leg	0.2930	0.0630	8.4e-15	0.135	NA	0.162	NA	0.197	2.9e-11	NA	2.1e-13	NA	3.7e-16
13	GTEx	Small Intestine Terminal Ileum	0.2390	0.0980	5.2e-03	0.127	NA	0.084	NA	0.099	9.2e-04	NA	6.4e-03	NA	3.3e-03
14	GTEx	Testis	0.1870	0.0600	6.9e-06	0.011	NA	0.049	NA	0.051	9.8e-02	NA	3.2e-03	NA	2.6e-03
15	METSIM	Adipose	0.0362	0.0165	5.5e-03	0.012	0.014	0.008	0.013	0.015	4.7e-03	2.7e-03	1.8e-02	4.4e-03	2.3e-03
16	ROSMAP	Brain Pre-frontal Cortex	0.1448	0.0308	0.0e+00	0.199	0.149	0.191	0.174	0.194	5.0e-25	1.1e-18	5.8e-24	7.2e-22	2.4e-24
17	TCGA	Colon Adenocarcinoma	0.1740	0.1170	6.3e-03	0.062	0.010	0.003	NA	0.038	1.7e-04	8.6e-02	2.0e-01	NA	2.8e-03
18	TCGA	Brain Lower Grade Glioma	0.1215	0.0485	1.0e-06	0.071	0.058	0.067	NA	0.067	1.7e-08	3.3e-07	4.0e-08	NA	4.3e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Bipolar Disorder (2018)	1.0	1.6	3.6	1.6	1.6	1.3	1.1	0.9	0.4	-0.3	1.8	1.8	-0.6	1.9	1.4	-0.7	1.1	0.8	1.6	-1.9	-0.4
Bipolar Disorder or Schizophrenia	0.3	0.8	4.9	1.0	0.9	0.6	0.2	0.3	0.5	0.4	1.3	0.7	-1.2	1.1	0.1	-0.8	0.3	0.2	1.0	-0.9	-2.2
Depressed Affect (Nagel 2018)	1.1	2.3	4.7	-0.8	-1.6	-1.2	-1.6	-1.7	-0.9	-1.9	-2.0	-2.0	-1.1	-2.2	-1.6	-0.5	-1.8	-1.2	-1.6	1.7	0.8
Depression (Nagel 2018)	0.4	0.7	2.5	-0.2	-1.1	-0.3	-0.7	-0.1	-0.6	-0.7	-1.1	-1.0	-0.7	-0.4	-0.6	-0.4	-1.6	-0.0	-0.9	0.3	1.6
Intelligence (Savage-Jansen 2018)	0.2	0.7	3.8	-0.1	-0.4	-0.3	-0.7	-1.4	1.9	-0.2	-0.1	0.2	-0.0	0.3	0.3	0.9	0.7	1.0	-0.5	1.7	-0.3
Neuroticism (Nagel 2018)	0.3	0.7	4.2	0.7	-0.5	-0.8	-0.6	-1.2	0.1	-0.8	-0.8	-1.0	-0.7	-1.1	-0.7	0.1	-0.4	-0.5	-0.4	2.0	-0.8
Schizophrenia (2018)	0.3	0.6	7.1	0.1	-0.2	0.0	-0.4	-0.4	0.6	0.7	0.3	-0.5	-1.1	-0.2	-0.9	-0.5	-0.5	-0.3	-0.0	0.3	-2.7
Schizophrenia vs Biploar Disorder	0.9	1.2	2.5	-0.9	-0.8	-0.8	-0.9	-1.1	-1.0	-0.7	-1.1	-1.2	-1.3	-1.0	-1.6	-1.6	-1.5	-1.5	-0.9	0.6	-0.7
Worry (Nagel 2018)	0.5	1.0	4.6	2.1	0.6	-0.0	0.5	-0.1	1.3	0.9	0.6	0.3	-0.4	0.8	0.7	0.9	0.7	0.4	0.8	1.4	-2.0
Alzheimer’s Disease (in mother)	0.2	0.3	1.0	0.3	-0.7	-0.4	-0.4	-0.6	0.8	-0.3	0.2	0.4	0.4	0.8	0.1	-0.1	0.1	0.0	-0.7	0.5	-1.0
Alzheimer’s Disease (in father)	1.8	2.0	3.8	-1.8	-1.9	-1.5	-1.4	-1.2	-1.5	-0.4	-1.7	-1.2	-1.2	-1.3	-1.9	-0.3	-1.5	-1.2	-1.9	1.5	0.5
Alzheimer’s Disease (including proxy)	0.8	1.2	4.9	-1.1	-1.4	-0.9	-1.4	-2.2	0.0	-0.7	-0.8	-0.7	0.0	-0.5	-0.9	0.1	-0.6	-0.7	-1.6	1.7	-1.0
Crohns Disease (2017)	0.2	0.5	3.5	0.1	-0.2	-0.5	-0.2	-0.7	-0.1	0.2	-0.5	-1.2	0.1	0.1	-0.5	-0.3	-0.6	-0.5	-0.0	1.3	-1.9
Irritable Bowel Disease (IBD)	0.9	2.1	5.5	-0.8	-0.8	-1.7	-0.9	-1.4	-1.4	-0.8	-1.2	-1.3	-0.8	-2.2	-2.2	-2.4	-1.4	-1.6	-0.7	1.7	-1.1
Ulcerative Colitis (UC)	1.4	2.7	8.4	-1.4	-0.9	-1.8	-1.0	-1.8	-1.6	-1.3	-1.0	-1.0	-1.5	-2.7	-2.4	-2.9	-1.6	-1.5	-0.8	1.8	-0.7
Major Depression (MDD)	0.5	0.6	3.5	0.5	0.0	0.0	-0.8	0.9	-1.0	-0.7	0.3	1.2	-0.6	-0.0	-0.7	-1.5	-0.2	-0.3	0.2	-0.6	1.9
Reaction Time	0.3	0.6	2.4	1.1	0.8	0.5	1.1	0.6	-0.1	1.2	0.6	0.2	0.1	1.4	0.6	0.6	0.4	-0.2	0.7	-0.3	-1.5
Verbal and Numeric Reasoning (VNR)	0.4	0.9	4.4	-0.5	-0.5	-0.1	-0.6	-1.5	2.0	-0.6	-0.2	0.2	-0.1	-0.0	0.1	1.2	0.8	0.6	-0.6	2.1	-1.0
Breast Cancer	0.2	0.5	2.4	0.5	-0.5	-1.0	0.2	0.1	-0.1	1.1	0.1	-1.0	-1.0	0.1	-0.5	-0.1	-1.2	-0.3	-0.1	-0.7	-1.5
Ovarian Cancer	0.2	0.3	1.1	0.4	0.6	0.0	0.5	-0.2	-0.1	-0.3	1.0	1.0	-0.7	0.4	0.1	0.5	0.8	-0.1	0.6	-0.2	-0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.8	1.2	5.9	-1.1	-1.3	-1.5	-1.7	-0.1	0.3	-0.6	-0.8	-0.6	-2.4	0.3	-1.1	0.1	-1.0	-1.4	-1.1	-0.4	-0.5
Bipolar Disorder (2011)	0.7	0.7	2.1	-0.1	0.9	0.6	1.0	1.0	-0.1	-0.1	0.5	1.4	1.2	1.3	0.9	-0.6	0.5	0.4	0.9	-1.2	0.3
Body Mass Index (BMI) (2010)	3.4	4.7	12.3	-2.2	-2.9	-0.9	-3.5	-2.5	-1.1	-2.1	-2.0	-2.8	-2.2	-2.0	-2.2	-0.9	-2.3	-1.6	-2.9	1.6	0.9
Coronary Artery Disease (CAD)	8.7	10.4	20.5	4.1	2.8	1.7	3.6	4.3	1.7	3.8	2.7	3.0	2.8	2.9	4.2	2.5	3.0	4.5	3.5	-3.7	0.3
Crohns Disease (2012)	0.4	0.7	5.1	0.2	-0.4	-0.3	-0.2	-1.2	1.3	0.4	-0.4	-0.9	-0.0	0.5	-0.3	-0.3	-0.4	-0.0	-0.2	1.1	-2.3
Mean Putamen Volume	1.3	1.5	4.0	-1.4	-1.9	-2.0	-0.9	0.2	-0.4	-0.2	-1.2	-1.1	-1.0	-0.5	-1.5	-0.6	-1.5	-1.9	-1.9	0.6	0.5
Fasting Glucose	1.3	1.6	5.8	1.0	0.9	0.7	2.4	1.6	1.4	1.9	0.9	0.1	2.0	0.3	1.2	1.0	0.1	1.3	1.0	-1.5	-0.5
HbA1C	0.8	0.8	2.7	0.5	1.3	1.4	0.4	0.2	1.6	0.8	1.4	0.6	0.9	0.8	0.3	0.4	0.8	0.4	1.3	-0.4	-1.1
HDL Cholesterol	1.1	1.9	11.7	0.4	0.0	1.9	0.8	-1.5	1.8	0.8	-0.6	0.0	3.4	0.4	1.8	1.0	0.8	2.2	-0.2	1.3	0.8
LDL Cholesterol	2.5	4.0	20.3	1.5	1.0	-1.1	3.1	4.5	-0.6	3.8	-0.2	1.8	1.4	1.6	1.6	1.3	0.8	1.4	1.9	-2.1	0.9
Lupus	0.8	1.1	3.4	1.5	0.7	-1.1	0.7	1.5	-0.3	0.7	-0.2	1.2	-1.5	1.2	-0.7	-0.0	1.0	-1.9	0.9	-1.0	-1.0
Neuroticism (2016)	1.1	1.6	7.2	-0.2	-0.9	-1.1	-1.2	-2.0	1.5	0.9	-0.8	-1.9	-0.8	-1.0	-1.1	0.9	-0.4	-0.6	-1.0	2.7	-1.5
Primary Biliary Cirrhosis	1.4	1.9	6.7	-1.3	-0.9	-1.0	-1.2	-0.9	-1.8	-2.6	-1.0	-0.4	-1.1	-1.6	-1.5	-1.8	-1.0	-1.3	-0.8	-0.2	2.3
Rheumatoid Arthritis	0.3	0.5	1.1	-0.6	0.3	0.9	0.1	-0.0	0.8	1.0	0.8	-0.5	0.9	-0.3	0.8	0.9	0.4	1.0	0.2	0.7	-0.6
Schizophrenia (2014)	0.2	0.5	4.2	-0.2	0.1	0.8	-0.7	-0.0	0.3	0.4	0.5	0.1	-1.2	0.3	-0.7	-0.5	-0.3	-0.3	0.3	-0.5	-2.0
Triglycerides	4.0	6.5	25.7	2.4	3.0	-0.5	3.5	5.1	1.2	3.1	2.4	3.3	0.9	2.5	1.5	1.0	2.4	-0.1	3.5	-2.9	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.9	0.7	-0.2	-1.0	-0.3	-0.1	-0.1	-0.0	-0.6	-0.1	-0.6	0.2	-0.7	-0.9	-0.4	-0.8	-0.5	0.1	0.7
Ulcerative Colitis	2.5	3.7	8.9	-1.2	-1.9	-2.5	-1.7	-1.8	-1.2	-1.4	-2.1	-1.6	-1.9	-2.3	-3.0	-2.3	-2.2	-2.4	-1.7	1.4	-0.2
Blood Eosinophil Count	0.0	0.4	2.4	0.5	-0.2	-0.5	-0.1	-0.7	0.5	0.2	-0.5	-0.3	-1.5	0.8	0.1	1.0	-0.1	-0.6	-0.3	-0.1	0.0
Blood Platelet Count	1.0	11.8	29.7	3.9	4.8	1.9	4.2	1.0	2.7	2.4	4.3	3.8	3.1	2.6	3.5	2.0	5.5	2.4	4.8	-0.3	-3.7
Blood Red Count	0.1	0.6	1.6	-0.9	0.3	0.9	0.2	-0.1	0.9	-0.3	0.5	0.7	-1.1	1.3	0.4	1.2	1.0	-0.2	0.4	0.7	-1.0
Blood White Count	0.2	1.2	6.0	0.1	0.5	-0.1	0.9	0.2	1.7	1.8	0.4	0.1	0.6	2.0	1.2	2.5	0.7	0.9	0.6	0.3	-0.8
Heel T-Score	0.1	0.7	4.0	0.5	0.2	1.5	0.5	-1.1	0.8	-0.0	0.4	0.1	-1.1	0.4	0.3	0.3	0.8	0.4	0.4	0.8	-2.0
BMI	3.8	22.0	38.4	-5.0	-5.2	-2.5	-6.2	-5.0	-3.5	-3.5	-5.5	-4.8	-5.7	-4.9	-6.1	-3.1	-5.4	-4.3	-5.2	4.5	1.0
Height	2.9	56.5	139.2	-7.0	-8.7	0.1	-10.8	-8.5	-6.3	-11.8	-8.1	-7.4	-5.2	-8.3	-7.0	-5.2	-7.5	-4.7	-9.3	5.6	6.0
Waist Hip Ratio (WHR)	10.6	47.5	76.9	8.2	7.7	3.6	8.8	8.5	5.7	6.4	7.4	8.3	4.4	8.3	7.8	4.9	8.3	4.5	8.0	-5.9	-2.5
Systolic Blood Pressure	1.5	7.7	16.8	4.1	2.3	0.6	3.2	0.9	4.1	3.8	2.7	1.4	1.7	3.2	3.2	2.8	2.7	2.8	2.7	-0.9	-3.4
Smoking Status	0.5	1.2	3.2	-0.8	-1.2	-0.9	-1.4	-1.1	-0.9	-1.8	-1.0	-0.9	-1.5	-1.3	-1.3	-0.6	-1.1	-0.2	-1.2	1.0	0.6
Allergy or Eczema	2.7	7.0	12.3	3.0	3.1	2.1	2.2	1.9	2.6	2.7	3.5	1.8	2.2	2.5	3.4	2.7	2.9	3.5	2.9	-2.1	-0.6
Cardiovascular Disease	3.1	10.4	27.6	4.7	2.9	0.6	3.3	4.1	2.5	4.4	2.8	2.3	-0.3	5.2	3.8	2.6	1.9	2.7	3.7	-3.9	-1.3
Hypothyroidism (self reported)	0.2	0.5	3.1	-1.2	-0.5	1.8	-1.2	-0.4	0.1	-0.1	-0.6	-0.7	0.1	0.4	0.1	0.7	-0.7	-0.1	-0.4	0.5	-0.5
Respiratory disease	0.4	0.8	2.2	-1.4	-0.4	0.2	-1.3	-1.5	-0.8	-0.1	-1.1	-1.3	0.6	-1.3	-0.5	-0.5	-1.2	0.3	-0.7	0.6	0.7
Type 2 Diabetes (T2D) (2018)	3.8	7.1	14.9	3.3	3.6	1.9	3.9	2.5	1.3	2.7	3.2	3.0	-0.2	3.2	2.6	1.8	3.0	1.4	3.5	-2.0	-1.7
Lung FEV1/FVC ratio	0.6	3.1	8.1	2.1	2.3	1.1	2.5	2.8	-0.3	1.0	2.7	1.4	-1.3	1.6	1.2	0.5	2.0	0.3	2.5	-1.6	-1.0
Lung FVC	0.5	2.5	5.9	1.6	1.3	0.2	2.3	2.4	1.0	2.4	1.7	1.9	2.2	1.0	1.2	0.2	1.3	1.2	1.2	-2.1	0.4
Neuroticism	0.6	1.4	3.1	0.3	-1.1	-1.0	-1.2	-1.4	-0.3	-1.4	-1.5	-1.1	-1.7	-1.0	-1.5	-0.4	-0.9	-1.8	-0.8	1.8	-0.7
Chronotype (morning person)	1.0	2.4	6.3	2.2	1.7	-1.4	2.5	1.2	-0.2	2.1	1.9	1.3	1.7	0.1	1.6	-0.9	0.9	2.0	1.8	-0.5	-1.3
Hair Pigment	0.1	1.5	6.6	0.4	-0.4	-1.0	-0.3	1.5	-2.1	-1.4	-0.8	0.4	-0.4	-0.4	-0.9	-1.7	-0.6	-0.9	-0.4	-2.2	2.6
Tanning	0.1	1.1	2.8	-0.1	-1.5	-0.2	-0.5	-0.9	-1.0	-1.0	-1.5	-0.7	-0.3	-0.7	-1.2	-1.3	-1.5	-1.0	-1.7	1.1	-0.1
Hand grip strength (left)	0.9	2.3	11.1	-1.3	-2.0	-0.3	-2.4	-1.7	-1.5	-3.3	-1.7	-1.3	-0.8	-0.7	-0.5	-0.4	-1.3	-1.0	-1.8	1.1	0.2
Number of treatments/medications taken	2.0	3.6	7.1	2.2	1.7	0.9	1.4	2.6	2.6	2.7	1.6	1.0	0.1	2.6	2.4	1.9	0.9	1.6	2.1	-2.1	-1.3
Average weekly spirits intake	1.1	1.4	4.7	1.5	-1.1	1.3	-0.4	-0.7	1.4	1.6	0.1	-0.7	1.3	-0.4	1.0	1.8	0.2	2.2	-1.0	1.1	0.8
Sensitivity / hurt feelings	1.2	2.0	6.5	-0.9	-1.3	-1.9	0.0	-2.0	0.8	-0.1	-1.6	-1.8	0.1	-1.1	-1.4	-0.3	-1.2	-1.4	-1.0	2.5	-2.5
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.2	-0.8	-0.9	-1.0	-0.9	-0.0	-0.9	-0.8	-1.0	-1.1	-1.1	-0.0	-0.9	-0.6	-1.5	-0.6	-0.7	0.0	0.5
Hearing difficulty/problems: Yes	0.6	0.9	6.4	0.2	-0.8	-0.9	-1.5	-0.2	-0.4	0.3	-0.5	-0.4	-2.5	-0.0	-1.5	-0.2	-0.9	-1.4	-0.6	0.2	-0.2
Relative age of first facial hair	0.7	1.5	4.0	-1.7	-0.4	-0.9	-1.9	-1.3	-2.0	-1.4	-0.7	-0.1	-1.1	-1.8	-1.6	-1.7	-0.6	-1.2	-0.2	0.5	-0.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.2	-0.6	-0.8	1.7	-0.5	-0.3	1.8	-0.0	-0.9	-0.8	-0.2	1.4	0.1	1.0	-0.5	-0.1	-0.6	0.4	-1.1
Ever used hormone-replacement therapy (HRT)	0.2	0.2	1.8	0.4	0.4	-0.3	0.3	-0.1	-0.1	0.2	0.6	0.3	0.1	-0.8	-0.3	-1.3	0.1	0.2	0.5	0.4	-0.4
Ever had hysterectomy (womb removed)	1.5	1.7	6.0	1.0	1.6	0.9	1.2	2.4	0.6	0.6	1.0	1.0	0.2	2.1	1.0	-0.0	0.6	0.0	1.9	-2.5	0.0
Systolic blood pressure, automated reading	0.4	1.1	7.5	1.2	0.3	0.1	0.7	-1.1	1.8	1.2	0.2	-0.5	0.0	1.0	0.6	1.0	0.7	-0.0	0.2	0.7	-2.7
Eye problems/disorders: Diabetes related eye disease	3.4	3.7	7.6	1.7	2.3	2.3	1.8	0.1	1.8	1.7	2.4	1.8	2.1	1.4	2.3	2.0	2.8	2.5	2.1	0.6	-1.3
Angina	8.8	11.6	28.6	5.3	2.6	3.0	3.6	4.6	1.9	3.7	2.7	3.0	1.2	4.3	4.2	3.1	2.7	3.8	3.2	-4.2	0.1
Medication for hormone replacement therapy	0.4	0.4	1.0	0.8	0.9	0.4	0.4	0.2	-0.2	0.5	0.8	0.2	1.0	-0.2	0.6	-0.9	-0.1	1.0	0.8	-0.7	-0.3
Vitamin and mineral supplements	1.3	1.8	10.2	-1.5	0.3	1.4	-0.9	-1.4	-1.9	-2.2	0.4	-0.2	-0.3	-3.2	-0.8	-1.6	-0.3	0.4	0.0	0.6	1.6
Supplements: Zinc	0.6	0.6	3.3	-0.8	-0.2	1.0	0.4	0.8	0.1	-0.3	0.4	0.5	1.4	1.8	1.0	0.9	0.3	-0.4	-0.3	-0.8	0.1
Medication: Co-codamol	0.7	0.8	2.2	-1.5	-0.3	0.7	-0.5	-0.7	-0.8	-1.4	-0.8	-1.2	-0.1	-1.3	-0.6	-1.4	-1.4	0.1	-0.2	-0.2	1.0
Medication: Metformin	2.0	2.9	5.9	2.4	2.3	1.5	2.0	1.0	0.0	2.1	2.1	2.4	0.6	1.0	1.7	0.9	2.4	1.6	2.3	-0.7	0.0
Diabetes (father)	1.9	2.4	6.2	1.7	2.5	0.5	1.3	2.0	1.1	0.4	2.4	2.3	-0.9	1.1	0.9	0.0	2.0	0.4	2.1	-2.0	0.4
Diabetes (mother)	1.5	1.9	5.6	1.3	1.6	-1.5	2.1	0.9	0.1	1.8	1.6	1.9	0.3	0.7	0.5	-0.8	1.7	-0.0	1.8	0.7	-2.4
Severe depression (siblings)	0.4	0.4	1.4	-0.8	0.2	-0.2	-0.2	-0.8	0.4	-0.2	0.6	0.9	-0.5	-1.2	-1.0	-0.4	1.1	-0.3	0.4	0.9	-0.0
Pack years adult smoking proportion	0.3	0.5	3.1	-0.6	-0.6	-1.8	0.1	0.5	-0.7	0.2	-0.1	0.5	-1.3	0.6	-0.6	-0.1	-0.1	-1.2	-0.3	0.0	-0.4
Impedance of leg (right)	1.0	5.0	9.5	0.7	2.5	0.7	3.1	2.3	3.0	2.6	2.8	2.5	1.5	2.8	2.1	1.4	2.4	1.1	2.7	-2.1	-2.0
Leg fat-free mass (left)	5.6	29.7	58.2	-4.7	-6.1	-2.1	-7.6	-6.3	-5.5	-6.6	-6.3	-5.8	-4.1	-6.4	-5.7	-3.6	-5.8	-3.7	-6.2	5.1	3.3
Trunk fat percentage	3.5	13.8	27.2	-4.4	-3.8	-1.9	-4.9	-4.1	-2.8	-3.1	-4.0	-3.8	-2.9	-5.2	-4.7	-3.0	-4.0	-2.9	-3.9	4.0	1.2
Hand grip strength (right)	2.4	6.7	24.5	-1.9	-3.4	-0.4	-3.8	-2.7	-2.1	-4.9	-2.7	-2.4	-2.0	-2.3	-1.8	-0.8	-2.5	-1.6	-3.3	2.3	1.4
Townsend deprivation index at recruitment	0.1	0.2	1.3	-0.9	0.5	0.4	-0.1	-0.1	0.1	0.1	0.3	0.6	1.1	-0.0	0.0	-0.4	0.2	0.4	0.3	-0.5	0.2
Current tobacco smoking	0.5	0.9	2.0	-1.1	-1.3	-1.2	-1.1	-0.5	-0.5	-0.9	-0.6	-0.6	-1.1	-1.2	-0.9	-0.1	-0.8	-0.1	-1.4	0.6	1.3
Average weekly fortified wine intake	0.4	0.5	1.7	0.3	0.1	0.2	-0.8	0.8	0.5	-0.5	0.2	-0.3	-1.2	1.0	-0.1	0.9	0.2	-1.3	-0.2	-0.5	0.8
Maternal smoking around birth	0.8	1.2	4.1	-0.1	-0.8	0.4	-1.8	0.4	-1.7	-2.0	-0.9	0.4	-1.5	-0.7	-1.0	-1.4	-0.4	-1.1	-0.9	-0.6	1.2
Fed-up feelings	1.1	1.9	4.5	-1.9	-1.6	-1.6	-1.8	-1.2	-0.3	-1.5	-1.5	-2.1	-0.8	-1.4	-1.3	0.4	-1.7	-1.1	-1.6	1.2	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.6	-1.1	-1.3	-1.0	-1.5	-1.2	-0.8	-0.7	-1.4	-1.8	-1.2	-0.9	-1.4	-0.5	-1.9	-0.8	-1.1	0.8	0.6
Relative age voice broke	0.2	0.3	1.1	-0.7	0.1	0.9	-0.8	0.0	0.1	-1.1	0.2	0.2	-0.5	-1.0	-0.8	-0.6	-0.1	-0.6	-0.1	-0.5	0.1
Taking other prescription medications	0.8	1.3	5.2	1.0	0.5	0.7	0.9	0.9	2.3	1.9	0.5	0.1	-1.1	1.4	0.9	1.8	0.6	0.3	0.6	-0.1	-1.5
Age when periods started (menarche)	0.2	0.4	1.4	-0.5	-1.1	-0.7	-0.9	-0.1	0.7	0.7	-0.2	-0.7	-1.2	0.3	-0.3	0.4	-0.9	0.3	-0.9	0.0	-0.3
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	5.0	2.2	0.9	0.4	0.9	1.6	-0.5	-0.4	1.3	0.9	0.1	1.5	1.2	-0.7	0.6	0.5	1.0	-1.3	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.9	-1.3	0.2	0.3	-0.3	-1.3	0.1	-1.7	0.5	0.2	-0.5	-0.3	0.3	-0.9	0.4	0.7	0.3	0.3	-0.9
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	3.4	0.9	0.7	1.4	0.3	0.8	-0.1	0.2	0.3	0.7	1.8	1.1	1.2	0.7	0.8	0.6	0.6	0.0	0.6
Qualifications: CSEs or equivalent	0.3	0.4	2.0	0.9	0.3	-0.8	0.3	1.0	-0.5	0.2	-0.0	-0.1	-0.9	0.9	0.0	-0.5	-0.9	-0.7	0.3	-1.4	0.2
Serious illness, injury or assault to yourself	1.9	2.3	5.2	1.2	2.1	1.2	1.1	1.4	0.9	2.0	1.5	1.1	1.1	2.0	2.0	1.1	1.3	1.0	2.0	-2.3	0.3
High blood pressure	0.8	2.2	8.9	3.0	1.7	0.7	1.1	1.0	1.4	1.2	1.3	1.2	-0.8	2.5	1.2	0.6	1.2	0.4	1.6	-1.7	-1.8
Hayfever, allergic rhinitis or eczema	2.0	4.3	8.2	2.9	2.7	1.1	2.2	1.6	1.2	1.8	2.5	1.5	2.5	1.7	2.5	1.5	2.5	2.6	2.6	-1.6	-0.3
Multivitamins +/- minerals	1.9	2.4	10.2	2.7	0.5	-1.4	1.9	2.3	0.7	2.3	0.4	0.8	0.8	3.2	1.7	1.5	0.8	0.2	0.7	-0.6	-1.1
Stomach or abdominal pain in last month	1.3	1.6	6.5	0.4	0.8	0.4	0.9	0.3	2.5	1.5	1.3	1.0	0.2	1.2	1.5	2.6	1.8	1.1	0.8	0.3	-0.8
Supplements: Glucosamine	1.1	1.4	4.6	1.6	0.9	1.4	1.7	1.1	-0.0	0.5	1.3	1.4	2.1	0.2	1.0	0.5	2.0	0.8	0.9	-0.1	0.9
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	7.7	0.0	0.9	-1.3	-0.2	1.8	-2.0	-0.4	-0.1	1.5	-2.4	0.1	-1.5	-1.8	0.5	-2.8	0.9	-1.7	0.7
Medication: Atenolol	0.9	1.1	6.4	2.5	0.2	1.1	0.3	1.1	0.9	1.9	0.3	0.2	-0.3	1.2	0.8	0.3	-0.1	1.4	0.4	-0.8	-1.0
Medication: Levothyroxine sodium	0.4	0.7	3.8	0.3	0.2	1.9	-0.1	0.5	0.7	0.9	-0.3	-0.1	0.5	1.6	0.6	1.5	0.2	-0.2	0.4	0.1	-0.9
Sitting height	3.1	22.1	50.3	-4.6	-5.5	-1.7	-6.5	-5.0	-3.8	-7.1	-5.1	-4.7	-2.7	-5.5	-4.6	-4.1	-5.2	-2.9	-5.5	3.6	3.2
Chronic bronchitis/emphysema (father)	3.1	3.6	9.4	-2.9	-1.5	-0.3	-2.8	-3.1	0.1	-1.9	-1.9	-1.9	-0.7	-2.3	-1.8	-0.9	-1.6	-0.9	-1.9	2.2	-2.0
High blood pressure (mother)	0.9	1.3	4.4	-1.2	-0.4	-1.9	-0.6	-1.2	-0.2	-1.2	-0.4	-0.9	-0.9	0.0	-0.6	-1.7	-1.3	-0.9	-0.5	1.2	-2.1
Body mass index (BMI)	1.8	7.7	16.0	-2.5	-2.5	-1.6	-3.5	-3.3	-2.9	-2.3	-3.3	-2.7	-2.6	-4.0	-3.6	-2.1	-2.5	-2.4	-2.6	3.2	0.7
Impedance of leg (left)	0.7	3.4	8.4	0.6	1.8	0.6	2.5	2.1	2.9	1.9	2.4	2.0	1.6	2.1	1.7	0.7	1.8	0.9	1.9	-2.0	-1.4
Leg predicted mass (left)	5.7	30.3	59.7	-4.8	-6.1	-2.3	-7.7	-6.4	-5.4	-6.6	-6.4	-5.9	-4.2	-6.4	-5.7	-3.7	-5.9	-3.8	-6.3	5.1	3.3
Trunk fat mass	5.1	21.9	40.4	-5.0	-5.0	-2.0	-6.4	-5.3	-3.6	-4.6	-5.3	-4.9	-3.7	-6.1	-5.5	-3.3	-5.0	-3.5	-5.2	4.7	1.9
Waist circumference	0.3	1.2	3.5	-0.8	-0.7	0.2	-1.9	-1.2	-0.7	-1.2	-1.4	-0.4	-1.2	-1.8	-1.2	-0.6	-0.4	-0.7	-0.8	1.2	1.2
Number of incorrect matches in round	0.4	0.7	2.7	0.8	0.9	0.3	1.2	1.0	0.3	1.5	0.3	1.6	0.4	0.2	0.6	0.7	0.9	0.3	0.5	-1.3	0.3
Past tobacco smoking	0.4	0.7	1.6	0.2	1.1	-0.2	1.1	1.1	0.8	1.3	1.1	0.6	0.4	0.7	1.0	0.9	1.1	0.3	1.0	-0.7	-0.5
Alcohol usually taken with meals	0.2	0.4	1.7	1.3	-0.1	-0.3	0.4	-0.2	0.6	0.6	-0.3	0.2	0.6	0.2	1.0	0.9	0.4	1.2	0.0	0.4	0.1
Nervous feelings	0.5	0.9	7.2	0.9	-0.3	-1.0	-0.2	-0.8	1.6	0.7	-0.6	-0.4	0.0	0.6	-0.1	0.4	-0.0	-0.7	-0.4	1.0	-2.7
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	5.8	-1.2	-1.6	-2.0	-1.5	-2.4	-1.1	-1.2	-1.8	-2.2	-0.6	-1.1	-1.3	-0.6	-2.1	-0.3	-1.5	1.9	-0.9
Hearing difficulty/problems with background noise	0.1	0.2	0.9	0.4	-0.0	-0.3	-1.0	-0.6	-0.5	-0.7	0.1	0.5	-0.3	-0.3	-0.5	-0.1	0.2	-0.0	-0.0	0.4	0.6
Hair/balding pattern: Pattern 2	1.5	1.9	6.6	1.8	1.0	0.0	1.6	2.5	0.3	0.6	1.8	1.2	1.0	1.3	1.5	0.1	0.8	0.6	0.9	-2.6	1.7
Had menopause	1.5	1.8	6.3	0.8	1.6	0.9	0.8	0.9	1.6	2.0	1.5	0.8	2.5	-0.3	1.3	0.8	1.3	2.2	1.5	-0.9	0.1
Had other major operations	0.3	0.4	2.9	-0.0	0.5	-1.7	-0.5	0.5	-0.1	0.5	0.4	-0.2	-1.3	0.7	-0.1	-0.1	-0.2	-0.6	0.5	-0.4	-0.2
Forced vital capacity (FVC)	0.5	1.8	6.0	-1.2	-1.7	0.4	-1.5	-1.1	-1.5	-2.4	-1.0	-0.8	-0.5	-1.2	-1.1	-1.8	-1.3	-1.1	-1.7	-0.5	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.5	-1.3	-0.7	-0.2	-1.1	-1.5	0.0	-1.6	-0.4	-0.4	-1.2	-1.2	-0.7	-1.3	-0.4	0.4	-0.5	0.7	-0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.9	1.4	0.7	-0.4	0.8	0.5	0.6	1.5	0.4	1.3	-0.8	1.8	0.5	1.0	1.4	0.2	1.0	0.1	-2.0
Qualifications: None of the above	0.3	0.7	2.5	0.1	1.0	-0.9	-0.1	1.5	-1.3	0.7	0.3	1.2	-0.9	0.6	-0.3	-0.5	0.1	-0.4	1.0	-1.6	0.8
Financial difficulties in last 2 years	0.6	0.9	3.4	0.4	1.2	-1.6	0.2	0.1	-0.6	1.0	1.4	0.1	0.6	-1.3	0.8	-0.6	0.5	1.9	1.1	-0.2	0.5
Mouth/teeth dental problems	0.3	0.5	1.9	-0.7	-1.2	-0.3	-0.6	-0.1	-0.9	-0.6	-1.4	-0.3	-0.5	0.1	-0.6	0.4	-0.5	-0.8	-1.4	0.4	0.5
Heart attack	7.2	9.2	34.2	5.8	2.2	1.8	4.0	4.9	0.1	3.1	2.0	2.7	1.1	4.0	3.1	1.7	1.7	2.7	2.8	-3.8	1.0
Allergy	1.2	2.8	6.2	-2.1	-2.5	-0.6	-1.5	-0.8	-0.3	-1.6	-2.2	-1.2	-2.2	-1.0	-2.0	-0.6	-1.9	-2.4	-2.3	1.2	0.6
Pain all over the body in last month	0.6	0.6	3.6	0.9	0.4	-1.4	0.8	-0.3	1.1	1.0	0.3	-0.8	-0.1	0.1	-0.1	0.5	0.0	-0.4	0.2	0.1	-1.9
Diabetes (self-reported)	3.5	5.4	8.6	2.8	2.7	2.6	2.9	1.3	2.0	2.0	2.7	2.6	0.8	2.5	2.9	1.9	2.8	2.5	2.8	-0.7	-1.1
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	5.3	2.0	1.8	0.5	2.3	1.9	-0.9	1.4	1.6	1.4	-0.3	0.7	0.1	-0.1	1.4	-0.2	1.8	-0.7	0.1
Medication: Ramipril	5.3	6.8	18.1	3.3	2.6	2.7	2.4	3.8	1.0	0.9	2.3	3.2	-0.2	4.3	2.7	1.9	2.0	2.0	2.9	-3.5	1.2
Medication: Simvastatin	4.7	7.0	18.8	4.1	2.6	0.2	2.9	4.3	0.8	2.9	1.6	2.9	1.7	3.5	3.0	0.4	1.3	1.9	3.1	-3.8	0.6
Fluid intelligence score	1.0	2.1	11.7	-1.6	-2.1	-0.6	-1.5	-2.0	0.9	-0.7	-1.7	-0.7	0.2	-1.1	-0.7	0.9	-0.4	-0.1	-2.0	3.4	-0.3
Illnesses of siblings	2.8	3.9	9.4	-2.9	-2.1	-1.2	-2.7	-2.7	-0.8	-1.1	-1.9	-1.9	-1.4	-2.6	-2.1	-0.4	-0.7	-2.1	-2.2	3.1	-0.2
Neuroticism score	1.0	2.0	3.9	-0.5	-1.5	-1.6	-1.7	-1.4	0.0	-1.6	-1.8	-1.6	-1.5	-0.9	-1.5	-0.1	-1.4	-1.9	-1.3	2.0	-0.7
Weight	5.2	25.6	49.0	-4.8	-5.4	-1.9	-7.0	-5.9	-4.5	-5.8	-5.9	-5.1	-4.0	-6.5	-5.7	-3.6	-5.1	-3.8	-5.6	4.9	2.7
Impedance of arm (right)	0.3	1.3	3.1	-0.9	1.1	0.9	1.1	1.1	1.8	1.2	1.4	1.5	1.4	1.2	0.7	0.5	1.2	0.4	1.2	-1.0	-0.5
Arm fat percentage (right)	1.9	7.4	13.7	-3.3	-2.5	-1.4	-3.5	-3.3	-2.0	-1.8	-3.2	-2.5	-2.3	-3.6	-3.7	-1.8	-2.4	-2.6	-2.6	3.4	0.2
Trunk fat-free mass	4.4	25.1	51.1	-3.9	-6.1	-1.3	-7.2	-5.9	-4.2	-6.8	-6.1	-5.3	-4.2	-5.1	-4.9	-2.9	-5.3	-3.5	-6.2	4.1	2.9
Hip circumference	5.2	22.2	40.7	-5.4	-4.7	-1.8	-6.4	-6.0	-3.9	-4.8	-5.5	-4.7	-3.4	-6.2	-5.6	-3.3	-4.7	-3.4	-5.0	4.7	2.4
Time employed in main current job	0.7	0.8	2.7	0.5	1.0	0.9	0.9	1.2	0.3	0.5	0.9	1.7	1.0	0.0	0.5	0.1	0.9	0.6	0.7	-1.4	1.3
Alcohol intake versus 10 years previously	1.2	1.9	4.4	0.6	1.8	-0.2	2.1	1.8	0.5	1.6	1.6	1.4	1.4	1.1	1.4	0.7	1.0	1.0	1.8	-1.9	-0.5
Father’s age at death	1.3	1.8	5.6	-1.6	-2.0	1.2	-1.2	-1.4	1.0	-1.5	-1.8	-1.0	0.6	-0.4	-1.3	-0.2	-0.7	-1.5	-2.4	1.8	-0.1
Worrier / anxious feelings	0.2	0.3	1.9	0.9	-0.3	-0.8	-0.3	0.2	-0.3	-1.4	-0.5	0.3	-0.5	0.4	-0.3	0.1	-0.3	-0.9	-0.1	0.6	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.0	-0.7	-0.2	-0.5	-0.7	-0.5	-0.0	-0.6	-0.5	-0.4	-0.2	-1.0	-0.6	-0.3	-0.7	-0.2	-0.2	0.6	-0.3
Falls in the last year	1.0	1.3	6.2	-0.8	-0.7	-0.7	-0.7	-0.8	-2.2	-0.4	-0.7	-1.2	-0.5	-0.9	-1.3	-2.5	-1.6	-1.3	-0.7	0.1	-0.8
Hair/balding pattern: Pattern 3	0.3	0.4	3.4	-0.4	0.2	0.7	0.0	-1.8	0.3	0.1	0.2	0.5	-0.1	-0.6	-0.4	-0.3	0.7	0.9	0.4	0.8	-0.7
Number of live births	0.4	0.6	1.9	-0.4	1.0	-0.6	0.3	0.6	-0.4	0.1	1.2	1.2	-0.4	1.1	0.4	-0.6	0.7	0.1	1.4	-1.4	0.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.8	-0.8	-1.3	0.1	-0.8	-0.3	-1.5	-1.6	-0.7	-0.7	-0.6	-0.8	-1.1	-1.7	-1.0	-1.3	-1.2	-0.5	1.2
Pulse rate	1.2	2.0	5.1	0.8	2.3	0.3	2.0	1.7	0.1	1.1	1.6	1.8	2.0	0.1	0.8	0.4	2.1	0.6	1.9	-1.3	1.0
Happiness	0.2	0.2	1.0	1.0	0.2	0.6	-0.5	0.3	0.8	-0.1	0.6	-0.1	-0.3	0.5	-0.0	0.5	0.0	-0.0	-0.2	-0.4	0.6
Noisy workplace	0.8	1.0	4.0	1.5	2.0	-0.0	1.2	0.5	-1.2	0.6	1.2	0.8	-0.6	-0.2	-0.2	-0.0	1.1	-0.7	1.7	-0.0	-0.7
Qualifications: A levels/AS levels or equivalent	0.6	1.2	4.5	0.4	-0.1	1.8	0.4	-1.3	2.1	0.3	1.0	0.1	1.2	0.4	0.9	1.5	1.4	1.5	-0.0	1.5	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.9	3.4	-1.9	-1.2	0.9	-0.4	-0.5	-0.3	-1.6	-1.1	-1.0	-0.4	0.2	-0.7	-0.6	-1.1	-0.7	-1.2	0.3	-0.2
Mouth/teeth dental problems: Dentures	0.1	0.2	1.1	0.4	0.6	0.7	-0.0	-0.0	-0.3	0.3	0.4	0.1	1.0	-0.4	-0.1	-1.0	0.1	0.1	0.5	-0.0	0.0
Asthma	0.2	0.3	1.1	-0.9	0.6	-0.3	-0.5	-1.1	-0.7	0.7	-0.4	-0.4	0.8	-0.4	0.2	-0.3	-0.1	0.4	0.3	-0.2	-0.5
Medication: Ibuprofen (e.g. Nurofen)	3.1	4.0	11.9	-3.4	-2.1	-0.4	-2.1	-2.8	-1.0	-2.1	-2.4	-2.1	0.6	-2.6	-1.8	-1.3	-1.8	-1.3	-2.2	2.4	0.2
Medication: Cholesterol lowering	4.2	6.5	18.8	4.1	1.6	0.1	2.7	4.3	0.4	3.1	0.8	2.6	0.9	3.7	2.9	1.1	0.7	2.8	2.3	-4.0	1.2
Depression (self-reported)	0.5	0.6	2.0	0.5	1.1	0.1	0.2	-0.1	0.3	-0.0	1.3	0.1	-0.5	0.8	0.7	-0.6	-0.3	1.1	1.4	-1.0	-1.1
Medication: Lansoprazole	3.7	4.2	9.0	3.0	3.0	0.9	2.5	2.8	0.9	1.8	2.1	2.0	1.0	2.4	1.5	0.7	2.0	1.4	3.0	-2.4	-0.5
Prospective memory result	0.9	1.1	3.5	0.5	0.4	-0.8	0.2	1.8	-1.7	0.0	-0.4	-0.3	0.7	0.3	-0.5	-1.8	-1.3	-0.8	0.3	-1.9	1.4
Lung cancer (father)	3.7	4.3	11.1	-2.2	-2.4	-0.3	-3.3	-2.9	0.3	-2.2	-1.5	-2.9	-1.4	-2.7	-1.6	-0.4	-2.3	-0.4	-2.6	2.8	0.5
Illnesses of mother	1.2	1.4	5.0	-1.3	-1.5	0.6	-1.2	-0.6	-1.2	-0.8	-1.5	-0.8	0.0	-1.7	-1.5	0.0	-0.5	-1.1	-1.6	0.7	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.7	-0.5	-0.7	0.2	-0.3	0.0	-0.1	-0.8	-0.2	-0.5	-0.6	-0.1	-0.4	-0.3	-0.5	-0.9	-0.7	-0.4	0.3
Pulse wave Arterial Stiffness index	1.4	1.6	4.6	-0.1	-1.0	-0.4	-0.7	-0.8	-1.1	-1.9	-0.6	-0.8	-1.4	-2.1	-2.1	-1.2	-0.7	-1.2	-1.0	1.8	1.2
Impedance of arm (left)	0.3	1.5	4.9	-0.6	1.2	1.0	1.1	1.4	2.2	1.4	1.9	1.3	1.2	1.3	0.9	0.6	1.0	0.8	1.2	-1.3	-0.3
Arm fat mass (right)	4.0	16.4	29.9	-4.3	-4.2	-1.9	-5.5	-4.8	-3.5	-4.0	-4.8	-4.0	-3.2	-5.1	-4.9	-2.9	-3.9	-3.5	-4.3	4.3	1.3
Trunk predicted mass	4.3	24.4	50.4	-3.8	-6.0	-1.2	-7.1	-5.8	-4.2	-6.8	-6.0	-5.2	-4.1	-5.1	-4.8	-2.9	-5.3	-3.4	-6.2	4.1	2.9
Standing height	3.3	33.0	70.9	-5.7	-7.2	-0.9	-8.4	-6.6	-4.0	-8.4	-6.5	-6.0	-3.6	-6.0	-5.3	-3.6	-6.1	-3.5	-7.3	4.5	4.2
Length of working week for main job	0.2	0.3	1.0	0.4	0.0	0.1	0.7	-0.4	-0.7	-0.4	0.8	-0.4	-0.4	-0.4	0.0	0.6	0.0	0.4	0.3	0.6	-1.0
Exposure to tobacco smoke at home	0.7	0.8	3.2	0.3	-0.2	0.3	0.8	0.2	1.1	1.8	0.3	0.3	1.7	1.3	1.1	1.3	0.5	1.0	-0.0	-0.4	-0.4
Breastfed as a baby	1.8	2.2	11.3	0.0	-1.7	-0.3	-1.1	-3.4	0.7	-0.2	-1.2	-2.2	0.1	-1.7	-1.1	1.2	-0.7	-0.0	-1.8	2.7	-0.9
Tense / ‘highly strung’	0.2	0.3	0.8	0.4	0.7	-0.1	0.4	0.1	0.6	0.5	0.9	0.2	-0.1	0.0	0.4	0.5	0.4	0.4	0.7	0.7	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.4	-0.4	-1.3	-0.8	-1.3	-0.6	-0.2	-1.5	-0.5	-0.4	-0.9	-0.5	-0.6	-0.7	-0.9	-0.6	-1.3	0.6	0.7
Hair/balding pattern: Pattern 4	0.9	2.2	5.0	-1.2	-2.0	-0.7	-2.2	-0.7	-0.6	-1.3	-1.9	-2.1	-1.9	-1.0	-1.1	-0.3	-2.1	-1.4	-2.0	1.2	0.9
Birth weight of first child	0.8	1.5	7.3	-0.7	-0.8	1.4	-0.9	-1.1	-1.2	-0.9	-0.6	-0.6	-0.2	-2.7	-0.7	-0.1	-0.7	0.6	-1.0	1.3	2.6
Peak expiratory flow (PEF)	0.2	0.4	1.0	0.4	-0.8	0.1	-0.1	0.7	-1.0	-0.2	-0.6	-0.6	-0.4	-0.1	-0.7	-0.6	-0.7	-0.9	-0.5	-0.0	0.9
Pulse wave reflection index	9.3	11.5	19.7	-3.0	-3.6	-2.4	-3.1	-3.4	-3.6	-4.4	-3.5	-3.0	-3.7	-3.1	-4.4	-3.2	-3.6	-3.7	-3.5	3.5	0.6
Ever highly irritable/argumentative for 2 days	2.4	2.9	7.1	-0.9	-2.6	-2.5	-2.0	-0.8	0.2	0.6	-1.8	-2.2	-1.9	-1.3	-1.9	-0.4	-2.4	-1.2	-2.7	1.5	-0.1
Loud music exposure frequency	0.9	0.9	3.5	1.0	0.3	0.9	0.7	0.5	0.6	0.8	1.2	0.6	1.1	1.8	1.7	0.2	0.5	1.9	0.3	-0.3	-0.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	4.5	-0.9	-1.7	0.4	-1.0	-2.1	1.0	-0.3	-1.1	-1.9	1.1	-0.1	-0.4	0.6	-0.7	0.1	-1.8	1.8	-1.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	5.0	1.1	1.3	1.0	0.5	0.0	1.8	-0.0	2.2	0.5	0.7	0.4	1.6	0.5	0.9	1.9	1.6	-0.7	-0.3
Blood clot in the leg (DVT)	0.3	0.3	1.2	0.3	-0.4	-0.2	0.3	-0.2	-0.2	1.0	-0.2	-0.9	0.7	-0.7	0.0	-0.4	-0.4	1.1	-0.5	0.9	-0.1
Medication: Paracetamol	0.5	0.9	6.0	-1.3	-0.4	-1.9	0.1	-1.0	1.1	0.5	0.0	-0.5	-0.0	0.1	0.0	0.4	0.2	-0.1	-0.2	1.2	-2.4
Headache pain in last month	1.5	2.6	8.1	-2.8	-2.8	-0.8	-1.2	-2.0	0.4	-0.8	-1.7	-2.1	0.0	-1.0	-0.5	0.3	-2.0	-0.1	-2.6	2.3	-0.4
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	8.5	-1.7	-0.5	0.1	-0.9	-1.9	-1.2	-1.8	-0.1	-1.4	0.3	-2.9	-1.6	-1.6	-0.3	-1.4	-1.0	1.9	-0.2
Glaucoma (self-reported)	0.4	0.5	1.7	-1.0	0.3	-0.0	0.3	-0.3	0.5	0.3	0.3	-0.2	1.3	-1.2	0.6	1.1	0.3	0.8	0.2	0.5	1.0
Gout (self-reported)	0.5	0.7	2.2	0.4	0.1	-1.0	1.4	1.3	0.7	1.0	-0.2	0.6	-0.2	1.3	0.3	1.5	0.8	-0.9	0.2	-0.9	-0.6
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	7.2	0.1	0.6	2.7	0.1	0.8	0.4	0.5	0.4	0.2	1.0	1.6	1.4	1.2	0.3	0.8	0.6	-0.7	-0.5
Medication: Amlodipine	0.3	0.4	1.8	0.7	0.7	-1.2	0.4	-0.5	0.2	0.7	0.0	0.3	1.3	0.3	0.5	-0.3	0.3	0.3	0.7	-0.2	-0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.8	0.1	0.7	-0.3	1.0	-0.3	0.5	1.3	0.1	-0.1	1.0	0.1	0.5	0.7	0.4	0.4	0.6	-0.1	-0.2
Birth weight	0.9	1.9	13.0	0.5	-0.8	2.0	-0.8	-1.0	-1.3	-2.8	-0.5	0.0	-0.5	-1.5	0.4	-0.3	-0.4	1.1	-0.8	0.8	3.6
Chronic bronchitis/emphysema (mother)	0.5	0.6	3.0	-1.1	-0.9	-0.0	-1.1	-1.7	0.6	0.2	-0.3	-0.9	0.4	-1.0	-0.2	0.1	-0.5	0.4	-1.0	0.6	-0.5
High blood pressure (siblings)	0.6	0.9	2.2	1.5	1.2	-0.0	1.0	0.7	-0.1	-0.7	0.6	1.4	-0.7	1.4	0.4	-1.2	0.1	0.1	1.3	-1.2	-1.0
Forced vital capacity (FVC), Best measure	0.3	0.9	2.6	-1.2	-1.4	0.3	-1.2	-1.1	-0.2	-1.6	-1.0	-0.9	-0.6	-0.7	-0.7	-0.6	-1.1	-1.0	-1.5	-0.2	0.6
Body fat percentage	2.5	9.8	20.7	-3.7	-3.2	-1.7	-3.9	-3.5	-2.1	-2.1	-3.6	-3.3	-2.4	-4.5	-4.1	-2.2	-3.2	-2.5	-3.3	3.7	0.7
Leg fat percentage (right)	0.7	2.7	7.1	-1.7	-1.2	-1.3	-1.8	-2.2	-0.9	-0.1	-2.0	-1.6	-1.6	-2.7	-2.4	-0.6	-1.1	-1.6	-1.3	2.5	-0.4
Arm fat-free mass (right)	4.6	23.6	46.4	-3.4	-5.5	-2.0	-6.8	-5.5	-4.9	-6.3	-5.6	-5.3	-4.1	-5.6	-4.7	-3.5	-5.4	-3.0	-5.7	4.1	3.0
Exposure to tobacco smoke outside home	0.8	1.1	4.8	0.7	-0.2	-0.5	-0.7	-1.5	-1.5	-0.5	-0.3	-0.7	0.2	-1.9	-0.8	-2.2	-0.9	1.3	-0.2	1.1	0.7
Comparative body size at age 10	1.3	3.5	7.6	-1.6	-1.9	-1.6	-1.9	-1.1	-2.1	-2.8	-2.6	-1.9	-1.5	-1.6	-2.0	-0.8	-2.5	-2.3	-2.1	0.3	1.3
Number of full brothers	0.3	0.4	1.8	-0.2	-0.2	-1.4	-0.8	0.3	0.6	0.5	-0.2	-0.5	-1.1	0.1	-0.5	0.5	-0.7	-0.8	-0.0	-0.3	-0.4
Worry too long after embarrassment	0.8	1.3	3.9	-0.2	-1.3	-2.0	-1.2	-0.0	0.1	-0.9	-1.6	-1.0	-1.7	-0.3	-1.5	-0.4	-1.1	-1.8	-1.1	1.0	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.2	0.9	-0.3	0.1	-0.7	-0.5	0.8	1.2	0.2	0.4	-0.9	1.6	0.7	1.8	0.9	0.2	-0.2	1.1	-1.7
Wheeze or whistling in the chest in last year	0.3	0.6	1.9	-1.4	-0.7	0.1	-0.8	-1.0	-0.2	0.8	-1.1	-0.9	0.6	-0.8	-0.4	0.8	-0.3	-0.5	-0.9	1.1	-0.0
Number of children fathered	1.1	1.2	3.8	-1.9	-1.2	-0.8	-0.5	-0.3	-1.9	-1.0	-1.0	-0.6	-0.5	-0.8	-1.4	-1.6	-1.1	-1.3	-1.0	0.8	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	2.2	-0.3	0.2	0.2	-0.5	-0.2	-1.2	-1.5	-0.4	-0.6	0.7	-0.3	-0.0	-1.1	-0.8	-0.3	0.5	-0.0	0.1
Age at first live birth	0.2	0.3	1.5	-0.2	-0.4	-0.5	-1.0	-0.2	-0.0	0.9	-0.3	-0.3	-1.1	0.5	-0.1	1.2	-0.1	-0.4	-0.3	0.1	-0.5
Pulse wave peak to peak time	0.9	1.1	3.8	-0.3	0.6	0.3	0.3	0.5	1.0	1.6	0.3	0.4	1.1	2.0	1.8	1.2	0.4	0.9	0.6	-1.5	-1.2
Health satisfaction	2.0	2.7	5.8	1.7	2.3	1.4	1.6	2.4	0.8	1.4	2.3	1.9	-0.9	1.7	1.2	0.2	1.1	1.1	2.2	-2.4	0.0
Shortness of breath walking on level ground	0.8	0.9	3.5	0.0	0.6	0.8	0.3	1.1	0.1	1.5	0.1	-0.9	1.4	0.6	1.2	0.5	-0.7	1.1	0.7	-1.9	1.2
Qualifications: College or University degree	0.3	0.8	2.9	0.2	0.2	1.4	-0.3	-1.1	0.8	1.0	0.6	0.4	0.5	0.2	1.2	1.7	1.1	1.6	0.5	0.8	-0.5
Eye problems/disorders: None of the above	2.2	2.6	5.7	-2.4	-2.0	-0.8	-2.4	-2.0	-0.7	-2.0	-1.9	-1.7	-1.3	-1.2	-1.6	-0.7	-1.4	-1.1	-2.0	1.4	0.4
Mouth/teeth dental problems: Loose teeth	1.4	1.7	5.1	0.8	1.0	-0.7	0.3	1.2	1.4	2.3	1.2	0.6	1.0	1.6	1.9	2.2	1.4	1.0	1.2	-1.3	-0.1
Emphysema/chronic bronchitis	1.2	1.3	3.8	-0.5	-0.8	-0.5	-1.2	-0.5	-2.0	-1.8	-1.0	-0.5	-1.6	-0.5	-1.6	-1.7	-1.4	-1.5	-0.7	-0.0	-0.2
Medication for pain relief, constipation, heartburn	0.6	1.0	2.9	-1.6	-0.2	-0.0	-1.0	-0.7	-1.7	-1.0	-0.5	-0.3	-0.4	-1.1	-1.4	-1.3	-0.7	-1.3	-0.5	-0.0	1.4
Neck or shoulder pain in last month	0.3	0.4	1.8	-0.2	-0.8	-0.1	0.5	-0.4	-0.0	1.1	-0.1	-0.8	0.7	0.2	0.7	0.4	-0.7	0.6	-0.4	1.1	-1.3
Medication: Blood pressure	0.5	0.8	3.7	1.9	0.5	-0.0	0.7	0.6	1.3	0.6	0.6	0.5	-0.4	1.6	1.0	1.4	0.5	1.0	0.6	-0.6	-0.4
Angina (self-reported)	10.0	13.1	33.6	5.8	2.9	3.1	3.9	5.0	1.8	4.0	2.9	3.2	1.2	4.5	4.4	3.1	2.8	4.0	3.5	-4.5	0.1
Migraine (self-reported)	2.5	3.1	11.0	-2.2	-1.5	-0.9	-1.6	-2.7	-1.8	-1.8	-1.5	-1.6	-0.6	-3.3	-1.5	-1.6	-1.4	-0.5	-1.7	2.2	0.5
Medication: Ibuprofen	3.4	4.0	12.6	-3.5	-2.0	0.0	-2.4	-3.1	-0.8	-2.6	-2.5	-1.7	0.4	-2.3	-1.8	-1.0	-1.5	-1.8	-2.1	2.1	0.1
Medication: Allopurinol	1.2	1.6	4.5	1.2	1.2	-0.7	2.1	1.3	1.1	1.6	0.7	0.8	1.5	1.5	1.6	1.8	1.3	0.5	1.1	-0.9	-0.9
Medication: Omeprazole	0.5	0.5	1.4	0.4	0.0	-0.3	0.8	1.2	1.2	1.0	0.0	-0.1	-1.0	1.0	0.4	0.8	0.3	-1.2	0.1	-0.6	-0.7
Medication: Seretide 50 evohaler	0.6	0.7	3.0	-1.7	-0.0	-1.0	-0.8	-1.7	-0.1	0.2	-0.2	-0.7	0.9	-0.4	0.2	0.7	0.0	0.5	-0.1	0.9	-1.5
Mean time to correctly identify matches	0.5	0.9	1.8	1.3	1.2	1.0	1.2	1.0	0.6	0.8	0.9	0.9	0.4	1.3	0.9	0.6	1.0	0.4	1.1	-0.9	-1.2
Heart disease (mother)	11.9	14.5	37.6	6.1	4.2	2.3	4.2	4.8	1.9	4.8	4.1	3.0	1.0	3.2	4.5	2.0	3.0	4.8	5.1	-3.7	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	6.2	0.9	1.7	0.7	1.3	2.2	0.6	0.7	2.0	2.0	-1.8	2.5	0.6	1.4	1.8	-0.5	1.8	-1.8	-0.6
Whole body fat mass	4.8	20.1	36.0	-4.9	-5.0	-2.0	-6.0	-5.2	-3.2	-4.0	-5.3	-4.9	-3.5	-5.8	-5.3	-2.8	-4.8	-3.3	-5.1	4.8	1.7
Leg fat mass (right)	3.4	13.1	24.0	-3.7	-3.9	-1.9	-4.9	-4.5	-2.9	-3.0	-4.4	-3.9	-3.1	-4.7	-4.3	-2.0	-3.6	-2.8	-3.9	4.1	1.1
Arm predicted mass (right)	5.0	25.7	50.3	-3.6	-5.8	-2.1	-7.1	-5.8	-5.0	-6.6	-5.9	-5.5	-4.1	-5.8	-5.0	-3.6	-5.6	-3.2	-6.0	4.2	3.2
Pulse rate, automated reading	0.2	0.5	3.4	-1.0	0.2	-1.9	-0.9	0.4	-0.7	-0.0	-0.1	0.0	-0.5	-0.5	-0.8	-0.3	0.0	-1.3	0.0	-0.2	0.6
Alcohol intake frequency.	2.2	5.2	13.8	2.5	3.0	0.6	3.7	3.0	1.4	1.4	2.4	2.5	1.8	2.6	2.3	1.3	2.3	1.1	3.2	-2.0	-1.0
Comparative height size at age 10	3.0	16.5	34.1	-3.7	-5.2	-0.3	-5.7	-4.8	-3.1	-5.8	-4.5	-4.7	-2.3	-4.0	-3.7	-2.5	-4.5	-2.6	-5.5	3.3	2.5
Number of full sisters	0.7	0.8	4.2	0.1	0.5	-1.1	0.4	1.1	-0.9	-0.4	-0.1	1.2	-0.0	2.0	0.2	-1.3	0.6	-1.2	0.6	-1.4	0.0
Suffer from ‘nerves’	1.0	1.6	8.2	-0.7	-0.9	-1.5	-1.1	-1.5	1.0	0.3	-0.4	-1.9	-0.2	0.3	0.1	1.5	-0.9	-0.1	-0.7	2.4	-2.9
Overall health rating	0.4	0.8	4.5	0.9	1.2	0.1	0.1	1.2	0.2	0.8	0.5	0.6	-1.2	1.1	0.2	-0.5	-0.3	0.0	1.3	-2.1	0.1
Chest pain or discomfort	2.2	3.2	6.8	2.2	2.1	1.3	1.6	0.8	1.5	2.6	1.4	1.0	0.8	2.5	2.5	1.7	1.4	2.3	2.2	-0.4	-1.5
Had major operations	1.1	1.3	3.2	0.4	1.4	1.8	1.1	0.7	-0.1	0.9	1.2	1.8	-0.1	1.8	1.3	0.0	0.9	1.0	1.7	-1.0	-0.9
Age at last live birth	0.5	0.7	1.9	0.5	1.0	-0.2	-0.2	1.1	-1.1	0.8	0.7	1.4	-0.7	1.0	0.9	0.7	1.0	0.0	1.3	-1.1	0.0
Family relationship satisfaction	1.0	1.2	4.5	1.8	0.5	-0.3	0.9	0.6	1.6	2.1	1.4	0.0	0.7	0.9	1.1	1.4	0.6	1.6	0.5	-0.1	0.1
Leg pain on walking	1.2	1.5	7.1	1.5	0.8	1.0	0.5	2.5	-1.0	0.4	0.5	0.8	-0.3	0.9	0.4	0.2	-0.1	-0.0	0.6	-2.3	2.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.1	0.2	1.2	-0.2	0.8	0.1	0.5	-0.2	0.6	0.5	0.5	0.3	0.2	0.7	1.5	-0.9	1.1	0.1	-1.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.2	-0.3	-0.3	-0.2	-0.5	0.6	-1.5	-1.4	-0.6	0.8	-0.8	0.0	-0.5	-1.1	-0.0	-1.3	-0.1	-0.5	1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.5	-0.3	-0.9	-1.2	-0.9	-0.4	-0.0	-0.2	-0.9	0.3	-1.5	-0.4	-1.3	-0.4	-0.3	-1.6	-0.8	0.6	-0.7
Medication: Aspirin	7.0	9.2	32.0	5.7	2.5	2.2	3.4	4.5	1.3	2.5	2.7	3.1	1.6	3.2	3.7	1.2	1.9	3.3	3.0	-3.7	1.0
Supplements: Vitamin C	0.9	1.1	7.4	-1.2	-0.8	0.2	-0.3	-0.7	2.7	0.7	-1.0	-0.3	0.6	0.9	0.1	1.9	-0.0	-0.1	-0.7	0.2	-1.5
Knee pain experienced in last month	0.4	0.7	1.7	0.6	1.2	-0.7	0.5	0.3	-0.6	1.3	0.7	1.2	1.2	0.3	0.3	-0.4	1.1	0.7	1.3	-0.0	-0.6
Hypertension (Self-reported)	1.1	3.1	11.3	3.4	1.8	1.3	1.2	1.2	1.8	1.4	1.4	1.4	-1.0	3.0	1.5	1.2	1.6	0.5	1.8	-1.8	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	2.1	0.0	-0.1	0.2	0.2	-0.4	0.6	0.3	-0.3	-0.6	0.1	-0.7	-0.3	0.5	0.2	0.2	-0.2	1.4	-0.1
Illnesses of father: Heart disease	13.9	19.3	51.4	7.2	4.7	2.6	5.1	5.5	1.6	4.4	4.0	3.2	3.3	3.8	5.4	2.2	2.6	5.9	5.3	-5.5	1.8
Illnesses of siblings: Diabetes	1.3	1.6	7.0	1.2	0.9	0.2	1.5	2.5	-0.6	-1.0	1.2	0.9	0.1	0.6	0.3	-0.9	-0.5	0.4	1.1	-2.6	2.0
Smoking status: Previous	0.1	0.2	1.0	0.8	0.4	1.0	0.4	0.0	0.1	-0.4	0.2	0.6	0.4	0.6	0.3	-0.1	0.3	0.5	0.6	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	8.6	-2.0	-1.7	0.1	-2.2	-2.9	-0.5	-2.1	-1.6	-1.9	-0.4	-1.9	-0.9	-0.2	-1.0	-0.5	-1.9	2.4	0.9
Whole body fat-free mass	5.0	28.5	57.0	-4.2	-6.2	-1.8	-7.5	-6.2	-5.0	-7.0	-6.3	-5.7	-4.3	-5.8	-5.3	-3.4	-5.7	-3.6	-6.4	4.6	3.2
Leg fat-free mass (right)	5.7	30.4	58.4	-4.5	-6.2	-2.1	-7.6	-6.3	-5.4	-6.9	-6.4	-5.9	-3.9	-6.6	-5.7	-3.9	-5.9	-3.7	-6.5	5.1	3.5
Arm fat percentage (left)	1.8	7.3	13.6	-3.1	-2.5	-1.5	-3.5	-3.1	-2.0	-1.7	-3.1	-2.7	-2.5	-3.7	-3.6	-1.9	-2.7	-2.5	-2.6	3.1	0.4
Average weekly red wine intake	0.9	1.3	9.4	3.1	0.1	0.8	0.8	1.0	0.6	0.9	0.4	0.3	-0.2	1.1	1.2	1.6	0.6	1.7	0.2	-0.4	1.0
Handedness (chirality/laterality): Left-handed	1.5	1.8	5.6	0.1	1.8	0.6	1.0	1.1	0.4	1.2	1.8	2.4	-0.3	2.0	1.1	0.6	1.8	1.0	1.8	-1.5	-0.2
Mood swings	1.2	2.2	7.2	-0.8	-1.8	-1.9	-1.2	-2.1	0.6	-0.5	-1.7	-2.3	0.3	-1.6	-1.1	0.5	-1.5	-0.6	-1.6	2.7	-0.8
Loneliness, isolation	1.2	1.6	4.6	-0.2	-1.2	-1.2	-1.4	0.3	-1.2	-1.8	-1.3	-1.2	-1.9	0.5	-1.2	-0.9	-1.7	-2.1	-1.2	-0.6	0.8
Long-standing illness, disability or infirmity	2.6	3.9	12.1	1.4	2.1	1.7	2.2	0.8	2.5	3.5	2.0	0.9	1.3	2.1	1.9	1.7	1.8	1.6	2.3	-0.2	-2.9
Ever had bowel cancer screening	0.9	1.1	4.0	-0.6	-1.2	-0.9	-1.2	-1.0	0.7	-0.3	-1.5	-0.7	-2.0	-0.5	-1.1	0.1	-0.6	-1.3	-1.5	1.3	-0.2
Diabetes diagnosed by doctor	4.0	6.5	11.2	3.3	2.8	2.6	3.1	1.8	2.4	2.7	2.8	2.3	0.6	3.2	3.0	2.6	2.8	2.4	2.9	-0.9	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	2.0	0.2	0.2	-0.3	0.5	0.1	0.4	1.4	0.7	0.4	1.2	-0.0	0.4	0.5	0.4	1.0	0.5	-0.3	-0.3
Friendships satisfaction	0.3	0.4	1.8	0.6	-0.8	-0.5	0.1	-0.3	0.7	1.0	-0.2	-1.4	0.2	0.2	-0.3	-0.3	-1.1	0.3	-0.9	0.7	0.1
Qualifications: nursing, teaching	0.7	1.2	1.9	1.1	0.9	1.3	0.8	1.1	1.1	1.3	0.8	1.3	0.7	1.0	1.3	1.4	1.3	1.1	0.9	-1.0	0.2
Commuting to job workplace: Walk	0.5	0.6	1.6	0.5	-0.2	-0.6	1.1	-0.8	0.6	1.2	0.3	-0.8	0.7	0.3	-0.2	1.0	0.4	-0.6	-0.3	1.0	-1.3
Eye problems/disorders: Cataract	1.1	1.2	3.6	1.3	1.3	0.2	1.8	1.8	-0.3	1.7	1.0	1.1	-0.0	0.7	0.2	-1.1	0.3	-0.1	1.4	-1.9	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.1	0.3	0.8	-1.0	0.0	-0.1	0.7	0.6	0.7	0.7	-0.3	-0.0	-0.2	-0.7	0.5	0.1	0.8	-0.1	-1.0
Medication for cholesterol	7.4	11.3	29.2	-5.4	-4.2	-3.5	-3.5	-3.6	-1.4	-3.8	-3.5	-3.2	-1.9	-3.2	-3.9	-1.0	-3.1	-3.3	-4.1	3.4	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.8	0.4	1.0	0.1	0.6	1.3	0.9	1.1	0.8	0.5	1.3	-0.5	0.7	0.7	1.2	1.0	0.9	-0.6	0.6
Back pain experienced in last month	0.3	0.5	1.2	-1.1	-0.7	0.2	-0.9	0.3	-0.7	-0.3	-0.7	0.2	-1.0	-0.5	-1.0	-1.0	-0.8	-0.7	-0.6	-0.2	0.7
Mineral and other dietary supplements	4.7	6.3	11.5	-3.1	-2.7	-1.6	-3.1	-3.4	-1.4	-1.2	-2.4	-2.5	-3.3	-3.0	-3.1	-1.3	-2.9	-1.5	-2.7	2.7	-0.8
Breast cancer (self-reported)	0.3	0.3	1.5	-0.9	-0.1	-0.2	-0.3	-1.1	-0.3	0.3	-0.0	-0.7	-0.9	-1.2	-0.4	0.2	-0.4	0.2	-0.3	0.7	0.3
Asthma (self-reported)	0.1	0.2	0.9	-0.7	0.9	-0.1	-0.2	-0.4	-0.5	0.6	-0.0	-0.1	0.5	-0.0	0.4	-0.2	0.1	0.3	0.6	-0.8	-0.1
Osteoporosis (self-reported)	1.4	1.8	9.3	3.0	1.4	0.8	1.8	1.7	-0.5	1.1	1.1	1.6	-0.6	1.6	0.9	0.2	1.2	0.5	1.5	-0.3	-0.2
Osteoarthritis (self-reported)	0.2	0.2	1.7	-0.0	-0.3	0.2	-0.3	0.4	-0.3	0.3	-0.4	0.3	0.7	0.3	-0.8	-0.4	0.1	-1.3	-0.1	0.2	-0.3
Medication: Aspirin	6.1	8.0	30.1	5.5	2.5	2.0	3.2	4.0	0.9	2.2	2.4	2.9	1.6	2.8	3.4	0.9	1.8	3.3	3.0	-3.3	0.8
Medication: Gliclazide	2.0	2.2	6.6	1.0	1.7	0.7	1.3	0.8	1.0	1.4	1.8	1.2	1.7	0.9	2.4	1.8	1.7	2.6	1.6	-0.9	-0.1
Illnesses of father: None of the above (group 1)	6.0	7.4	18.3	-4.3	-2.8	-1.9	-3.0	-2.8	-1.2	-2.9	-2.7	-2.5	-2.0	-2.3	-3.4	-1.2	-2.0	-4.1	-3.0	3.3	-0.6
Smoking status: Current	0.8	1.2	2.6	-1.1	-1.4	-1.2	-1.4	-0.6	-0.8	-1.2	-0.8	-0.8	-1.5	-1.4	-1.1	-0.1	-1.0	-0.2	-1.6	0.7	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.7	0.8	-0.4	0.5	1.5	1.4	1.7	1.3	-0.0	-0.0	0.3	1.7	0.6	0.9	-0.1	-0.4	-0.3	-0.6	-0.8
Whole body water mass	4.9	27.8	55.4	-4.1	-6.2	-1.8	-7.4	-6.1	-5.1	-6.9	-6.3	-5.6	-4.2	-5.8	-5.2	-3.4	-5.6	-3.6	-6.4	4.5	3.2
Leg predicted mass (right)	5.6	30.1	58.4	-4.5	-6.2	-2.1	-7.6	-6.3	-5.4	-6.9	-6.3	-5.8	-3.9	-6.5	-5.6	-3.9	-5.9	-3.6	-6.4	5.0	3.5
Arm fat mass (left)	4.1	16.7	31.1	-4.3	-4.2	-2.2	-5.6	-4.7	-3.5	-3.8	-4.8	-4.2	-3.5	-5.2	-5.0	-2.9	-4.1	-3.4	-4.3	4.2	1.4
Number of self-reported non-cancer illnesses	2.7	4.7	9.0	3.0	2.8	1.1	1.8	2.9	1.2	2.4	2.1	2.7	-0.1	2.9	2.0	0.8	2.3	0.9	3.0	-2.3	-1.2
Average weekly champagne plus white wine intake	0.4	0.6	3.5	0.2	-0.1	0.4	-0.8	-1.7	-0.2	-0.2	-0.2	-0.5	-0.5	-1.9	0.2	0.4	0.0	1.1	-0.2	1.3	-0.0
Miserableness	1.6	2.8	7.7	-1.1	-1.5	-1.2	-2.2	-2.0	-1.5	-2.8	-2.1	-1.8	-1.6	-1.2	-1.8	-1.1	-1.9	-1.7	-1.2	1.6	0.1
Guilty feelings	0.4	0.6	3.1	0.3	-0.5	0.7	-0.9	-0.0	0.2	-1.8	-0.6	-0.4	-1.6	-0.4	-0.7	0.0	-0.4	-0.7	-0.2	0.4	0.9
Wears glasses or contact lenses	1.1	1.3	4.6	1.0	0.8	2.1	0.7	0.6	1.9	0.3	1.1	1.4	0.2	0.8	1.0	1.8	1.5	1.2	0.7	-0.2	0.2
Ever taken oral contraceptive pill	1.0	1.1	3.7	-1.5	-1.5	-0.5	-1.4	-0.7	-0.0	0.3	-1.6	-1.9	-0.0	0.3	-0.5	0.3	-1.6	-0.9	-1.7	-0.0	-0.8
Hearing aid user	0.5	0.5	3.1	0.7	0.6	0.9	0.3	-0.9	0.3	1.1	0.9	0.2	0.0	-0.8	0.4	-0.6	-0.4	1.8	0.7	0.0	-0.3
Mother’s age at death	1.1	1.4	7.0	-2.4	-0.7	0.2	-0.3	-1.8	1.1	-0.0	-0.0	-0.9	1.5	-1.4	-0.4	0.2	-0.3	0.2	-0.9	2.6	-0.8
Financial situation satisfaction	0.4	0.5	2.5	-0.4	-0.4	-1.6	-1.5	-0.5	-0.3	0.1	-0.3	-1.1	0.0	-0.4	-0.2	-0.6	-1.1	-0.3	-0.8	-0.2	0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	3.4	-0.8	0.4	0.9	-0.2	-0.2	1.8	0.1	0.3	-0.1	0.8	1.0	0.7	1.4	0.4	0.7	0.2	-0.6	-0.7
Commuting to job workplace: Public transport	0.5	0.6	2.4	-0.8	-0.6	0.7	-0.7	-0.9	0.9	-0.2	-0.5	-0.3	-1.5	0.7	-0.3	1.4	-0.0	-0.1	-0.5	1.1	-0.9
Eye problems/disorders: Glaucoma	0.3	0.4	2.4	-0.8	0.1	0.1	0.1	-0.8	1.1	-0.1	0.1	-0.3	0.5	-0.7	0.6	1.6	0.4	0.6	0.1	0.7	-0.2
Medication: Blood pressure	2.5	4.7	18.8	4.3	3.1	2.7	1.9	1.6	0.7	1.6	2.6	1.9	0.2	1.5	2.3	0.2	2.1	2.0	2.8	-1.8	-1.6
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.8	0.0	-0.0	0.1	-1.1	0.2	-1.1	-0.6	-0.3	0.2	-1.1	0.2	-0.1	0.1	-0.5	0.3	-0.0	-0.6	1.3
Supplements: Fish oil (including cod liver oil)	5.0	6.6	13.5	3.5	2.8	1.7	3.7	3.6	1.0	1.4	2.3	2.9	2.7	2.9	2.8	0.9	2.9	1.4	2.8	-2.9	1.0
High cholesterol (Self-reported)	15.1	26.7	56.6	7.1	5.4	2.4	5.5	7.5	1.2	5.6	4.3	5.6	2.7	6.9	6.3	2.0	3.7	5.2	6.5	-6.7	0.6
Medication: Bendroflumethiazide	0.3	0.5	2.5	0.9	0.3	0.3	-0.0	0.2	-0.7	-0.7	-0.5	0.9	-0.8	0.1	-0.8	-1.0	0.4	-1.6	0.2	0.4	-0.9
Medication: Paracetamol	0.9	1.4	6.2	-1.6	-0.8	-2.3	-0.4	-1.5	0.5	0.2	-1.0	-0.6	-0.8	-0.1	-1.0	-0.4	-0.2	-1.4	-0.7	1.4	-2.5
Medication: Lisinopril	2.1	2.7	6.7	1.5	2.2	1.1	2.0	0.8	1.5	1.6	1.8	1.3	1.6	1.0	2.6	1.3	1.9	2.2	2.2	-1.1	-0.4
Medication: Atorvastatin	8.5	10.6	24.1	4.9	3.2	2.8	3.4	4.6	1.0	3.1	2.7	3.3	0.4	4.5	3.8	0.9	1.8	4.1	3.9	-4.0	-0.4
Illnesses of father: High blood pressure	0.7	0.9	2.9	0.7	0.8	0.2	0.2	-0.1	0.9	1.0	1.3	0.7	0.7	1.7	1.3	0.7	1.0	0.9	0.9	-0.8	-1.1
Alcohol drinker status: Never	0.5	0.5	1.8	0.1	0.5	-0.4	0.9	1.1	0.7	1.3	0.6	0.7	0.5	0.9	0.4	1.3	0.6	0.6	0.8	-0.3	0.1
Ever smoked	0.4	0.7	1.7	-0.6	-1.2	0.1	-1.0	-1.3	-1.0	-1.1	-0.8	-0.6	-0.4	-0.9	-0.9	-0.8	-0.9	-0.0	-1.1	0.7	0.8
Basal metabolic rate	5.4	30.0	59.0	-4.6	-6.3	-2.0	-7.7	-6.4	-5.1	-6.8	-6.5	-5.8	-4.4	-6.3	-5.7	-3.6	-5.8	-3.9	-6.5	4.9	3.1
Leg fat percentage (left)	0.9	3.2	8.7	-1.6	-1.6	-1.3	-2.1	-2.1	-0.9	-0.5	-2.2	-1.9	-1.5	-3.0	-2.5	-0.9	-1.5	-1.6	-1.8	2.5	0.0
Arm fat-free mass (left)	4.5	22.7	44.6	-3.6	-5.3	-1.9	-6.7	-5.6	-4.8	-6.3	-5.7	-4.9	-3.5	-5.5	-4.8	-3.2	-4.9	-3.2	-5.6	4.2	3.0
Number of operations (self-reported)	0.9	1.3	4.7	-0.3	0.7	0.5	0.3	2.2	0.8	1.2	0.9	1.1	-1.6	2.1	0.7	0.8	0.1	-0.1	1.0	-2.2	0.6
Average weekly beer plus cider intake	0.6	0.9	3.8	0.2	-0.0	-2.0	-0.3	-0.6	-1.0	0.9	0.5	-1.2	1.2	-1.1	-0.2	-1.6	-0.8	0.1	-0.0	0.4	-1.3
Irritability	1.3	2.2	6.6	-1.4	-1.8	-0.9	-2.0	-2.6	0.6	-0.6	-1.5	-1.7	-0.1	-2.0	-1.5	0.1	-1.1	-0.5	-1.7	2.5	-0.2
Risk taking	1.1	1.6	6.7	-0.5	-0.9	-0.6	-1.4	-2.1	-1.4	0.5	-0.7	-1.8	0.2	-2.6	-0.3	0.0	-1.1	1.8	-0.7	1.5	1.0
Ever had prostate specific antigen (PSA) test	0.5	0.5	3.4	-0.2	-0.5	1.3	1.0	0.5	1.8	0.2	0.2	-0.4	-1.0	0.6	-0.3	0.8	0.0	-0.5	-0.4	-0.0	-0.2
Fractured/broken bones in last 5 years	0.5	0.7	2.9	0.5	1.0	-1.4	0.4	-0.8	-1.7	-0.4	-0.2	0.3	1.5	-0.5	0.3	-0.3	0.9	-0.1	0.8	0.7	1.0
Age started oral contraceptive pill	0.2	0.2	0.9	0.9	0.1	-0.3	-0.4	0.3	-0.1	0.7	0.3	-0.1	-0.5	-0.5	-0.9	-0.3	-0.1	-0.6	-0.0	0.2	-0.2
Diastolic blood pressure, automated reading	2.6	7.9	14.5	-2.9	-2.7	-2.7	-3.2	-3.4	-1.9	-2.8	-3.3	-3.1	-3.2	-1.8	-3.4	-2.3	-2.7	-3.8	-2.8	2.2	-1.0
Ever depressed for a whole week	0.4	0.5	1.6	0.9	-0.6	-0.7	-0.3	-0.3	1.0	0.9	-0.1	-0.3	-1.2	0.6	-0.0	0.8	0.0	0.4	-0.5	1.1	-1.2
Unable to work because of sickness or disability	1.3	1.7	4.5	1.0	0.9	1.4	1.6	1.3	0.4	1.3	1.5	0.5	1.5	1.9	2.1	1.2	0.6	2.1	0.9	-1.3	0.1
Commuting to job workplace: Cycle	0.7	0.9	4.0	0.3	0.3	-0.3	1.0	0.3	1.0	2.0	1.0	0.1	0.6	1.0	0.7	1.7	1.0	0.4	0.5	-0.0	-1.6
Myopia	0.3	0.4	3.1	-0.5	0.3	0.6	-0.0	-0.5	1.8	0.8	0.6	-0.4	-0.0	-0.5	0.2	0.4	0.5	1.1	0.1	0.3	-0.2
Vascular/heart problems diagnosed by doctor	1.2	3.4	15.6	-3.9	-1.6	-1.0	-1.4	-2.0	-1.3	-1.9	-1.3	-1.5	1.1	-2.9	-1.6	-1.1	-1.2	-0.9	-1.8	2.3	1.1
Cholesterol lowering medication	17.1	25.2	48.6	6.6	6.0	3.1	5.6	7.0	1.8	5.4	5.0	5.1	3.3	5.7	6.0	1.6	4.1	4.6	6.5	-6.2	0.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.9	0.5	0.4	-0.8	0.6	1.0	1.4	0.8	0.3	0.3	-1.0	1.0	0.3	0.7	0.7	-1.0	0.4	-0.5	-1.0
Pain experienced in last month	0.8	1.4	4.8	0.9	1.3	2.2	0.9	0.3	1.1	0.4	1.4	0.9	1.1	1.0	1.6	0.7	1.4	1.3	1.1	-1.2	0.4
Supplements: Calcium	0.7	0.8	3.3	-0.7	0.5	-0.5	0.8	-0.0	1.3	1.5	-0.3	0.4	1.5	0.9	0.5	0.7	0.7	0.5	0.7	0.7	-1.8
Basal cell carcinoma (self-reported)	0.7	0.8	3.5	0.0	0.1	-0.1	1.2	0.2	1.9	1.1	0.0	-0.0	0.8	0.8	0.3	1.9	0.8	-0.6	0.2	1.0	-1.4
Heart attack/myocardial infarction (self-reported)	7.4	9.5	34.1	5.8	2.2	1.7	4.0	4.9	0.2	3.3	2.1	2.8	1.2	4.1	3.2	1.8	1.8	2.7	2.8	-3.8	1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.6	-0.2	-0.9	-0.4	-0.1	-0.4	-0.2	0.7	-0.6	-1.3	0.6	-1.0	-0.4	-0.4	-0.8	0.6	-1.0	1.1	-0.0
Heart disease (siblings)	9.5	11.6	29.2	5.0	3.6	2.8	3.0	5.4	0.7	3.2	3.2	2.8	1.8	3.4	4.1	1.1	1.5	4.6	3.8	-4.8	2.1
Alcohol drinker status: Previous	1.0	1.1	4.2	2.0	1.1	0.8	0.7	0.8	0.7	0.4	1.2	0.7	-0.5	2.0	1.0	0.6	0.9	0.7	1.1	-0.9	-1.1
Pack years of smoking	0.6	0.8	3.6	-0.8	-1.0	-1.9	-0.4	0.5	-0.7	-0.2	-0.6	0.3	-1.9	0.4	-1.2	-0.2	-0.4	-1.7	-0.7	0.1	-0.2
Impedance of whole body	0.5	2.8	6.5	-0.1	1.8	0.8	1.9	2.0	2.5	1.7	2.4	1.9	1.8	1.9	1.5	0.6	1.6	1.0	1.9	-1.8	-0.9
Leg fat mass (left)	3.6	14.0	26.1	-3.7	-4.0	-2.0	-5.1	-4.5	-2.9	-3.3	-4.5	-4.0	-3.1	-4.9	-4.4	-2.3	-3.8	-2.8	-4.2	4.1	1.3
Arm predicted mass (left)	4.8	24.3	48.2	-3.9	-5.5	-2.0	-6.9	-5.8	-4.8	-6.2	-5.9	-5.2	-3.8	-5.7	-5.0	-3.4	-5.1	-3.4	-5.7	4.5	2.7