Best TWAS P=2.62e-15 · Best GWAS P=9.41e-14 conditioned to 0.0366
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | AMZ1 | 0.19 | 0.12 | enet | 22 | 0.13 | 5.7e-16 | 5.0 | 6.3 | 3.7e-10 | -0.43 | 1.00 | 0.00 | FALSE |
2 | GTEx | Artery Tibial | GNA12 | 0.24 | 0.13 | enet | 20 | 0.22 | 3.5e-17 | -7.1 | -5.4 | 6.4e-08 | 0.84 | 0.03 | 0.97 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | GNA12 | 0.46 | 0.51 | lasso | 5 | 0.50 | 7.9e-19 | -7.4 | -7.3 | 2.1e-13 | 0.99 | 0.00 | 1.00 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | GNA12 | 0.21 | 0.11 | lasso | 11 | 0.15 | 1.7e-11 | -7.1 | -5.2 | 2.5e-07 | 0.86 | 0.03 | 0.97 | FALSE |
5 | GTEx | Colon Sigmoid | GNA12 | 0.14 | 0.05 | lasso | 3 | 0.03 | 3.6e-02 | -3.0 | -5.2 | 1.5e-07 | 0.87 | 0.03 | 0.89 | FALSE |
6 | GTEx | Esophagus Gastroesophageal Junction | GNA12 | 0.20 | 0.12 | lasso | 6 | 0.12 | 3.4e-05 | -3.2 | -5.5 | 4.4e-08 | 0.86 | 0.04 | 0.95 | FALSE |
7 | GTEx | Esophagus Mucosa | GNA12 | 0.16 | 0.13 | lasso | 3 | 0.13 | 3.0e-09 | -6.4 | -5.5 | 3.9e-08 | 0.87 | 0.06 | 0.94 | FALSE |
8 | GTEx | Esophagus Muscularis | GNA12 | 0.32 | 0.31 | lasso | 3 | 0.34 | 2.1e-21 | -7.1 | -6.9 | 5.5e-12 | 0.94 | 0.02 | 0.98 | FALSE |
9 | GTEx | Whole Blood | GNA12 | 0.09 | 0.01 | enet | 4 | 0.00 | 3.3e-01 | -7.1 | -7.3 | 3.6e-13 | 0.94 | 0.02 | 0.92 | FALSE |
10 | NTR | Blood | GNA12 | 0.07 | 0.03 | bslmm | 597 | 0.06 | 1.3e-17 | -4.7 | -5.7 | 1.4e-08 | 0.63 | 0.92 | 0.08 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | AMZ1 | 0.09 | 0.05 | lasso | 6 | 0.04 | 2.4e-06 | -7.1 | 7.9 | 2.6e-15 | -0.90 | 0.04 | 0.96 | TRUE |
12 | YFS | Blood | GNA12 | 0.23 | 0.15 | bslmm | 570 | 0.25 | 4.5e-82 | 5.4 | -5.9 | 3.2e-09 | 0.52 | 1.00 | 0.00 | FALSE |
13 | The Cancer Genome Atlas | Esophageal Carcinoma | AMZ1 | 0.18 | 0.05 | blup | 69 | 0.05 | 1.4e-02 | 4.9 | -7.1 | 1.5e-12 | 0.71 | 0.01 | 0.71 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AMZ1 | 0.04 | 0.04 | lasso | 3 | 0.02 | 1.3e-03 | 4.9 | 5.4 | 5.2e-08 | -0.60 | 0.04 | 0.90 | FALSE |
15 | The Cancer Genome Atlas | Lung Adenocarcinoma | GNA12 | 0.03 | 0.01 | enet | 7 | 0.02 | 1.5e-03 | 1.9 | -5.5 | 3.8e-08 | 0.78 | 0.05 | 0.77 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MAD1L1 | 0.09 | 0.01 | blup | 206 | 0.04 | 1.1e-04 | 4.4 | -5.3 | 1.1e-07 | -0.10 | 0.09 | 0.43 | TRUE |