Best TWAS P=7.84e-12 · Best GWAS P=3.56e-10 conditioned to 0.00241
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SLC35E2 | 0.35 | 0.15 | enet | 24 | 0.17 | 1.0e-20 | -6.0 | 5.4 | 6.1e-08 | 0.32 | 0.02 | 0.98 | FALSE |
2 | GTEx | Adipose Subcutaneous | C1orf86 | 0.15 | 0.05 | enet | 10 | 0.04 | 2.0e-04 | -4.6 | -6.2 | 6.0e-10 | -0.11 | 0.38 | 0.14 | FALSE |
3 | GTEx | Adipose Visceral Omentum | RP1-283E3.4 | 0.26 | 0.05 | enet | 25 | 0.16 | 1.5e-08 | -3.0 | -5.7 | 9.8e-09 | -0.27 | 0.14 | 0.15 | TRUE |
4 | GTEx | Brain Cerebellar Hemisphere | NADK | 0.18 | 0.11 | lasso | 7 | 0.09 | 3.1e-03 | -5.7 | -5.8 | 5.8e-09 | -0.27 | 0.03 | 0.64 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | RP5-890O3.9 | 0.24 | 0.02 | lasso | 9 | 0.02 | 1.3e-01 | -6.2 | 6.8 | 7.8e-12 | 0.28 | 0.02 | 0.66 | TRUE |
6 | GTEx | Esophagus Gastroesophageal Junction | RP11-181G12.2 | 0.16 | 0.02 | enet | 18 | 0.01 | 1.1e-01 | 4.9 | 5.2 | 1.7e-07 | 0.01 | 0.11 | 0.07 | TRUE |
7 | GTEx | Esophagus Mucosa | TMEM52 | 0.17 | 0.18 | lasso | 2 | 0.20 | 2.9e-13 | -5.6 | 5.6 | 2.8e-08 | 0.24 | 0.28 | 0.72 | FALSE |
8 | GTEx | Esophagus Muscularis | RP11-181G12.2 | 0.23 | 0.14 | lasso | 4 | 0.19 | 1.0e-11 | 4.3 | 5.2 | 2.0e-07 | 0.00 | 0.97 | 0.03 | FALSE |
9 | GTEx | Lung | NADK | 0.07 | 0.03 | lasso | 3 | 0.02 | 8.5e-03 | 5.3 | -5.9 | 4.5e-09 | -0.27 | 0.03 | 0.90 | FALSE |
10 | GTEx | Muscle Skeletal | NADK | 0.06 | 0.00 | enet | 9 | 0.00 | 1.3e-01 | -5.7 | -6.0 | 1.5e-09 | -0.23 | 0.05 | 0.83 | FALSE |
11 | GTEx | Muscle Skeletal | TMEM52 | 0.11 | 0.08 | lasso | 6 | 0.10 | 7.2e-10 | -5.8 | 5.8 | 5.1e-09 | 0.26 | 0.13 | 0.87 | FALSE |
12 | GTEx | Skin Not Sun Exposed Suprapubic | TMEM52 | 0.19 | 0.18 | lasso | 4 | 0.14 | 2.6e-08 | 5.3 | 5.7 | 1.4e-08 | 0.25 | 0.04 | 0.96 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | TMEM52 | 0.17 | 0.14 | lasso | 7 | 0.15 | 2.0e-12 | 5.9 | 6.0 | 2.6e-09 | 0.26 | 0.04 | 0.96 | FALSE |
14 | GTEx | Spleen | TMEM52 | 0.47 | 0.21 | lasso | 5 | 0.22 | 2.3e-06 | -3.6 | -5.2 | 2.2e-07 | -0.15 | 0.26 | 0.32 | FALSE |
15 | METSIM | Adipose | TNFRSF14 | 0.07 | 0.05 | blup | 373 | 0.05 | 1.9e-07 | 3.8 | 6.4 | 1.9e-10 | -0.01 | 0.91 | 0.05 | TRUE |
16 | ROSMAP | Brain Pre-frontal Cortex | C1orf222 | 0.11 | 0.14 | enet | 18 | 0.14 | 1.8e-17 | -4.2 | 5.8 | 5.9e-09 | 0.22 | 0.98 | 0.02 | FALSE |
17 | ROSMAP | Brain Pre-frontal Cortex | MMP23B | 0.05 | 0.04 | lasso | 2 | 0.03 | 1.9e-04 | -5.4 | -5.4 | 8.1e-08 | -0.24 | 0.08 | 0.90 | FALSE |
18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM52 | 0.02 | 0.01 | blup | 37 | 0.02 | 6.6e-03 | -5.6 | 5.9 | 4.1e-09 | 0.26 | 0.01 | 0.77 | FALSE |