Best TWAS P=2.36e-11 · Best GWAS P=1.05e-14 conditioned to 2.21e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | SLC22A3 | 0.13 | 0.06 | enet | 7 | 0.09 | 1.3e-05 | -5.3 | -5.3 | 8.6e-08 | -0.63 | 0.58 | 0.40 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | SLC22A3 | 0.15 | 0.10 | enet | 39 | 0.11 | 5.6e-04 | -6.4 | -6.7 | 2.4e-11 | -0.71 | 0.06 | 0.86 | TRUE |
| 3 | GTEx | Brain Frontal Cortex BA9 | SLC22A3 | 0.26 | 0.08 | lasso | 6 | 0.05 | 1.5e-02 | -4.1 | -5.6 | 2.1e-08 | -0.62 | 0.14 | 0.62 | FALSE |
| 4 | GTEx | Esophagus Mucosa | SLC22A3 | 0.19 | 0.08 | enet | 47 | 0.12 | 1.7e-08 | 5.4 | -6.3 | 3.0e-10 | -0.58 | 0.52 | 0.48 | FALSE |
| 5 | GTEx | Nerve Tibial | SLC22A3 | 0.20 | 0.10 | lasso | 7 | 0.13 | 3.2e-09 | -5.3 | -5.7 | 1.1e-08 | -0.56 | 0.99 | 0.00 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | SLC22A3 | 0.15 | 0.05 | lasso | 9 | 0.05 | 9.9e-04 | -3.0 | -5.5 | 3.1e-08 | -0.65 | 0.05 | 0.94 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | SLC22A3 | 0.14 | 0.20 | lasso | 10 | 0.19 | 2.4e-24 | -5.2 | -5.6 | 2.8e-08 | -0.67 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LPAL2 | 0.07 | 0.00 | blup | 74 | 0.04 | 1.1e-03 | -3.5 | 5.4 | 5.9e-08 | 0.75 | 0.04 | 0.54 | FALSE |