TWAS
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Usage
Models
Genes
Traits
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Traits
:
Arm fat-free mass (left)
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chr7:22,946,782-24,382,726
Best TWAS P=3.11e-14 · Best GWAS P=3.55e-15 conditioned to 0.00367
23M
23.2M
23.4M
23.6M
23.8M
24M
24.2M
24.4M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Esophageal Carcinoma
TRA2A
0.18
0.02
blup
40
0.05
0.012
-7.4
-7.6
3.1e-14
0.82
0.01
0.40
TRUE
1
GTEx
Esophagus Mucosa
CCDC126
0.12
0.03
lasso
7
0.01
0.043
-6.2
5.7
1.1e-08
-0.51
0.12
0.39
FALSE
3
The Cancer Genome Atlas
Soft Tissue Sarcoma
RPS2P32
0.08
0.02
blup
27
0.02
0.031
-4.7
5.2
1.6e-07
-0.45
0.03
0.14
FALSE