Best TWAS P=6.21e-13 · Best GWAS P=1.28e-13 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | COL14A1 | 0.07 | 0.02 | enet | 21 | 0.04 | 2.1e-05 | -2.1 | 5.8 | 6.6e-09 | -0.02 | 0.01 | 0.99 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | NOV | 0.06 | 0.02 | enet | 8 | 0.05 | 1.5e-06 | -4.0 | -5.4 | 6.2e-08 | 0.71 | 0.05 | 0.95 | TRUE |
3 | GTEx | Artery Aorta | NOV | 0.12 | 0.05 | enet | 18 | 0.04 | 3.7e-03 | -5.1 | -6.2 | 5.3e-10 | 0.80 | 0.04 | 0.82 | TRUE |
4 | GTEx | Cells Transformed fibroblasts | NOV | 0.10 | 0.04 | enet | 30 | 0.03 | 3.7e-03 | -7.2 | -5.2 | 1.9e-07 | 0.55 | 0.03 | 0.95 | TRUE |
5 | GTEx | Colon Sigmoid | NOV | 0.15 | 0.16 | lasso | 4 | 0.15 | 6.6e-06 | -7.2 | -7.2 | 6.2e-13 | 0.90 | 0.02 | 0.97 | TRUE |
6 | GTEx | Lung | NOV | 0.06 | 0.02 | enet | 23 | 0.03 | 2.5e-03 | -2.9 | -5.6 | 1.9e-08 | 0.66 | 0.17 | 0.52 | TRUE |
7 | GTEx | Nerve Tibial | TAF2 | 0.14 | 0.04 | enet | 10 | 0.07 | 1.5e-05 | 4.3 | -5.4 | 5.7e-08 | 0.20 | 0.89 | 0.04 | TRUE |
8 | GTEx | Skin Sun Exposed Lower leg | NOV | 0.11 | 0.03 | lasso | 7 | 0.04 | 1.4e-04 | -6.8 | -6.2 | 6.9e-10 | 0.95 | 0.02 | 0.98 | TRUE |
9 | NTR | Blood | NOV | 0.02 | 0.01 | bslmm | 481 | 0.01 | 1.7e-04 | -7.2 | -5.4 | 5.2e-08 | 0.77 | 0.02 | 0.98 | TRUE |
10 | YFS | Blood | ENPP2 | 0.03 | 0.02 | enet | 8 | 0.03 | 7.6e-09 | -4.6 | -5.8 | 7.7e-09 | 0.11 | 1.00 | 0.00 | TRUE |
11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NOV | 0.03 | 0.00 | blup | 42 | 0.01 | 5.3e-02 | -6.8 | -7.1 | 1.4e-12 | 0.96 | 0.02 | 0.77 | FALSE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | NOV | 0.31 | 0.10 | blup | 42 | 0.10 | 1.2e-06 | -7.4 | -6.1 | 1.1e-09 | 0.80 | 0.01 | 0.98 | FALSE |
13 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NOV | 0.11 | 0.02 | enet | 15 | 0.05 | 2.9e-03 | -7.4 | -7.1 | 8.8e-13 | 0.83 | 0.01 | 0.62 | TRUE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NOV | 0.04 | 0.05 | blup | 42 | 0.05 | 8.7e-06 | -7.2 | -6.2 | 5.9e-10 | 0.79 | 0.02 | 0.98 | TRUE |