TWAS
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Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Arm fat-free mass (left)
:
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chr14:102,544,860-104,699,495
Best TWAS P=5.25e-09 · Best GWAS P=4.4e-11 conditioned to 0.000731
102.5M
103M
103.5M
104M
104.5M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
YFS
Blood
MARK3
0.04
0.04
lasso
3
0.04
1.6e-12
5.9
5.8
5.2e-09
-0.01
0.01
0.99
TRUE
3
METSIM
Adipose
TRAF3
0.04
0.02
enet
7
0.04
4.5e-06
5.6
5.8
7.9e-09
0.79
0.05
0.94
TRUE
1
GTEx
Esophagus Mucosa
MARK3
0.11
0.03
lasso
4
0.04
1.5e-03
5.9
5.8
6.3e-09
-0.01
0.04
0.82
FALSE
2
GTEx
Thyroid
TRMT61A
0.11
0.03
lasso
4
0.02
1.2e-02
5.9
-5.5
4.4e-08
-0.01
0.01
0.98
FALSE
5
The Cancer Genome Atlas
Thyroid Carcinoma
MARK3
0.10
0.03
blup
61
0.03
4.0e-04
-4.3
-5.4
5.8e-08
0.04
0.03
0.15
FALSE