Best TWAS P=1.18e-33 · Best GWAS P=1.52e-118 conditioned to 1.93e-53
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FTO | 0.11 | 0.00 | bslmm | 739 | 0.02 | 1.6e-03 | 0.53 | 12.1 | 1.2e-33 | 0.38 | 0.09 | 0.55 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RBL2 | 0.22 | 0.24 | enet | 15 | 0.26 | 1.8e-31 | 4.59 | -5.9 | 3.0e-09 | 0.02 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | RBL2 | 0.34 | 0.28 | enet | 18 | 0.30 | 1.0e-24 | 4.68 | -5.4 | 5.4e-08 | 0.02 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | RBL2 | 0.16 | 0.17 | enet | 11 | 0.20 | 2.1e-15 | 4.71 | -5.8 | 8.2e-09 | 0.02 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | RBL2 | 0.55 | 0.55 | enet | 20 | 0.46 | 2.1e-13 | 4.68 | -5.1 | 2.8e-07 | 0.04 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Brain Cortex | RBL2 | 0.51 | 0.45 | enet | 12 | 0.46 | 3.5e-14 | 4.14 | -5.9 | 3.6e-09 | 0.02 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Colon Sigmoid | RBL2 | 0.38 | 0.37 | lasso | 12 | 0.29 | 8.4e-11 | 4.68 | -5.4 | 6.6e-08 | 0.03 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Esophagus Mucosa | RBL2 | 0.36 | 0.36 | enet | 37 | 0.37 | 2.9e-26 | 4.68 | -5.3 | 1.2e-07 | 0.00 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Heart Left Ventricle | RBL2 | 0.12 | 0.11 | enet | 12 | 0.08 | 3.3e-05 | 4.60 | -5.2 | 1.9e-07 | -0.03 | 0.94 | 0.01 | FALSE |
| 10 | GTEx | Muscle Skeletal | RBL2 | 0.11 | 0.00 | lasso | 5 | 0.00 | 2.9e-01 | 6.51 | -9.1 | 1.1e-19 | -0.10 | 0.28 | 0.23 | FALSE |
| 11 | GTEx | Spleen | RBL2 | 0.59 | 0.47 | enet | 51 | 0.46 | 3.2e-13 | 4.72 | -6.2 | 4.0e-10 | -0.06 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Testis | AKTIP | 0.19 | 0.00 | enet | 26 | 0.00 | 1.9e-01 | 4.14 | 11.9 | 1.0e-32 | 0.51 | 0.03 | 0.40 | TRUE |
| 13 | GTEx | Vagina | RBL2 | 0.41 | 0.37 | enet | 13 | 0.34 | 1.6e-08 | 5.08 | -5.2 | 1.5e-07 | 0.03 | 0.89 | 0.01 | FALSE |
| 14 | YFS | Blood | AKTIP | 0.19 | 0.27 | lasso | 13 | 0.30 | 3.3e-99 | 7.22 | 6.4 | 1.4e-10 | -0.01 | 1.00 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Esophageal Carcinoma | RBL2 | 0.08 | 0.04 | lasso | 3 | 0.03 | 4.4e-02 | 7.22 | 5.8 | 7.7e-09 | 0.00 | 0.01 | 0.82 | FALSE |
| 16 | The Cancer Genome Atlas | Glioblastoma Multiforme | FTO | 0.27 | 0.16 | enet | 13 | 0.14 | 6.7e-05 | -2.19 | 8.9 | 7.4e-19 | 0.33 | 0.11 | 0.32 | TRUE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RBL2 | 0.03 | 0.06 | enet | 5 | 0.05 | 8.2e-07 | 4.14 | -5.2 | 1.5e-07 | 0.04 | 0.81 | 0.19 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RBL2 | 0.11 | 0.08 | blup | 44 | 0.06 | 1.5e-03 | 6.55 | -6.3 | 3.6e-10 | -0.03 | 0.01 | 0.78 | FALSE |