TWAS
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Traits
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Traits
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Arm fat-free mass (left)
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chr4:144,882,744-146,788,825
Best TWAS P=9.16e-33 · Best GWAS P=4.76e-40 conditioned to 0.409
145M
145.5M
146M
146.5M
0
10
20
30
40
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
ROSMAP
Brain Pre-frontal Cortex
OTUD4
0.04
0.03
lasso
2
0.03
1.4e-04
11.7
-11.9
9.2e-33
-0.85
0.14
0.79
TRUE
3
GTEx
Pancreas
ANAPC10
0.14
0.10
lasso
3
0.10
4.3e-05
-11.3
11.0
2.7e-28
0.60
0.32
0.10
TRUE
2
GTEx
Brain Hypothalamus
HHIP-AS1
0.12
0.02
enet
16
0.04
4.6e-02
7.9
8.0
9.6e-16
0.21
0.06
0.22
TRUE
1
CommonMind
Brain Pre-frontal Cortex
OTUD4
0.06
0.04
bslmm
272
0.04
2.6e-05
-10.2
-8.3
1.2e-16
-0.39
0.52
0.40
FALSE