TWAS hub - HHIP-AS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hypothalamus	0.119	0.058	0.0063	0.02	NA	0.038	NA	0.004	0.1100	NA	0.046	NA	0.250
2	GTEx	Vagina	0.163	0.071	0.0021	0.10	NA	0.056	NA	0.060	0.0028	NA	0.020	NA	0.018

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Lung FEV1/FVC ratio	47.4	240.7	449.4	21.2	5.7
Peak expiratory flow (PEF)	29.6	68.6	132.7	11.5	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	21.3	67.9	132.2	11.5	1.9
Forced expiratory volume in 1-second (FEV1)	18.1	60.9	121.0	11.0	0.9
Heel bone mineral density (BMD) T-score, automated (right)	14.9	34.1	40.7	-5.2	-6.4
Heel T-Score	13.9	110.4	118.8	-10.1	-10.9
Sitting height	13.5	96.1	174.2	13.2	-4.2
Heel bone mineral density (BMD) T-score, automated (left)	12.0	27.1	30.4	-4.9	-5.5
Height	11.8	226.9	453.7	21.3	-0.1
Standing height	10.8	106.9	213.2	14.6	-0.8
Chronic bronchitis/emphysema (mother)	9.7	11.3	21.7	-4.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	9.0	19.0	36.5	6.0	1.2
Trunk fat-free mass	8.1	46.6	92.7	9.6	-0.6
Trunk predicted mass	8.0	45.7	91.0	9.5	-0.6
Whole body fat-free mass	7.8	44.4	88.0	9.4	-0.9
Whole body water mass	7.6	43.5	86.1	9.3	-0.9
Shortness of breath walking on level ground	7.4	8.9	9.5	-2.9	-3.1
Chronic bronchitis/emphysema (father)	7.2	8.4	16.3	-4.0	-0.7
Comparative height size at age 10	7.2	39.5	77.1	8.8	-1.4
Basal metabolic rate	7.0	38.9	76.2	8.7	-1.3
Leg fat-free mass (left)	6.7	35.2	68.2	8.3	-1.5
Leg predicted mass (left)	6.7	35.3	68.4	8.3	-1.5
Arm predicted mass (right)	6.7	34.2	68.1	8.2	-0.6
Arm fat-free mass (right)	6.6	33.7	67.2	8.2	-0.4
Leg fat-free mass (right)	6.5	34.9	68.2	8.3	-1.2
Arm predicted mass (left)	6.5	33.2	65.8	8.1	-0.8
Leg predicted mass (right)	6.4	34.2	66.7	8.2	-1.3
Arm fat-free mass (left)	6.4	32.6	64.5	8.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	5.9	12.2	23.4	4.8	-1.0
Forced vital capacity (FVC), Best measure	5.8	21.3	42.6	6.5	-0.1
Hip circumference	5.1	21.8	34.6	5.9	-3.0
Forced vital capacity (FVC)	4.8	18.6	36.5	6.0	-0.8
Emphysema/chronic bronchitis	4.7	5.2	10.0	-3.2	0.7
Weight	4.6	22.5	39.2	6.3	-2.4
Eye problems/disorders: Cataract	4.6	5.3	8.4	1.5	2.9
Wheeze or whistling in the chest in last year	4.3	7.7	15.0	-3.9	-0.7
Supplements: Calcium	4.3	4.7	9.3	0.2	3.1
Birth weight of first child	3.8	7.0	13.1	3.6	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.6	4.2	5.5	-2.3	-1.7
Medication: Seretide 50 evohaler	3.4	4.0	4.3	-2.1	-1.9
Illnesses of mother	3.1	3.9	5.7	2.4	1.4
Medication: Omeprazole	3.1	3.7	3.9	-1.8	-2.0
Chest pain or discomfort	3.1	4.5	8.1	-2.8	-0.9
Waist Hip Ratio (WHR)	3.0	13.3	25.7	-5.1	1.0
Serious illness, injury or assault to yourself	3.0	3.7	4.7	-1.6	-2.2
Osteoporosis (self-reported)	2.8	3.4	4.5	-1.5	2.1
Past tobacco smoking	2.7	5.0	5.3	2.3	2.2
Birth weight	2.7	5.9	11.1	3.3	-0.9
High blood pressure (siblings)	2.7	3.8	3.8	-2.0	-2.0
Trunk fat mass	2.6	11.2	12.5	3.5	-3.1
Medication: Aspirin	2.6	3.4	5.8	1.0	-2.4
Illnesses of father: High blood pressure	2.6	3.2	5.9	-0.6	2.4
Ulcerative Colitis	2.5	3.6	3.8	-1.9	-1.8
Illnesses of siblings	2.5	3.4	4.5	1.5	2.1
Comparative body size at age 10	2.5	6.8	12.4	-3.5	-1.1
Medication: Aspirin	2.5	3.3	4.4	1.5	-2.1
Hearing difficulty/problems: Yes	2.4	3.7	3.9	-2.0	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	4.3	-1.1	-2.1
Handedness (chirality/laterality): Left-handed	2.4	2.9	5.4	-0.7	-2.3
Ever smoked	2.4	4.2	4.3	-2.0	-2.1
Crohns Disease (2012)	2.3	3.7	6.7	-2.6	-0.9
Severe depression (siblings)	2.3	2.6	3.5	-1.9	-1.3
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	4.8	2.2	0.9
Lung cancer (father)	2.2	2.5	2.9	-1.5	-1.7
Pulse wave Arterial Stiffness index	2.2	2.6	5.0	2.2	0.4
Overall health rating	2.2	4.6	8.9	-3.0	-0.6
Ever had bowel cancer screening	2.2	2.6	3.7	-1.9	-1.2
Tinnitus: Yes, now most or all of the time	2.2	2.6	5.1	-2.2	-0.3
Sensitivity / hurt feelings	2.1	3.6	3.6	-1.9	-1.9
High blood pressure (mother)	2.1	2.9	4.5	-2.1	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	3.9	-2.0	-1.0
Whole body fat mass	2.1	8.9	9.3	2.9	-3.1
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	3.9	-2.0	-1.2
Neck or shoulder pain in last month	2.0	2.9	5.7	-2.4	-0.2
Family relationship satisfaction	2.0	2.4	4.8	0.3	2.2
Miserableness	2.0	3.4	5.3	-2.3	-1.2
HDL Cholesterol	1.9	3.2	6.3	0.3	2.5
Eye problems/disorders: None of the above	1.9	2.2	2.8	-1.2	-1.7
Smoking status: Previous	1.9	2.8	3.7	-1.9	-1.4
Medication: Atenolol	1.8	2.3	4.6	0.0	-2.1
Wears glasses or contact lenses	1.8	2.1	3.0	-1.7	-1.1
Commuting to job workplace: Cycle	1.8	2.1	2.4	1.4	1.5
Respiratory disease	1.7	3.8	7.7	-2.8	-0.1
Taking other prescription medications	1.7	2.7	3.0	-1.7	-1.6
Loud music exposure frequency	1.7	1.8	3.6	1.9	0.1
Long-standing illness, disability or infirmity	1.7	2.5	2.7	-1.6	-1.6
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	2.6	-1.6	-1.2
Ulcerative Colitis (UC)	1.6	3.0	3.9	-2.0	-1.5
Blood Platelet Count	1.6	18.9	23.0	-3.9	4.8
Average weekly spirits intake	1.6	2.0	3.2	-1.8	-0.9
Townsend deprivation index at recruitment	1.6	2.2	4.2	0.5	-2.1
Arm fat mass (right)	1.6	6.8	7.6	2.4	-2.8
Ever highly irritable/argumentative for 2 days	1.6	2.0	3.9	-2.0	0.1
Alcohol drinker status: Previous	1.6	1.8	2.9	-1.7	-0.8
Neuroticism	1.5	3.5	5.9	-2.4	1.1
Number of treatments/medications taken	1.5	2.7	3.7	-1.9	-1.3
Diabetes (mother)	1.5	1.9	2.7	-1.6	-1.1
Trunk fat percentage	1.5	6.0	11.2	0.9	-3.4
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.4	1.8	0.5
Waist circumference	1.5	5.6	9.3	1.4	-3.1
Heart attack	1.5	2.0	2.1	-1.4	-1.4
Alcohol intake versus 10 years previously	1.5	2.3	4.5	-0.1	-2.1
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	2.7	-1.6	-1.5
Heart disease (mother)	1.5	1.9	3.7	-1.9	0.2
Heart attack/myocardial infarction (self-reported)	1.5	1.9	2.0	-1.4	-1.4
Bipolar Disorder or Schizophrenia	1.4	3.3	4.9	2.2	1.3
Depression (Nagel 2018)	1.4	2.1	2.7	-1.2	1.7
Ever used hormone-replacement therapy (HRT)	1.4	1.7	3.0	-1.7	-0.7
Arm fat percentage (right)	1.4	5.5	10.5	-0.6	-3.2
Medication for pain relief, constipation, heartburn	1.4	2.3	4.2	0.6	2.1
Leg fat mass (right)	1.4	5.4	7.1	1.9	-2.7
Illnesses of siblings: Diabetes	1.4	1.7	3.5	1.9	-0.0
Ever taken oral contraceptive pill	1.4	1.6	3.1	-1.8	-0.3
Neuroticism (Nagel 2018)	1.3	3.1	6.1	-2.5	0.1
Schizophrenia (2018)	1.3	2.8	4.2	2.1	1.2
Ovarian Cancer	1.3	1.8	3.5	-1.9	0.1
Mean Putamen Volume	1.3	1.4	1.8	1.1	1.3
Age when periods started (menarche)	1.3	3.1	6.1	2.5	-0.1
Neuroticism score	1.3	2.7	5.3	-2.3	-0.2
Father’s age at death	1.3	1.8	3.3	1.8	0.5
Noisy workplace	1.3	1.6	2.2	-1.0	-1.5
Body fat percentage	1.3	5.2	10.4	-0.2	-3.2
Mood swings	1.3	2.4	4.7	-2.2	-0.3
Arm fat mass (left)	1.3	5.4	6.2	2.1	-2.5
Medication: Blood pressure	1.3	2.4	2.7	-1.4	-1.6
Medication: Lisinopril	1.3	1.7	2.1	-1.1	-1.4
Leg fat mass (left)	1.3	4.9	6.5	1.8	-2.5
Depressed Affect (Nagel 2018)	1.2	2.5	4.9	-2.2	-0.1
Supplements: Zinc	1.2	1.3	2.5	0.2	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	2.2	-0.9	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	2.5	-1.6	1.1
Medication: Cholesterol lowering	1.2	1.9	3.9	0.0	-2.0
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.7	-1.6	-0.5
Leg fat percentage (right)	1.2	4.4	6.1	-1.6	-2.5
Arm fat percentage (left)	1.2	4.8	8.9	-0.8	-3.0
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	3.0	-1.7	-0.2
Worry (Nagel 2018)	1.1	2.2	4.3	-2.1	0.4
Irritable Bowel Disease (IBD)	1.1	2.7	3.1	-1.8	-1.5
Neuroticism (2016)	1.1	1.5	2.7	-1.6	0.7
Medication: Co-codamol	1.1	1.3	1.7	-1.3	-0.9
Hair/balding pattern: Pattern 3	1.1	1.6	1.8	-1.3	1.2
Worry too long after embarrassment	1.1	1.9	2.7	-1.7	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.2	-1.5	-0.6
Medication: Paracetamol	1.1	1.7	2.3	-1.5	-1.0
Irritability	1.1	1.8	3.2	-1.8	0.7
Coronary Artery Disease (CAD)	1.0	1.2	2.3	-1.5	-0.2
BMI	1.0	5.5	11.1	0.0	-3.3
Asthma	1.0	1.9	3.8	-2.0	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	2.9	-0.6	1.7
Blood clot in the leg (DVT)	1.0	1.3	2.6	-1.6	-0.2
Headache pain in last month	1.0	1.6	3.2	-1.8	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.1	-1.4	0.8
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.3	-0.3	1.5
Leg fat percentage (left)	1.0	3.6	4.5	-1.6	-2.1
Diastolic blood pressure, automated reading	1.0	3.0	5.6	0.6	2.4
Crohns Disease (2017)	0.9	2.0	3.0	-1.7	-1.0
Type 2 Diabetes (T2D) (2018)	0.9	1.7	2.0	-1.2	-1.4
Hand grip strength (left)	0.9	2.3	3.3	1.8	1.1
Relative age of first facial hair	0.9	1.8	2.3	1.5	1.2
Maternal smoking around birth	0.9	1.3	2.5	-1.6	-0.3
Multivitamins +/- minerals	0.9	1.2	2.3	-0.0	1.5
Time employed in main current job	0.9	1.0	1.9	0.3	1.4
Falls in the last year	0.9	1.2	1.7	-0.9	1.3
Exposure to tobacco smoke at home	0.9	1.0	1.6	1.3	0.7
Tense / ‘highly strung’	0.9	1.5	2.5	-1.6	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	1.6	-1.1	1.3
Illnesses of father: None of the above (group 1)	0.9	1.1	2.0	1.4	0.4
Heart disease (siblings)	0.9	1.1	1.8	-0.7	-1.3
Bipolar Disorder (2011)	0.8	0.8	1.5	0.3	-1.2
Systolic blood pressure, automated reading	0.8	2.3	4.3	0.6	2.1
Supplements: Glucosamine	0.8	1.0	1.1	1.1	1.0
Medication: Simvastatin	0.8	1.2	2.0	-0.7	-1.4
Depression (self-reported)	0.8	0.9	1.6	0.5	1.3
Commuting to job workplace: Walk	0.8	0.8	1.2	0.6	-1.1
Breast cancer (self-reported)	0.8	1.0	1.9	1.4	-0.2
Asthma (self-reported)	0.8	1.6	3.1	-1.8	-0.3
Ever depressed for a whole week	0.8	1.0	1.8	-0.5	-1.3
Unable to work because of sickness or disability	0.8	1.0	1.9	-1.4	0.3
Schizophrenia vs Biploar Disorder	0.7	0.9	1.2	0.8	1.1
Reaction Time	0.7	1.2	2.5	0.1	1.6
Body Mass Index (BMI) (2010)	0.7	1.0	1.7	0.6	-1.3
Blood White Count	0.7	5.1	8.4	-2.9	1.4
Vitamin and mineral supplements	0.7	1.0	1.2	0.9	-1.1
Fed-up feelings	0.7	1.2	2.2	-1.5	0.4
Impedance of leg (left)	0.7	3.3	6.7	-2.6	0.0
Had menopause	0.7	0.9	1.8	-1.3	-0.1
Financial difficulties in last 2 years	0.7	1.0	1.9	-1.4	0.1
Mouth/teeth dental problems	0.7	1.1	2.2	1.5	0.2
Diabetes (self-reported)	0.7	1.0	2.1	0.1	-1.4
Medication: Ramipril	0.7	0.9	1.5	0.6	-1.2
Happiness	0.7	0.8	1.2	-0.7	1.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.3	0.2	1.5
Diabetes diagnosed by doctor	0.7	1.1	2.1	0.4	-1.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	0.3	-1.1
Blood Eosinophil Count	0.6	4.3	8.0	-2.8	-0.8
Blood Red Count	0.6	5.5	10.0	-1.0	-3.2
Hypothyroidism (self reported)	0.6	1.4	1.5	-1.1	-1.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.3	-1.1	0.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.4	0.3	1.2
Impedance of leg (right)	0.6	3.1	6.0	-2.4	-0.5
Body mass index (BMI)	0.6	2.5	4.9	-0.3	-2.2
Number of incorrect matches in round	0.6	0.9	1.5	-1.2	-0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.5	1.6	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.1	-1.0	-0.6
Pulse wave reflection index	0.6	0.8	1.0	1.0	0.7
Number of children fathered	0.6	0.7	0.9	1.0	0.6
Age at first live birth	0.6	1.1	2.1	1.4	-0.1
Pulse wave peak to peak time	0.6	0.7	1.1	-1.0	-0.5
Mean time to correctly identify matches	0.6	1.1	1.7	0.7	1.3
Financial situation satisfaction	0.6	0.7	1.0	-1.0	-0.7
High cholesterol (Self-reported)	0.6	1.1	2.2	-0.1	-1.5
Risk taking	0.6	0.9	1.6	0.4	1.3
Pain experienced in last month	0.6	1.0	2.0	-0.1	-1.4
Bipolar Disorder (2018)	0.5	0.7	1.0	1.0	0.6
Chronotype (morning person)	0.5	1.2	2.4	-1.5	-0.1
Diabetes (father)	0.5	0.7	1.1	-0.5	-1.0
Qualifications: CSEs or equivalent	0.5	0.6	1.0	-0.5	-1.0
Stomach or abdominal pain in last month	0.5	0.7	1.3	-0.3	1.1
Alcohol usually taken with meals	0.5	0.8	0.9	-0.9	-0.8
Nervous feelings	0.5	1.0	1.5	-0.7	1.2
Impedance of arm (right)	0.5	2.1	3.2	-1.0	-1.8
Pulse rate	0.5	0.9	1.6	-0.4	-1.3
Number of full brothers	0.5	0.6	0.6	0.8	0.8
Health satisfaction	0.5	0.7	1.4	-1.2	-0.2
Qualifications: College or University degree	0.5	1.4	2.4	1.5	0.7
Suffer from ‘nerves’	0.5	0.8	1.6	-0.2	1.3
Age at last live birth	0.5	0.7	0.9	0.6	-1.0
Medication for cholesterol	0.5	0.7	1.0	1.0	0.6
Number of self-reported non-cancer illnesses	0.5	0.8	1.3	-1.1	-0.6
Age started oral contraceptive pill	0.5	0.6	0.8	0.6	-0.9
Cholesterol lowering medication	0.5	0.7	1.2	-1.1	-0.5
LDL Cholesterol	0.4	0.6	0.6	0.8	0.7
Primary Biliary Cirrhosis	0.4	0.6	1.1	-1.1	0.3
Schizophrenia (2014)	0.4	1.0	1.8	1.4	0.3
Hand grip strength (right)	0.4	1.2	1.6	1.3	0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.5	0.7	0.7
Hair/balding pattern: Pattern 2	0.4	0.5	1.1	0.0	-1.0
Allergy	0.4	0.9	1.6	1.3	-0.4
Fluid intelligence score	0.4	0.9	1.4	1.2	0.6
Worrier / anxious feelings	0.4	0.7	1.4	-1.2	-0.2
Medication: Paracetamol	0.4	0.7	0.9	-1.0	-0.6
Exposure to tobacco smoke outside home	0.4	0.5	0.6	-0.8	0.7
Pulse rate, automated reading	0.4	1.3	2.5	-1.6	-0.3
Supplements: Vitamin C	0.4	0.4	0.7	-0.8	0.4
Illnesses of father: Heart disease	0.4	0.6	0.8	-0.6	-0.9
Medication: Bendroflumethiazide	0.4	0.5	0.6	-0.8	-0.7
Medication: Atorvastatin	0.4	0.5	0.9	1.0	0.3
Impedance of whole body	0.4	2.1	4.0	-2.0	-0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	0.5	0.7	0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.5	1.2	0.4
Systolic Blood Pressure	0.3	1.5	3.0	0.2	1.7
Relative age voice broke	0.3	0.5	0.6	-0.8	-0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	-0.8	0.2
Hearing difficulty/problems with background noise	0.3	0.5	0.8	-0.5	-0.9
Impedance of arm (left)	0.3	1.2	1.5	-1.2	-0.9
Length of working week for main job	0.3	0.4	0.7	0.2	0.8
Medication: Amlodipine	0.3	0.4	0.7	-0.8	0.2
Number of full sisters	0.3	0.4	0.4	-0.7	0.6
Medication: Gliclazide	0.3	0.3	0.6	0.8	0.0
Guilty feelings	0.3	0.5	0.9	0.2	1.0
Alcohol drinker status: Never	0.3	0.3	0.6	-0.0	0.8
Fasting Glucose	0.2	0.2	0.3	0.5	0.4
HbA1C	0.2	0.3	0.5	0.0	0.7
Rheumatoid Arthritis	0.2	0.2	0.4	0.2	0.6
Triglycerides	0.2	0.2	0.5	0.7	0.2
Smoking Status	0.2	0.6	0.8	-0.9	-0.6
Allergy or Eczema	0.2	0.4	0.8	0.9	0.1
Cardiovascular Disease	0.2	0.8	1.6	0.0	-1.3
Angina	0.2	0.3	0.3	0.6	-0.4
Medication: Metformin	0.2	0.3	0.6	0.4	-0.7
Current tobacco smoking	0.2	0.3	0.6	-0.3	-0.7
Qualifications: None of the above	0.2	0.4	0.7	-0.8	-0.4
Pain all over the body in last month	0.2	0.2	0.2	0.4	-0.4
Number of live births	0.2	0.3	0.6	-0.8	0.2
Medication: Lansoprazole	0.2	0.3	0.5	-0.7	0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.5	-0.7	-0.5
Medication: Ibuprofen	0.2	0.2	0.3	-0.6	0.3
Had major operations	0.2	0.2	0.5	0.1	0.7
Friendships satisfaction	0.2	0.3	0.4	-0.4	0.6
Back pain experienced in last month	0.2	0.3	0.5	0.7	0.2
Osteoarthritis (self-reported)	0.2	0.3	0.3	0.5	0.5
Smoking status: Current	0.2	0.3	0.4	-0.4	-0.7
Hearing aid user	0.2	0.2	0.4	0.1	-0.7
Commuting to job workplace: Public transport	0.2	0.2	0.2	0.5	0.5
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	0.1	-0.8
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	0.4	-0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.1	0.4
Major Depression (MDD)	0.1	0.1	0.2	-0.5	-0.1
Breast Cancer	0.1	0.3	0.3	-0.5	-0.6
Prostate Cancer	0.1	0.1	0.3	0.0	0.5
Age at First Birth	0.1	0.1	0.2	0.4	0.0
Lupus	0.1	0.2	0.2	0.4	-0.4
Lung FVC	0.1	0.3	0.4	0.6	-0.3
Tanning	0.1	0.6	1.1	-1.1	0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.1	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.4	-0.0
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.4	0.2
Average weekly fortified wine intake	0.1	0.1	0.2	-0.5	-0.1
High blood pressure	0.1	0.2	0.3	0.2	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	0.6	0.1
Had other major operations	0.1	0.1	0.2	0.2	-0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	0.4	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	-0.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	0.1	0.6
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.7	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.1	0.5
Gout (self-reported)	0.1	0.2	0.3	0.2	0.6
Medication: Blood pressure	0.1	0.1	0.2	-0.4	-0.3
Angina (self-reported)	0.1	0.2	0.2	0.5	-0.3
Alcohol intake frequency.	0.1	0.2	0.2	-0.5	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.1	-0.4
Hypertension (Self-reported)	0.1	0.1	0.3	0.0	-0.5
Loneliness, isolation	0.1	0.1	0.2	-0.4	0.0
Qualifications: nursing, teaching	0.1	0.1	0.2	0.4	-0.1
Mineral and other dietary supplements	0.1	0.1	0.2	0.0	-0.4
Average weekly champagne plus white wine intake	0.1	0.1	0.2	0.0	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	-0.3	0.3
Average weekly beer plus cider intake	0.1	0.2	0.3	0.1	-0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.1	-0.4
Fractured/broken bones in last 5 years	0.1	0.2	0.2	-0.5	0.3
Myopia	0.1	0.1	0.2	0.2	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	-0.0	0.7
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.1	-0.3	0.1
Hair Pigment	0.0	1.2	2.2	0.6	1.5
Pack years adult smoking proportion	0.0	0.1	0.1	-0.4	0.1
Medication: Levothyroxine sodium	0.0	0.1	0.1	-0.0	0.4
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	-0.2	-0.2
Prospective memory result	0.0	0.0	0.0	0.1	-0.2
Breastfed as a baby	0.0	0.1	0.1	-0.3	-0.0
Glaucoma (self-reported)	0.0	0.0	0.0	0.2	-0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.0	0.0
Migraine (self-reported)	0.0	0.0	0.1	0.2	-0.2
Medication: Allopurinol	0.0	0.0	0.0	-0.1	-0.2
Leg pain on walking	0.0	0.1	0.1	-0.2	0.2
Knee pain experienced in last month	0.0	0.1	0.1	0.1	0.4
Average weekly red wine intake	0.0	0.0	0.1	-0.1	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	-0.1	-0.3
Mother’s age at death	0.0	0.0	0.0	-0.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.2	0.1
Number of operations (self-reported)	0.0	0.0	0.1	0.3	-0.1
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	0.1	-0.1
Pack years of smoking	0.0	0.1	0.1	-0.1	0.3

Hub : Genes

HHIP-AS1

Models

Trait associations