TWAS hub - OTUD4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0600	0.0240	2.5e-05	0.038	0.036	0.035	0.036	0.025	1.6e-05	2.9e-05	3.9e-05	2.6e-05	0.00039
2	ROSMAP	Brain Pre-frontal Cortex	0.0358	0.0169	4.1e-03	0.032	0.020	0.026	0.022	0.028	5.5e-05	1.1e-03	2.1e-04	7.4e-04	0.00013
3	TCGA	Esophageal Carcinoma	0.1530	0.0900	6.1e-03	0.062	0.054	0.038	NA	0.042	5.1e-03	8.3e-03	2.3e-02	NA	0.01700

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Sitting height	19.3	137.0	265.7	-12.0	-16.3	1.1
Forced expiratory volume in 1-second (FEV1)	17.3	58.2	85.2	-9.1	-9.2	-2.7
Forced expiratory volume in 1-second (FEV1), Best measure	17.0	54.3	79.2	-8.9	-8.4	-3.6
Peak expiratory flow (PEF)	15.4	35.8	49.3	-7.0	-6.5	-3.9
Whole body water mass	14.1	80.7	163.8	-8.8	-12.8	-1.2
Trunk fat-free mass	14.0	80.1	156.2	-9.0	-12.5	-1.7
Arm predicted mass (right)	14.0	71.6	141.6	-8.5	-11.9	-1.2
Whole body fat-free mass	14.0	80.2	161.3	-8.8	-12.7	-1.2
Arm fat-free mass (left)	13.9	70.3	141.6	-8.3	-11.9	-0.8
Trunk predicted mass	13.8	78.7	153.8	-8.9	-12.4	-1.6
Basal metabolic rate	13.7	75.7	158.8	-8.2	-12.6	-0.7
Arm fat-free mass (right)	13.6	69.6	135.8	-8.5	-11.7	-1.3
Arm predicted mass (left)	13.0	66.1	134.6	-7.9	-11.6	-0.8
Leg fat-free mass (left)	12.7	67.2	144.0	-7.6	-12.0	-0.3
Leg predicted mass (left)	12.6	66.9	144.0	-7.5	-12.0	-0.2
Lung FEV1/FVC ratio	12.5	63.3	80.1	-8.6	-8.9	-5.9
Leg fat-free mass (right)	12.5	66.9	141.6	-7.7	-11.9	-0.6
Standing height	12.4	123.5	225.0	-11.8	-15.0	-2.5
Leg predicted mass (right)	12.4	66.3	141.6	-7.5	-11.9	-0.6
Hip circumference	12.3	52.8	123.2	-5.7	-11.1	1.6
Height	12.2	236.0	416.2	-16.5	-20.4	-4.4
Heel T-Score	11.7	92.7	146.4	12.1	3.3	11.0
Forced vital capacity (FVC)	10.7	41.2	65.1	-7.5	-8.1	-1.3
Weight	10.5	51.5	121.0	-5.7	-11.0	0.9
Forced vital capacity (FVC), Best measure	9.6	35.1	52.1	-7.1	-7.2	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	9.0	18.6	42.6	-3.6	-6.5	-0.3
Waist Hip Ratio (WHR)	8.8	39.6	71.6	6.9	8.5	0.4
Comparative height size at age 10	8.6	47.2	102.0	-6.3	-10.1	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	7.5	17.0	29.3	4.6	-0.6	5.4
Birth weight of first child	7.5	13.7	22.8	-4.1	-4.8	1.1
Heel bone mineral density (BMD) T-score, automated (right)	7.3	16.8	32.9	4.1	-0.6	5.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.9	12.4	24.3	-4.9	-2.9	-2.1
Trunk fat mass	5.5	23.8	59.2	-2.5	-7.7	2.5
Shortness of breath walking on level ground	5.4	6.5	11.3	2.8	-0.4	3.4
Whole body fat mass	5.1	21.4	53.0	-2.2	-7.3	2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.9	5.8	13.4	3.7	1.8	0.9
Arm fat mass (right)	4.7	19.3	48.9	-2.0	-7.0	2.2
Arm fat mass (left)	4.5	18.3	46.4	-2.2	-6.8	1.9
Illness, injury, bereavement, stress in last 2 years	4.3	5.2	9.3	-3.0	-2.2	-1.3
Leg fat mass (right)	4.2	16.2	40.2	-1.7	-6.3	2.3
Leg fat mass (left)	4.1	16.2	40.8	-1.7	-6.4	2.2
Supplements: Calcium	3.6	4.0	8.7	-1.2	1.4	-2.9
Birth weight	3.4	7.4	12.5	-3.1	-3.5	0.2
Commuting to job workplace: Walk	3.3	3.6	8.4	-1.4	-2.9	0.6
Waist circumference	3.2	11.9	28.7	-0.7	-5.4	2.5
Nervous feelings	3.0	5.6	9.8	2.6	3.1	-0.5
Medication: Seretide 50 evohaler	3.0	3.4	6.1	1.9	0.8	2.5
Impedance of leg (right)	2.9	14.3	25.5	4.1	5.0	0.9
Chronic bronchitis/emphysema (father)	2.9	3.4	4.9	1.6	2.2	1.7
Impedance of leg (left)	2.9	13.8	25.6	4.0	5.1	0.4
Townsend deprivation index at recruitment	2.8	3.9	6.1	0.3	-2.5	2.3
Trunk fat percentage	2.7	10.9	21.9	0.0	-4.7	3.3
Eye problems/disorders: Cataract	2.7	3.1	5.1	-2.0	-0.1	-2.3
Worry (Nagel 2018)	2.6	5.4	11.7	2.1	3.4	0.1
Osteoporosis (self-reported)	2.6	3.2	6.3	-0.4	1.8	-2.5
BMI	2.5	14.8	34.6	-1.1	-5.9	2.9
Depression (Nagel 2018)	2.4	3.6	7.6	0.5	2.8	-1.7
Medication: Omeprazole	2.4	2.8	6.4	2.5	-0.5	1.4
Impedance of whole body	2.4	12.3	23.2	3.6	4.8	0.9
Diabetes (father)	2.3	2.8	5.4	2.3	0.2	1.7
HDL Cholesterol	2.2	3.7	7.6	-0.1	2.8	-1.9
Arm fat percentage (right)	2.2	8.8	13.4	1.2	-3.7	3.4
Body fat percentage	2.2	8.8	14.5	0.8	-3.8	3.3
Financial situation satisfaction	2.2	2.7	4.5	2.1	1.3	1.4
Alcohol intake versus 10 years previously	2.1	3.1	4.8	2.2	-0.2	2.1
Lung cancer (father)	2.1	2.5	4.3	1.8	0.3	2.1
Pulse wave Arterial Stiffness index	2.1	2.4	3.5	-1.9	-1.8	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	4.1	2.0	1.5	1.0
Severe depression (siblings)	2.0	2.3	3.8	2.0	0.5	1.7
Body mass index (BMI)	2.0	8.6	21.2	-0.5	-4.6	2.1
Impedance of arm (right)	2.0	9.3	14.3	3.8	3.1	1.9
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	6.5	1.2	-0.0	2.6
Chronic bronchitis/emphysema (mother)	2.0	2.4	4.7	2.2	0.9	1.3
Illnesses of mother	1.9	2.4	3.6	-1.9	-0.1	-1.9
Arm fat percentage (left)	1.9	7.6	12.3	0.9	-3.5	3.1
Supplements: Zinc	1.8	1.9	3.2	-1.2	-1.0	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.3	4.2	1.5	2.0	-0.8
Hair/balding pattern: Pattern 3	1.8	2.6	5.4	1.2	2.3	-1.0
Impedance of arm (left)	1.8	8.3	14.1	3.2	3.7	1.0
Medication: Allopurinol	1.8	2.3	4.7	2.2	1.5	0.3
Handedness (chirality/laterality): Left-handed	1.8	2.2	4.1	-0.0	-1.6	2.0
Diabetes (mother)	1.7	2.2	3.6	1.9	0.5	1.7
Medication: Atenolol	1.7	2.2	4.2	0.6	-1.4	2.1
Noisy workplace	1.7	2.1	3.4	0.8	-1.5	1.8
Eye problems/disorders: None of the above	1.7	2.0	3.2	1.5	0.7	1.8
Hand grip strength (left)	1.6	4.3	6.5	-2.5	-1.8	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	3.0	-1.2	-1.7	-1.7
Heart attack/myocardial infarction (self-reported)	1.6	2.0	4.2	1.1	0.8	2.1
Neuroticism (2016)	1.5	2.1	3.8	1.5	1.9	-0.5
Blood Platelet Count	1.5	17.7	45.0	0.9	6.7	-2.7
Hearing difficulty/problems: Yes	1.5	2.2	3.9	1.7	0.0	2.0
Hand grip strength (right)	1.5	4.0	5.2	-2.3	-2.1	-1.6
Serious illness, injury or assault to yourself	1.5	1.8	4.0	0.8	-1.0	2.0
Medication: Aspirin	1.5	1.9	3.9	1.2	-0.6	2.0
Neuroticism (Nagel 2018)	1.4	3.2	5.5	2.0	2.3	-0.0
Mean Putamen Volume	1.4	1.6	2.9	-0.8	1.2	-1.7
Lung FVC	1.4	7.1	15.4	-3.9	-2.3	-0.5
Taking other prescription medications	1.4	2.1	3.2	1.8	0.5	1.7
Multivitamins +/- minerals	1.4	1.7	3.5	-0.9	-0.9	-1.9
Illnesses of siblings	1.4	2.0	3.8	-0.7	1.3	-1.9
Leg fat percentage (right)	1.4	5.1	7.9	1.7	-2.2	2.8
Back pain experienced in last month	1.4	2.1	4.2	-1.4	-2.0	0.1
Bipolar Disorder or Schizophrenia	1.3	3.2	5.9	-1.6	-0.9	-2.4
Neuroticism	1.3	3.1	7.6	1.2	2.8	-0.5
Average weekly spirits intake	1.3	1.6	3.0	1.7	-0.0	1.4
Heart attack	1.3	1.7	3.9	0.9	0.5	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	2.9	1.7	0.9	1.7
Prospective memory result	1.3	1.6	3.1	-1.2	-1.8	0.4
Ever had bowel cancer screening	1.3	1.6	3.2	1.0	1.8	0.7
Alcohol drinker status: Never	1.3	1.5	2.4	1.0	1.5	-1.1
Leg fat percentage (left)	1.3	4.5	5.9	1.5	-2.3	2.4
Qualifications: None of the above	1.2	2.5	3.7	1.9	1.5	1.2
Father’s age at death	1.2	1.7	3.9	-2.0	-0.7	-0.8
Depression (self-reported)	1.2	1.5	2.0	-1.4	-0.7	-1.4
Family relationship satisfaction	1.2	1.5	2.8	-1.3	0.2	-1.7
Medication: Aspirin	1.2	1.6	2.4	0.9	-1.2	1.5
Supplements: Vitamin C	1.2	1.5	2.2	-1.5	-1.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.6	0.7	0.2	1.9
Risk taking	1.2	1.7	2.7	-1.6	-1.0	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.9	2.0	-0.3	0.8
Depressed Affect (Nagel 2018)	1.1	2.4	3.6	1.9	1.9	0.1
Number of treatments/medications taken	1.1	2.0	2.6	1.6	1.5	1.1
Qualifications: CSEs or equivalent	1.1	1.5	2.2	1.0	-1.1	1.5
Medication: Ramipril	1.1	1.5	2.8	-0.6	-1.7	1.1
Exposure to tobacco smoke at home	1.1	1.2	2.3	-1.5	-1.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.8	0.7	0.8	1.7
Medication for pain relief, constipation, heartburn	1.1	1.9	2.7	-1.4	1.0	-1.6
Myopia	1.1	1.6	3.0	1.4	1.7	-0.3
Schizophrenia (2018)	1.0	2.2	4.4	-1.1	-0.9	-2.1
Schizophrenia vs Biploar Disorder	1.0	1.3	2.3	0.4	1.5	-1.1
Ovarian Cancer	1.0	1.4	2.2	1.5	1.1	0.8
Ulcerative Colitis	1.0	1.4	3.5	0.3	-0.8	1.9
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.8	-1.1	0.1	-1.7
Fed-up feelings	1.0	1.9	3.2	1.8	1.5	-0.5
Supplements: Glucosamine	1.0	1.3	3.5	-0.6	0.2	-1.9
Medication: Cholesterol lowering	1.0	1.5	3.2	0.9	-0.8	1.8
Tense / ‘highly strung’	1.0	1.7	2.2	1.5	1.3	1.1
High blood pressure (siblings)	1.0	1.5	3.3	0.1	-1.1	1.8
Qualifications: nursing, teaching	1.0	1.6	2.6	-1.6	-1.2	-0.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.4	0.5	2.1	-0.4
Illnesses of father: High blood pressure	1.0	1.2	2.9	0.2	0.9	-1.7
Blood Red Count	0.9	8.7	13.2	3.5	0.8	3.6
Systolic Blood Pressure	0.9	4.3	9.3	1.9	3.0	0.2
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.0	1.7	-1.0	1.1
Medication: Simvastatin	0.9	1.4	2.2	1.4	0.3	1.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.2	-0.6	1.0	-1.8
Gout (self-reported)	0.9	1.2	2.0	1.4	1.1	-0.7
Exposure to tobacco smoke outside home	0.9	1.2	1.9	1.3	1.4	0.1
Long-standing illness, disability or infirmity	0.9	1.4	2.8	1.7	-0.2	1.2
Ever smoked	0.9	1.7	3.1	1.3	0.4	1.8
Commuting to job workplace: Cycle	0.9	1.1	2.1	-1.0	-0.2	-1.4
Heart disease (siblings)	0.9	1.1	1.4	1.2	-0.8	1.1
Pack years of smoking	0.9	1.3	3.1	-0.5	-1.8	-0.8
Crohns Disease (2017)	0.8	1.8	4.6	2.1	0.6	0.6
Ulcerative Colitis (UC)	0.8	1.4	2.2	1.4	-0.1	1.5
Body Mass Index (BMI) (2010)	0.8	1.2	1.9	-1.0	-1.4	0.8
Crohns Disease (2012)	0.8	1.3	1.8	1.4	0.7	1.2
Triglycerides	0.8	1.3	1.9	-1.3	-1.4	-0.7
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.2	0.8	1.5	-0.6
Pack years adult smoking proportion	0.8	1.2	3.0	-0.5	-1.7	-0.5
Past tobacco smoking	0.8	1.5	4.0	-0.8	0.2	-2.0
Number of children fathered	0.8	1.0	1.5	-1.2	0.3	-1.1
Chest pain or discomfort	0.8	1.1	2.2	0.6	0.9	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.7	-0.1	-1.6	0.5
Diabetes diagnosed by doctor	0.8	1.3	3.5	0.4	-1.9	0.3
Eye problems/disorders: Glaucoma	0.8	0.9	2.3	0.4	-1.5	-0.5
Age started oral contraceptive pill	0.8	1.0	1.8	1.3	0.5	0.9
Ever depressed for a whole week	0.8	1.0	2.2	0.8	-0.1	1.5
Irritable Bowel Disease (IBD)	0.7	1.8	4.0	2.0	0.0	1.1
Medication: Co-codamol	0.7	0.8	1.6	1.3	0.2	0.9
Relative age voice broke	0.7	1.1	2.8	0.2	-0.5	1.7
Diabetes (self-reported)	0.7	1.0	2.1	1.0	-1.4	0.3
Neuroticism score	0.7	1.5	2.2	1.5	1.4	0.6
Happiness	0.7	0.9	1.3	0.6	1.1	-1.0
Glaucoma (self-reported)	0.7	0.8	1.8	0.7	-0.0	-1.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	0.9	-0.9	0.8	-0.9
Illnesses of father: Heart disease	0.7	1.0	2.0	1.4	-0.2	1.0
Guilty feelings	0.7	1.1	2.5	-1.6	-0.7	-0.4
Ever taken oral contraceptive pill	0.7	0.8	1.6	1.3	0.6	0.6
Medication: Paracetamol	0.7	1.0	2.2	0.7	-0.7	1.5
Medication: Atorvastatin	0.7	0.8	2.0	-1.4	-0.5	-0.5
Bipolar Disorder (2018)	0.6	1.0	1.6	-1.1	-0.4	-1.3
Coronary Artery Disease (CAD)	0.6	0.7	1.5	0.5	1.2	0.7
Fasting Glucose	0.6	0.8	1.8	-1.3	-0.1	-0.7
Schizophrenia (2014)	0.6	1.2	1.5	-0.9	-1.1	-1.2
Blood White Count	0.6	4.2	11.8	0.8	3.4	-0.4
Cardiovascular Disease	0.6	2.1	3.0	-1.1	-1.4	1.7
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.0	1.4	0.5	0.2
Falls in the last year	0.6	0.8	1.5	0.1	1.2	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	0.9	1.0	0.7	0.8
Loud music exposure frequency	0.6	0.7	1.5	-0.4	-1.2	0.7
Medication: Ibuprofen	0.6	0.7	1.0	1.0	0.5	-0.9
Leg pain on walking	0.6	0.8	2.3	1.5	0.2	-0.1
Mineral and other dietary supplements	0.6	0.8	2.0	-0.1	-0.6	1.4
Hearing aid user	0.6	0.7	1.8	1.4	-0.2	0.4
Medication: Blood pressure	0.6	1.1	3.1	0.5	0.1	1.8
Medication: Lisinopril	0.6	0.8	1.5	1.2	0.2	1.0
Pain experienced in last month	0.6	1.1	1.8	0.6	1.0	1.4
Alzheimer’s Disease (in mother)	0.5	0.6	0.7	0.9	0.7	0.8
Major Depression (MDD)	0.5	0.6	1.0	-1.0	-0.9	-0.2
Bipolar Disorder (2011)	0.5	0.5	1.3	-0.3	-1.1	0.0
LDL Cholesterol	0.5	0.8	1.5	-0.7	-1.2	-0.6
Sensitivity / hurt feelings	0.5	0.9	1.7	0.8	-0.4	1.3
Systolic blood pressure, automated reading	0.5	1.5	3.8	0.2	1.9	-0.8
Vitamin and mineral supplements	0.5	0.7	1.9	-0.1	-0.4	1.4
Average weekly fortified wine intake	0.5	0.6	1.6	-0.0	1.3	-0.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	1.0	0.6	-0.3
Hearing difficulty/problems with background noise	0.5	0.8	1.1	0.5	1.0	1.1
Mouth/teeth dental problems	0.5	0.7	1.8	-0.4	-0.5	-1.3
Time employed in main current job	0.5	0.6	1.5	-0.0	1.2	-0.4
Blood clot in the leg (DVT)	0.5	0.6	0.7	0.9	0.7	0.8
Headache pain in last month	0.5	0.8	1.4	1.2	-0.4	1.0
Pulse wave peak to peak time	0.5	0.6	1.0	1.0	0.6	0.5
Health satisfaction	0.5	0.6	1.1	1.1	0.7	0.5
Migraine (self-reported)	0.5	0.6	1.1	-0.6	1.0	0.5
Mean time to correctly identify matches	0.5	0.9	1.2	1.0	1.1	-0.7
Suffer from ‘nerves’	0.5	0.9	1.9	0.2	1.4	-0.8
Age at last live birth	0.5	0.7	1.6	1.3	0.7	0.0
Illnesses of father: None of the above (group 1)	0.5	0.6	0.8	-0.9	-0.7	-0.8
Average weekly champagne plus white wine intake	0.5	0.8	1.2	-1.1	-1.0	0.3
Miserableness	0.5	0.8	1.3	1.0	-0.3	1.1
Commuting to job workplace: Public transport	0.5	0.5	0.9	0.0	0.9	-0.9
Ever had prostate specific antigen (PSA) test	0.5	0.5	0.8	0.9	0.8	0.3
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.9	-0.6	-1.7	-0.1
High blood pressure (mother)	0.4	0.6	1.3	0.7	-0.3	1.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.4	0.1	-0.2	1.2
Financial difficulties in last 2 years	0.4	0.6	1.2	0.7	1.1	-0.1
Pain all over the body in last month	0.4	0.4	0.9	0.5	-1.0	0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	-0.9	-0.7	0.4
Pulse rate	0.4	0.7	0.9	0.5	-1.0	0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.8	-1.3	-0.3	-0.5
Wheeze or whistling in the chest in last year	0.4	0.7	1.9	0.4	0.4	1.4
Emphysema/chronic bronchitis	0.4	0.4	1.2	-0.0	1.1	-0.3
Heart disease (mother)	0.4	0.5	1.2	1.1	0.6	0.1
Pulse rate, automated reading	0.4	1.2	1.4	1.0	1.2	1.0
Alcohol intake frequency.	0.4	0.9	1.9	1.4	-0.4	0.8
Had major operations	0.4	0.5	0.7	0.4	0.9	-0.7
Average weekly red wine intake	0.4	0.6	0.6	0.8	0.7	-0.8
Asthma (self-reported)	0.4	0.7	2.0	0.1	-1.4	0.4
Medication: Gliclazide	0.4	0.4	1.2	0.1	-1.1	0.2
Mother’s age at death	0.4	0.5	0.8	0.5	0.9	0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	0.1	0.6	-1.1
Average weekly beer plus cider intake	0.4	0.6	1.6	0.2	-1.3	0.3
Irritability	0.4	0.7	1.9	0.1	1.4	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.6	0.7	0.7	0.8
Alcohol drinker status: Previous	0.4	0.5	0.8	0.2	-0.7	0.9
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	-1.0	-0.4	-0.3
Breast Cancer	0.3	0.7	1.8	1.4	0.6	0.2
Hypothyroidism (self reported)	0.3	0.7	1.0	-0.5	-1.0	0.9
Relative age of first facial hair	0.3	0.7	1.7	-1.3	-0.5	-0.4
Medication for hormone replacement therapy	0.3	0.3	1.0	-0.0	-0.2	-1.0
Current tobacco smoking	0.3	0.5	0.7	0.7	-0.8	0.6
High blood pressure	0.3	0.8	1.2	-0.7	-1.1	1.0
Stomach or abdominal pain in last month	0.3	0.4	0.6	-0.6	-0.5	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.5	0.5	0.7	-0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.8	0.6	0.3	0.9
Number of live births	0.3	0.4	1.1	1.1	-0.1	-0.2
Medication: Lansoprazole	0.3	0.4	0.5	0.5	0.7	0.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	0.4	1.0	0.2
Medication: Paracetamol	0.3	0.5	1.2	0.3	-0.6	1.1
Medication: Amlodipine	0.3	0.4	1.1	0.2	1.0	0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	0.4	-0.2	0.9
Comparative body size at age 10	0.3	0.8	1.7	-0.8	-1.3	0.4
Number of full brothers	0.3	0.4	0.7	-0.0	-0.8	-0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	0.7	0.6	-0.3
Medication: Blood pressure	0.3	0.5	1.0	0.6	0.1	1.0
Number of full sisters	0.3	0.4	1.0	1.0	0.3	-0.2
Overall health rating	0.3	0.6	1.2	1.1	0.8	0.3
Medication for cholesterol	0.3	0.5	1.1	-0.4	-1.1	-0.2
Smoking status: Current	0.3	0.5	0.8	0.7	-0.9	0.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	1.0	-0.1	0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	0.2	-1.0	-0.3
High cholesterol (Self-reported)	0.3	0.5	0.9	0.6	-0.3	1.0
Number of operations (self-reported)	0.3	0.4	1.2	1.1	0.1	-0.1
Diastolic blood pressure, automated reading	0.3	1.1	1.7	-0.3	1.2	-1.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.2	0.6	1.0	-1.1
Cholesterol lowering medication	0.3	0.4	0.5	0.7	0.7	0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.6	0.0	-0.4
Reaction Time	0.2	0.3	0.6	0.4	0.5	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.6	-0.8	-0.6	-0.8
Primary Biliary Cirrhosis	0.2	0.2	0.6	0.0	0.1	-0.8
Rheumatoid Arthritis	0.2	0.3	0.4	-0.6	0.3	-0.7
Blood Eosinophil Count	0.2	1.5	3.8	0.8	2.0	0.3
Smoking Status	0.2	0.4	0.7	-0.4	-0.5	0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.5	0.6	-0.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.6	-0.6	-0.1
Angina	0.2	0.2	0.4	-0.3	0.6	0.3
Medication: Metformin	0.2	0.2	0.4	0.6	-0.6	0.1
Age when periods started (menarche)	0.2	0.4	1.0	1.0	0.4	-0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	0.1	0.5	-0.6
Number of incorrect matches in round	0.2	0.3	0.6	0.5	0.2	0.8
Alcohol usually taken with meals	0.2	0.4	1.0	0.3	1.0	0.3
Had menopause	0.2	0.2	0.5	0.1	0.7	0.1
Had other major operations	0.2	0.2	0.6	0.8	-0.1	0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.4	-0.5	-0.7	-0.6
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	0.4	1.0	-0.2
Asthma	0.2	0.4	0.9	0.3	-0.9	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.5	0.2	-0.7
Breastfed as a baby	0.2	0.2	0.6	0.2	0.7	-0.3
Hair/balding pattern: Pattern 4	0.2	0.6	0.9	0.5	-0.7	1.0
Pulse wave reflection index	0.2	0.2	0.5	-0.2	0.7	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.2	0.4	-0.9
Age at first live birth	0.2	0.4	0.7	0.0	0.6	-0.8
Qualifications: College or University degree	0.2	0.7	1.6	-0.8	-0.1	-1.3
Knee pain experienced in last month	0.2	0.3	0.7	0.8	0.1	-0.5
Smoking status: Previous	0.2	0.4	0.8	0.4	0.3	0.9
Mood swings	0.2	0.3	0.8	0.9	0.3	-0.1
Loneliness, isolation	0.2	0.3	0.4	0.3	-0.7	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.4	-0.5	0.4
Friendships satisfaction	0.2	0.2	0.3	-0.3	0.5	-0.6
Wears glasses or contact lenses	0.2	0.2	0.4	0.4	-0.1	0.7
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	0.9	0.3	0.0
Prostate Cancer	0.1	0.2	0.4	0.3	0.6	-0.2
Age at First Birth	0.1	0.2	0.5	0.3	0.7	0.0
HbA1C	0.1	0.2	0.2	0.3	0.3	-0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.5	-0.3	0.3
Chronotype (morning person)	0.1	0.3	0.8	0.1	-0.2	-0.9
Hair Pigment	0.1	2.6	3.9	-1.9	0.7	-2.0
Maternal smoking around birth	0.1	0.1	0.2	0.4	0.4	0.0
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.8	-0.9	-0.2	0.0
Fluid intelligence score	0.1	0.2	0.4	-0.4	0.2	-0.6
Worrier / anxious feelings	0.1	0.1	0.2	0.4	0.4	0.1
Worry too long after embarrassment	0.1	0.2	0.6	0.3	0.0	0.8
Neck or shoulder pain in last month	0.1	0.1	0.2	0.1	-0.4	0.3
Angina (self-reported)	0.1	0.2	0.4	-0.6	0.3	0.1
Hypertension (Self-reported)	0.1	0.3	0.7	-0.3	-0.4	0.8
Illnesses of siblings: Diabetes	0.1	0.2	0.5	0.7	-0.1	0.1
Breast cancer (self-reported)	0.1	0.1	0.1	-0.3	-0.3	0.4
Osteoarthritis (self-reported)	0.1	0.1	0.1	0.4	0.2	-0.2
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.5	-0.2	0.3
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.2	-0.4	0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.3	0.2	-0.6
Lupus	0.0	0.1	0.2	0.0	-0.4	-0.2
Allergy or Eczema	0.0	0.1	0.1	-0.3	-0.1	-0.3
Respiratory disease	0.0	0.1	0.2	0.5	-0.0	0.3
Tanning	0.0	0.1	0.1	0.3	-0.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.0	0.1	0.1	0.3	-0.2	-0.1
Medication: Levothyroxine sodium	0.0	0.1	0.2	-0.2	0.4	-0.2
Allergy	0.0	0.1	0.2	0.4	0.2	-0.0
Length of working week for main job	0.0	0.0	0.0	0.0	-0.1	0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	0.0	0.0	0.1
Unable to work because of sickness or disability	0.0	0.1	0.1	-0.0	-0.4	0.1

Hub : Genes

OTUD4

Models

Trait associations