Best TWAS P=4.82e-28 · Best GWAS P=7.05e-27 conditioned to 0.0541
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AMZ1 | 0.19 | 0.12 | enet | 22 | 0.13 | 5.7e-16 | 5.5 | 6.9 | 5.9e-12 | -0.43 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | GNA12 | 0.11 | 0.08 | lasso | 4 | 0.07 | 1.3e-06 | -6.3 | -7.0 | 2.3e-12 | 0.76 | 0.10 | 0.90 | FALSE |
| 3 | GTEx | Artery Tibial | GNA12 | 0.24 | 0.13 | enet | 20 | 0.22 | 3.5e-17 | -10.6 | -9.0 | 2.1e-19 | 0.84 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | GNA12 | 0.46 | 0.51 | lasso | 5 | 0.50 | 7.9e-19 | -10.7 | -10.7 | 1.5e-26 | 0.99 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | GNA12 | 0.21 | 0.11 | lasso | 11 | 0.15 | 1.7e-11 | -10.6 | -8.5 | 2.5e-17 | 0.86 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Colon Sigmoid | GNA12 | 0.14 | 0.05 | lasso | 3 | 0.03 | 3.6e-02 | -6.3 | -8.8 | 2.2e-18 | 0.87 | 0.02 | 0.92 | FALSE |
| 7 | GTEx | Colon Transverse | GNA12 | 0.19 | 0.08 | lasso | 4 | 0.10 | 2.3e-05 | 5.2 | -5.9 | 3.2e-09 | 0.58 | 0.33 | 0.64 | FALSE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | GNA12 | 0.20 | 0.12 | lasso | 6 | 0.12 | 3.4e-05 | -6.3 | -8.7 | 3.6e-18 | 0.86 | 0.04 | 0.95 | FALSE |
| 9 | GTEx | Esophagus Mucosa | GNA12 | 0.16 | 0.13 | lasso | 3 | 0.13 | 3.0e-09 | -10.4 | -9.5 | 2.0e-21 | 0.87 | 0.02 | 0.98 | FALSE |
| 10 | GTEx | Esophagus Muscularis | GNA12 | 0.32 | 0.31 | lasso | 3 | 0.34 | 2.1e-21 | -10.6 | -10.2 | 1.8e-24 | 0.94 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Lung | GNA12 | 0.16 | 0.08 | enet | 21 | 0.12 | 1.2e-09 | -10.3 | -8.2 | 2.4e-16 | 0.78 | 0.01 | 0.99 | FALSE |
| 12 | GTEx | Nerve Tibial | GNA12 | 0.31 | 0.34 | lasso | 7 | 0.36 | 9.6e-27 | -6.4 | -8.5 | 2.0e-17 | 0.86 | 0.74 | 0.26 | FALSE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | GNA12 | 0.10 | 0.15 | lasso | 3 | 0.12 | 4.2e-07 | 4.7 | -5.2 | 1.6e-07 | 0.54 | 0.30 | 0.69 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | GNA12 | 0.17 | 0.16 | lasso | 3 | 0.18 | 1.3e-14 | -6.2 | -8.4 | 4.0e-17 | 0.87 | 0.12 | 0.88 | FALSE |
| 15 | GTEx | Small Intestine Terminal Ileum | GNA12 | 0.34 | 0.20 | lasso | 5 | 0.16 | 2.4e-04 | -6.3 | -6.9 | 4.7e-12 | 0.72 | 0.05 | 0.83 | FALSE |
| 16 | GTEx | Stomach | GNA12 | 0.18 | 0.16 | lasso | 2 | 0.13 | 6.6e-07 | -6.3 | -6.3 | 2.4e-10 | 0.70 | 0.25 | 0.74 | FALSE |
| 17 | GTEx | Whole Blood | GNA12 | 0.09 | 0.01 | enet | 4 | 0.00 | 3.3e-01 | -10.3 | -10.4 | 3.7e-25 | 0.94 | 0.02 | 0.92 | FALSE |
| 18 | METSIM | Adipose | GNA12 | 0.07 | 0.05 | lasso | 3 | 0.05 | 3.3e-08 | -6.3 | -6.4 | 1.7e-10 | 0.72 | 0.25 | 0.75 | FALSE |
| 19 | NTR | Blood | GNA12 | 0.07 | 0.03 | bslmm | 597 | 0.06 | 1.3e-17 | -7.6 | -7.7 | 2.0e-14 | 0.63 | 0.89 | 0.11 | FALSE |
| 20 | ROSMAP | Brain Pre-frontal Cortex | AMZ1 | 0.09 | 0.05 | lasso | 6 | 0.04 | 2.4e-06 | -10.6 | 11.0 | 4.8e-28 | -0.90 | 0.01 | 0.99 | TRUE |
| 21 | YFS | Blood | GNA12 | 0.23 | 0.15 | bslmm | 570 | 0.25 | 4.5e-82 | 5.5 | -7.2 | 8.0e-13 | 0.52 | 1.00 | 0.00 | FALSE |
| 22 | The Cancer Genome Atlas | Esophageal Carcinoma | AMZ1 | 0.18 | 0.05 | blup | 69 | 0.05 | 1.4e-02 | 6.8 | -9.4 | 5.1e-21 | 0.71 | 0.01 | 0.70 | FALSE |
| 23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GNA12 | 0.03 | 0.04 | lasso | 1 | 0.04 | 3.0e-05 | -6.3 | -6.3 | 3.3e-10 | 0.72 | 0.07 | 0.78 | FALSE |
| 24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AMZ1 | 0.04 | 0.04 | lasso | 3 | 0.02 | 1.3e-03 | 6.8 | 7.8 | 4.5e-15 | -0.60 | 0.03 | 0.91 | FALSE |
| 25 | The Cancer Genome Atlas | Lung Adenocarcinoma | GNA12 | 0.03 | 0.01 | enet | 7 | 0.02 | 1.5e-03 | 4.1 | -8.6 | 7.8e-18 | 0.78 | 0.06 | 0.74 | FALSE |