Best TWAS P=4.37e-22 · Best GWAS P=2.09e-38 conditioned to 2.05e-18
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-446E9.1 | 0.07 | 0.00 | lasso | 6 | 0.00 | 6.6e-01 | -5.9 | 7.0 | 3.6e-12 | -0.76 | 0.03 | 0.68 | FALSE |
| 2 | GTEx | Brain Cerebellum | RPS20 | 0.26 | 0.07 | enet | 17 | 0.10 | 5.4e-04 | -8.3 | -7.5 | 4.5e-14 | 0.60 | 0.16 | 0.59 | FALSE |
| 3 | GTEx | Brain Cerebellum | RP11-446E9.1 | 0.15 | 0.05 | lasso | 3 | 0.03 | 3.7e-02 | -5.9 | 5.7 | 1.4e-08 | -0.53 | 0.05 | 0.50 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | RPS20 | 0.41 | 0.05 | lasso | 8 | 0.13 | 3.1e-04 | -6.1 | -5.8 | 7.2e-09 | 0.53 | 0.04 | 0.36 | FALSE |
| 5 | GTEx | Esophagus Muscularis | RPS20 | 0.12 | 0.04 | lasso | 6 | 0.05 | 7.2e-04 | -8.3 | -8.3 | 1.4e-16 | 0.76 | 0.20 | 0.67 | FALSE |
| 6 | GTEx | Muscle Skeletal | RPS20 | 0.07 | 0.09 | lasso | 1 | 0.07 | 1.5e-07 | -5.8 | -5.8 | 5.2e-09 | 0.49 | 0.94 | 0.06 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | RPS20 | 0.18 | 0.03 | enet | 12 | 0.07 | 1.5e-04 | -8.0 | -9.7 | 4.4e-22 | 0.81 | 0.14 | 0.51 | TRUE |
| 8 | GTEx | Stomach | RP11-446E9.1 | 0.12 | 0.08 | lasso | 4 | 0.03 | 1.7e-02 | -5.4 | 5.2 | 1.6e-07 | -0.48 | 0.27 | 0.17 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | RPS20 | 0.24 | 0.20 | lasso | 6 | 0.23 | 3.4e-29 | -7.3 | -6.6 | 4.6e-11 | 0.51 | 1.00 | 0.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | RP11-446E9.1 | 0.23 | 0.32 | lasso | 7 | 0.34 | 2.0e-45 | -5.9 | 6.7 | 2.4e-11 | -0.53 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPS20 | 0.04 | 0.02 | blup | 29 | 0.03 | 4.8e-04 | -7.1 | -6.3 | 2.4e-10 | 0.49 | 0.03 | 0.03 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPS20 | 0.33 | 0.07 | enet | 8 | 0.07 | 1.7e-08 | -7.3 | -8.3 | 1.0e-16 | 0.49 | 0.96 | 0.03 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPS20 | 0.04 | 0.03 | lasso | 3 | 0.04 | 1.3e-04 | -7.3 | -7.2 | 6.8e-13 | 0.58 | 0.15 | 0.05 | FALSE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | LYN | 0.09 | 0.12 | lasso | 2 | 0.12 | 8.4e-12 | -5.4 | 5.4 | 6.4e-08 | -0.49 | 1.00 | 0.00 | FALSE |