Best TWAS P=6.2e-15 · Best GWAS P=1.83e-19 conditioned to 1.02e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC441454 | 0.05 | 0.01 | lasso | 3 | 0.02 | 1.5e-03 | 4.9 | 5.5 | 4.1e-08 | 0.05 | 0.04 | 0.55 | FALSE |
| 2 | GTEx | Artery Tibial | RP11-435O5.5 | 0.09 | 0.04 | lasso | 2 | 0.02 | 7.3e-03 | 8.0 | -7.8 | 6.2e-15 | 0.18 | 0.22 | 0.15 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | CDC14B | 0.16 | 0.02 | enet | 21 | 0.02 | 3.7e-02 | 6.5 | -5.4 | 7.4e-08 | -0.01 | 0.07 | 0.86 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | AAED1 | 0.17 | 0.02 | lasso | 3 | 0.04 | 2.4e-02 | 6.5 | 5.8 | 6.1e-09 | 0.00 | 0.05 | 0.47 | FALSE |
| 5 | GTEx | Liver | PTCH1 | 0.25 | 0.06 | enet | 11 | 0.03 | 4.9e-02 | 8.1 | 5.2 | 1.9e-07 | -0.11 | 0.16 | 0.07 | FALSE |
| 6 | GTEx | Nerve Tibial | ZNF367 | 0.10 | 0.05 | lasso | 3 | 0.02 | 7.9e-03 | 6.8 | 6.1 | 1.1e-09 | -0.01 | 0.04 | 0.95 | FALSE |
| 7 | GTEx | Testis | HABP4 | 0.19 | 0.22 | lasso | 9 | 0.21 | 1.1e-09 | 6.6 | 6.6 | 4.4e-11 | -0.02 | 0.06 | 0.94 | FALSE |
| 8 | GTEx | Thyroid | CDC14B | 0.15 | 0.10 | lasso | 5 | 0.08 | 5.3e-07 | 6.1 | -6.3 | 3.7e-10 | -0.03 | 0.22 | 0.77 | FALSE |
| 9 | NTR | Blood | PTCH1 | 0.04 | 0.02 | blup | 433 | 0.02 | 4.1e-08 | 5.9 | 5.2 | 1.5e-07 | -0.08 | 0.92 | 0.07 | TRUE |
| 10 | YFS | Blood | HABP4 | 0.08 | 0.09 | enet | 24 | 0.11 | 5.9e-34 | 6.7 | -6.4 | 1.7e-10 | 0.03 | 0.03 | 0.97 | FALSE |
| 11 | YFS | Blood | PTCH1 | 0.09 | 0.05 | lasso | 8 | 0.05 | 1.2e-15 | 5.8 | 6.8 | 1.0e-11 | -0.10 | 0.31 | 0.69 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CDC14B | 0.02 | 0.01 | lasso | 1 | 0.01 | 3.0e-03 | 6.7 | -6.7 | 1.6e-11 | 0.02 | 0.03 | 0.56 | FALSE |
| 13 | The Cancer Genome Atlas | Glioblastoma Multiforme | CDC14B | 0.16 | 0.17 | blup | 41 | 0.19 | 2.6e-06 | 6.5 | -5.9 | 3.2e-09 | 0.02 | 0.05 | 0.92 | FALSE |
| 14 | The Cancer Genome Atlas | Glioblastoma Multiforme | HABP4 | 0.08 | 0.06 | blup | 44 | 0.05 | 1.6e-02 | 6.0 | -6.8 | 1.1e-11 | 0.02 | 0.03 | 0.49 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HABP4 | 0.02 | 0.02 | blup | 44 | 0.02 | 7.1e-03 | 6.5 | 6.7 | 1.9e-11 | -0.03 | 0.03 | 0.65 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CDC14B | 0.03 | 0.02 | blup | 42 | 0.02 | 2.1e-03 | 6.5 | -6.7 | 2.8e-11 | 0.02 | 0.04 | 0.63 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CDC14B | 0.05 | 0.06 | lasso | 5 | 0.06 | 6.5e-07 | 6.5 | -6.1 | 9.5e-10 | 0.01 | 0.07 | 0.93 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HABP4 | 0.05 | 0.08 | lasso | 5 | 0.08 | 6.9e-09 | 5.9 | -6.2 | 7.5e-10 | 0.01 | 0.11 | 0.89 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PTCH1 | 0.02 | 0.01 | blup | 54 | 0.02 | 1.1e-03 | 6.8 | -6.6 | 5.6e-11 | 0.27 | 0.06 | 0.07 | FALSE |
| 20 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CDC14B | 0.08 | 0.02 | blup | 41 | 0.04 | 1.0e-03 | 4.9 | -7.0 | 2.4e-12 | 0.03 | 0.02 | 0.59 | TRUE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | CDC14B | 0.05 | 0.07 | blup | 42 | 0.08 | 4.8e-08 | 6.5 | -6.5 | 7.3e-11 | 0.03 | 0.06 | 0.94 | FALSE |