Hub : Genes

LOC441454

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0460 0.0270 0.0110 0.010 0.004 0.001 0.003 0.020 0.0190 0.1100 0.240 0.14 0.0015
2 TCGA Brain Lower Grade Glioma 0.0315 0.0383 0.0075 0.023 0.014 0.011 NA 0.018 0.0011 0.0087 0.017 NA 0.0031

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.6 1.0 2.0 -1.4 0.0
Bipolar Disorder or Schizophrenia 0.7 1.7 3.3 -1.8 0.0
Depressed Affect (Nagel 2018) 0.3 0.6 1.2 1.1 0.3
Depression (Nagel 2018) 0.4 0.7 1.3 -0.3 -1.1
Intelligence (Savage-Jansen 2018) 4.6 14.0 28.1 5.3 0.1
Neuroticism (Nagel 2018) 0.5 1.2 2.0 1.4 -0.7
Schizophrenia (2018) 0.4 0.7 1.5 -1.2 0.0
Schizophrenia vs Biploar Disorder 0.1 0.1 0.3 0.5 0.0
Worry (Nagel 2018) 0.9 1.9 2.9 0.9 -1.7
Alzheimer’s Disease (in mother) 1.8 2.1 2.6 1.6 1.3
Alzheimer’s Disease (in father) 0.2 0.3 0.5 0.0 -0.7
Alzheimer’s Disease (including proxy) 0.6 0.9 1.4 1.2 0.6
Crohns Disease (2017) 0.1 0.3 0.6 -0.8 -0.0
Irritable Bowel Disease (IBD) 0.2 0.6 0.9 -0.5 -1.0
Ulcerative Colitis (UC) 0.7 1.3 2.5 -0.3 -1.6
Major Depression (MDD) 0.0 0.0 0.0 -0.1 0.0
Reaction Time 1.0 1.8 2.7 -1.7 1.0
Verbal and Numeric Reasoning (VNR) 4.0 9.7 19.3 4.4 -0.2
Breast Cancer 1.2 2.8 5.4 -2.3 -0.5
Ovarian Cancer 0.6 0.8 1.6 -1.2 0.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 2.5 3.6 5.1 2.3 1.5
Bipolar Disorder (2011) 1.0 1.0 2.0 -1.4 0.0
Body Mass Index (BMI) (2010) 1.6 2.2 4.0 0.5 2.0
Coronary Artery Disease (CAD) 0.3 0.4 0.7 0.8 0.0
Crohns Disease (2012) 0.2 0.3 0.6 -0.8 0.0
Mean Putamen Volume 0.8 0.9 1.7 -1.3 0.0
Fasting Glucose 0.5 0.6 1.1 1.1 -0.1
HbA1C 2.3 2.5 4.5 -2.1 0.8
HDL Cholesterol 0.3 0.5 1.0 0.0 1.0
LDL Cholesterol 1.2 1.9 3.0 1.7 0.9
Lupus 0.1 0.1 0.2 0.5 0.0
Neuroticism (2016) 0.1 0.1 0.1 -0.4 0.0
Primary Biliary Cirrhosis 0.7 1.0 1.9 -1.4 0.3
Rheumatoid Arthritis 0.3 0.4 0.8 0.9 0.0
Schizophrenia (2014) 0.4 0.9 1.9 -1.4 0.0
Triglycerides 0.2 0.4 0.5 -0.7 -0.5
Type 2 Diabetes (T2D) (2012) 3.1 3.6 7.2 -2.7 0.0
Ulcerative Colitis 0.0 0.0 0.0 -0.1 0.0
Blood Eosinophil Count 0.1 0.8 1.6 -1.3 -0.1
Blood Platelet Count 5.3 61.5 118.8 -10.9 -2.1
Blood Red Count 0.0 0.4 0.7 0.8 -0.3
Blood White Count 0.3 1.9 3.4 -1.8 -0.7
Heel T-Score 0.3 2.5 4.8 -0.4 2.2
BMI 0.4 2.4 3.5 -1.9 -1.1
Height 6.6 126.5 252.8 15.9 -0.5
Waist Hip Ratio (WHR) 0.3 1.5 2.9 0.4 1.7
Systolic Blood Pressure 0.4 2.2 3.3 1.8 1.0
Smoking Status 1.0 2.4 4.9 -2.2 -0.0
Allergy or Eczema 0.0 0.0 0.0 -0.2 0.1
Cardiovascular Disease 0.0 0.0 0.1 0.1 -0.3
Hypothyroidism (self reported) 0.3 0.7 1.3 -0.1 1.2
Respiratory disease 0.4 1.0 1.3 1.2 0.8
Type 2 Diabetes (T2D) (2018) 0.6 1.1 1.5 -0.9 -1.2
Lung FEV1/FVC ratio 0.1 0.4 0.9 -0.9 0.2
Lung FVC 0.1 0.4 0.8 0.2 -0.9
Neuroticism 0.9 2.1 4.0 2.0 -0.4
Chronotype (morning person) 2.8 6.4 12.7 -3.6 -0.4
Hair Pigment 0.1 1.6 1.6 -1.3 -1.2
Tanning 0.0 0.5 0.9 0.4 -0.9
Hand grip strength (left) 0.5 1.3 2.0 1.4 -0.7
Number of treatments/medications taken 0.7 1.2 2.3 0.4 -1.5
Average weekly spirits intake 0.2 0.3 0.5 -0.7 -0.3
Sensitivity / hurt feelings 0.2 0.3 0.6 -0.8 -0.2
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.3 0.7 -1.1
Hearing difficulty/problems: Yes 0.3 0.5 1.0 0.3 -1.0
Relative age of first facial hair 0.4 0.9 1.4 -1.2 0.6
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 2.2 1.5 0.3
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.7 1.3 -0.2
Ever had hysterectomy (womb removed) 0.6 0.7 1.0 -1.0 -0.5
Systolic blood pressure, automated reading 0.1 0.2 0.4 0.6 0.1
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 1.5 -1.2 0.7
Angina 0.0 0.0 0.0 0.1 -0.2
Medication for hormone replacement therapy 0.8 0.9 1.8 0.0 -1.3
Vitamin and mineral supplements 1.0 1.3 1.9 1.4 0.8
Supplements: Zinc 0.3 0.3 0.6 0.8 0.3
Medication: Co-codamol 2.4 2.8 4.5 1.1 2.1
Medication: Metformin 0.1 0.1 0.2 0.4 -0.1
Diabetes (father) 0.5 0.7 1.3 -0.1 -1.1
Diabetes (mother) 0.8 1.0 1.7 -0.6 -1.3
Severe depression (siblings) 0.3 0.3 0.7 0.1 0.8
Pack years adult smoking proportion 0.2 0.3 0.5 -0.4 -0.7
Impedance of leg (right) 0.7 3.3 6.2 -2.5 0.6
Leg fat-free mass (left) 3.1 16.2 30.5 5.5 -1.4
Trunk fat percentage 0.7 2.6 5.1 -0.5 -2.2
Hand grip strength (right) 1.0 2.8 3.3 1.8 -1.5
Townsend deprivation index at recruitment 0.0 0.0 0.0 0.0 -0.2
Current tobacco smoking 0.4 0.7 1.0 -1.0 -0.6
Average weekly fortified wine intake 0.3 0.4 0.7 0.2 -0.8
Maternal smoking around birth 0.7 1.0 1.0 1.0 -1.0
Fed-up feelings 1.0 1.8 3.5 1.9 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.5 0.6 -0.6 -0.7
Relative age voice broke 0.6 0.9 1.6 -1.3 0.4
Taking other prescription medications 1.0 1.5 2.1 1.0 -1.4
Age when periods started (menarche) 0.8 1.9 3.8 0.0 1.9
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 0.7 0.7 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 5.5 -2.3 -0.4
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 1.8 -1.3 -0.6
Qualifications: CSEs or equivalent 2.6 3.4 3.5 -1.8 1.9
Serious illness, injury or assault to yourself 0.2 0.3 0.3 -0.5 -0.6
High blood pressure 1.0 2.9 5.8 2.4 -0.3
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.5 -0.7 -0.4
Multivitamins +/- minerals 0.7 0.9 1.5 -1.2 0.5
Stomach or abdominal pain in last month 0.6 0.7 0.9 1.0 0.7
Supplements: Glucosamine 1.4 1.8 2.3 -1.5 -1.1
Diverticular disease/diverticulitis (self-reported) 2.3 2.7 2.9 1.7 1.6
Medication: Atenolol 1.3 1.6 2.8 1.7 0.6
Medication: Levothyroxine sodium 0.2 0.3 0.5 -0.3 0.7
Sitting height 6.2 44.1 86.9 9.3 -1.1
Chronic bronchitis/emphysema (father) 0.6 0.7 0.8 0.9 0.8
High blood pressure (mother) 4.8 6.7 8.0 -2.8 -2.3
Body mass index (BMI) 0.3 1.2 2.4 -0.3 -1.5
Impedance of leg (left) 1.1 5.3 9.4 -3.1 1.1
Leg predicted mass (left) 3.0 15.7 29.5 5.4 -1.4
Trunk fat mass 0.9 3.9 4.9 1.7 -2.2
Waist circumference 0.6 2.1 2.9 1.7 -1.1
Number of incorrect matches in round 0.2 0.3 0.6 -0.8 0.1
Past tobacco smoking 0.9 1.6 2.4 1.6 -0.8
Alcohol usually taken with meals 2.7 4.4 4.6 -2.1 2.0
Nervous feelings 1.3 2.4 2.6 1.5 -1.6
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.1 3.6 -1.9 -0.8
Hearing difficulty/problems with background noise 0.0 0.0 0.0 0.0 -0.1
Hair/balding pattern: Pattern 2 1.4 1.8 3.3 0.5 -1.8
Had menopause 1.0 1.2 2.2 0.5 -1.5
Had other major operations 0.4 0.5 1.0 1.0 0.1
Forced vital capacity (FVC) 2.3 8.9 17.7 4.2 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 3.8 -1.9 1.3
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 3.3 -0.0 1.8
Qualifications: None of the above 0.3 0.6 1.2 -0.3 -1.1
Financial difficulties in last 2 years 0.5 0.7 1.3 0.3 1.2
Mouth/teeth dental problems 0.0 0.0 0.0 -0.2 0.0
Heart attack 1.9 2.4 4.4 0.6 -2.1
Allergy 0.3 0.6 1.0 0.4 1.0
Pain all over the body in last month 0.2 0.2 0.3 0.6 0.4
Diabetes (self-reported) 0.9 1.4 1.5 -1.2 -1.1
Hayfever/allergic rhinitis (self-reported) 2.1 2.8 5.4 2.3 0.5
Medication: Ramipril 0.7 0.9 1.0 -0.9 -1.0
Medication: Simvastatin 0.9 1.3 2.1 -1.4 0.7
Fluid intelligence score 3.1 6.5 13.0 3.6 0.1
Illnesses of siblings 2.0 2.9 3.5 1.5 1.9
Neuroticism score 1.2 2.5 4.6 2.2 -0.6
Weight 2.2 10.9 18.1 4.3 -1.9
Impedance of arm (right) 0.7 3.3 6.5 -2.5 -0.3
Arm fat percentage (right) 0.6 2.4 3.8 -1.0 -2.0
Trunk fat-free mass 4.7 26.9 53.9 7.3 -0.1
Hip circumference 1.5 6.3 8.5 2.9 -2.0
Time employed in main current job 0.1 0.1 0.1 0.4 0.3
Alcohol intake versus 10 years previously 0.2 0.3 0.3 -0.6 0.6
Father’s age at death 2.3 3.1 3.4 1.7 1.8
Worrier / anxious feelings 1.2 2.3 3.9 2.0 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.0 0.0 -0.1 0.0
Falls in the last year 1.5 2.1 3.7 -1.9 -0.7
Hair/balding pattern: Pattern 3 0.7 1.0 1.9 -1.4 -0.4
Number of live births 1.0 1.4 1.9 -1.4 1.0
Forced expiratory volume in 1-second (FEV1) 1.7 5.8 11.4 3.4 -0.5
Pulse rate 0.1 0.2 0.3 -0.5 -0.5
Happiness 1.3 1.5 2.2 0.9 1.5
Noisy workplace 1.9 2.3 4.1 -0.7 -2.0
Qualifications: A levels/AS levels or equivalent 0.9 1.9 2.7 1.1 1.6
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 2.4 1.6 1.6
Mouth/teeth dental problems: Dentures 0.7 1.1 2.0 -1.4 0.5
Asthma 1.0 1.9 2.1 1.4 -1.4
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 2.2 1.5 -0.9
Medication: Cholesterol lowering 0.8 1.2 2.2 -1.5 -0.5
Depression (self-reported) 0.1 0.1 0.2 -0.0 -0.5
Medication: Lansoprazole 0.3 0.3 0.5 0.3 -0.7
Prospective memory result 1.8 2.2 3.8 -0.8 2.0
Lung cancer (father) 0.1 0.1 0.3 0.5 -0.2
Illnesses of mother 1.1 1.4 2.3 1.5 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.8 9.0 3.0 -0.8
Pulse wave Arterial Stiffness index 1.4 1.6 2.5 -0.8 1.6
Impedance of arm (left) 0.4 2.0 3.7 -1.9 -0.6
Arm fat mass (right) 0.6 2.5 4.0 1.0 -2.0
Trunk predicted mass 4.7 27.0 54.0 7.3 -0.1
Standing height 5.4 53.1 106.1 10.3 -0.4
Length of working week for main job 0.3 0.3 0.6 -0.1 -0.8
Exposure to tobacco smoke at home 0.1 0.1 0.3 -0.0 -0.5
Breastfed as a baby 0.5 0.6 1.1 1.1 -0.1
Tense / ‘highly strung’ 0.1 0.1 0.3 0.5 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 2.4 1.6 0.9
Hair/balding pattern: Pattern 4 0.4 1.0 1.7 0.6 1.3
Birth weight of first child 1.6 2.9 3.0 1.7 1.7
Peak expiratory flow (PEF) 1.1 2.6 4.0 2.0 -1.0
Pulse wave reflection index 1.0 1.3 1.7 -0.9 1.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 0.9 0.5 -0.9
Loud music exposure frequency 0.7 0.8 0.9 -0.8 1.0
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.3 -0.6 1.1
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 2.0 1.0 -1.4
Blood clot in the leg (DVT) 0.7 0.9 1.0 -0.9 -1.0
Medication: Paracetamol 0.5 0.9 1.8 -0.1 -1.3
Headache pain in last month 0.4 0.7 1.3 1.1 0.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.6 -0.8 -0.1
Glaucoma (self-reported) 0.2 0.3 0.5 -0.7 -0.3
Gout (self-reported) 0.8 1.1 1.5 -1.2 -0.9
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.2 -0.2 0.4
Medication: Amlodipine 0.6 0.8 1.6 1.2 -0.1
Medication: Ventolin 100micrograms inhaler 1.4 1.8 3.5 -0.1 -1.9
Birth weight 0.5 1.1 1.6 1.2 0.9
Chronic bronchitis/emphysema (mother) 1.8 2.1 2.8 1.2 1.7
High blood pressure (siblings) 1.5 2.2 3.0 -1.7 -1.2
Forced vital capacity (FVC), Best measure 2.1 7.8 15.2 3.9 -0.6
Body fat percentage 0.7 2.9 5.2 -0.8 -2.3
Leg fat percentage (right) 0.7 2.6 4.5 -0.9 -2.1
Arm fat-free mass (right) 3.8 19.6 38.5 6.2 -0.8
Exposure to tobacco smoke outside home 1.1 1.4 2.8 0.0 -1.7
Comparative body size at age 10 0.5 1.4 2.4 -0.7 -1.5
Number of full brothers 0.5 0.6 0.7 -0.8 -0.8
Worry too long after embarrassment 0.9 1.5 2.9 1.7 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.4 4.7 2.2 0.3
Wheeze or whistling in the chest in last year 1.3 2.3 4.0 -2.0 -0.8
Number of children fathered 2.3 2.6 4.5 -0.8 -2.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 0.8 -0.0 0.9
Age at first live birth 0.2 0.4 0.7 -0.3 0.8
Pulse wave peak to peak time 2.0 2.4 2.7 1.4 -1.6
Health satisfaction 0.7 0.9 1.5 0.5 1.2
Shortness of breath walking on level ground 0.5 0.5 0.6 -0.7 0.8
Qualifications: College or University degree 1.2 3.8 3.9 1.9 2.0
Eye problems/disorders: None of the above 0.7 0.8 1.2 -1.1 -0.7
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.9 -0.0 -1.0
Emphysema/chronic bronchitis 0.5 0.5 0.7 -0.6 -0.8
Medication for pain relief, constipation, heartburn 2.1 3.6 4.2 -1.7 2.1
Neck or shoulder pain in last month 0.2 0.3 0.5 0.3 -0.7
Medication: Blood pressure 1.6 2.8 5.7 2.4 -0.1
Angina (self-reported) 0.0 0.0 0.0 0.1 -0.1
Migraine (self-reported) 0.7 0.9 1.1 0.8 -1.0
Medication: Ibuprofen 0.7 0.8 1.0 1.0 -0.8
Medication: Allopurinol 0.9 1.2 1.9 -0.7 -1.4
Medication: Omeprazole 0.2 0.3 0.5 -0.7 -0.2
Medication: Seretide 50 evohaler 2.1 2.4 2.5 1.5 -1.6
Mean time to correctly identify matches 0.1 0.2 0.3 -0.5 0.4
Heart disease (mother) 1.0 1.3 1.4 -1.2 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 0.8 -0.5 0.9
Whole body fat mass 0.8 3.2 4.8 1.3 -2.2
Leg fat mass (right) 0.7 2.9 4.6 1.1 -2.1
Arm predicted mass (right) 3.8 19.5 38.3 6.2 -0.9
Pulse rate, automated reading 0.3 1.0 1.6 -1.2 0.7
Alcohol intake frequency. 0.6 1.4 2.2 -0.8 -1.5
Comparative height size at age 10 3.2 17.7 33.6 5.8 -1.3
Number of full sisters 0.8 1.0 1.6 -0.7 -1.3
Suffer from ‘nerves’ 0.8 1.2 2.4 1.5 -0.2
Overall health rating 0.1 0.3 0.6 -0.1 -0.7
Chest pain or discomfort 1.6 2.3 2.3 1.5 -1.5
Had major operations 1.3 1.6 2.8 0.6 -1.7
Age at last live birth 1.0 1.5 3.0 0.1 1.7
Family relationship satisfaction 1.1 1.4 2.4 0.6 1.6
Leg pain on walking 0.5 0.6 1.2 -0.2 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 2.5 -1.6 -0.6
Commuting to job workplace: Car/motor vehicle 1.3 1.5 3.0 -1.7 -0.0
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.2 1.1 -0.0
Medication: Aspirin 1.7 2.3 2.5 1.4 -1.6
Supplements: Vitamin C 0.9 1.1 1.2 -1.0 -1.1
Knee pain experienced in last month 0.4 0.6 0.8 0.7 -0.9
Hypertension (Self-reported) 0.7 2.1 4.0 2.0 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.7 -0.9 0.1
Illnesses of father: Heart disease 0.2 0.2 0.4 -0.2 0.7
Illnesses of siblings: Diabetes 0.0 0.1 0.1 -0.0 -0.3
Smoking status: Previous 0.7 1.0 1.8 -0.5 1.3
Forced expiratory volume in 1-second (FEV1), predicted 2.8 5.7 5.9 2.4 2.3
Whole body fat-free mass 3.9 22.5 44.6 6.7 -0.6
Leg fat-free mass (right) 2.9 15.4 29.6 5.4 -1.1
Arm fat percentage (left) 0.7 2.7 5.0 -0.6 -2.2
Average weekly red wine intake 1.1 1.6 2.8 1.7 0.7
Handedness (chirality/laterality): Left-handed 0.5 0.6 0.9 -0.9 0.6
Mood swings 0.6 1.1 2.0 1.4 0.4
Loneliness, isolation 0.0 0.0 0.1 -0.1 0.3
Long-standing illness, disability or infirmity 1.6 2.4 4.0 2.0 -0.9
Ever had bowel cancer screening 0.5 0.5 1.0 1.0 -0.2
Diabetes diagnosed by doctor 0.4 0.6 1.0 -0.5 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.7 0.3 0.8
Friendships satisfaction 0.5 0.7 0.8 0.9 0.8
Qualifications: nursing, teaching 1.2 1.9 3.0 0.9 1.7
Commuting to job workplace: Walk 1.3 1.4 1.5 1.2 -1.1
Eye problems/disorders: Cataract 1.7 2.0 2.0 1.4 1.4
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.4 0.6 -0.3
Medication for cholesterol 0.4 0.6 1.0 0.4 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.0 0.1 -0.1 -0.2
Back pain experienced in last month 0.1 0.2 0.2 0.3 0.5
Mineral and other dietary supplements 0.2 0.2 0.3 0.5 -0.4
Breast cancer (self-reported) 1.3 1.5 2.9 1.7 0.4
Asthma (self-reported) 0.8 1.6 2.0 1.1 -1.4
Osteoporosis (self-reported) 1.9 2.3 4.3 0.5 2.1
Osteoarthritis (self-reported) 0.6 0.8 1.5 1.2 -0.4
Medication: Aspirin 1.5 1.9 2.0 1.4 -1.4
Medication: Gliclazide 0.5 0.6 0.7 -0.8 0.7
Illnesses of father: None of the above (group 1) 0.0 0.0 0.1 -0.3 -0.1
Smoking status: Current 0.6 1.0 1.1 -1.1 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 2.5 1.6 -0.5
Whole body water mass 4.0 22.8 45.3 6.7 -0.6
Leg predicted mass (right) 2.8 14.7 28.2 5.3 -1.1
Arm fat mass (left) 0.7 2.7 3.3 1.5 -1.8
Number of self-reported non-cancer illnesses 0.8 1.4 2.6 1.6 -0.6
Average weekly champagne plus white wine intake 0.2 0.3 0.5 -0.3 0.7
Miserableness 0.7 1.3 2.5 1.6 -0.2
Guilty feelings 1.2 1.8 2.5 1.0 -1.6
Wears glasses or contact lenses 0.2 0.2 0.3 -0.3 0.6
Ever taken oral contraceptive pill 1.7 1.9 3.5 -0.5 1.9
Hearing aid user 0.7 0.8 1.6 1.3 0.1
Mother’s age at death 1.1 1.3 2.6 -1.6 0.2
Financial situation satisfaction 0.8 1.1 1.3 -0.9 1.1
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.5 0.7 0.2
Commuting to job workplace: Public transport 2.0 2.4 4.6 2.1 0.5
Eye problems/disorders: Glaucoma 0.8 0.9 1.3 -1.1 -0.8
Medication: Blood pressure 0.4 0.7 1.4 0.3 -1.2
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.5 0.7 0.3
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.4 -1.2 0.4
High cholesterol (Self-reported) 0.4 0.7 1.3 -1.2 0.0
Medication: Bendroflumethiazide 0.1 0.2 0.4 0.1 0.6
Medication: Paracetamol 0.4 0.6 1.1 -0.2 -1.1
Medication: Lisinopril 0.4 0.5 0.7 -0.8 -0.6
Medication: Atorvastatin 0.9 1.1 2.3 1.5 -0.1
Illnesses of father: High blood pressure 0.3 0.4 0.4 -0.6 -0.6
Alcohol drinker status: Never 1.4 1.7 2.2 1.1 -1.5
Ever smoked 2.4 4.2 7.9 -2.8 0.8
Basal metabolic rate 3.6 19.8 38.8 6.2 -0.9
Leg fat percentage (left) 0.6 2.3 3.1 -1.3 -1.8
Arm fat-free mass (left) 3.0 15.3 30.4 5.5 -0.4
Number of operations (self-reported) 2.1 3.1 4.9 2.2 -1.2
Average weekly beer plus cider intake 0.4 0.6 0.8 0.9 0.5
Irritability 0.2 0.4 0.8 0.9 -0.0
Risk taking 0.5 0.8 0.8 -0.9 -0.8
Ever had prostate specific antigen (PSA) test 1.6 1.9 2.2 1.5 1.2
Fractured/broken bones in last 5 years 0.4 0.5 1.0 0.2 1.0
Age started oral contraceptive pill 0.3 0.4 0.8 -0.2 0.9
Diastolic blood pressure, automated reading 0.2 0.5 0.9 0.3 0.9
Ever depressed for a whole week 0.0 0.0 0.1 0.3 -0.0
Unable to work because of sickness or disability 0.3 0.4 0.8 -0.9 0.2
Commuting to job workplace: Cycle 2.2 2.7 4.2 1.1 2.0
Myopia 0.0 0.0 0.0 0.2 0.2
Vascular/heart problems diagnosed by doctor 0.7 2.0 3.4 -1.8 0.7
Cholesterol lowering medication 0.4 0.5 0.9 -0.9 0.4
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.2 -0.5 -0.3
Pain experienced in last month 0.2 0.3 0.6 -0.8 -0.1
Supplements: Calcium 0.0 0.0 0.0 -0.1 0.2
Basal cell carcinoma (self-reported) 0.6 0.7 1.2 -0.4 1.1
Heart attack/myocardial infarction (self-reported) 2.1 2.8 5.3 0.4 -2.3
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 0.9 -0.7 -1.0
Heart disease (siblings) 0.5 0.6 0.8 -0.9 -0.7
Alcohol drinker status: Previous 1.0 1.1 1.4 -0.9 -1.2
Pack years of smoking 0.2 0.3 0.6 -0.0 -0.8
Impedance of whole body 0.9 4.5 9.0 -3.0 0.1
Leg fat mass (left) 0.6 2.2 3.8 0.8 -1.9
Arm predicted mass (left) 3.0 15.2 30.0 5.5 -0.7