Hub : Genes

HABP4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.1870	0.0510	3.4e-07	0.217	NA	0.210	NA	0.210	5.6e-10	NA	1.1e-09	NA	1.1e-09
2	METSIM	Adipose	0.0481	0.0224	3.8e-03	-0.001	0.007	0.001	0.009	-0.001	6.6e-01	3.1e-02	2.2e-01	1.5e-02	6.2e-01
3	YFS	Blood	0.0840	0.0181	0.0e+00	0.089	0.105	0.110	0.107	0.103	1.3e-27	1.2e-32	5.9e-34	3.3e-33	1.0e-31
4	TCGA	Glioblastoma Multiforme	0.0760	0.0540	7.1e-03	0.059	0.045	0.032	NA	0.034	7.4e-03	1.6e-02	3.8e-02	NA	3.2e-02
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0178	0.0151	6.8e-03	0.017	0.015	0.014	NA	0.010	4.2e-03	7.1e-03	1.0e-02	NA	2.1e-02
6	TCGA	Brain Lower Grade Glioma	0.0523	0.0249	3.2e-10	0.078	0.074	0.066	NA	0.075	3.3e-09	9.3e-09	6.3e-08	NA	6.9e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.7	-0.7	0.1	1.3	0.6	-0.5	0.5
Bipolar Disorder or Schizophrenia	1.2	3.0	4.0	-2.0	-1.3	1.7	1.8	-1.9	1.7
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	-0.2	-0.5	0.4	0.3	-0.1	0.3
Depression (Nagel 2018)	0.7	1.1	1.3	-1.1	-1.2	0.9	1.0	-0.9	1.1
Intelligence (Savage-Jansen 2018)	7.8	23.9	30.9	5.4	2.2	-4.7	-5.3	5.6	-5.3
Neuroticism (Nagel 2018)	0.3	0.7	1.3	0.9	0.7	-0.2	-0.9	1.1	-0.9
Schizophrenia (2018)	1.5	3.1	4.2	-2.0	-1.6	1.2	1.8	-2.1	1.8
Schizophrenia vs Biploar Disorder	2.9	3.9	5.8	-1.8	-1.8	1.9	2.1	-1.8	2.4
Worry (Nagel 2018)	1.0	2.1	3.1	1.5	1.7	-0.6	-1.5	1.8	-1.4
Alzheimer’s Disease (in mother)	0.9	1.0	1.3	1.0	1.2	-1.0	-0.9	1.0	-1.0
Alzheimer’s Disease (in father)	0.8	0.8	4.1	-0.2	0.7	2.0	0.4	0.1	0.3
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	0.5	1.0	0.4	-0.4	0.8	-0.4
Crohns Disease (2017)	0.2	0.3	1.5	-0.3	-1.2	-0.6	0.2	-0.3	-0.1
Irritable Bowel Disease (IBD)	0.3	0.7	3.5	-0.4	-1.9	-0.6	0.3	-0.4	-0.0
Ulcerative Colitis (UC)	0.1	0.3	1.4	0.0	-1.2	-0.4	-0.1	0.1	-0.2
Major Depression (MDD)	0.9	1.1	1.5	-0.9	-0.8	1.1	1.0	-1.2	1.1
Reaction Time	0.4	0.8	2.1	-0.8	-1.4	-0.6	0.6	-1.0	0.5
Verbal and Numeric Reasoning (VNR)	7.2	17.3	21.4	4.4	1.8	-4.3	-4.6	4.6	-4.5
Breast Cancer	1.1	2.6	3.9	-2.0	-0.1	1.7	1.7	-1.8	1.6
Ovarian Cancer	0.8	1.1	1.9	-1.3	-0.1	0.8	1.1	-1.4	1.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	6.7	9.8	15.5	3.0	1.8	-3.9	-3.2	3.1	-3.3
Bipolar Disorder (2011)	0.2	0.2	1.0	0.0	1.0	0.5	0.2	-0.0	-0.2
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	0.2	-0.5	-1.0	-0.4	0.3	-0.3
Coronary Artery Disease (CAD)	0.7	0.8	2.9	-0.6	-1.7	0.4	0.6	-0.7	0.8
Crohns Disease (2012)	0.1	0.2	0.3	-0.5	-0.6	0.1	0.4	-0.4	-0.0
Mean Putamen Volume	0.1	0.1	0.2	-0.2	-0.0	-0.5	-0.4	0.0	0.0
Fasting Glucose	0.6	0.7	1.6	-1.0	-1.3	0.0	0.4	-1.1	0.7
HbA1C	0.5	0.5	1.4	-0.5	-0.4	1.2	0.8	-0.4	0.7
HDL Cholesterol	0.2	0.3	1.0	-0.5	-1.0	0.3	0.5	-0.4	0.6
LDL Cholesterol	0.2	0.3	0.5	0.6	0.3	-0.4	-0.4	0.6	-0.7
Lupus	0.2	0.3	1.3	0.4	0.1	-1.1	-0.6	0.4	-0.1
Neuroticism (2016)	0.3	0.4	0.6	-0.6	-0.6	0.8	0.6	-0.5	0.6
Primary Biliary Cirrhosis	0.3	0.4	0.9	-0.6	-0.3	0.9	0.7	-0.6	0.7
Rheumatoid Arthritis	0.1	0.2	0.4	0.4	0.2	-0.6	-0.6	0.5	-0.2
Schizophrenia (2014)	1.2	2.6	3.3	-1.8	-0.7	1.8	1.7	-1.8	1.5
Triglycerides	0.4	0.6	1.3	-0.9	0.1	-0.0	0.8	-1.2	0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.8	0.5	0.4	0.6	-0.6	0.5
Ulcerative Colitis	0.1	0.1	0.4	-0.2	-0.7	-0.2	-0.0	-0.1	-0.2
Blood Eosinophil Count	1.3	9.6	13.0	-3.1	-1.9	3.6	3.5	-3.0	3.3
Blood Platelet Count	11.2	129.7	243.4	-11.8	-3.6	15.6	12.2	-9.9	11.6
Blood Red Count	0.1	1.3	2.1	1.1	1.5	-0.7	-1.0	1.0	-1.4
Blood White Count	2.8	21.1	26.0	-4.9	-3.5	4.0	5.1	-5.1	4.8
Heel T-Score	0.0	0.1	0.3	-0.4	0.1	-0.4	0.4	-0.5	0.3
BMI	3.0	17.2	21.9	-4.3	-3.2	4.1	4.2	-4.2	4.7
Height	24.3	467.8	571.2	22.7	13.2	-22.5	-23.9	23.2	-22.4
Waist Hip Ratio (WHR)	0.0	0.1	0.2	0.2	0.5	-0.2	0.1	0.2	-0.2
Systolic Blood Pressure	0.5	2.6	4.3	1.8	2.1	0.3	-1.2	1.9	-1.6
Smoking Status	1.4	3.2	4.3	-2.0	-1.4	1.1	1.9	-2.1	2.0
Allergy or Eczema	0.6	1.5	2.3	-1.3	-1.5	0.8	1.0	-1.2	1.3
Cardiovascular Disease	0.1	0.2	0.4	0.5	0.3	0.7	-0.5	0.6	-0.3
Hypothyroidism (self reported)	0.8	1.8	4.0	1.1	-0.5	-2.0	-1.4	1.2	-1.3
Respiratory disease	0.1	0.2	0.4	0.3	-0.1	-0.7	-0.4	0.5	-0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.6	-0.4	1.0	1.2	0.6	-0.3	0.5
Lung FEV1/FVC ratio	0.6	3.0	4.2	-1.7	-1.0	1.8	1.8	-2.0	1.9
Lung FVC	0.1	0.7	1.1	-1.0	0.9	0.5	0.8	-1.1	0.5
Neuroticism	0.4	1.0	1.6	1.1	0.5	-0.4	-1.1	1.3	-1.2
Chronotype (morning person)	3.0	7.0	9.9	-2.8	-1.0	3.1	2.7	-2.7	2.9
Hair Pigment	0.0	0.5	1.1	-1.0	-0.2	0.2	0.4	-0.6	1.0
Tanning	0.0	0.2	0.9	0.4	-0.9	0.1	-0.2	0.4	-0.3
Hand grip strength (left)	5.8	15.2	20.4	4.5	2.1	-3.3	-4.2	4.5	-4.2
Number of treatments/medications taken	0.6	1.1	2.1	-1.4	-0.9	-0.0	0.8	-1.3	1.2
Average weekly spirits intake	0.3	0.4	1.6	0.0	-1.3	-0.6	-0.5	0.3	-0.3
Sensitivity / hurt feelings	0.1	0.2	0.5	0.4	0.7	0.1	-0.3	0.4	-0.5
Frequency of depressed mood in last 2 weeks	0.7	0.9	1.4	-0.8	-1.0	1.2	0.9	-0.8	0.9
Hearing difficulty/problems: Yes	1.5	2.3	4.9	-1.6	-2.2	0.4	1.0	-1.6	1.4
Relative age of first facial hair	0.1	0.3	0.6	-0.6	-0.8	0.6	0.4	-0.3	0.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	-0.3	-0.8	-0.8	0.0	-0.1	0.3
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.8	-1.6	-0.6	0.4	1.3	-1.7	0.9
Ever had hysterectomy (womb removed)	0.3	0.3	0.5	-0.7	-0.7	-0.2	0.4	-0.7	0.7
Systolic blood pressure, automated reading	0.3	0.8	2.6	-0.6	0.5	1.6	0.9	-0.5	0.6
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	2.4	-1.6	-1.5	1.0	1.1	-1.4	1.6
Angina	0.1	0.2	0.5	-0.4	-0.7	-0.3	0.2	-0.4	0.3
Medication for hormone replacement therapy	1.5	1.6	2.4	-1.5	-1.5	0.8	1.3	-1.4	1.1
Vitamin and mineral supplements	2.6	3.6	5.4	2.3	1.3	-1.8	-1.8	2.1	-1.9
Supplements: Zinc	0.3	0.3	1.3	-0.0	-1.1	-0.7	-0.2	0.1	0.4
Medication: Co-codamol	0.3	0.3	0.6	-0.6	-0.8	-0.7	0.1	-0.4	0.4
Medication: Metformin	0.4	0.6	0.8	-0.8	0.0	0.8	0.9	-0.8	0.9
Diabetes (father)	0.1	0.1	0.2	0.2	0.5	0.2	0.1	0.2	0.4
Diabetes (mother)	0.5	0.6	2.1	-0.6	1.4	0.7	0.6	-0.5	0.6
Severe depression (siblings)	0.3	0.4	1.7	0.2	-1.3	-0.4	-0.0	0.4	0.2
Pack years adult smoking proportion	3.4	5.1	6.5	-2.4	-2.5	1.3	2.3	-2.6	2.3
Impedance of leg (right)	1.1	5.2	6.4	-2.3	-1.1	2.4	2.5	-2.5	2.5
Leg fat-free mass (left)	6.4	34.1	43.8	6.3	2.6	-5.9	-6.6	6.6	-5.9
Trunk fat percentage	3.0	12.0	15.6	-3.5	-3.5	3.3	3.3	-3.3	4.0
Hand grip strength (right)	8.7	23.7	30.1	5.3	4.1	-3.7	-5.1	5.5	-5.3
Townsend deprivation index at recruitment	0.7	1.0	1.3	-1.0	-0.9	0.8	1.2	-1.1	1.1
Current tobacco smoking	3.9	6.4	8.1	-2.8	-1.6	2.1	2.8	-2.9	2.7
Average weekly fortified wine intake	0.2	0.2	1.2	0.0	-0.1	-1.1	-0.3	-0.1	0.3
Maternal smoking around birth	0.6	0.8	1.5	-0.9	-1.2	0.3	0.8	-0.8	1.1
Fed-up feelings	0.4	0.8	1.5	-0.8	-0.8	1.2	0.8	-0.7	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	4.0	5.3	6.0	-2.4	-2.3	1.9	2.4	-2.3	2.4
Relative age voice broke	0.3	0.4	0.8	0.5	0.9	0.8	-0.1	0.7	-0.5
Taking other prescription medications	0.2	0.2	1.2	-0.2	0.2	-1.1	-0.5	-0.1	-0.1
Age when periods started (menarche)	0.6	1.3	4.0	1.0	0.5	-2.0	-1.1	0.8	-1.0
Bilateral oophorectomy (both ovaries removed)	0.0	0.1	0.1	0.1	-0.4	-0.4	-0.1	-0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.2	3.6	-0.9	0.6	1.9	1.1	-0.9	0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.6	-0.1	1.2	0.4	-0.4	0.2	-0.1
Qualifications: CSEs or equivalent	3.0	4.0	5.9	-2.4	-0.0	1.9	2.3	-2.4	1.8
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.7	-0.2	-0.1	0.6	-0.8	0.9
High blood pressure	0.3	0.7	1.5	1.0	-0.0	-0.5	-1.1	1.2	-0.8
Hayfever, allergic rhinitis or eczema	1.3	2.8	3.4	-1.7	-1.7	1.4	1.5	-1.8	1.8
Multivitamins +/- minerals	3.0	3.8	6.4	-2.5	-1.4	1.2	1.9	-2.4	2.0
Stomach or abdominal pain in last month	0.2	0.3	0.4	-0.6	-0.6	0.6	0.5	-0.5	0.5
Supplements: Glucosamine	1.2	1.6	2.7	-1.7	-0.7	0.8	1.3	-1.6	1.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.4	5.4	-0.8	-2.3	0.3	0.8	-0.8	0.7
Medication: Atenolol	1.2	1.5	2.5	1.2	0.2	-1.6	-1.4	1.2	-1.3
Medication: Levothyroxine sodium	1.1	1.8	4.6	1.0	-0.2	-2.1	-1.7	1.1	-1.2
Sitting height	19.1	135.8	163.8	12.3	7.0	-12.0	-12.8	12.5	-12.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	-0.5	-0.5	0.5	0.3	-0.3	0.4
High blood pressure (mother)	2.1	3.0	5.0	-1.7	-1.4	2.2	1.7	-1.6	1.6
Body mass index (BMI)	2.7	11.6	14.3	-3.4	-3.2	3.4	3.4	-3.3	3.8
Impedance of leg (left)	1.2	6.0	8.1	-2.6	-1.0	2.5	2.9	-2.7	2.6
Leg predicted mass (left)	6.2	32.8	42.1	6.2	2.5	-5.8	-6.5	6.5	-5.8
Trunk fat mass	0.2	1.1	3.5	-0.7	-1.9	0.6	0.4	-0.4	1.2
Waist circumference	0.1	0.4	1.6	-0.3	-1.2	-0.1	0.1	-0.1	0.7
Number of incorrect matches in round	0.2	0.3	0.6	-0.6	-0.8	-0.4	0.2	-0.5	0.0
Past tobacco smoking	0.3	0.5	1.1	0.8	1.1	0.2	-0.5	0.8	-0.6
Alcohol usually taken with meals	0.1	0.1	0.5	-0.3	0.7	0.5	0.0	-0.0	-0.3
Nervous feelings	0.1	0.2	0.3	0.3	-0.4	0.3	-0.4	0.5	-0.4
Frequency of tenseness / restlessness in last 2 weeks	3.2	5.0	6.2	-2.2	-2.0	2.5	2.1	-2.1	2.3
Hearing difficulty/problems with background noise	2.1	3.4	8.6	-1.9	-2.9	0.3	1.2	-1.9	1.7
Hair/balding pattern: Pattern 2	0.4	0.6	1.1	0.7	1.0	0.5	-0.6	0.8	-0.7
Had menopause	1.0	1.2	3.5	0.8	1.9	-0.9	-1.0	0.7	-0.9
Had other major operations	0.1	0.1	0.6	-0.1	-0.1	-0.8	-0.1	-0.1	0.2
Forced vital capacity (FVC)	8.1	31.2	37.6	5.9	4.1	-5.2	-5.9	6.0	-6.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.2	5.2	-1.3	0.1	2.3	1.7	-1.4	1.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.2	-1.5	-1.4	0.4	1.3	-1.5	1.2
Qualifications: None of the above	3.8	8.2	11.2	-3.1	-2.0	2.5	3.1	-3.3	3.0
Financial difficulties in last 2 years	1.0	1.3	3.1	-1.2	-0.4	1.8	1.4	-1.0	0.8
Mouth/teeth dental problems	0.3	0.5	0.8	0.7	0.5	-0.4	-0.7	0.9	-0.8
Heart attack	0.5	0.6	1.9	-0.5	-1.4	-0.8	-0.0	-0.8	0.6
Allergy	1.6	3.6	4.2	2.1	1.9	-1.5	-1.8	2.0	-2.0
Pain all over the body in last month	2.8	3.0	4.3	-1.8	-1.6	1.1	1.8	-1.9	2.1
Diabetes (self-reported)	1.5	2.4	3.2	-1.6	-0.6	1.7	1.7	-1.5	1.8
Hayfever/allergic rhinitis (self-reported)	2.2	2.8	4.4	1.6	1.5	-2.1	-1.8	1.5	-1.6
Medication: Ramipril	0.6	0.8	1.2	-1.1	0.1	0.8	1.0	-1.1	1.0
Medication: Simvastatin	0.7	1.1	1.6	-1.2	0.5	0.9	1.2	-1.3	1.0
Fluid intelligence score	5.8	12.1	15.8	3.7	1.3	-4.0	-3.7	3.7	-3.7
Illnesses of siblings	0.4	0.5	0.8	0.9	-0.1	-0.9	-0.8	0.8	-0.6
Neuroticism score	0.2	0.5	1.1	0.8	0.1	0.2	-0.8	1.1	-0.8
Weight	1.8	8.9	12.5	3.3	0.5	-3.1	-3.5	3.5	-2.7
Impedance of arm (right)	0.4	1.8	2.2	-1.5	-1.0	1.3	1.3	-1.4	1.4
Arm fat percentage (right)	4.5	17.9	21.4	-4.3	-4.0	4.1	4.2	-4.2	4.6
Trunk fat-free mass	13.2	75.9	91.4	9.3	4.8	-9.1	-9.6	9.4	-9.0
Hip circumference	0.5	2.0	3.1	1.4	-0.9	-1.6	-1.8	1.6	-1.1
Time employed in main current job	0.4	0.5	1.5	0.8	-0.2	-1.2	-0.6	0.5	-0.5
Alcohol intake versus 10 years previously	2.4	3.5	4.8	-2.1	-0.9	1.5	2.0	-2.2	2.2
Father’s age at death	1.4	1.8	3.6	1.3	1.2	-1.9	-1.3	1.3	-1.0
Worrier / anxious feelings	2.5	4.7	6.2	2.4	2.3	-1.5	-2.2	2.5	-1.9
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.0	-1.4	-0.2	1.0	1.0	-1.1	1.4
Falls in the last year	3.5	4.7	6.4	-2.3	-1.8	2.2	2.0	-2.1	2.5
Hair/balding pattern: Pattern 3	0.6	1.0	1.7	0.9	1.3	-0.7	-1.0	1.0	-0.9
Number of live births	0.4	0.5	2.5	-0.0	1.6	0.7	0.4	-0.1	0.1
Forced expiratory volume in 1-second (FEV1)	5.9	20.0	24.3	4.8	3.6	-3.8	-4.8	4.8	-4.9
Pulse rate	1.2	2.0	2.9	-1.6	-0.8	1.5	1.4	-1.7	1.4
Happiness	0.1	0.2	0.7	-0.2	-0.8	-0.6	-0.1	0.0	-0.1
Noisy workplace	4.8	5.9	6.8	-2.5	-2.6	2.2	2.4	-2.5	2.3
Qualifications: A levels/AS levels or equivalent	4.1	9.2	13.4	3.4	1.4	-2.6	-3.3	3.7	-3.2
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	5.2	1.6	0.1	-2.3	-2.1	1.8	-1.5
Mouth/teeth dental problems: Dentures	2.5	4.2	5.3	-2.2	-1.5	1.8	2.2	-2.3	2.2
Asthma	0.0	0.0	0.0	-0.1	0.2	0.0	-0.2	0.2	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	-0.2	-0.6	0.3	-0.2	0.1	-0.1
Medication: Cholesterol lowering	1.2	1.9	2.6	-1.6	-0.3	1.2	1.6	-1.5	1.5
Depression (self-reported)	0.1	0.2	0.4	0.1	0.2	-0.7	-0.4	0.2	-0.5
Medication: Lansoprazole	0.8	0.9	1.1	-0.9	-0.9	0.7	0.9	-1.0	1.1
Prospective memory result	0.6	0.7	1.2	-0.9	-0.9	-0.0	0.7	-1.1	1.0
Lung cancer (father)	0.2	0.2	0.4	-0.4	0.6	0.6	0.5	-0.3	0.3
Illnesses of mother	1.5	1.8	2.4	1.5	0.6	-1.5	-1.4	1.3	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	6.2	19.8	24.6	4.8	3.2	-3.9	-4.8	4.8	-5.0
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	0.6	-0.4	-0.2	-0.5	0.8	-0.8
Impedance of arm (left)	0.1	0.4	0.7	-0.8	-0.1	0.8	0.6	-0.7	0.6
Arm fat mass (right)	0.6	2.3	5.3	-1.3	-2.3	1.2	1.1	-1.2	1.7
Trunk predicted mass	13.1	75.0	90.2	9.3	4.8	-9.1	-9.5	9.4	-9.0
Standing height	19.3	191.1	231.0	14.7	7.9	-14.3	-15.2	15.0	-14.4
Length of working week for main job	0.0	0.0	0.1	-0.1	-0.2	0.3	-0.1	0.0	0.1
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.6	-0.6	-0.1	0.3	-0.7	0.5
Breastfed as a baby	1.2	1.5	1.9	1.4	1.3	-0.8	-1.2	1.3	-1.3
Tense / ‘highly strung’	0.2	0.4	0.9	-0.9	-0.6	-0.5	0.2	-0.7	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.5	0.7	-0.5	-1.2	-1.0	0.8	-0.9
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	0.4	-0.2	-0.9	-0.3	0.2	-0.7
Birth weight of first child	0.0	0.0	0.2	0.1	0.2	0.0	0.2	-0.1	0.4
Peak expiratory flow (PEF)	4.8	11.1	14.1	3.6	2.7	-2.3	-3.6	3.7	-3.8
Pulse wave reflection index	2.9	3.6	5.6	1.9	1.3	-1.4	-2.0	2.2	-2.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	0.7	0.5	-0.5	-0.9	1.0	-0.6
Loud music exposure frequency	0.3	0.4	1.3	-0.4	-1.1	0.4	0.5	-0.3	0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.5	1.1	-0.1	0.3	-0.4	1.2	-0.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.4	0.9	1.6	-0.3	-1.0	1.1	-1.0
Blood clot in the leg (DVT)	0.1	0.2	0.5	-0.3	0.7	0.5	0.2	-0.2	0.3
Medication: Paracetamol	1.3	2.1	2.5	-1.6	-1.6	0.9	1.5	-1.5	1.6
Headache pain in last month	0.2	0.4	1.2	-0.3	-1.1	0.4	0.5	-0.4	0.6
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.1	-0.0	0.3	-0.1	-0.0	-0.2
Glaucoma (self-reported)	0.6	0.7	1.3	-1.1	-0.3	-0.4	0.7	-1.1	1.0
Gout (self-reported)	2.6	3.6	4.8	-1.9	-1.1	2.2	2.0	-1.8	2.1
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	4.7	1.2	0.2	-2.2	-1.8	1.4	-1.5
Medication: Amlodipine	1.3	1.8	3.9	1.0	0.8	-2.0	-1.4	1.3	-1.1
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	0.4	0.6	0.5	-0.2	0.5	-0.1
Birth weight	0.4	0.8	2.1	0.7	-1.1	-1.5	-0.7	0.7	-0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.0	-0.5	-0.5	-0.4	0.3	-0.1
High blood pressure (siblings)	0.1	0.2	0.9	-0.0	0.9	0.3	-0.0	0.1	-0.1
Forced vital capacity (FVC), Best measure	8.8	32.3	39.6	6.0	3.7	-5.5	-6.2	6.0	-6.3
Body fat percentage	4.6	18.3	23.2	-4.3	-3.9	4.2	4.2	-4.1	4.8
Leg fat percentage (right)	6.9	24.8	31.0	-5.0	-4.2	5.1	5.1	-4.9	5.6
Arm fat-free mass (right)	8.8	45.0	55.2	7.3	3.6	-7.0	-7.4	7.4	-6.8
Exposure to tobacco smoke outside home	1.4	1.8	2.8	-1.5	-0.1	1.7	1.4	-1.3	1.5
Comparative body size at age 10	0.6	1.6	2.1	-1.2	-1.1	1.4	1.2	-1.3	1.2
Number of full brothers	0.2	0.2	0.4	-0.5	-0.4	0.4	0.4	-0.6	0.1
Worry too long after embarrassment	2.1	3.5	4.6	2.1	1.1	-1.5	-2.1	2.1	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	2.8	1.7	1.4	-1.4	-1.5	1.6	-1.6
Wheeze or whistling in the chest in last year	6.0	10.8	12.3	-3.5	-2.9	3.2	3.4	-3.2	3.5
Number of children fathered	0.2	0.2	0.4	0.4	0.6	0.6	0.0	0.4	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.9	-0.5	-2.0	-0.4	0.4	-0.7	0.5
Age at first live birth	1.8	3.1	4.2	2.0	0.8	-2.1	-1.8	2.0	-1.7
Pulse wave peak to peak time	0.3	0.4	1.1	0.4	1.1	-0.8	-0.5	0.2	-0.2
Health satisfaction	1.2	1.5	3.4	-1.2	-1.9	0.5	1.1	-1.0	1.4
Shortness of breath walking on level ground	0.2	0.3	0.5	-0.6	-0.4	-0.7	0.4	-0.5	0.6
Qualifications: College or University degree	5.4	17.0	22.4	4.4	1.2	-4.7	-4.5	4.5	-4.3
Eye problems/disorders: None of the above	0.5	0.5	1.7	-0.2	1.1	1.3	0.5	-0.0	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	0.2	-0.3	-0.6	-0.5	0.1	-0.5
Emphysema/chronic bronchitis	0.3	0.3	1.4	0.0	-0.5	1.2	0.1	0.3	0.5
Medication for pain relief, constipation, heartburn	0.3	0.4	1.1	0.5	1.1	-0.5	-0.5	0.6	-0.7
Neck or shoulder pain in last month	1.7	2.5	7.3	-1.4	-2.7	0.8	1.1	-1.5	1.2
Medication: Blood pressure	0.4	0.7	1.3	0.8	0.6	-1.2	-0.8	0.9	-0.6
Angina (self-reported)	0.1	0.2	0.6	-0.3	-0.8	-0.2	0.3	-0.3	0.3
Migraine (self-reported)	0.1	0.1	0.5	0.3	-0.7	-0.3	-0.2	0.0	0.0
Medication: Ibuprofen	0.0	0.0	0.1	-0.3	0.0	-0.0	-0.2	0.0	-0.1
Medication: Allopurinol	1.5	2.0	4.5	-1.4	-0.5	2.1	1.6	-1.1	1.3
Medication: Omeprazole	1.5	1.8	3.2	-1.1	-1.0	1.8	1.4	-1.2	1.4
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.1	-0.2	0.3	0.2	0.1	0.5
Mean time to correctly identify matches	0.2	0.4	0.8	-0.7	-0.9	-0.7	0.3	-0.8	0.3
Heart disease (mother)	1.6	2.0	2.9	-1.4	-0.1	1.3	1.6	-1.7	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.7	0.2	1.3	-0.4	-0.2	0.1	-0.4
Whole body fat mass	0.6	2.3	4.6	-1.2	-2.1	1.4	1.1	-1.1	1.9
Leg fat mass (right)	1.1	4.4	6.7	-1.8	-2.6	2.1	1.8	-1.7	2.4
Arm predicted mass (right)	8.7	44.4	54.4	7.2	3.7	-6.8	-7.4	7.3	-6.8
Pulse rate, automated reading	7.1	22.9	27.1	-5.0	-3.5	4.4	5.2	-5.2	5.2
Alcohol intake frequency.	3.4	7.9	11.6	-3.0	-1.3	2.6	3.0	-3.0	3.4
Comparative height size at age 10	10.2	56.0	67.8	7.9	4.6	-7.8	-8.2	8.1	-7.7
Number of full sisters	0.1	0.1	0.4	0.6	0.5	0.3	0.1	0.3	0.1
Suffer from ‘nerves’	0.7	1.0	1.9	1.2	0.5	-0.6	-1.1	1.4	-1.1
Overall health rating	2.1	4.6	6.7	-2.6	-2.0	1.4	1.9	-2.4	2.3
Chest pain or discomfort	0.1	0.2	0.4	-0.5	-0.6	-0.2	0.2	-0.3	0.7
Had major operations	1.7	2.0	3.0	1.3	0.8	-1.6	-1.7	1.4	-1.6
Age at last live birth	3.0	4.3	6.0	2.2	1.5	-2.5	-1.9	2.2	-2.1
Family relationship satisfaction	0.2	0.2	0.7	-0.1	-0.7	-0.8	0.0	-0.0	-0.4
Leg pain on walking	2.4	3.1	3.9	-2.0	-1.3	1.3	1.9	-1.9	1.9
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.9	4.1	-2.0	-0.4	2.0	1.8	-1.9	1.6
Commuting to job workplace: Car/motor vehicle	3.3	3.8	4.4	-2.0	-1.9	2.0	2.0	-2.1	1.7
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.3	1.1	1.0	-0.6	-1.0	1.0	-1.1
Medication: Aspirin	0.8	1.1	1.4	1.2	1.2	-1.1	-1.0	0.9	-0.9
Supplements: Vitamin C	1.2	1.4	2.3	-1.3	-1.2	1.5	1.0	-1.0	1.1
Knee pain experienced in last month	0.4	0.7	1.3	-1.1	-1.1	0.6	0.5	-0.7	0.8
Hypertension (Self-reported)	0.3	0.7	1.6	1.0	0.2	-0.3	-1.1	1.2	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.7	-0.5	-0.4	0.8	0.6	-0.6	0.9
Illnesses of father: Heart disease	0.1	0.2	0.3	-0.4	0.6	0.4	0.4	-0.5	0.1
Illnesses of siblings: Diabetes	0.4	0.5	1.7	0.4	1.3	-0.4	-0.5	0.5	-0.8
Smoking status: Previous	0.3	0.4	1.2	0.4	-0.2	-1.1	-0.6	0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	6.1	12.6	16.5	4.0	1.3	-3.6	-3.8	4.1	-3.7
Whole body fat-free mass	10.4	59.4	73.0	8.3	4.1	-8.0	-8.5	8.5	-7.9
Leg fat-free mass (right)	7.2	38.4	48.2	6.7	3.0	-6.3	-6.9	6.9	-6.4
Arm fat percentage (left)	4.1	16.3	19.7	-4.1	-3.6	4.1	4.0	-3.9	4.4
Average weekly red wine intake	3.3	4.9	7.1	2.4	2.3	-1.1	-2.3	2.7	-2.2
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.1	-0.3	0.2	0.1	-0.0	0.0
Mood swings	0.1	0.1	0.3	-0.3	-0.3	0.5	0.5	-0.2	0.3
Loneliness, isolation	0.1	0.1	0.7	0.0	-0.9	-0.1	-0.0	-0.1	0.1
Long-standing illness, disability or infirmity	0.3	0.4	0.9	0.5	-0.6	-1.0	-0.8	0.5	-0.3
Ever had bowel cancer screening	0.3	0.3	0.9	-0.5	-0.3	1.0	0.4	-0.4	0.5
Diabetes diagnosed by doctor	0.5	0.9	1.2	-1.0	0.2	1.1	1.1	-0.9	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.1	0.8	0.9	-0.0	0.1	-0.2
Friendships satisfaction	0.4	0.4	1.9	-0.3	-1.4	0.3	0.6	-0.3	0.2
Qualifications: nursing, teaching	4.4	6.9	10.2	3.1	1.9	-2.1	-2.6	3.2	-2.7
Commuting to job workplace: Walk	1.6	1.7	1.9	1.4	1.4	-1.3	-1.3	1.3	-1.2
Eye problems/disorders: Cataract	0.6	0.6	2.2	0.3	-0.8	-1.5	-0.5	0.3	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	1.8	-0.9	-0.5	1.1	1.3	-1.4	1.2
Medication for cholesterol	0.1	0.1	0.4	0.1	0.7	0.4	0.3	-0.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	-0.3	0.6	0.9	0.3	-0.2	0.2
Back pain experienced in last month	0.1	0.2	0.4	-0.6	-0.1	-0.5	0.1	-0.5	0.3
Mineral and other dietary supplements	1.3	1.7	2.5	1.6	1.6	-0.8	-1.1	1.3	-1.3
Breast cancer (self-reported)	1.1	1.3	2.4	1.0	1.0	-1.5	-1.1	1.1	-1.0
Asthma (self-reported)	0.0	0.1	0.2	-0.0	0.2	-0.4	-0.4	0.2	-0.3
Osteoporosis (self-reported)	0.2	0.2	0.3	-0.5	0.5	-0.1	0.5	-0.6	0.3
Osteoarthritis (self-reported)	0.1	0.1	0.5	0.0	0.7	0.1	-0.1	0.1	0.1
Medication: Aspirin	0.4	0.5	1.1	0.7	0.8	-1.0	-0.6	0.4	-0.4
Medication: Gliclazide	1.3	1.5	2.2	-0.9	-0.9	1.3	1.5	-1.3	1.4
Illnesses of father: None of the above (group 1)	0.4	0.4	1.2	0.5	-0.3	-1.1	-0.8	0.5	-0.6
Smoking status: Current	4.0	6.4	8.0	-2.8	-1.6	2.2	2.8	-2.8	2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.0	0.9	1.0	-0.7	-0.8	0.8	-1.0
Whole body water mass	10.7	60.9	74.7	8.4	4.2	-8.1	-8.6	8.6	-8.0
Leg predicted mass (right)	7.0	37.5	47.3	6.6	3.0	-6.2	-6.8	6.9	-6.3
Arm fat mass (left)	0.4	1.6	4.0	-1.0	-2.0	1.0	0.8	-0.9	1.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.1	-0.7	-0.6	-0.3	0.1	-0.1
Average weekly champagne plus white wine intake	0.4	0.6	0.9	0.8	1.0	0.3	-0.5	0.7	-0.9
Miserableness	0.2	0.4	1.1	-0.4	-0.8	1.1	0.5	-0.2	0.7
Guilty feelings	0.9	1.3	2.0	1.3	-0.2	-0.6	-1.4	1.3	-1.4
Wears glasses or contact lenses	0.5	0.6	1.1	-1.0	-0.2	1.0	0.8	-0.8	0.5
Ever taken oral contraceptive pill	0.2	0.2	0.9	-0.0	-0.9	-0.7	0.0	0.1	0.3
Hearing aid user	0.2	0.2	0.6	-0.5	-0.4	0.0	0.5	-0.7	0.5
Mother’s age at death	0.6	0.7	2.0	0.6	0.3	-1.4	-1.0	0.6	-0.8
Financial situation satisfaction	3.0	3.7	5.2	-2.3	-1.4	1.2	2.1	-2.2	2.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.6	0.6	-0.2	-1.3	-0.7	0.7	-0.9
Commuting to job workplace: Public transport	2.7	3.2	4.7	1.8	1.0	-2.2	-1.9	1.9	-1.8
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	-1.0	-0.7	0.2	0.8	-1.1	0.9
Medication: Blood pressure	0.7	1.3	2.3	1.2	0.2	-0.6	-1.5	1.4	-1.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.4	-1.1	-1.6	0.5	0.7	-1.0	0.9
Supplements: Fish oil (including cod liver oil)	2.6	3.4	4.6	-2.1	-1.7	1.8	1.7	-2.0	1.7
High cholesterol (Self-reported)	0.3	0.5	1.1	-1.1	0.3	0.4	0.6	-0.9	0.5
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.5	0.1	-0.6	-0.7	0.7	-0.6
Medication: Paracetamol	0.7	1.1	1.8	-1.2	-1.4	0.2	1.0	-1.2	1.1
Medication: Lisinopril	0.1	0.1	0.6	-0.1	-0.0	0.8	0.1	0.2	0.0
Medication: Atorvastatin	0.4	0.5	2.5	-0.2	-1.6	-0.4	-0.0	-0.2	0.2
Illnesses of father: High blood pressure	0.3	0.3	1.2	-0.3	-0.5	1.1	0.5	-0.3	0.4
Alcohol drinker status: Never	1.1	1.3	2.1	1.1	0.4	-1.5	-1.3	1.1	-1.1
Ever smoked	1.0	1.7	2.3	-1.5	-1.1	0.7	1.4	-1.5	1.5
Basal metabolic rate	8.1	44.8	56.0	7.2	3.3	-7.0	-7.5	7.4	-6.8
Leg fat percentage (left)	6.8	24.6	30.9	-5.0	-4.0	5.0	5.1	-4.9	5.6
Arm fat-free mass (left)	7.2	36.4	45.2	6.5	2.9	-6.5	-6.7	6.6	-6.1
Number of operations (self-reported)	2.2	3.2	4.5	1.7	1.1	-2.1	-2.1	1.8	-1.8
Average weekly beer plus cider intake	0.2	0.3	1.0	0.5	0.1	-1.0	-0.4	0.4	-0.2
Irritability	0.1	0.1	0.3	0.2	-0.0	0.6	-0.3	0.5	-0.2
Risk taking	0.3	0.4	0.7	-0.6	-0.1	0.6	0.8	-0.6	0.8
Ever had prostate specific antigen (PSA) test	3.3	3.8	5.1	2.1	0.6	-2.1	-2.3	2.1	-2.1
Fractured/broken bones in last 5 years	0.4	0.5	0.9	0.7	0.9	-0.3	-0.6	0.9	-0.8
Age started oral contraceptive pill	0.4	0.5	2.4	0.2	0.2	-1.6	-0.5	-0.0	0.2
Diastolic blood pressure, automated reading	0.5	1.5	3.4	-1.0	-0.4	1.8	1.4	-1.0	1.2
Ever depressed for a whole week	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.0	-0.4	0.3
Unable to work because of sickness or disability	2.0	2.6	3.5	-1.9	-1.8	1.1	1.4	-1.7	1.6
Commuting to job workplace: Cycle	8.6	10.4	13.2	3.6	2.6	-3.0	-3.4	3.6	-3.0
Myopia	0.5	0.7	1.8	0.7	1.3	0.1	-0.6	0.9	-0.7
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.6	-0.6	0.5	0.5	0.7	-0.8	0.4
Cholesterol lowering medication	0.1	0.1	0.2	-0.4	0.0	-0.4	0.0	-0.3	0.2
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.8	-1.1	-1.1	1.7	1.3	-1.1	1.5
Pain experienced in last month	1.1	1.9	2.7	1.5	1.6	-1.1	-1.1	1.3	-1.4
Supplements: Calcium	0.2	0.3	0.6	-0.8	-0.3	0.2	0.5	-0.6	0.5
Basal cell carcinoma (self-reported)	0.2	0.2	1.0	-0.2	-1.0	-0.4	-0.0	-0.0	0.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.5	-0.8	-1.6	-0.5	0.3	-1.1	0.9
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.4	0.0	1.2	0.3	-0.0	0.2	0.1
Heart disease (siblings)	0.4	0.4	0.6	-0.8	-0.7	0.0	0.7	-0.8	0.7
Alcohol drinker status: Previous	9.2	10.5	14.8	-3.2	-2.3	3.0	3.4	-3.4	3.8
Pack years of smoking	2.7	3.9	5.4	-2.2	-2.0	0.9	2.0	-2.3	2.0
Impedance of whole body	0.7	3.6	4.4	-2.1	-0.8	2.1	2.1	-2.1	2.0
Leg fat mass (left)	1.1	4.4	6.3	-1.9	-2.5	2.1	1.9	-1.7	2.5
Arm predicted mass (left)	7.3	37.0	46.1	6.6	3.0	-6.4	-6.8	6.7	-6.2