Best TWAS P=1.84e-12 · Best GWAS P=9.1e-12 conditioned to 3.07e-57
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Heart Atrial Appendage | ADCY4 | 0.28 | 0.14 | lasso | 4 | 0.10 | 2.1e-05 | 6.6 | 5.6 | 2.3e-08 | 0.88 | 0.01 | 0.97 | TRUE |
2 | GTEx | Spleen | NFATC4 | 0.45 | 0.00 | enet | 24 | 0.00 | 2.5e-01 | 4.1 | -5.8 | 6.4e-09 | -0.28 | 0.06 | 0.06 | TRUE |
3 | GTEx | Thyroid | ADCY4 | 0.13 | 0.13 | lasso | 6 | 0.09 | 1.0e-07 | 3.8 | 5.2 | 2.1e-07 | 0.78 | 0.08 | 0.92 | FALSE |
4 | METSIM | Adipose | ADCY4 | 0.07 | 0.03 | lasso | 5 | 0.03 | 2.2e-05 | 6.8 | 7.0 | 1.8e-12 | 0.93 | 0.01 | 0.99 | TRUE |
5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ADCY4 | 0.03 | 0.01 | blup | 75 | 0.03 | 1.1e-03 | 4.3 | 5.3 | 9.9e-08 | 0.78 | 0.03 | 0.86 | FALSE |
6 | The Cancer Genome Atlas | Colon Adenocarcinoma | ADCY4 | 0.07 | 0.02 | lasso | 4 | 0.03 | 4.7e-03 | 4.8 | 5.4 | 6.3e-08 | 0.79 | 0.03 | 0.77 | TRUE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADCY4 | 0.06 | 0.06 | lasso | 6 | 0.09 | 3.0e-10 | 5.7 | 6.7 | 1.6e-11 | 0.87 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADCY4 | 0.07 | 0.09 | lasso | 3 | 0.08 | 4.4e-10 | 4.8 | 5.9 | 4.9e-09 | 0.81 | 0.85 | 0.15 | FALSE |
9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LTB4R2 | 0.04 | 0.04 | lasso | 1 | 0.02 | 2.5e-02 | 5.3 | -5.3 | 1.4e-07 | -0.55 | 0.04 | 0.50 | FALSE |