Best TWAS P=4.6e-12 · Best GWAS P=1.45e-08 conditioned to 0.0527
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | NTAN1 | 0.05 | 0.03 | lasso | 2 | 0.04 | 6.7e-04 | -5.6 | 6.2 | 6.6e-10 | -0.93 | 0.01 | 0.96 | TRUE |
2 | GTEx | Artery Tibial | RRN3 | 0.11 | 0.06 | lasso | 2 | 0.07 | 2.0e-06 | 5.5 | 5.2 | 1.7e-07 | -0.49 | 0.02 | 0.98 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | RRN3 | 0.36 | 0.14 | lasso | 5 | 0.20 | 4.5e-07 | 5.5 | 5.7 | 1.6e-08 | -0.60 | 0.02 | 0.98 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | RP11-958N24.1 | 0.22 | 0.02 | lasso | 5 | 0.06 | 4.8e-03 | -2.7 | 5.2 | 1.9e-07 | -0.60 | 0.02 | 0.45 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | RRN3 | 0.10 | 0.12 | enet | 13 | 0.13 | 6.3e-10 | 5.5 | 6.2 | 6.5e-10 | -0.59 | 0.02 | 0.98 | FALSE |
6 | GTEx | Colon Transverse | RRN3 | 0.13 | 0.00 | lasso | 5 | 0.00 | 1.9e-01 | 5.3 | -5.8 | 5.8e-09 | 0.30 | 0.02 | 0.44 | FALSE |
7 | GTEx | Esophagus Mucosa | RRN3 | 0.13 | 0.13 | lasso | 4 | 0.13 | 3.2e-09 | 5.3 | 5.1 | 2.9e-07 | -0.51 | 0.02 | 0.98 | FALSE |
8 | GTEx | Heart Atrial Appendage | NOMO1 | 0.19 | 0.12 | lasso | 6 | 0.10 | 3.7e-05 | 5.3 | 5.3 | 1.2e-07 | -0.48 | 0.03 | 0.89 | FALSE |
9 | GTEx | Heart Atrial Appendage | NTAN1 | 0.10 | 0.09 | lasso | 1 | 0.07 | 3.7e-04 | 5.3 | 5.3 | 1.1e-07 | -0.49 | 0.02 | 0.74 | FALSE |
10 | GTEx | Heart Left Ventricle | RRN3 | 0.24 | 0.12 | lasso | 7 | 0.17 | 2.2e-09 | 5.3 | -6.6 | 4.2e-11 | 0.39 | 0.03 | 0.97 | FALSE |
11 | GTEx | Heart Left Ventricle | NTAN1 | 0.09 | 0.04 | lasso | 3 | 0.02 | 2.0e-02 | 5.5 | 5.4 | 5.3e-08 | -0.48 | 0.02 | 0.80 | FALSE |
12 | GTEx | Muscle Skeletal | RRN3 | 0.18 | 0.03 | enet | 17 | 0.11 | 5.7e-11 | 4.8 | -6.0 | 2.3e-09 | 0.37 | 0.15 | 0.74 | FALSE |
13 | GTEx | Muscle Skeletal | NTAN1 | 0.12 | 0.07 | lasso | 6 | 0.09 | 1.4e-09 | 5.3 | 6.1 | 1.4e-09 | -0.46 | 0.02 | 0.98 | FALSE |
14 | GTEx | Nerve Tibial | NTAN1 | 0.07 | 0.00 | enet | 14 | 0.00 | 1.7e-01 | 5.5 | 6.9 | 4.6e-12 | -0.17 | 0.02 | 0.26 | TRUE |
15 | GTEx | Skin Sun Exposed Lower leg | RRN3 | 0.10 | 0.12 | lasso | 1 | 0.11 | 4.5e-09 | 5.5 | 5.5 | 3.3e-08 | -0.48 | 0.02 | 0.98 | FALSE |
16 | GTEx | Testis | RRN3 | 0.10 | 0.10 | lasso | 2 | 0.07 | 3.9e-04 | 5.5 | 5.5 | 3.3e-08 | -0.48 | 0.02 | 0.85 | FALSE |
17 | GTEx | Thyroid | RP11-65J21.3 | 0.35 | 0.32 | lasso | 2 | 0.31 | 2.6e-24 | -5.2 | -5.2 | 1.9e-07 | -0.03 | 0.03 | 0.97 | TRUE |
18 | NTR | Blood | NTAN1 | 0.01 | 0.00 | bslmm | 110 | 0.00 | 4.2e-02 | 5.5 | 6.1 | 1.1e-09 | -0.23 | 0.01 | 0.26 | FALSE |
19 | NTR | Blood | PDXDC1 | 0.12 | 0.12 | enet | 26 | 0.15 | 1.3e-46 | -5.6 | 6.8 | 1.4e-11 | -0.84 | 0.01 | 0.99 | FALSE |
20 | ROSMAP | Brain Pre-frontal Cortex | NTAN1 | 0.12 | 0.10 | lasso | 3 | 0.11 | 1.4e-13 | 5.3 | 5.4 | 8.0e-08 | -0.48 | 0.03 | 0.97 | FALSE |