[Hub]/) : Traits : Arm predicted mass (left) :

chr17:42,041,273-43,913,030

Best TWAS P=1.78e-14 · Best GWAS P=1.16e-14 conditioned to 0.783

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous DCAKD 0.21 0.09 lasso 6 0.14 6.1e-12 5.3 5.7 1.6e-08 -0.35 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous ACBD4 0.10 0.06 enet 8 0.06 1.8e-05 -6.4 -7.2 4.1e-13 0.52 0.51 0.37 FALSE
3 GTEx Adrenal Gland PLEKHM1 0.21 0.00 enet 20 0.08 1.0e-03 4.1 5.5 3.1e-08 -0.13 0.08 0.13 FALSE
4 GTEx Artery Aorta DCAKD 0.22 0.16 enet 26 0.19 1.1e-10 -3.7 6.5 6.7e-11 -0.46 0.92 0.07 FALSE
5 GTEx Artery Coronary NMT1 0.13 0.06 enet 7 0.11 1.5e-04 5.2 -6.2 8.0e-10 0.53 0.12 0.26 TRUE
6 GTEx Artery Tibial NMT1 0.11 0.09 lasso 5 0.10 6.3e-08 -3.9 -5.2 1.9e-07 0.36 0.98 0.02 FALSE
7 GTEx Artery Tibial ACBD4 0.10 0.09 lasso 2 0.08 4.8e-07 -6.5 -6.5 1.0e-10 0.58 0.75 0.19 FALSE
8 GTEx Brain Cerebellar Hemisphere ACBD4 0.43 0.12 lasso 8 0.18 1.7e-05 -6.0 -5.6 1.9e-08 0.37 0.11 0.43 FALSE
9 GTEx Brain Cerebellar Hemisphere CTD-2020K17.4 0.23 0.02 enet 20 0.11 1.1e-03 -5.9 -5.7 1.1e-08 0.46 0.03 0.16 FALSE
10 GTEx Brain Cerebellum ACBD4 0.40 0.06 lasso 8 0.17 1.0e-05 5.9 -5.7 1.5e-08 0.27 0.09 0.14 FALSE
11 GTEx Brain Hippocampus CCDC43 0.23 0.09 enet 9 0.16 1.8e-04 -6.0 5.2 2.4e-07 -0.46 0.05 0.29 FALSE
12 GTEx Breast Mammary Tissue KANSL1 0.31 0.00 enet 9 0.11 2.6e-06 2.5 -5.2 1.9e-07 0.08 0.00 0.00 TRUE
13 GTEx Cells Transformed fibroblasts HEXIM1 0.11 0.10 lasso 2 0.08 1.6e-06 5.1 5.2 2.5e-07 -0.58 0.72 0.22 FALSE
14 GTEx Esophagus Gastroesophageal Junction NMT1 0.24 0.21 lasso 4 0.22 2.8e-08 3.9 -6.0 2.4e-09 0.54 0.48 0.48 FALSE
15 GTEx Esophagus Gastroesophageal Junction DCAKD 0.42 0.36 lasso 7 0.37 3.8e-14 -5.0 5.1 3.1e-07 -0.58 0.96 0.04 FALSE
16 GTEx Esophagus Mucosa ACBD4 0.14 0.10 lasso 4 0.10 4.5e-07 5.6 -6.0 2.7e-09 0.13 0.59 0.08 FALSE
17 GTEx Muscle Skeletal PLCD3 0.18 0.10 enet 8 0.10 1.7e-10 5.6 6.0 2.1e-09 -0.12 1.00 0.00 FALSE
18 GTEx Muscle Skeletal DCAKD 0.12 0.06 enet 16 0.07 9.9e-08 -5.0 5.4 6.5e-08 -0.54 0.82 0.18 FALSE
19 GTEx Nerve Tibial ACBD4 0.21 0.10 lasso 5 0.11 4.2e-08 -6.0 -7.3 3.5e-13 0.47 0.89 0.10 FALSE
20 GTEx Skin Not Sun Exposed Suprapubic DCAKD 0.30 0.21 lasso 6 0.20 5.0e-11 -5.0 5.5 3.5e-08 -0.58 1.00 0.00 FALSE
21 GTEx Skin Sun Exposed Lower leg DCAKD 0.33 0.20 enet 30 0.31 2.4e-26 -3.7 5.3 1.2e-07 -0.27 1.00 0.00 FALSE
22 GTEx Skin Sun Exposed Lower leg ACBD4 0.06 0.05 lasso 4 0.02 3.8e-03 5.9 -7.4 1.7e-13 0.33 0.19 0.08 FALSE
23 GTEx Stomach DCAKD 0.29 0.17 enet 25 0.20 9.4e-10 -3.7 5.8 5.5e-09 -0.48 0.58 0.42 FALSE
24 GTEx Thyroid PLCD3 0.12 0.01 enet 20 0.07 8.2e-06 5.6 5.5 3.7e-08 -0.04 0.77 0.01 FALSE
25 GTEx Thyroid ACBD4 0.20 0.16 enet 23 0.15 1.2e-11 -6.4 -7.7 1.8e-14 0.51 0.91 0.09 TRUE
26 METSIM Adipose C17orf104 0.05 0.02 bslmm 404 0.04 4.2e-06 4.3 -5.4 5.8e-08 0.11 0.91 0.00 FALSE
27 YFS Blood HEXIM2 0.02 0.01 bslmm 279 0.01 1.0e-05 5.2 -5.5 4.7e-08 0.61 0.31 0.66 FALSE
28 YFS Blood NMT1 0.02 0.01 lasso 6 0.01 5.0e-03 6.0 -6.1 9.4e-10 0.37 0.28 0.03 FALSE
29 The Cancer Genome Atlas Bladder Urothelial Carcinoma LOC644172 0.08 0.00 blup 79 0.04 3.2e-04 2.6 5.1 3.1e-07 -0.51 0.07 0.28 FALSE
30 The Cancer Genome Atlas Breast Invasive Carcinoma LOC644172 0.14 0.07 enet 10 0.12 1.2e-23 1.9 5.2 2.2e-07 -0.35 1.00 0.00 FALSE
31 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma LOC644172 0.19 -0.01 blup 81 0.03 1.3e-02 1.8 5.2 1.7e-07 -0.47 0.02 0.56 FALSE
32 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DCAKD 0.07 0.07 lasso 4 0.07 1.4e-08 -5.0 6.2 6.9e-10 -0.56 0.19 0.81 FALSE
33 The Cancer Genome Atlas Brain Lower Grade Glioma ACBD4 0.08 0.04 enet 9 0.04 6.9e-06 -6.4 -6.3 2.8e-10 0.50 0.87 0.09 FALSE
34 The Cancer Genome Atlas Brain Lower Grade Glioma LOC644172 0.04 0.00 enet 15 0.02 4.0e-03 -7.7 5.2 1.7e-07 -0.60 0.00 0.75 FALSE
35 The Cancer Genome Atlas Lung Adenocarcinoma NMT1 0.04 0.00 blup 81 0.01 1.9e-02 -3.8 -5.6 2.1e-08 0.27 0.03 0.66 FALSE
36 The Cancer Genome Atlas Lung Adenocarcinoma PLCD3 0.04 0.01 blup 64 0.01 2.3e-02 5.6 -5.2 1.9e-07 0.27 0.05 0.08 FALSE
37 The Cancer Genome Atlas Pancreatic Adenocarcinoma NMT1 0.23 0.08 blup 82 0.12 1.1e-05 3.6 -5.9 3.2e-09 0.55 0.06 0.88 FALSE
38 The Cancer Genome Atlas Prostate Adenocarcinoma ACBD4 0.04 0.01 enet 7 0.03 2.2e-04 4.1 -5.9 4.4e-09 0.44 0.09 0.15 FALSE
39 The Cancer Genome Atlas Prostate Adenocarcinoma LOC644172 0.15 0.01 blup 77 0.06 1.0e-06 6.0 5.8 5.9e-09 -0.40 0.19 0.28 FALSE
40 The Cancer Genome Atlas Testicular Germ Cell Tumors LOC644172 0.20 0.01 enet 12 0.06 4.5e-03 -3.3 5.3 1.2e-07 -0.47 0.06 0.09 FALSE
41 The Cancer Genome Atlas Thyroid Carcinoma HEXIM1 0.05 0.05 blup 47 0.04 8.5e-05 -7.7 7.1 1.2e-12 -0.84 0.00 1.00 FALSE
42 The Cancer Genome Atlas Thyroid Carcinoma PLCD3 0.24 0.16 lasso 5 0.20 2.8e-19 5.6 6.3 3.1e-10 -0.15 1.00 0.00 FALSE