Best TWAS P=2.85e-13 · Best GWAS P=1.67e-13 conditioned to 0.0852
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | REXO1 | 0.07 | 0.01 | bslmm | 391 | 0.01 | 1.7e-02 | -2.3 | 6.2 | 5.6e-10 | -0.10 | 0.28 | 0.03 | TRUE |
| 2 | GTEx | Artery Tibial | DOT1L | 0.09 | 0.06 | lasso | 5 | 0.05 | 7.3e-05 | 7.0 | 6.6 | 4.7e-11 | -0.52 | 0.05 | 0.93 | TRUE |
| 3 | NTR | Blood | C19orf35 | 0.03 | 0.01 | enet | 9 | 0.02 | 3.7e-07 | -2.7 | -6.1 | 1.0e-09 | 0.17 | 0.97 | 0.02 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DOT1L | 0.08 | 0.12 | enet | 8 | 0.10 | 2.5e-11 | 7.0 | 7.3 | 2.8e-13 | -0.53 | 0.02 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DOT1L | 0.09 | 0.08 | blup | 60 | 0.07 | 4.1e-04 | -6.2 | 7.0 | 2.7e-12 | -0.42 | 0.08 | 0.84 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | JSRP1 | 0.03 | 0.00 | blup | 33 | 0.02 | 2.1e-03 | -3.3 | -5.6 | 1.8e-08 | -0.01 | 0.01 | 0.23 | TRUE |