Best TWAS P=3.32e-15 · Best GWAS P=2.33e-16 conditioned to 0.000441
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SHISA4 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.5e-03 | -6.2 | -7.0 | 2.6e-12 | -0.56 | 0.20 | 0.33 | FALSE |
| 2 | GTEx | Esophagus Muscularis | LMOD1 | 0.16 | 0.09 | enet | 9 | 0.08 | 7.8e-06 | 8.2 | -7.7 | 2.1e-14 | -0.98 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Esophagus Muscularis | RP11-307B6.3 | 0.20 | 0.12 | lasso | 3 | 0.12 | 5.6e-08 | 8.2 | -7.5 | 6.1e-14 | -0.97 | 0.01 | 0.99 | FALSE |
| 4 | METSIM | Adipose | LMOD1 | 0.09 | 0.07 | bslmm | 496 | 0.07 | 4.8e-10 | 8.1 | -7.8 | 8.8e-15 | -0.97 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SHISA4 | 0.03 | 0.01 | enet | 5 | 0.00 | 2.5e-01 | -7.1 | -5.7 | 1.1e-08 | -0.55 | 0.04 | 0.17 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LMOD1 | 0.02 | 0.01 | blup | 59 | 0.02 | 1.2e-04 | 8.2 | -6.0 | 2.5e-09 | -0.85 | 0.01 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LMOD1 | 0.07 | 0.06 | blup | 59 | 0.03 | 2.1e-02 | 8.1 | -7.4 | 1.3e-13 | -0.90 | 0.01 | 0.86 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMOD1 | 0.04 | 0.07 | enet | 6 | 0.05 | 9.4e-07 | -7.1 | -7.9 | 3.3e-15 | -0.74 | 0.24 | 0.76 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | LMOD1 | 0.04 | 0.01 | blup | 59 | 0.01 | 5.7e-02 | 8.0 | -7.6 | 2.5e-14 | -0.84 | 0.01 | 0.81 | FALSE |