Best TWAS P=6.11e-14 · Best GWAS P=2.58e-14 conditioned to 0.858
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | TSEN15 | 0.23 | 0.18 | lasso | 9 | 0.18 | 4.7e-21 | 7.1 | 7.0 | 1.9e-12 | 0.90 | 0.02 | 0.98 | FALSE |
2 | GTEx | Adipose Visceral Omentum | RP11-181K3.4 | 0.13 | 0.06 | lasso | 3 | 0.14 | 8.3e-08 | 5.0 | 5.5 | 3.6e-08 | 0.04 | 0.04 | 0.95 | TRUE |
3 | GTEx | Brain Cerebellar Hemisphere | TSEN15 | 0.38 | 0.08 | lasso | 13 | 0.16 | 5.3e-05 | 7.2 | 6.6 | 3.9e-11 | 0.83 | 0.01 | 0.96 | TRUE |
4 | GTEx | Brain Cerebellum | COLGALT2 | 0.49 | 0.05 | lasso | 8 | 0.10 | 9.2e-04 | 4.6 | -5.1 | 2.9e-07 | -0.39 | 0.10 | 0.17 | FALSE |
5 | GTEx | Esophagus Muscularis | RP11-181K3.4 | 0.05 | 0.09 | lasso | 1 | 0.07 | 3.9e-05 | 5.2 | 5.2 | 2.1e-07 | 0.03 | 0.04 | 0.94 | FALSE |
6 | GTEx | Nerve Tibial | LAMC1 | 0.07 | 0.08 | enet | 30 | 0.05 | 1.1e-04 | 5.3 | 5.3 | 1.3e-07 | 0.07 | 0.03 | 0.96 | FALSE |
7 | METSIM | Adipose | TSEN15 | 0.06 | 0.02 | enet | 28 | 0.04 | 1.3e-06 | 7.1 | 6.2 | 4.9e-10 | 0.76 | 0.02 | 0.98 | FALSE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GLT25D2 | 0.05 | 0.01 | enet | 10 | 0.04 | 6.3e-05 | 4.7 | -7.5 | 6.1e-14 | -0.69 | 0.01 | 0.94 | TRUE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GLT25D2 | 0.11 | 0.02 | blup | 119 | 0.05 | 5.1e-06 | -1.8 | -5.5 | 3.4e-08 | -0.50 | 0.14 | 0.31 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TSEN15 | 0.11 | 0.08 | blup | 52 | 0.10 | 6.7e-12 | 7.2 | 5.9 | 3.0e-09 | 0.78 | 0.02 | 0.98 | FALSE |