Best TWAS P=3.93e-12 · Best GWAS P=5.7e-12 conditioned to 0.265
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | WNT2B | 0.43 | 0.46 | enet | 44 | 0.47 | 7.4e-64 | -6.8 | -6.6 | 5.7e-11 | 0.93 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Brain Cortex | WNT2B | 0.36 | 0.19 | lasso | 5 | 0.23 | 5.5e-07 | -6.6 | -6.5 | 6.6e-11 | 0.89 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | WNT2B | 0.29 | 0.28 | lasso | 3 | 0.29 | 2.6e-08 | -6.9 | -6.9 | 6.0e-12 | 0.93 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Pituitary | ST7L | 0.31 | 0.18 | lasso | 7 | 0.18 | 3.0e-05 | -5.6 | -6.4 | 1.4e-10 | 0.81 | 0.02 | 0.97 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | MOV10 | 0.05 | 0.02 | lasso | 5 | 0.02 | 1.1e-02 | -6.6 | -6.2 | 7.4e-10 | 0.80 | 0.02 | 0.93 | FALSE |
| 6 | GTEx | Testis | RLIMP2 | 0.35 | 0.00 | enet | 47 | 0.06 | 1.1e-03 | 2.3 | 5.8 | 6.9e-09 | -0.33 | 0.18 | 0.08 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | WNT2B | 0.34 | 0.40 | enet | 30 | 0.42 | 1.5e-59 | -6.6 | -6.4 | 1.5e-10 | 0.93 | 0.02 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | ST7L | 0.33 | 0.19 | lasso | 3 | 0.21 | 1.7e-12 | -3.5 | -5.1 | 3.1e-07 | 0.71 | 0.89 | 0.11 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | MOV10 | 0.06 | 0.06 | lasso | 7 | 0.05 | 9.4e-06 | -6.5 | -6.9 | 3.9e-12 | 0.94 | 0.01 | 0.99 | TRUE |