Best TWAS P=2.75e-08 · Best GWAS P=5.44e-09 conditioned to 0.0209
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | KIAA1598 | 0.07 | 0.02 | lasso | 2 | 0.02 | 5.1e-03 | 5.2 | 5.4 | 5.1e-08 | 0.96 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Colon Transverse | RP11-539I5.1 | 0.12 | 0.05 | lasso | 2 | 0.04 | 5.8e-03 | 5.8 | 5.3 | 1.2e-07 | 0.96 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Lung | KIAA1598 | 0.10 | 0.10 | lasso | 6 | 0.09 | 1.2e-07 | 5.2 | 5.3 | 1.0e-07 | 0.97 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Thyroid | KIAA1598 | 0.08 | 0.07 | lasso | 1 | 0.06 | 4.1e-05 | 5.5 | -5.5 | 3.0e-08 | -0.97 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Whole Blood | KIAA1598 | 0.27 | 0.22 | lasso | 3 | 0.21 | 5.7e-19 | 5.3 | 5.4 | 7.5e-08 | 0.97 | 0.03 | 0.97 | FALSE |
| 6 | GTEx | Whole Blood | ENO4 | 0.17 | 0.09 | lasso | 3 | 0.11 | 5.3e-10 | 5.2 | 5.4 | 6.1e-08 | 0.92 | 0.02 | 0.98 | FALSE |
| 7 | METSIM | Adipose | KIAA1598 | 0.07 | 0.11 | lasso | 8 | 0.10 | 2.0e-14 | 5.3 | 5.2 | 2.2e-07 | 0.96 | 0.03 | 0.97 | FALSE |
| 8 | NTR | Blood | KIAA1598 | 0.12 | 0.20 | lasso | 4 | 0.19 | 3.3e-59 | 5.2 | 5.3 | 1.3e-07 | 0.98 | 0.06 | 0.94 | FALSE |
| 9 | YFS | Blood | KIAA1598 | 0.39 | 0.64 | enet | 21 | 0.64 | 1.0e-279 | 5.3 | 5.4 | 6.4e-08 | 0.97 | 0.04 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | KIAA1598 | 0.02 | 0.03 | enet | 8 | 0.04 | 2.4e-05 | 5.3 | 5.3 | 1.0e-07 | 0.95 | 0.02 | 0.98 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | KIAA1598 | 0.04 | 0.04 | enet | 6 | 0.06 | 2.1e-07 | 5.4 | 5.3 | 1.2e-07 | 0.93 | 0.03 | 0.97 | FALSE |
| 12 | The Cancer Genome Atlas | Stomach Adenocarcinoma | KIAA1598 | 0.05 | 0.03 | enet | 5 | 0.02 | 2.2e-02 | 4.9 | 5.6 | 2.8e-08 | 0.80 | 0.03 | 0.57 | TRUE |