Best TWAS P=7.35e-17 · Best GWAS P=1.21e-21 conditioned to 7.53e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LIN7C | 0.08 | 0.06 | lasso | 1 | 0.04 | 4.1e-04 | 8.3 | 8.3 | 8.1e-17 | 0.63 | 0.72 | 0.16 | FALSE |
| 2 | GTEx | Brain Putamen basal ganglia | BDNF-AS | 0.22 | 0.17 | lasso | 4 | 0.13 | 5.5e-04 | -6.1 | 7.2 | 5.8e-13 | 0.33 | 0.23 | 0.05 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | LIN7C | 0.26 | 0.22 | lasso | 6 | 0.25 | 1.4e-18 | 8.3 | 6.8 | 7.3e-12 | 0.62 | 0.99 | 0.01 | FALSE |
| 4 | GTEx | Esophagus Muscularis | LIN7C | 0.14 | 0.08 | enet | 11 | 0.07 | 5.4e-05 | 2.4 | 5.9 | 3.3e-09 | 0.60 | 0.68 | 0.17 | FALSE |
| 5 | GTEx | Liver | METTL15 | 0.18 | 0.05 | lasso | 3 | 0.09 | 1.9e-03 | 1.3 | -7.2 | 7.5e-13 | -0.68 | 0.02 | 0.83 | FALSE |
| 6 | GTEx | Nerve Tibial | LIN7C | 0.18 | 0.08 | enet | 27 | 0.12 | 4.2e-09 | 8.3 | 5.1 | 3.0e-07 | 0.56 | 0.62 | 0.35 | FALSE |
| 7 | GTEx | Thyroid | LIN7C | 0.08 | 0.04 | lasso | 4 | 0.04 | 6.0e-04 | 8.3 | 7.9 | 2.5e-15 | 0.69 | 0.49 | 0.40 | FALSE |
| 8 | NTR | Blood | LIN7C | 0.01 | 0.00 | lasso | 3 | 0.01 | 2.2e-03 | 8.5 | -8.3 | 7.3e-17 | -0.72 | 0.10 | 0.80 | TRUE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | LIN7C | 0.10 | 0.03 | blup | 32 | 0.08 | 2.8e-05 | 8.7 | 7.0 | 3.2e-12 | 0.57 | 0.01 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIN7C | 0.05 | 0.02 | lasso | 3 | 0.03 | 2.9e-04 | 8.7 | 7.6 | 2.4e-14 | 0.63 | 0.01 | 0.98 | FALSE |