Best TWAS P=5.97e-08 · Best GWAS P=2.39e-07 conditioned to 0.000729
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | ARL3 | 0.20 | 0.09 | enet | 32 | 0.07 | 3.7e-03 | 5.0 | 5.4 | 6.0e-08 | 0.38 | 0.08 | 0.80 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Female) | CYP17A1-AS1 | 0.14 | 0.01 | lasso | 11 | 0.00 | 4.7e-01 | 4.3 | 5.4 | 6.4e-08 | 0.87 | 0.04 | 0.42 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | CYP17A1-AS1 | 0.23 | 0.08 | enet | 23 | 0.13 | 1.9e-05 | 5.0 | 5.2 | 2.6e-07 | 0.64 | 0.04 | 0.82 | FALSE |
| 4 | GTEx | Nerve Tibial | CYP17A1-AS1 | 0.14 | 0.08 | lasso | 6 | 0.06 | 7.2e-05 | 4.9 | 5.1 | 2.8e-07 | 0.44 | 0.03 | 0.94 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CYP17A1-AS1 | 0.15 | 0.18 | lasso | 6 | 0.19 | 1.3e-23 | 5.0 | 5.2 | 1.7e-07 | 0.52 | 0.03 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | AS3MT | 0.06 | 0.09 | enet | 6 | 0.07 | 1.3e-06 | 4.7 | -5.3 | 8.7e-08 | -0.69 | 0.04 | 0.94 | FALSE |