Best TWAS P=1.47e-09 · Best GWAS P=2.93e-25 conditioned to 1.83e-17
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | PIGK | 0.22 | 0.00 | lasso | 8 | -0.01 | 9.0e-01 | 5.0 | -5.4 | 6.0e-08 | -0.10 | 0.08 | 0.06 | TRUE |
| 2 | GTEx | Spleen | GIPC2 | 0.43 | 0.07 | enet | 19 | 0.22 | 2.9e-06 | -5.3 | 5.6 | 1.7e-08 | 0.22 | 0.83 | 0.02 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | DNAJB4 | 0.08 | 0.09 | lasso | 2 | 0.09 | 1.3e-11 | -5.2 | -5.2 | 2.0e-07 | -0.18 | 1.00 | 0.00 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | GIPC2 | 0.04 | 0.01 | blup | 65 | 0.00 | 2.5e-01 | -4.6 | 6.0 | 1.5e-09 | 0.28 | 0.07 | 0.06 | TRUE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GIPC2 | 0.02 | 0.02 | lasso | 3 | 0.02 | 1.0e-03 | -5.2 | 5.3 | 1.5e-07 | 0.22 | 0.37 | 0.02 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | DNAJB4 | 0.04 | 0.04 | lasso | 2 | 0.04 | 1.2e-05 | 5.7 | -5.7 | 1.2e-08 | -0.45 | 0.00 | 1.00 | FALSE |