TWAS hub - PIGK

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1570	0.0420	1.8e-05	0.065	0.054	0.052	0.057	0.057	2.1e-08	3.3e-07	6.1e-07	1.6e-07	1.6e-07
2	GTEx	Adipose Subcutaneous	0.1390	0.0430	1.5e-04	0.017	NA	0.020	NA	0.028	1.3e-02	NA	8.6e-03	NA	2.4e-03
3	GTEx	Artery Aorta	0.2240	0.0610	3.1e-05	0.158	NA	0.105	NA	0.118	4.5e-09	NA	2.1e-06	NA	4.8e-07
4	GTEx	Artery Coronary	0.2210	0.0810	6.7e-03	-0.004	NA	-0.009	NA	-0.009	4.8e-01	NA	9.7e-01	NA	9.0e-01
5	GTEx	Artery Tibial	0.1212	0.0428	5.5e-04	0.085	NA	0.020	NA	0.051	3.3e-07	NA	9.1e-03	NA	7.2e-05
6	GTEx	Heart Atrial Appendage	0.1910	0.0690	3.0e-03	0.010	NA	0.077	NA	0.016	1.1e-01	NA	2.3e-04	NA	6.0e-02
7	GTEx	Muscle Skeletal	0.0813	0.0339	8.4e-03	0.003	NA	0.014	NA	0.020	1.3e-01	NA	1.3e-02	NA	3.8e-03
8	GTEx	Nerve Tibial	0.1934	0.0524	7.4e-06	0.088	NA	0.118	NA	0.103	8.9e-07	NA	1.1e-08	NA	9.4e-08
9	YFS	Blood	0.0431	0.0125	7.2e-07	0.028	0.016	0.023	0.024	0.024	1.4e-09	4.8e-06	3.3e-08	2.2e-08	1.9e-08
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0516	0.0244	2.7e-04	0.038	0.038	0.021	NA	0.028	4.2e-05	3.4e-05	1.9e-03	NA	3.5e-04
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0518	0.0248	6.0e-03	0.023	0.002	0.009	NA	0.015	1.1e-03	1.7e-01	3.0e-02	NA	6.9e-03
12	TCGA	Thyroid Carcinoma	0.0650	0.0270	7.0e-04	0.031	0.021	0.031	NA	0.032	5.3e-04	3.5e-03	4.8e-04	NA	3.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Age started oral contraceptive pill	7.3	9.1	14.5	1.4	3.7	3.6	3.6	3.6	2.9	1.0	3.6	1.6	2.7	2.8	3.8
Ever unenthusiastic/disinterested for a whole week	4.7	5.8	14.0	1.3	2.6	2.0	1.4	2.0	2.9	2.0	2.3	-0.0	2.1	3.7	3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.5	4.6	8.1	2.1	2.8	2.1	1.4	2.1	2.5	1.3	2.3	1.0	1.8	2.7	2.8
Age at last live birth	3.5	5.1	13.6	1.7	2.4	2.3	1.9	2.3	1.9	-0.4	1.6	0.8	2.2	3.6	3.7
Ever depressed for a whole week	3.2	3.9	8.1	1.4	2.5	1.8	1.8	1.7	1.4	1.6	2.1	0.1	2.2	2.8	2.9
Father’s age at death	3.1	4.2	10.1	2.3	2.8	1.7	3.2	1.7	2.1	1.7	1.9	0.7	1.1	2.0	2.2
Alcohol intake versus 10 years previously	2.7	4.1	14.1	-1.7	-2.5	-1.7	-3.8	-1.7	0.5	-0.2	-2.5	0.0	-2.4	-1.8	-2.2
Worrier / anxious feelings	2.5	4.7	12.2	2.9	3.1	2.1	3.5	2.0	1.2	0.1	2.4	0.8	2.1	1.3	1.9
Alzheimer’s Disease (in father)	2.2	2.4	5.4	2.0	2.3	1.7	1.0	1.7	0.2	-0.7	1.3	1.1	1.2	1.9	2.2
Chronic bronchitis/emphysema (mother)	2.2	2.5	5.8	0.9	1.5	0.5	0.5	0.5	2.4	1.9	2.1	-1.1	1.5	2.4	1.9
Commuting to job workplace: Cycle	2.2	2.6	8.1	1.9	2.1	2.3	1.0	2.3	0.8	-0.5	1.2	2.8	0.7	-0.3	1.0
Smoking status: Previous	2.1	3.1	6.7	-1.1	-1.9	-2.1	-0.6	-2.1	-2.0	-1.6	-1.4	-1.7	-0.7	-2.2	-2.6
Average weekly champagne plus white wine intake	2.1	2.9	6.6	0.5	-1.8	-1.5	-0.6	-1.5	-1.9	-2.6	-1.1	-0.8	-1.5	-2.6	-2.5
Type 2 Diabetes (T2D) (2018)	2.0	3.7	7.1	1.4	2.0	2.6	2.4	2.7	2.4	-1.0	1.2	2.4	1.6	-0.1	1.3
Leg fat-free mass (left)	2.0	10.3	32.5	-3.8	-4.0	-3.5	-5.7	-3.5	-1.1	1.7	-2.7	-3.5	-2.5	-0.9	-2.5
Noisy workplace	2.0	2.5	5.8	1.0	2.2	1.8	0.2	1.8	0.8	0.2	1.5	0.4	2.1	2.1	2.4
Medication: Gliclazide	2.0	2.3	6.0	0.4	1.2	2.3	1.5	2.3	0.7	-1.6	0.4	2.4	1.6	-1.1	0.5
Sensitivity / hurt feelings	1.9	3.2	5.9	2.4	2.4	2.1	1.6	2.1	1.6	0.9	1.5	0.8	2.3	0.6	1.6
Leg predicted mass (left)	1.9	10.1	31.2	-3.8	-3.9	-3.4	-5.6	-3.4	-1.0	1.8	-2.6	-3.5	-2.5	-0.8	-2.4
Hearing difficulty/problems with background noise	1.9	3.1	6.4	2.0	2.5	1.6	1.2	1.6	2.1	1.1	2.5	-0.5	2.0	1.1	1.6
Length of working week for main job	1.9	2.1	5.9	-0.2	-1.3	-0.7	-2.1	-0.7	-1.6	-1.0	-2.4	1.3	-2.1	-0.9	-1.0
Taking other prescription medications	1.8	2.7	8.9	1.1	1.6	2.2	0.2	2.1	3.0	0.5	1.7	0.4	2.2	0.6	1.6
Arm fat-free mass (right)	1.8	9.2	26.3	-3.8	-3.7	-3.4	-5.1	-3.4	-1.5	1.3	-2.3	-3.7	-2.2	-0.8	-2.3
Leg fat mass (right)	1.8	7.0	31.1	-2.0	-3.0	-2.9	-5.6	-2.9	-0.4	1.2	-2.1	-2.6	-2.2	-0.9	-2.2
Leg fat-free mass (right)	1.8	9.4	27.8	-4.2	-3.9	-3.2	-5.3	-3.2	-0.9	1.4	-2.7	-3.2	-2.5	-0.9	-2.3
Leg predicted mass (right)	1.8	9.5	28.2	-4.2	-3.9	-3.2	-5.3	-3.2	-1.0	1.4	-2.7	-3.2	-2.5	-0.9	-2.3
HbA1C	1.7	1.9	3.6	-1.3	-1.1	-1.6	-1.0	-1.6	-1.5	-1.0	-1.4	-0.7	-1.4	-1.4	-1.9
Medication: Atenolol	1.7	2.1	5.8	0.2	-1.2	-1.2	-0.7	-1.2	-1.6	-1.8	-2.4	0.6	-1.3	-1.8	-1.8
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	5.6	2.4	1.8	1.6	-0.6	1.6	1.6	-0.6	1.8	1.1	1.5	0.7	1.3
Loud music exposure frequency	1.7	1.8	3.8	1.6	1.8	1.9	1.1	1.9	0.4	-1.2	1.4	1.4	1.1	-0.3	0.9
Eye problems/disorders: None of the above	1.7	2.0	5.5	1.2	1.1	0.3	1.5	0.2	1.3	1.9	1.8	-1.0	0.7	2.4	1.8
Weight	1.6	8.1	33.3	-3.0	-3.3	-2.9	-5.8	-2.9	-0.4	1.8	-2.2	-3.2	-2.0	-0.7	-2.0
Leg fat mass (left)	1.6	6.3	30.0	-2.3	-2.9	-2.6	-5.5	-2.6	-0.2	1.0	-2.0	-2.5	-2.0	-0.8	-2.0
Medication: Co-codamol	1.5	1.7	7.1	-1.1	-1.3	-0.9	-2.7	-0.9	-0.2	-0.0	-2.1	-0.4	-1.7	-0.7	-1.0
Diabetes (father)	1.5	1.8	5.1	-0.9	-1.2	-1.8	-2.2	-1.8	-0.5	0.2	-1.1	-2.3	-0.9	0.2	-0.8
Townsend deprivation index at recruitment	1.5	2.1	3.6	1.6	1.8	1.9	-0.3	1.9	1.7	0.3	1.8	1.5	1.4	0.4	1.3
Trunk fat mass	1.5	6.4	29.4	-2.2	-2.9	-2.6	-5.4	-2.6	-0.0	1.6	-2.0	-2.8	-1.8	-0.5	-1.8
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	7.0	2.6	1.8	1.5	0.1	1.5	2.5	0.4	1.5	0.0	1.6	1.2	1.6
Whole body fat mass	1.5	6.3	30.2	-2.2	-2.8	-2.6	-5.5	-2.6	0.0	1.4	-2.0	-2.6	-1.9	-0.6	-1.8
Arm predicted mass (right)	1.5	7.9	24.7	-3.4	-3.4	-3.0	-5.0	-3.0	-1.4	1.4	-2.1	-3.4	-1.9	-0.7	-2.1
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.7	-1.6	-1.5	-1.9	-0.8	-1.9	-1.3	0.0	-0.9	-1.8	-1.2	0.4	-0.8
Whole body fat-free mass	1.5	8.4	25.4	-3.7	-3.6	-3.0	-5.0	-3.0	-1.0	1.6	-2.3	-3.4	-2.0	-0.9	-2.2
Diabetes diagnosed by doctor	1.5	2.4	6.0	0.6	1.4	2.3	2.4	2.3	1.1	-1.4	0.6	2.2	1.2	-0.8	0.6
Medication: Bendroflumethiazide	1.5	2.3	7.9	2.8	2.1	1.4	1.4	1.4	0.8	-0.6	1.8	1.1	1.2	0.9	1.3
Basal metabolic rate	1.5	8.3	28.5	-3.6	-3.5	-2.9	-5.3	-3.0	-0.8	1.8	-2.2	-3.4	-1.9	-0.7	-2.1
Medication: Metformin	1.4	1.9	4.1	0.6	1.2	2.0	2.0	2.0	1.5	-1.1	0.5	1.8	1.2	-0.9	0.4
Average weekly fortified wine intake	1.4	1.6	7.8	0.2	0.5	1.6	0.6	1.6	1.6	0.7	0.5	2.8	-0.9	-1.5	-0.1
Waist circumference	1.4	5.1	21.0	-1.8	-2.6	-2.4	-4.6	-2.4	0.1	1.5	-2.1	-2.4	-1.7	-0.5	-1.6
Mouth/teeth dental problems: Dentures	1.4	2.4	7.4	-1.6	-1.6	-1.8	-0.2	-1.8	1.0	2.4	-0.6	-2.7	-0.2	-0.8	-1.5
Exposure to tobacco smoke at home	1.4	1.5	3.3	-0.8	-1.7	-1.8	-0.9	-1.8	-0.2	-0.5	-0.6	-1.7	-0.9	-0.8	-1.5
Breastfed as a baby	1.4	1.7	4.6	1.7	1.7	1.3	2.1	1.4	1.3	0.4	0.5	1.6	0.7	0.5	1.0
Blood clot in the leg (DVT)	1.4	1.8	3.6	-0.4	1.4	1.7	1.4	1.7	0.9	-0.9	1.3	0.5	1.6	1.4	1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	7.6	-2.6	-2.2	-1.5	-2.8	-1.5	-1.2	0.4	-1.9	-1.9	-0.7	-0.4	-1.0
Osteoarthritis (self-reported)	1.4	1.8	4.5	-0.2	-1.6	-1.4	-1.6	-1.4	-1.5	-0.2	-2.1	-0.5	-1.3	-1.1	-1.5
Smoking status: Current	1.4	2.2	9.0	0.1	0.9	1.6	1.1	1.6	3.0	1.6	1.0	0.1	1.7	1.1	1.5
Whole body water mass	1.4	8.0	24.5	-3.7	-3.5	-2.9	-5.0	-2.9	-1.0	1.6	-2.2	-3.4	-1.9	-0.8	-2.1
Medication for hormone replacement therapy	1.3	1.4	3.4	0.7	-0.8	-1.2	-1.6	-1.2	-1.6	-0.1	-1.7	0.6	-1.8	-0.6	-1.0
Severe depression (siblings)	1.3	1.4	3.6	1.7	1.6	0.6	1.0	0.6	-0.9	1.9	1.1	-0.1	1.1	1.2	1.2
Supplements: Glucosamine	1.3	1.7	4.5	-0.3	-1.3	-0.9	-0.8	-0.9	-0.6	-1.6	-1.5	0.5	-1.6	-2.1	-1.9
Bipolar Disorder (2011)	1.2	1.2	3.8	0.6	1.2	0.8	1.0	0.8	1.4	1.1	1.9	-0.3	1.3	1.1	0.0
Number of incorrect matches in round	1.2	2.0	4.2	-0.2	-0.9	-2.1	-0.6	-2.1	-1.6	-0.7	-1.5	-1.8	-1.2	-1.2	-1.8
Trunk fat-free mass	1.2	6.6	19.6	-3.3	-3.2	-2.6	-4.4	-2.6	-1.0	1.7	-2.0	-3.1	-1.6	-0.9	-2.0
Hip circumference	1.2	5.3	21.7	-2.3	-2.8	-2.2	-4.7	-2.2	0.2	1.5	-2.0	-2.7	-1.4	-0.7	-1.7
Health satisfaction	1.2	1.6	10.9	-1.0	-1.0	-0.8	-3.3	-0.8	0.2	0.8	-1.7	-0.5	-0.9	-0.1	-0.5
Illnesses of father: High blood pressure	1.2	1.5	3.0	1.1	-0.7	-1.4	-0.5	-1.4	-0.9	-1.7	-1.4	-0.4	-0.9	-1.6	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.8	-0.5	1.3	1.6	1.4	1.5	0.8	-0.8	1.0	0.4	1.4	1.2	1.7
Chronotype (morning person)	1.1	2.6	12.4	-3.5	-2.6	-1.4	0.4	-1.3	-0.6	0.0	-1.7	0.4	-1.4	-0.8	-1.3
Relative age of first facial hair	1.1	2.3	5.0	-1.1	-1.9	-1.1	-1.7	-1.1	-0.6	-1.5	-1.6	0.8	-2.2	-1.8	-1.8
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	2.6	-0.8	-1.5	-0.7	-1.3	-0.7	-1.1	-0.9	-1.5	0.4	-0.7	-1.6	-1.5
Hand grip strength (right)	1.1	2.9	7.4	-1.1	-1.6	-2.1	-1.5	-2.1	-2.7	-1.6	-1.0	-1.6	-1.3	-0.9	-1.8
Age when periods started (menarche)	1.1	2.6	6.9	-1.4	-1.4	-2.2	-1.3	-2.2	-2.6	1.0	-1.0	-2.0	-1.2	-0.4	-1.4
Trunk predicted mass	1.1	6.3	19.4	-3.3	-3.1	-2.5	-4.4	-2.5	-0.9	1.9	-1.9	-3.0	-1.6	-0.8	-1.9
Peak expiratory flow (PEF)	1.1	2.6	7.5	-1.4	-1.2	-1.4	-1.8	-1.4	-2.7	-1.0	-1.7	-0.0	-2.2	-1.3	-1.6
Medication: Paracetamol	1.1	1.8	3.9	0.2	-1.2	-1.9	-1.1	-1.9	-2.0	0.0	-1.5	-1.0	-1.8	-0.2	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	2.9	1.3	1.2	1.7	-0.7	1.7	0.6	0.1	1.0	1.6	0.8	-1.0	0.3
Arm fat mass (left)	1.1	4.6	24.4	-1.9	-2.3	-2.0	-4.9	-2.0	0.3	1.8	-1.4	-2.3	-1.4	-0.3	-1.3
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.1	-1.0	-1.1	-1.1	-1.4	-1.1	-1.5	-0.6	-1.5	0.1	-1.8	-0.4	-0.9
High cholesterol (Self-reported)	1.1	2.0	3.6	-1.6	-1.7	-1.9	-1.5	-1.9	-1.2	0.1	-1.2	-1.7	-1.0	-0.4	-1.4
Arm fat-free mass (left)	1.1	5.4	22.8	-2.7	-2.7	-2.2	-4.8	-2.2	-0.6	1.5	-1.6	-2.6	-1.5	-0.7	-1.6
Body Mass Index (BMI) (2010)	1.0	1.4	9.2	-1.6	-1.1	-0.3	-3.0	-0.3	-0.2	-1.4	-0.2	-0.7	-0.7	-0.3	-0.4
Blood Eosinophil Count	1.0	7.8	14.1	2.6	3.0	3.2	3.8	3.2	3.3	-0.2	3.1	2.4	2.0	1.9	3.0
Arm fat mass (right)	1.0	4.1	23.8	-1.5	-2.2	-1.8	-4.9	-1.8	0.4	1.8	-1.3	-2.0	-1.3	-0.4	-1.2
Tense / ‘highly strung’	1.0	1.6	4.9	1.7	1.3	0.7	2.2	0.7	-0.2	0.5	0.8	-0.3	1.3	1.9	1.6
Birth weight	1.0	2.1	5.1	-2.3	-1.7	-1.4	-1.9	-1.4	-0.8	-1.4	-1.0	-1.2	-1.4	-1.1	-1.5
Leg fat percentage (right)	1.0	3.5	18.8	-0.9	-1.9	-2.0	-4.3	-2.0	0.0	1.0	-1.4	-1.4	-1.7	-0.8	-1.6
Shortness of breath walking on level ground	1.0	1.2	6.4	-0.2	-0.5	-0.6	-2.5	-0.6	1.9	1.3	-0.8	-0.5	-0.9	0.2	-0.2
Migraine (self-reported)	1.0	1.2	2.8	-0.2	1.4	1.1	0.7	1.1	1.4	-0.6	1.0	0.4	1.1	1.6	1.7
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.0	-1.0	0.8	0.2	1.3	0.2	0.2	-0.6	1.3	-1.7	1.4	1.7	1.2
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.4	1.3	1.0	0.3	1.5	0.3	0.9	-0.9	1.4	-0.3	1.2	1.1	0.9
BMI	0.9	4.9	23.2	-3.1	-2.4	-1.8	-4.8	-1.8	0.9	1.0	-0.9	-3.0	-0.7	-0.4	-1.3
Hand grip strength (left)	0.9	2.4	7.3	-1.1	-1.2	-1.4	-1.2	-1.4	-2.2	-2.7	-0.6	-1.0	-1.1	-1.4	-1.7
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.5	-1.4	-1.4	-0.7	-1.6	-0.7	0.3	-0.4	-1.6	-0.5	-0.6	-1.4	-1.4
Supplements: Zinc	0.9	0.9	3.2	-0.1	0.7	1.3	-0.6	1.3	1.8	-0.5	0.4	1.4	-0.7	0.1	0.8
Trunk fat percentage	0.9	3.6	20.2	-1.3	-2.0	-1.9	-4.5	-1.9	0.4	1.2	-1.4	-2.0	-1.4	-0.1	-1.1
Nervous feelings	0.9	1.6	4.3	0.7	1.5	1.0	2.1	1.0	0.7	0.4	1.6	-0.9	1.5	1.4	1.5
Forced vital capacity (FVC)	0.9	3.3	6.0	-2.4	-2.0	-1.8	-2.3	-1.8	-2.4	-0.0	-1.9	-1.1	-1.4	-1.4	-1.9
Mouth/teeth dental problems	0.9	1.4	4.7	1.9	0.9	1.3	-0.0	1.3	0.5	-1.8	0.5	2.2	0.5	0.1	0.9
Diabetes (self-reported)	0.9	1.3	3.9	0.2	0.7	1.5	2.0	1.6	0.6	-0.9	0.1	1.9	0.6	-1.4	-0.2
Depression (self-reported)	0.9	1.1	4.4	2.1	1.3	0.7	0.2	0.7	1.0	0.7	1.0	-0.3	0.9	1.1	1.2
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.4	1.3	1.3	1.3	1.3	1.3	0.1	1.1	0.8	1.6	-0.6	0.4	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	5.4	0.9	-0.4	0.1	1.0	0.1	-0.9	-0.9	-0.2	1.1	0.3	-2.3	-1.5
Age at first live birth	0.9	1.5	4.3	0.6	1.0	1.3	1.5	1.3	1.0	-0.4	0.5	0.5	1.2	2.0	2.1
Heart disease (mother)	0.9	1.1	6.0	-1.6	-0.8	-1.2	0.6	-1.2	0.7	0.5	-0.2	-2.4	-0.3	0.7	-0.3
Long-standing illness, disability or infirmity	0.9	1.3	3.2	-1.8	-1.0	0.1	-1.8	0.1	0.9	-0.3	-1.8	0.0	0.0	-1.8	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.3	-0.3	0.3	0.4	0.3	0.3	0.2	0.3	1.2	-1.8	1.6	1.6	1.2
Illnesses of father: None of the above (group 1)	0.9	1.1	2.2	-1.3	-1.2	-0.3	-0.3	-0.3	-0.5	1.4	-0.6	1.2	-1.3	-1.5	-1.2
Medication: Paracetamol	0.9	1.3	3.5	0.4	-1.0	-1.5	-0.6	-1.5	-1.7	0.8	-1.4	-0.2	-1.9	-0.3	-1.0
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.8	-1.7	-1.1	0.0	-0.6	0.0	1.5	-1.6	-1.1	1.0	-1.1	-1.0	-0.7
Arm predicted mass (left)	0.9	4.4	20.4	-2.4	-2.4	-1.9	-4.5	-1.9	-0.4	1.5	-1.4	-2.4	-1.2	-0.7	-1.5
Major Depression (MDD)	0.8	1.0	5.6	-0.8	0.1	-0.4	-0.2	-0.5	0.6	0.3	0.1	-1.8	0.2	2.4	1.4
Coronary Artery Disease (CAD)	0.8	1.0	3.7	-0.2	-0.9	-1.4	-0.5	-1.5	-0.4	-1.0	0.3	-1.9	0.5	-0.5	-1.2
Fasting Glucose	0.8	1.0	2.5	-1.5	0.5	1.6	0.9	1.6	0.9	-0.8	0.7	0.3	1.0	-0.3	0.6
Height	0.8	15.1	45.6	-3.9	-4.7	-4.3	-6.8	-4.3	-2.9	1.4	-3.8	-4.0	-3.0	-1.3	-3.1
Ever had hysterectomy (womb removed)	0.8	0.9	1.8	-1.0	-0.8	-1.0	-0.7	-1.0	-1.0	-1.1	-1.0	-0.4	-0.9	-1.1	-1.3
Current tobacco smoking	0.8	1.3	6.9	-0.4	0.4	1.0	0.7	1.0	2.6	1.3	0.6	-0.1	1.1	0.9	1.1
Multivitamins +/- minerals	0.8	1.0	2.6	-1.2	-1.1	-0.9	-1.4	-0.8	-0.7	0.7	-1.6	-0.3	-1.6	-0.3	-0.6
Sitting height	0.8	5.7	16.4	-2.7	-2.8	-2.3	-4.0	-2.3	-1.6	1.7	-2.5	-1.9	-1.9	-1.6	-2.3
Chronic bronchitis/emphysema (father)	0.8	0.9	2.2	1.1	-0.7	-1.3	-1.1	-1.3	-0.8	-0.5	-0.9	-1.5	-0.5	0.0	-0.7
Had other major operations	0.8	0.9	2.5	-1.3	-0.2	0.1	-1.5	0.1	0.3	1.6	-1.1	0.2	-0.5	1.4	1.0
Pain all over the body in last month	0.8	0.9	3.7	-0.8	-0.4	-0.3	-1.8	-0.3	-0.6	1.9	-0.4	0.7	-1.3	0.4	0.2
Medication: Ramipril	0.8	1.1	2.4	-1.2	-1.3	-1.4	-0.3	-1.4	-0.2	0.9	-1.3	-0.3	-1.6	-0.3	-0.9
Illnesses of siblings	0.8	1.1	4.1	-0.6	-1.1	-1.1	-1.5	-1.1	-2.0	0.2	-0.7	0.2	-1.6	0.1	-0.5
Happiness	0.8	0.9	5.2	-0.6	0.8	0.7	-0.2	0.7	1.1	2.3	-0.0	0.0	0.2	1.1	1.2
Lung cancer (father)	0.8	0.9	2.8	-1.0	-1.3	-0.6	-1.5	-0.7	0.6	0.5	-0.6	-1.7	0.7	-0.4	-0.7
Standing height	0.8	7.6	19.7	-3.6	-3.4	-3.0	-4.4	-3.0	-1.6	1.5	-2.7	-3.2	-1.9	-0.4	-1.9
Body fat percentage	0.8	3.1	18.9	-1.2	-1.8	-1.7	-4.3	-1.7	0.5	1.1	-1.2	-1.7	-1.3	-0.2	-1.1
Exposure to tobacco smoke outside home	0.8	1.0	2.7	-0.2	-0.9	-1.3	-0.1	-1.3	-0.9	-1.0	-0.9	-1.6	0.2	-0.8	-1.3
Chest pain or discomfort	0.8	1.1	5.5	0.2	0.9	1.2	-0.2	1.2	2.4	0.6	1.1	-0.2	1.3	0.4	0.9
Arm fat percentage (left)	0.8	3.3	18.8	-1.3	-1.9	-1.6	-4.3	-1.6	0.5	1.6	-1.3	-1.6	-1.3	-0.3	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	3.4	-1.8	-0.8	-1.3	-1.0	-1.3	-1.4	-0.0	-0.4	-1.8	-0.5	0.6	-0.4
Breast cancer (self-reported)	0.8	0.9	2.3	0.8	1.0	1.5	0.8	1.5	0.7	-0.4	0.8	0.9	1.3	-0.5	0.5
Financial situation satisfaction	0.8	1.0	6.8	1.3	-0.2	-0.3	-2.6	-0.3	0.1	1.3	-0.1	-0.7	0.5	0.6	0.3
Myopia	0.8	1.2	3.0	-0.2	-1.2	-1.7	-0.5	-1.7	-0.7	0.2	-0.8	-1.5	-1.4	-0.2	-1.1
Worry (Nagel 2018)	0.7	1.5	6.6	1.7	1.6	0.6	2.6	0.6	-0.7	-0.9	1.1	0.2	1.0	0.8	0.9
Vitamin and mineral supplements	0.7	0.9	3.1	1.2	1.0	0.8	1.1	0.8	0.4	-0.3	1.3	0.0	1.8	0.8	0.9
Stomach or abdominal pain in last month	0.7	0.9	2.3	-0.8	-1.0	-1.5	0.1	-1.5	-0.0	-0.2	-1.1	-1.3	-0.9	0.4	-0.5
Past tobacco smoking	0.7	1.2	3.0	0.6	1.3	1.2	0.2	1.2	0.3	0.8	0.9	1.7	-0.5	1.5	1.7
Financial difficulties in last 2 years	0.7	0.9	4.9	0.2	-0.8	-0.4	-2.2	-0.3	-0.8	-0.9	-1.4	0.6	-0.4	-1.0	-0.8
Heart attack	0.7	0.9	2.8	-1.3	-0.8	0.3	-0.4	0.3	1.7	-1.5	-0.7	1.0	-0.7	-0.8	-0.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	6.3	-1.8	-1.4	-1.3	-2.1	-1.3	-2.5	-0.3	-1.7	-0.4	-1.5	-1.2	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	3.1	1.1	-0.5	-1.2	-0.3	-1.1	-0.6	1.8	-1.4	-0.6	-1.0	0.9	0.0
Medication: Omeprazole	0.7	0.8	1.9	0.7	0.5	1.2	-1.0	1.2	1.4	-0.6	0.3	1.0	0.5	-1.3	-0.2
Illnesses of siblings: Diabetes	0.7	0.8	2.8	-0.1	0.3	0.9	0.5	0.9	1.3	-1.7	-0.5	1.0	-0.0	-1.4	-0.5
Average weekly red wine intake	0.7	1.1	3.4	1.4	1.3	0.8	1.9	0.8	-0.8	0.7	0.7	1.1	0.3	0.8	0.9
Qualifications: nursing, teaching	0.7	1.1	5.5	-0.8	-1.1	-1.0	0.2	-1.0	-1.0	-2.3	-1.0	-0.3	-0.7	-0.8	-1.0
Eye problems/disorders: Cataract	0.7	0.8	3.6	-1.0	-0.3	0.5	0.6	0.5	-0.5	-0.3	-0.8	1.2	-0.4	-1.9	-1.0
Leg fat percentage (left)	0.7	2.7	17.6	-1.1	-1.6	-1.4	-4.2	-1.4	0.3	0.5	-1.1	-1.2	-1.3	-0.6	-1.2
Basal cell carcinoma (self-reported)	0.7	0.8	3.1	-0.3	0.1	0.7	0.8	0.7	1.3	1.8	0.8	0.7	-0.4	-1.2	-0.4
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	0.9	1.2	0.8	0.9	0.8	0.2	-0.3	0.2	1.2	0.8	1.5	1.4
Verbal and Numeric Reasoning (VNR)	0.6	1.4	4.8	-2.2	-1.5	-1.2	-0.5	-1.3	-1.3	0.5	-0.5	-2.0	0.0	0.6	-0.3
Age at First Birth	0.6	0.9	2.8	-1.7	-0.9	-1.0	0.8	-1.0	-1.2	0.8	-0.6	-1.1	-0.4	0.5	-0.2
Hearing difficulty/problems: Yes	0.6	1.0	2.0	1.0	1.0	0.3	0.3	0.2	1.4	-0.9	1.4	-1.2	0.9	1.3	1.0
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.7	0.7	-0.1	-0.2	-0.5	-0.2	-0.8	-0.4	-0.7	0.9	-1.2	-1.6	-1.2
Serious illness, injury or assault to yourself	0.6	0.8	2.5	-0.2	-0.5	0.7	-1.6	0.7	0.4	0.7	-0.9	1.2	0.3	-1.5	-0.7
High blood pressure (mother)	0.6	0.8	1.7	-1.1	-0.8	-0.7	-0.1	-0.7	-1.2	0.1	-1.1	0.6	-1.2	-1.3	-1.2
Body mass index (BMI)	0.6	2.7	15.1	-1.2	-1.8	-1.5	-3.9	-1.5	0.5	1.3	-0.9	-1.8	-1.1	-0.5	-1.2
Arm fat percentage (right)	0.6	2.2	16.7	-0.6	-1.3	-1.0	-4.1	-1.0	0.9	1.4	-0.9	-1.0	-0.9	-0.2	-0.7
Prospective memory result	0.6	0.8	1.6	0.7	-0.7	-0.8	-0.0	-0.8	0.8	-0.5	-1.1	-0.0	-1.2	-1.3	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	4.0	2.0	0.2	-0.6	0.8	-0.6	-1.0	1.0	0.0	-1.6	1.1	-0.0	-0.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	4.9	-2.2	-1.3	-0.7	-1.6	-0.7	-0.4	-0.7	-0.0	-0.9	0.2	-0.3	-0.6
Glaucoma (self-reported)	0.6	0.7	2.2	-0.6	-0.3	0.1	-1.0	0.1	-1.5	-1.1	-0.1	0.8	-0.0	-1.5	-0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	4.4	-0.2	0.1	-0.1	-2.1	-0.1	0.8	1.3	0.4	-1.2	-0.1	0.8	0.5
Had major operations	0.6	0.6	3.6	-0.1	-0.3	0.7	-0.8	0.7	-0.1	-1.9	0.4	0.3	0.6	-1.3	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.4	-1.0	-0.7	-0.5	-1.5	-0.5	0.1	-0.8	0.0	-1.8	0.3	-0.4	-0.6
Illnesses of father: Heart disease	0.6	0.8	2.3	-0.0	0.8	0.9	-0.4	0.9	0.7	-1.2	0.2	0.4	0.6	1.5	1.5
Mineral and other dietary supplements	0.6	0.7	2.3	-0.5	0.2	0.2	-0.2	0.1	0.0	0.2	1.1	-1.5	1.4	1.4	1.0
Number of self-reported non-cancer illnesses	0.6	1.0	2.3	0.8	1.1	1.5	0.1	1.5	0.9	-1.4	0.4	0.8	1.2	-0.6	0.4
Guilty feelings	0.6	0.9	2.4	1.5	1.2	0.9	-0.8	0.9	-0.2	1.3	0.9	0.2	0.4	0.8	1.0
Ever taken oral contraceptive pill	0.6	0.7	2.8	-1.7	-0.8	-0.2	-1.7	-0.2	-0.3	-0.6	-0.7	0.0	-0.6	-0.6	-0.5
Hearing aid user	0.6	0.7	2.4	1.5	0.9	0.5	1.4	0.5	-0.9	-0.5	0.4	1.1	0.3	0.0	0.2
Alcohol drinker status: Never	0.6	0.7	2.7	0.3	1.2	1.1	0.3	1.1	0.6	0.1	0.7	0.3	1.6	0.2	0.6
Unable to work because of sickness or disability	0.6	0.8	2.9	0.6	0.4	0.7	-0.5	0.7	0.8	-1.5	-1.0	1.7	-0.3	-1.0	-0.2
Supplements: Calcium	0.6	0.7	5.6	0.1	0.3	0.6	0.1	0.6	0.7	2.4	0.3	0.8	-0.4	-0.1	0.3
Alcohol drinker status: Previous	0.6	0.7	5.0	0.3	0.4	0.8	0.8	0.8	0.7	-2.2	0.5	0.4	0.6	-0.2	0.3
Crohns Disease (2012)	0.5	0.8	5.8	-0.4	-0.6	-1.1	-0.2	-1.2	0.1	-0.2	0.3	-2.4	0.3	0.3	-0.4
Rheumatoid Arthritis	0.5	0.6	3.6	-0.6	-0.8	-0.6	-1.9	-0.6	-0.0	0.5	-0.5	-0.3	-1.1	-0.5	-0.6
Smoking Status	0.5	1.3	4.1	-0.7	-1.6	-1.0	-0.6	-1.0	0.3	-0.3	-0.9	-1.0	-0.1	-2.0	-1.9
Respiratory disease	0.5	1.1	5.1	2.3	1.0	0.8	-1.0	0.8	-0.3	-1.8	0.1	1.3	0.2	-0.0	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.7	1.3	1.2	0.4	0.4	0.4	0.5	0.9	0.8	0.2	0.7	1.0	0.9
Angina	0.5	0.6	2.6	-0.5	-0.8	-0.6	-1.6	-0.6	1.1	0.1	-0.7	-0.2	-0.7	-0.7	-0.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.9	0.6	0.1	0.4	0.5	0.4	-0.6	-0.4	-0.4	1.7	-0.6	-1.0	-0.5
Impedance of leg (left)	0.5	2.6	6.7	2.6	2.1	1.8	1.8	1.8	0.0	-1.4	1.1	2.1	1.4	0.2	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.5	1.9	1.1	0.8	-0.0	0.8	1.2	-0.6	0.6	-0.0	1.1	0.4	0.7
Pulse rate	0.5	0.9	1.6	-1.3	-1.0	-1.2	-1.1	-1.2	-0.6	-0.5	-1.1	-1.2	-0.7	-0.0	-0.7
Illnesses of mother	0.5	0.7	3.1	0.1	0.1	0.5	-0.7	0.5	-0.9	-1.8	-0.1	1.0	0.0	-1.2	-0.5
Birth weight of first child	0.5	1.0	1.9	-1.4	-1.4	-0.9	-0.1	-0.9	-0.1	-0.9	-1.1	-0.1	-1.2	-1.2	-1.3
Gout (self-reported)	0.5	0.6	3.0	0.1	-0.3	-0.5	-0.6	-0.5	0.1	-1.7	-0.0	-1.2	0.7	-1.0	-0.9
Neck or shoulder pain in last month	0.5	0.7	2.5	0.5	0.2	0.7	-0.6	0.7	0.3	-1.1	-0.6	1.4	-0.1	-1.6	-0.7
Pulse rate, automated reading	0.5	1.7	4.0	-1.1	-1.4	-1.2	-2.0	-1.2	-1.3	0.3	-1.6	-0.1	-1.1	-1.4	-1.7
Alcohol intake frequency.	0.5	1.1	4.4	-1.4	-0.0	0.1	-2.1	0.1	1.6	-0.4	0.2	-0.5	-0.6	1.4	1.0
Number of full sisters	0.5	0.6	2.2	-1.2	0.3	0.6	0.4	0.6	1.5	-0.1	-0.0	-0.6	1.2	0.7	0.8
Leg pain on walking	0.5	0.6	2.4	-0.6	-0.1	-0.5	-0.5	-0.6	1.1	-0.5	-0.3	-1.6	0.3	1.1	0.5
Medication: Aspirin	0.5	0.6	3.3	-0.3	-0.5	-0.3	1.8	-0.3	0.9	-0.7	0.1	0.1	-0.2	-1.1	-1.0
Ever had bowel cancer screening	0.5	0.6	1.9	0.5	1.0	0.9	1.4	0.9	-0.5	-0.7	0.3	0.7	0.2	0.2	0.6
Miserableness	0.5	0.8	2.2	0.6	1.1	0.7	1.1	0.6	-0.0	1.2	1.1	-0.7	1.5	0.8	0.9
Wears glasses or contact lenses	0.5	0.6	2.0	1.4	-0.1	0.3	0.7	0.3	0.3	-0.9	-0.8	1.3	-0.5	-0.9	-0.4
Mother’s age at death	0.5	0.6	2.4	-0.5	-0.8	-0.4	-1.1	-0.4	-0.3	-1.2	-1.6	0.1	-0.5	-0.6	-0.6
Medication: Atorvastatin	0.5	0.6	2.3	-0.3	-0.8	-0.4	-0.2	-0.4	0.3	-0.2	-1.1	0.6	-0.8	-1.5	-1.3
Number of operations (self-reported)	0.5	0.7	2.0	-0.1	0.7	1.4	-1.1	1.4	0.4	-0.3	-0.2	1.4	0.6	-0.5	0.4
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.1	0.2	-0.6	-0.8	0.8	-0.8	0.8	-0.9	-1.1	-0.8	-0.9	0.7	0.0
Diastolic blood pressure, automated reading	0.5	1.5	3.2	-0.7	-0.7	-1.1	-0.7	-1.1	-1.8	1.3	-0.8	0.3	-1.7	-1.7	-1.7
Pack years of smoking	0.5	0.7	1.2	1.0	0.8	0.2	-1.1	0.2	1.0	-0.2	1.0	-1.0	0.4	1.1	0.8
Tanning	0.4	5.1	16.9	4.1	3.1	2.1	2.4	2.0	0.2	1.2	2.8	0.8	2.5	1.2	1.9
Average weekly spirits intake	0.4	0.4	2.0	-0.4	-0.5	0.1	-0.7	0.1	0.3	-0.9	0.4	-0.2	0.8	-1.4	-0.9
Systolic blood pressure, automated reading	0.4	1.1	5.8	-1.0	-0.4	-1.1	-0.1	-1.1	-1.1	2.4	-0.3	-0.3	-1.2	-0.5	-0.9
Impedance of leg (right)	0.4	1.9	8.5	2.9	1.8	1.1	1.5	1.1	-0.3	-0.7	0.9	1.5	1.3	0.3	0.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.8	-1.3	-0.5	-0.7	-0.9	-0.7	0.2	0.9	-0.6	-0.4	-0.7	-0.4	-0.6
Falls in the last year	0.4	0.5	2.2	0.9	-0.2	0.1	-1.0	0.1	0.1	0.5	-0.9	0.8	0.4	-1.5	-0.9
Medication: Cholesterol lowering	0.4	0.6	2.0	-0.3	-0.3	0.3	-0.4	0.3	0.3	-1.3	-1.0	1.4	-0.9	-0.7	-0.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	1.3	-0.1	0.1	-0.8	0.1	1.1	-1.1	-0.6	0.6	0.1	-0.2	-0.0
Emphysema/chronic bronchitis	0.4	0.5	1.2	0.4	0.7	0.8	0.9	0.8	-0.6	-1.1	0.1	1.1	-0.3	-0.4	0.2
Medication: Seretide 50 evohaler	0.4	0.4	3.4	0.2	-0.0	0.1	-1.8	0.1	-0.9	0.6	-0.3	0.1	0.4	-0.1	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.5	0.6	0.7	0.9	0.4	0.9	-0.5	-0.4	0.4	1.2	0.2	-0.1	0.4
Suffer from ‘nerves’	0.4	0.6	4.4	2.1	0.7	-0.2	0.6	-0.2	-0.9	0.6	0.2	0.2	0.5	0.0	-0.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.6	0.3	0.6	0.5	-1.3	0.5	0.9	-0.9	0.5	0.4	0.1	0.7	0.8
Commuting to job workplace: Walk	0.4	0.4	1.7	0.9	0.4	0.5	0.6	0.5	-0.6	-1.3	0.8	0.3	0.2	-0.6	-0.2
Medication: Aspirin	0.4	0.6	3.1	-0.1	-0.3	-0.0	1.8	-0.0	1.5	-0.5	-0.2	0.4	-0.2	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.1	0.5	1.4	0.7	0.2	0.7	-1.8	-0.1	0.8	-0.2	0.9	1.2	1.2
Commuting to job workplace: Public transport	0.4	0.5	2.3	0.3	-0.0	0.7	-0.1	0.7	0.4	-0.2	-0.5	1.3	0.5	-1.5	-0.6
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	0.1	0.2	0.6	-0.8	0.6	-0.9	-0.9	0.1	1.0	0.7	-1.0	-0.3
Medication: Lisinopril	0.4	0.5	2.0	-1.2	-0.5	0.1	-0.4	0.2	-0.8	-0.3	-0.8	0.5	-0.4	-1.4	-0.8
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-0.8	-1.1	-0.5	-0.9	-0.5	0.5	-0.7	-0.8	-0.1	-0.6	-0.5	-0.7
Schizophrenia (2018)	0.3	0.6	1.4	-0.8	-0.8	-0.8	0.5	-0.8	0.6	-0.1	-0.9	-1.2	-0.6	1.0	0.4
Schizophrenia vs Biploar Disorder	0.3	0.4	1.7	-0.3	-0.4	-0.3	0.1	-0.3	-0.8	-1.3	-1.3	-0.3	-0.1	-0.6	-0.5
Crohns Disease (2017)	0.3	0.6	2.6	0.2	-0.2	-1.0	0.5	-1.0	0.6	0.2	0.7	-1.6	-0.2	1.0	0.1
Ulcerative Colitis (UC)	0.3	0.5	1.4	1.0	0.4	0.4	0.4	0.4	1.0	-1.2	0.4	-0.2	1.2	0.4	0.5
Reaction Time	0.3	0.5	2.5	-0.1	-0.6	-0.1	1.6	-0.1	0.7	-0.8	-1.1	-0.4	-0.2	-0.8	-0.5
Breast Cancer	0.3	0.8	1.5	0.5	0.8	1.2	1.1	1.2	0.6	-0.5	1.2	0.7	0.9	-0.6	0.3
Mean Putamen Volume	0.3	0.4	1.4	1.0	0.5	0.1	-0.8	0.1	0.5	0.0	-0.0	0.1	-0.5	1.2	0.9
LDL Cholesterol	0.3	0.4	1.5	0.8	0.7	0.7	-0.2	0.8	0.3	-0.8	0.1	1.2	0.7	0.1	0.5
Ulcerative Colitis	0.3	0.4	1.8	1.0	-0.1	0.3	-0.5	0.3	0.5	-1.4	-0.0	-0.4	1.1	-0.4	-0.1
Allergy or Eczema	0.3	0.8	2.8	-0.5	-1.0	-0.9	-1.7	-0.9	-0.5	-0.3	-1.0	-0.0	-1.4	-0.1	-0.6
Cardiovascular Disease	0.3	1.0	2.5	-1.6	-0.9	-0.9	-1.3	-0.8	-1.4	0.7	-0.9	-0.5	-0.7	-0.8	-0.9
Diabetes (mother)	0.3	0.4	3.7	-0.8	-0.4	-0.3	0.4	-0.3	-0.4	1.9	-0.1	0.2	-0.3	-0.3	-0.4
Pack years adult smoking proportion	0.3	0.5	1.8	1.0	0.5	-0.1	-1.4	-0.1	0.8	-0.2	0.7	-0.8	0.2	0.9	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	3.5	-0.7	-0.1	0.6	-1.4	0.6	0.5	0.3	-0.9	1.9	-0.5	-0.2	0.2
High blood pressure	0.3	0.7	1.7	-0.1	1.1	0.9	0.9	0.9	0.4	1.3	1.0	0.6	0.3	0.7	1.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.6	0.1	0.2	-0.3	0.8	-0.3	-0.4	1.3	0.6	-0.9	0.4	0.6	0.1
Medication: Levothyroxine sodium	0.3	0.6	2.4	0.4	0.1	-0.5	-0.6	-0.5	-0.6	-0.2	0.2	-1.5	0.1	1.6	0.8
Alcohol usually taken with meals	0.3	0.5	3.1	-0.0	0.3	0.3	1.8	0.3	0.4	-0.5	0.5	1.1	-0.8	-0.2	0.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.7	-0.0	0.3	0.7	0.5	0.8	0.3	-1.3	0.2	0.9	-0.3	-1.0	-0.2
Had menopause	0.3	0.4	1.6	-0.3	0.7	0.6	1.1	0.6	-0.2	0.7	-0.3	1.3	-0.3	0.2	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	5.3	-0.6	0.2	0.6	-0.5	0.7	0.4	0.2	-0.8	2.3	-0.8	0.1	0.5
Fluid intelligence score	0.3	0.6	2.0	-0.6	-1.1	-0.7	-0.2	-0.7	-1.4	-0.7	-0.5	-1.0	0.2	-0.5	-0.7
Neuroticism score	0.3	0.7	1.7	1.3	1.3	0.7	0.7	0.7	-0.2	0.2	1.0	-0.4	1.3	0.5	0.8
Impedance of arm (right)	0.3	1.5	4.3	2.1	1.4	1.4	1.1	1.5	0.6	0.4	0.2	2.0	0.8	0.1	0.9
Time employed in main current job	0.3	0.3	1.1	-0.3	-0.1	-0.3	-0.5	-0.3	-0.6	-0.1	-0.8	0.5	-1.1	-0.6	-0.5
Hair/balding pattern: Pattern 3	0.3	0.5	2.3	0.1	0.1	-0.8	0.1	-0.8	-1.5	0.2	-0.1	-0.3	-1.2	0.6	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	2.6	0.6	0.3	0.4	0.1	0.4	-0.8	-0.6	0.1	1.6	-0.4	-0.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	-0.4	0.3	0.8	0.2	0.8	0.7	-0.8	-0.0	-0.1	0.7	0.7	0.9
Pulse wave Arterial Stiffness index	0.3	0.4	1.2	-0.9	-0.7	-0.7	-0.4	-0.7	1.1	0.4	-0.1	-0.6	-0.6	0.0	-0.4
Hair/balding pattern: Pattern 4	0.3	0.8	3.8	1.9	0.8	0.4	1.4	0.4	0.6	-0.1	0.4	-0.0	1.3	0.3	0.5
Pulse wave reflection index	0.3	0.4	1.2	0.8	0.4	0.8	0.6	0.8	0.9	0.1	0.5	1.1	0.1	-0.1	0.4
High blood pressure (siblings)	0.3	0.4	1.1	-0.5	0.1	-0.1	0.6	-0.1	0.9	-0.9	-0.0	-1.1	0.8	-0.7	-0.5
Forced vital capacity (FVC), Best measure	0.3	0.9	3.0	-0.8	-0.7	-0.9	-1.6	-0.9	-1.7	-0.0	-0.8	-1.0	-0.4	-0.5	-0.8
Wheeze or whistling in the chest in last year	0.3	0.5	1.3	1.1	0.8	0.7	-1.2	0.7	0.6	-0.5	0.0	0.2	0.4	0.8	0.8
Number of children fathered	0.3	0.4	1.3	-0.1	0.5	0.7	0.2	0.6	0.6	-0.2	1.1	-0.3	0.9	0.6	0.7
Angina (self-reported)	0.3	0.4	2.0	-0.3	-0.6	-0.2	-1.4	-0.2	1.1	0.2	-0.5	0.1	-0.4	-0.7	-0.7
Medication: Allopurinol	0.3	0.4	1.1	0.4	0.8	0.6	0.2	0.6	0.7	-1.1	0.9	-0.1	1.0	-0.1	0.3
Mean time to correctly identify matches	0.3	0.6	2.3	-0.4	-0.5	0.1	1.5	0.1	1.5	-0.2	-1.4	-0.1	-0.1	-0.2	-0.1
Overall health rating	0.3	0.5	3.1	0.3	0.3	0.3	-0.9	0.3	1.8	0.5	-0.4	-0.7	0.9	-0.6	-0.2
Knee pain experienced in last month	0.3	0.5	2.6	1.6	1.2	0.6	-0.4	0.7	0.5	0.1	0.2	0.2	0.3	0.2	0.4
Loneliness, isolation	0.3	0.4	1.4	0.3	0.5	0.6	0.4	0.6	-0.7	1.2	0.8	0.7	-0.4	0.5	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	2.1	0.3	-0.2	-0.2	0.6	-0.2	1.4	-0.9	-0.3	-0.5	0.5	-0.4	-0.3
Medication: Blood pressure	0.3	0.5	2.7	-0.5	0.3	0.9	0.5	0.9	-0.3	-0.1	-0.4	1.6	0.1	-0.9	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.4	-1.2	-0.0	0.3	-0.3	0.3	-0.8	-0.2	-0.8	0.1	0.5	-0.6	-0.2
Irritability	0.3	0.6	2.3	-0.7	0.3	0.9	-0.4	0.9	0.9	1.0	0.3	-0.4	1.5	-0.1	0.3
Cholesterol lowering medication	0.3	0.4	1.8	-0.9	0.3	0.7	0.8	0.7	0.4	-0.0	0.7	-0.2	1.4	-0.5	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.9	0.4	0.1	0.2	-1.4	0.2	0.3	-0.8	-0.3	0.5	-0.4	-1.1	-0.6
Pain experienced in last month	0.3	0.4	1.4	-0.5	-0.3	-0.5	0.8	-0.5	0.2	-0.5	0.7	-1.1	0.6	1.2	0.4
Impedance of whole body	0.3	1.8	4.0	2.0	1.8	1.4	1.8	1.5	0.2	-0.3	0.8	1.7	1.2	0.6	1.2
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	-0.6	-0.6	-0.8	0.7	-0.8	-0.2	0.2	-0.6	-0.8	-0.7	1.1	0.3
Depressed Affect (Nagel 2018)	0.2	0.3	2.3	0.6	-0.0	-0.2	0.3	-0.2	-1.5	-0.0	-0.1	0.2	-0.6	-0.7	-0.6
Depression (Nagel 2018)	0.2	0.3	0.6	0.7	0.6	0.0	0.6	0.0	0.4	0.4	0.8	0.2	-0.2	0.8	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.4	-0.2	-0.6	-0.7	-0.6	-0.7	-1.6	0.2	0.2	-1.1	0.7	0.6	0.0
Neuroticism (Nagel 2018)	0.2	0.4	2.2	0.7	0.6	0.1	1.2	0.0	-1.5	-0.5	0.3	0.1	0.1	-0.1	-0.1
Irritable Bowel Disease (IBD)	0.2	0.5	1.3	1.1	0.3	-0.2	0.7	-0.2	1.1	-0.8	0.7	-1.0	0.8	0.7	0.4
Ovarian Cancer	0.2	0.2	0.9	0.4	-0.1	-0.3	-0.8	-0.3	-0.3	-1.0	-0.4	-0.1	-0.6	0.5	0.2
Prostate Cancer	0.2	0.3	1.1	0.6	0.2	-0.2	0.6	-0.2	0.1	-0.3	1.0	-0.6	0.4	0.9	0.5
Lupus	0.2	0.3	2.3	0.9	-0.2	0.0	-0.5	0.0	0.1	-1.5	0.0	0.5	-0.1	-0.6	-0.4
Neuroticism (2016)	0.2	0.4	1.6	1.0	0.8	0.5	-1.3	0.5	-0.1	0.2	-0.3	-0.2	0.0	-0.5	0.1
Schizophrenia (2014)	0.2	0.4	0.9	-0.2	-0.2	-0.5	0.9	-0.5	0.7	-0.4	-0.7	-0.7	-0.8	1.0	0.5
Systolic Blood Pressure	0.2	1.2	4.5	-0.5	-0.7	-1.1	0.3	-1.1	-1.1	2.1	-1.1	0.7	-1.3	-0.7	-1.1
Hypothyroidism (self reported)	0.2	0.5	1.3	0.6	0.7	0.1	-0.5	0.1	0.1	-0.2	0.9	-1.1	0.5	1.1	0.9
Neuroticism	0.2	0.5	1.7	0.6	0.9	-0.0	1.3	-0.0	-1.2	0.1	0.5	-0.2	0.3	0.9	0.6
Number of treatments/medications taken	0.2	0.3	1.2	0.1	-0.4	-0.5	-0.8	-0.4	1.1	-0.2	-0.9	-0.0	-0.6	-0.5	-0.5
Maternal smoking around birth	0.2	0.3	1.2	-0.2	0.1	0.6	-0.3	0.6	0.4	0.3	-0.3	1.1	-0.1	-1.1	-0.5
Fed-up feelings	0.2	0.4	1.5	1.0	0.8	0.5	0.3	0.5	0.4	1.2	0.6	0.3	0.3	0.2	0.4
Relative age voice broke	0.2	0.3	1.1	-1.0	-0.2	-0.4	0.7	-0.4	-0.2	-0.9	-0.1	-0.2	-0.8	0.6	0.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.6	0.0	-0.5	-0.7	-1.6	-0.7	0.0	-0.0	-0.1	-0.4	-0.8	0.9	0.2
Qualifications: None of the above	0.2	0.4	1.3	1.0	0.7	0.6	0.3	0.7	0.5	0.5	0.1	1.1	-0.2	-1.0	-0.3
Medication: Simvastatin	0.2	0.3	1.4	-1.2	-0.6	0.1	-0.1	0.1	0.0	-0.8	-0.6	0.2	0.0	-0.7	-0.5
Number of live births	0.2	0.3	1.0	0.4	1.0	0.5	-0.0	0.5	-0.4	0.0	0.8	0.3	0.8	-0.1	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	0.1	0.1	0.5	-0.7	0.5	-0.6	-0.2	0.8	0.0	0.6	1.1	1.0
Asthma	0.2	0.3	2.0	0.2	0.2	-0.2	-1.4	-0.2	-0.4	0.3	-0.1	-0.4	0.2	1.1	0.6
Medication: Lansoprazole	0.2	0.3	1.6	0.1	0.5	0.3	-1.3	0.3	-0.0	-0.5	0.3	0.1	-0.1	0.7	0.6
Headache pain in last month	0.2	0.3	1.2	1.1	1.0	0.5	-0.3	0.5	-0.3	0.2	0.4	1.0	-0.2	0.0	0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.7	-0.3	0.3	-0.2	-1.0	-0.2	-0.5	-0.2	0.7	-1.3	0.2	1.2	0.8
Medication: Amlodipine	0.2	0.2	1.0	-0.7	-0.5	0.1	-1.0	0.1	0.4	0.6	-0.6	0.2	0.1	-0.2	-0.1
Number of full brothers	0.2	0.2	0.9	-0.6	-0.1	0.0	-0.4	0.0	-0.9	0.4	-0.8	0.7	0.0	-0.4	-0.3
Worry too long after embarrassment	0.2	0.3	1.3	0.5	0.6	0.5	-0.2	0.5	-0.6	-0.6	0.7	0.1	0.5	-1.1	-0.5
Pulse wave peak to peak time	0.2	0.2	1.5	0.5	0.4	0.5	-0.0	0.5	-1.2	-0.1	0.0	0.3	0.5	0.1	0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	2.4	-0.4	0.1	0.3	0.4	0.3	1.5	0.4	-0.2	-0.1	-0.1	0.4	0.4
Medication for pain relief, constipation, heartburn	0.2	0.3	1.3	0.3	0.6	0.8	0.2	0.8	-0.4	0.0	0.4	1.1	0.4	-0.0	0.4
Medication: Blood pressure	0.2	0.4	1.4	0.5	0.5	0.3	0.1	0.3	1.2	1.0	-0.1	0.8	-0.5	0.5	0.5
Medication: Ibuprofen	0.2	0.2	0.9	-1.0	0.0	0.4	-0.2	0.3	0.6	-0.4	-0.6	-0.2	0.1	0.5	0.5
Comparative height size at age 10	0.2	1.4	4.8	-1.3	-1.1	-0.3	-2.2	-0.3	0.2	1.3	-1.6	-0.1	-0.6	-1.6	-1.2
Supplements: Vitamin C	0.2	0.3	0.9	-0.9	-0.7	-0.5	-0.5	-0.5	-0.2	-0.3	-0.3	-0.4	-0.9	0.0	-0.2
Back pain experienced in last month	0.2	0.4	1.1	-0.3	0.5	1.1	-0.3	1.1	0.6	-0.2	0.2	0.9	0.5	-0.4	0.3
Asthma (self-reported)	0.2	0.5	3.1	0.0	-0.3	-0.6	-1.7	-0.6	-0.7	0.1	-0.4	-0.5	-0.4	0.8	0.2
Osteoporosis (self-reported)	0.2	0.2	1.0	0.3	-0.3	0.2	-0.5	0.2	0.2	1.0	0.2	0.1	-0.1	-1.0	-0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.3	1.1	0.2	-0.2	0.4	-0.2	0.3	-0.6	-0.2	0.7	-0.8	-0.5	-0.4
Ever smoked	0.2	0.4	1.4	-0.1	-0.4	-0.5	0.9	-0.5	0.4	-0.3	-0.0	-1.2	0.8	-0.7	-0.8
Average weekly beer plus cider intake	0.2	0.3	1.2	-0.1	0.5	0.9	1.1	0.9	0.1	-0.1	0.8	0.2	0.1	0.0	0.5
Heart disease (siblings)	0.2	0.2	1.9	-0.2	-0.1	0.2	0.2	0.2	0.4	1.4	-0.8	0.3	0.1	-0.1	0.0
Bipolar Disorder (2018)	0.1	0.1	0.4	0.1	-0.1	-0.2	0.5	-0.2	-0.6	0.5	0.1	0.2	-0.3	0.4	0.1
Alzheimer’s Disease (in mother)	0.1	0.2	0.9	-0.3	0.0	-0.1	1.0	-0.1	0.0	0.5	-0.1	0.4	0.4	0.6	0.3
Primary Biliary Cirrhosis	0.1	0.1	0.3	0.3	0.2	0.1	-0.5	0.1	-0.1	-0.5	-0.0	0.3	-0.4	0.4	0.3
Triglycerides	0.1	0.2	0.8	0.4	0.1	0.2	-0.6	0.2	0.5	-0.8	0.3	0.9	-0.2	0.4	0.3
Blood Red Count	0.1	0.8	2.8	-0.9	0.9	1.0	0.5	1.0	-0.8	1.7	0.8	0.5	0.0	0.5	0.9
Blood White Count	0.1	0.7	4.3	0.3	0.5	1.1	0.0	1.1	0.1	-0.0	-0.1	2.1	0.1	-1.1	-0.2
Heel T-Score	0.1	0.9	2.8	0.2	0.8	0.6	0.9	0.6	1.2	1.7	0.5	1.0	0.1	1.3	1.2
Lung FEV1/FVC ratio	0.1	0.3	1.0	-1.0	0.4	0.4	-0.8	0.4	-0.1	0.2	-0.3	-0.5	0.4	0.9	0.8
Lung FVC	0.1	0.5	1.5	0.8	0.7	0.7	0.1	0.7	-0.8	0.2	0.2	1.0	0.2	-1.2	-0.4
Hair Pigment	0.1	1.8	9.8	-1.4	-1.2	-1.2	-3.1	-1.2	0.7	-0.5	-1.1	-1.8	0.1	0.7	-0.2
Qualifications: CSEs or equivalent	0.1	0.2	1.5	-0.4	-0.1	0.2	-1.2	0.2	0.1	0.0	-0.6	0.3	0.3	-0.3	-0.1
Allergy	0.1	0.3	1.3	-0.2	-0.0	0.4	1.1	0.4	-0.3	0.4	-0.4	0.4	0.3	-1.1	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.8	-0.5	0.0	-0.2	-1.2	-0.2	-1.3	0.4	-0.3	-0.3	-0.3	-0.1	-0.2
Impedance of arm (left)	0.1	0.5	1.6	0.8	0.8	0.7	1.3	0.7	0.1	0.8	0.0	1.2	0.4	0.4	0.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	0.3	0.1	-0.2	0.2	-0.2	-0.8	-0.3	0.5	-0.6	0.6	-0.1	-0.2
Comparative body size at age 10	0.1	0.3	1.8	-0.4	-0.2	0.2	-1.4	0.2	0.1	-0.8	0.3	0.3	-0.2	-0.6	-0.3
Qualifications: College or University degree	0.1	0.2	1.0	-0.4	-0.3	0.1	0.3	0.1	-0.3	-0.2	-0.6	1.0	-0.6	0.5	0.4
Family relationship satisfaction	0.1	0.1	0.5	0.4	-0.1	0.0	-0.3	0.0	0.1	0.6	0.0	-0.0	-0.0	-0.7	-0.5
Hypertension (Self-reported)	0.1	0.2	0.9	-0.7	0.5	0.3	0.2	0.3	-0.3	0.9	-0.0	0.3	-0.3	0.2	0.3
Mood swings	0.1	0.2	0.9	-0.0	0.4	0.5	-0.2	0.5	-0.4	-0.5	-0.2	0.4	0.1	-0.9	-0.4
Friendships satisfaction	0.1	0.2	0.7	-0.6	0.1	0.5	0.5	0.5	0.3	0.9	0.2	0.1	0.3	0.0	0.3
Medication for cholesterol	0.1	0.2	0.9	0.1	-0.5	-0.4	-0.9	-0.4	0.4	0.1	-0.2	-0.5	-0.5	0.2	-0.1
Risk taking	0.1	0.2	0.6	0.8	-0.1	0.1	-0.1	0.1	-0.6	-0.8	-0.3	0.1	0.3	-0.6	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.5	0.1	-0.6	-0.5	-0.5	-0.5	-0.8	-1.2	-0.3	-0.6	0.1	-0.3	-0.5
HDL Cholesterol	0.0	0.1	0.3	-0.6	-0.3	-0.2	0.1	-0.2	-0.0	-0.3	-0.5	-0.1	0.0	0.0	-0.1
Blood Platelet Count	0.0	0.4	1.3	0.6	0.2	0.0	-1.1	0.0	0.1	-0.4	0.3	0.5	-0.7	-1.2	-0.8
Waist Hip Ratio (WHR)	0.0	0.1	0.4	0.5	0.3	-0.2	-0.5	-0.2	-0.4	0.5	-0.3	0.1	0.2	0.7	0.4

Hub : Genes

PIGK

Models

Trait associations