Best TWAS P=1.64e-16 · Best GWAS P=1.32e-18 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SHISA4 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.5e-03 | -5.6 | -6.0 | 1.7e-09 | -0.56 | 0.20 | 0.33 | FALSE |
| 2 | GTEx | Esophagus Muscularis | LMOD1 | 0.16 | 0.09 | enet | 9 | 0.08 | 7.8e-06 | 8.7 | -8.2 | 1.6e-16 | -0.98 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Esophagus Muscularis | RP11-307B6.3 | 0.20 | 0.12 | lasso | 3 | 0.12 | 5.6e-08 | 8.7 | -8.1 | 5.2e-16 | -0.97 | 0.01 | 0.99 | FALSE |
| 4 | METSIM | Adipose | LMOD1 | 0.09 | 0.07 | bslmm | 496 | 0.07 | 4.8e-10 | 8.7 | -8.0 | 1.5e-15 | -0.97 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LMOD1 | 0.02 | 0.01 | blup | 59 | 0.02 | 1.2e-04 | 8.6 | -5.8 | 5.3e-09 | -0.85 | 0.01 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LMOD1 | 0.07 | 0.06 | blup | 59 | 0.03 | 2.1e-02 | 8.7 | -8.2 | 1.8e-16 | -0.90 | 0.01 | 0.87 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMOD1 | 0.04 | 0.07 | enet | 6 | 0.05 | 9.4e-07 | -6.0 | -7.2 | 7.5e-13 | -0.74 | 0.24 | 0.76 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | LMOD1 | 0.04 | 0.01 | blup | 59 | 0.01 | 5.7e-02 | 8.6 | -7.7 | 1.2e-14 | -0.84 | 0.01 | 0.82 | FALSE |